{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:08:27Z","timestamp":1761581307473},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Joint Funds of NSFC-Guangdong of China","award":["U1201215"],"award-info":[{"award-number":["U1201215"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["41176150"],"award-info":[{"award-number":["41176150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program of the Pearl River Young Talents of Science and Technology in Guangzhou of China","award":["2013J2200095"],"award-info":[{"award-number":["2013J2200095"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.fsi.2015.04.034","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T07:24:05Z","timestamp":1431156245000},"page":"510-516","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Expression and function analysis of two naturally truncated MyD88 variants in the Pacific oyster Crassostrea gigas"],"prefix":"10.1016","volume":"45","author":[{"given":"Fengjiao","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuehuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiming","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziniu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2015.04.034_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrg2303","article-title":"Toll-like receptors\u2014taking an evolutionary approach","volume":"9","author":"Leulier","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.fsi.2015.04.034_bib2","doi-asserted-by":"crossref","first-page":"25404","DOI":"10.1074\/jbc.M109.022392","article-title":"An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4","volume":"284","author":"Motshwene","year":"2009","journal-title":"J\u00a0Biological Chem"},{"key":"10.1016\/j.fsi.2015.04.034_bib3","doi-asserted-by":"crossref","first-page":"e71120","DOI":"10.1371\/journal.pone.0071120","article-title":"Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes","volume":"8","author":"Dimicoli","year":"2013","journal-title":"PloS one"},{"key":"10.1016\/j.fsi.2015.04.034_bib4","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0968-0004(02)02145-X","article-title":"A\u00a0universal role for MyD88 in TLR\/IL-1R-mediated signaling","volume":"27","author":"Janssens","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.fsi.2015.04.034_bib5","doi-asserted-by":"crossref","first-page":"12203","DOI":"10.1074\/jbc.273.20.12203","article-title":"MyD88, an adapter protein involved in interleukin-1 signaling","volume":"273","author":"Burns","year":"1998","journal-title":"J\u00a0Biological Chem"},{"key":"10.1016\/j.fsi.2015.04.034_bib6","doi-asserted-by":"crossref","first-page":"e76464","DOI":"10.1371\/journal.pone.0076464","article-title":"Characteristic and functional analysis of toll-like receptors (TLRs) in the lophotrocozoan, Crassostrea gigas, reveals ancient origin of TLR-mediated innate immunity","volume":"8","author":"Zhang","year":"2013","journal-title":"PloS one"},{"key":"10.1016\/j.fsi.2015.04.034_bib7","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.1230612","article-title":"The evolutionary landscape of alternative splicing in vertebrate species","volume":"338","author":"Barbosa-Morais","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.fsi.2015.04.034_bib8","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.fsi.2015.04.034_bib9","doi-asserted-by":"crossref","first-page":"e18772","DOI":"10.1371\/journal.pone.0018772","article-title":"Cell-type specific expression of a dominant negative PKA mutation in mice","volume":"6","author":"Willis","year":"2011","journal-title":"PloS one"},{"key":"10.1016\/j.fsi.2015.04.034_bib10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0960-9822(02)00712-1","article-title":"Regulation of interleukin-1-and lipopolysaccharide-induced NF-\u03baB activation by alternative splicing of MyD88","volume":"12","author":"Janssens","year":"2002","journal-title":"Curr Biol"},{"key":"10.1016\/j.fsi.2015.04.034_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2105-4-29","article-title":"MatGAT: an application that generates similarity\/identity matrices using protein or DNA sequences","volume":"4","author":"Campanella","year":"2003","journal-title":"BMC Bioinforma"},{"key":"10.1016\/j.fsi.2015.04.034_bib12","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"methods"},{"key":"10.1016\/j.fsi.2015.04.034_bib13","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.fsi.2011.03.008","article-title":"Two homologues of inhibitor of NF-kappa B (I\u03baB) are involved in the immune defense of the Pacific oyster, Crassostrea gigas","volume":"30","author":"Zhang","year":"2011","journal-title":"Fish shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.04.034_bib14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/bbrc.1994.1206","article-title":"Macrophage differentiation marker MyD88 is a member of the Toll\/IL-1 receptor family","volume":"199","author":"Hultmark","year":"1994","journal-title":"Biochem biophysical Res Commun"},{"key":"10.1016\/j.fsi.2015.04.034_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0925-4773(00)00447-0","article-title":"The Toll\/IL-1 receptor binding protein MyD88 is required for Xenopus axis formation","volume":"97","author":"Prothmann","year":"2000","journal-title":"Mech Dev"},{"key":"10.1016\/j.fsi.2015.04.034_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.dci.2005.11.003","article-title":"Identification and characterization of a myeloid differentiation factor 88 (MyD88) cDNA and gene in Japanese flounder, Paralichthys olivaceus","volume":"30","author":"Takano","year":"2006","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.fsi.2015.04.034_bib17","doi-asserted-by":"crossref","first-page":"12654","DOI":"10.1073\/pnas.231471798","article-title":"Drosophila MyD88 is an adapter in the Toll signaling pathway","volume":"98","author":"Horng","year":"2001","journal-title":"Proc Natl Acad Sci U. S. A"},{"key":"10.1016\/j.fsi.2015.04.034_bib18","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.fsi.2006.05.003","article-title":"Molecular cloning and expression of a Toll receptor gene homologue from Zhikong Scallop, Chlamys farreri","volume":"22","author":"Qiu","year":"2007","journal-title":"Fish shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.04.034_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1074-7613(00)80402-1","article-title":"MyD88: an adapter that recruits IRAK to the IL-1 receptor complex","volume":"7","author":"Wesche","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2015.04.034_bib20","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/nar\/30.5.1083","article-title":"A\u00a0question of size: the eukaryotic proteome and the problems in defining it","volume":"30","author":"Harrison","year":"2002","journal-title":"Nucleic acids Res"},{"key":"10.1016\/j.fsi.2015.04.034_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/ng0102-13","article-title":"A\u00a0genomic view of alternative splicing","volume":"30","author":"Modrek","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.fsi.2015.04.034_bib22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1101\/gr.3266405","article-title":"Complex genomic rearrangements lead to novel primate gene function","volume":"15","author":"Ciccarelli","year":"2005","journal-title":"Genome Res"},{"key":"10.1016\/j.fsi.2015.04.034_bib23","first-page":"735","article-title":"Gene duplication and the evolution of proteins","volume":"14","author":"Urbain","year":"1969","journal-title":"Revue francaise d'etudes cliniques biologiques"},{"key":"10.1016\/j.fsi.2015.04.034_bib24","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/genetics\/147.3.1259","article-title":"Comparable rates of gene loss and functional divergence after genome duplications early in vertebrate evolution","volume":"147","author":"Nadeau","year":"1997","journal-title":"Genetics"},{"key":"10.1016\/j.fsi.2015.04.034_bib25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/35057039","article-title":"Evolutionary analyses of the human genome","volume":"409","author":"Li","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2015.04.034_bib26","doi-asserted-by":"crossref","first-page":"15661","DOI":"10.1073\/pnas.2536672100","article-title":"Organismal complexity, protein complexity, and gene duplicability","volume":"100","author":"Yang","year":"2003","journal-title":"Proc Natl Acad Sci U. S. A"},{"key":"10.1016\/j.fsi.2015.04.034_bib27","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.1007\/s00018-014-1688-y","article-title":"Differential evolution of signal-responsive RNA elements and upstream factors that control alternative splicing. Cellular and molecular life sciences","volume":"71","author":"Xie","year":"2014","journal-title":"CMLS"},{"key":"10.1016\/j.fsi.2015.04.034_bib28","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1203\/00006450-199306000-00003","article-title":"Mucosal immune response in a case of sudden infant death syndrome","volume":"33","author":"Gleeson","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1016\/j.fsi.2015.04.034_bib29","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature09121","article-title":"Helical assembly in the MyD88\u2013IRAK4\u2013IRAK2 complex in TLR\/IL-1R signalling","volume":"465","author":"Lin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2015.04.034_bib30","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.fsi.2007.01.012","article-title":"Identification and characterization of a myeloid differentiation factor 88 (MyD88) cDNA from Zhikong scallop Chlamys farreri","volume":"23","author":"Qiu","year":"2007","journal-title":"Fish shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.04.034_bib31","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.fsi.2011.08.003","article-title":"Characterization of a novel molluscan MyD88 family protein from manila clam, Ruditapes philippinarum","volume":"31","author":"Lee","year":"2011","journal-title":"Fish shellfish Immunol"},{"key":"10.1016\/j.fsi.2015.04.034_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1378\/chest.99.1.169","article-title":"Endotoxemia in human septic shock","volume":"99","author":"Danner","year":"1991","journal-title":"CHEST J"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815001965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815001965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T18:41:07Z","timestamp":1651948867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464815001965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S1050464815001965"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2015.04.034","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression and function analysis of two naturally truncated MyD88 variants in the Pacific oyster Crassostrea gigas","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2015.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}