{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T07:41:38Z","timestamp":1768549298774,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National High Technology Development Program of China","award":["2014AA093507"],"award-info":[{"award-number":["2014AA093507"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31202022"],"award-info":[{"award-number":["31202022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31461163007"],"award-info":[{"award-number":["31461163007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31572643"],"award-info":[{"award-number":["31572643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology and industrial development Marine fishery Project of Guangdong Province, China","award":["A201501C01"],"award-info":[{"award-number":["A201501C01"]}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB114402"],"award-info":[{"award-number":["2012CB114402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Knowledge Innovation Program of the Chinese Academy of Sciences","award":["SQ201203"],"award-info":[{"award-number":["SQ201203"]}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"crossref","award":["2015285"],"award-info":[{"award-number":["2015285"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Planning Project of Guangdong Province, China","award":["2014B030301064"],"award-info":[{"award-number":["2014B030301064"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["2014J4100213"],"award-info":[{"award-number":["2014J4100213"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.fsi.2015.10.008","type":"journal-article","created":{"date-parts":[[2015,10,25]],"date-time":"2015-10-25T07:53:04Z","timestamp":1445759584000},"page":"807-816","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Function analysis of fish Tollip gene in response to virus infection"],"prefix":"10.1016","volume":"47","author":[{"given":"Jingguang","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shina","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2015.10.008_bib1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.dci.2013.02.011","article-title":"Litopenaeus vannamei toll-interacting protein (LvTollip) is a potential negative regulator of the shrimp Toll pathway involved in the regulation of the shrimp antimicrobial peptide gene penaeidin-4 (PEN4)","volume":"40","author":"Wang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib2","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35014038","article-title":"Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor","volume":"2","author":"Burns","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.fsi.2015.10.008_bib3","doi-asserted-by":"crossref","first-page":"7059","DOI":"10.1074\/jbc.M109537200","article-title":"Negative regulation of toll-like receptor-mediated signaling by Tollip","volume":"277","author":"Zhang","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2015.10.008_bib4","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/j.cub.2006.09.062","article-title":"Intracellular trafficking of interleukin-1 receptor I requires Tollip","volume":"16","author":"Brissoni","year":"2006","journal-title":"Curr. Biol. CB"},{"key":"10.1016\/j.fsi.2015.10.008_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.micinf.2011.08.018","article-title":"Tollip: a multitasking protein in innate immunity and protein trafficking","volume":"14","author":"Capelluto","year":"2012","journal-title":"Microbes Infection\/Institut Pasteur"},{"key":"10.1016\/j.fsi.2015.10.008_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004404","article-title":"Tollip is a mediator of protein sumoylation","volume":"4","author":"Ciarrocchi","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2015.10.008_bib7","doi-asserted-by":"crossref","first-page":"25780","DOI":"10.1074\/jbc.M113.484170","article-title":"Ubiquitin interacts with the Tollip C2 and CUE domains and inhibits binding of Tollip to phosphoinositides","volume":"288","author":"Mitra","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2015.10.008_bib8","doi-asserted-by":"crossref","first-page":"39653","DOI":"10.1074\/jbc.M112.388009","article-title":"Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-beta signaling pathway","volume":"287","author":"Zhu","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2015.10.008_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.molimm.2004.03.009","article-title":"Characterization of Tollip protein upon Lipopolysaccharide challenge","volume":"41","author":"Li","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fsi.2008.04.002","article-title":"Tollip, a negative regulator of TLR-signalling, is encoded by twin genes in salmonid fish","volume":"25","author":"Rebl","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3354\/dao053001","article-title":"Characterization of a novel ranavirus isolated from grouper Epinephelus tauvina","volume":"53","author":"Qin","year":"2003","journal-title":"Dis. Aquatic Org."},{"key":"10.1016\/j.fsi.2015.10.008_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0166-0934(02)00139-8","article-title":"Antigenic characterization of a marine fish iridovirus from grouper, Epinephelus spp","volume":"106","author":"Qin","year":"2002","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.fsi.2015.10.008_bib13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","article-title":"Innate immunity of fish (overview)","volume":"20","author":"Magnadottir","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib14","first-page":"77","article-title":"Conservation of toll-like receptor signaling pathways in Teleost Fish. Comparative biochemistry and physiology part D","volume":"1","author":"Purcell","year":"2006","journal-title":"Genom. Proteom."},{"key":"10.1016\/j.fsi.2015.10.008_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.vetimm.2011.02.016","article-title":"Cloning and expression of toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides","volume":"141","author":"Wei","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2015.10.008_bib16","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.fsi.2011.04.012","article-title":"Orange-spotted grouper (Epinephelus coioides) TLR2, MyD88 and IL-1 beta involved in anti-Cryptocaryon irritans response","volume":"30","author":"Li","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1095-8649.2010.02676.x","article-title":"Differential profiles of gene expression in grouper Epinephelus coioides, infected with Singapore grouper iridovirus, revealed by suppression subtractive hybridization and DNA microarray","volume":"77","author":"Xu","year":"2010","journal-title":"J.\u00a0Fish Biol."},{"key":"10.1016\/j.fsi.2015.10.008_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.fsi.2011.11.021","article-title":"Molecular cloning of orange-spotted grouper (Epinephelus coioides) TLR21 and expression analysis post Cryptocaryon irritans infection","volume":"32","author":"Li","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib19","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.fsi.2012.05.034","article-title":"Orange-spotted grouper (Epinephelus coioides) toll-like receptor 22: molecular characterization, expression pattern and pertinent signaling pathways","volume":"33","author":"Ding","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib20","first-page":"288","article-title":"Cloning and expression of MyD88 gene in orange-spotted grouper Epinephelus coioides","volume":"30","author":"Wei","year":"2011","journal-title":"Jiyinzuxue Yu Yingyong Shengwuxue"},{"key":"10.1016\/j.fsi.2015.10.008_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fsi.2014.10.041","article-title":"Grouper (Epinephelus coioides) MyD88 and tollip: intracellular localization and signal transduction function","volume":"42","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aquaculture.2010.11.037","article-title":"Establishment of a cell line from the brain of grouper (Epinephelus akaara) for cytotoxicity testing and virus pathogenesis","volume":"311","author":"Huang","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2015.10.008_bib23","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.fsi.2012.08.001","article-title":"Grouper translationally controlled tumor protein prevents cell death and inhibits the replication of Singapore grouper iridovirus (SGIV)","volume":"33","author":"Wei","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.fsi.2014.04.022","article-title":"Isolation and characterization of tumor necrosis factor receptor-associated factor 6 (TRAF6) from grouper, Epinephelus tauvina","volume":"39","author":"Wei","year":"2014","journal-title":"Fish shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib25","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.dci.2011.01.021","article-title":"Identification and functional characterization of an interferon regulatory factor 7-like (IRF7-like) gene from orange-spotted grouper, Epinephelus coioides","volume":"35","author":"Cui","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.fsi.2014.11.025","article-title":"Identification of orange-spotted grouper (Epinephelus coioides) interferon regulatory factor 3 involved in antiviral immune response against fish RNA virus","volume":"42","author":"Huang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib27","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1007\/s11434-012-5126-y","article-title":"Functional genomic studies on an immune- and antiviral-related gene of MyD88 in orange-spotted grouper, Epinephelus coioides","volume":"57","author":"Yan","year":"2012","journal-title":"Chin. Sci. Bull."},{"key":"10.1016\/j.fsi.2015.10.008_bib28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nri1630","article-title":"Negative regulation of toll-like receptor-mediated immune responses","volume":"5","author":"Liew","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib29","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/emboj.2011.4","article-title":"Drosophila Ras\/MAPK signalling regulates innate immune responses in immune and intestinal stem cells","volume":"30","author":"Ragab","year":"2011","journal-title":"Embo J."},{"key":"10.1016\/j.fsi.2015.10.008_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2006-7-2-r10","article-title":"Alternate transcription of the toll-like receptor signaling cascade","volume":"7","author":"Wells","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.fsi.2015.10.008_bib31","doi-asserted-by":"crossref","first-page":"52865","DOI":"10.1074\/jbc.M306740200","article-title":"Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin","volume":"278","author":"Yamakami","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2015.10.008_bib32","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/emboj\/cdg140","article-title":"A\u00a0ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain","volume":"22","author":"Shih","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2015.10.008_bib33","doi-asserted-by":"crossref","first-page":"24435","DOI":"10.1074\/jbc.M400059200","article-title":"Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes","volume":"279","author":"Katoh","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2015.10.008_bib34","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.fsi.2012.05.025","article-title":"Identification, characterization and the interaction of Tollip and IRAK-1 in grass carp (Ctenopharyngodon idellus)","volume":"33","author":"Huang","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/fsim.1998.0181","article-title":"The morphology of the immune system in teleost fishes","volume":"9","author":"Press","year":"1999","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2015.10.008_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/4de7ddfd-52df-4f87-8ca4-d48afe646ca8","article-title":"IRF-3, IRF-5, and IRF-7 coordinately regulate the Type I IFN response in myeloid dendritic cells downstream of MAVS signaling","volume":"9","author":"Lazear","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2015.10.008_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0014-5793(96)01506-2","article-title":"The cloning and characterization of human MyD88: a member of an IL-1 receptor related family","volume":"402","author":"Bonnert","year":"1997","journal-title":"FEBS Lett."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815301856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464815301856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T01:09:58Z","timestamp":1589591398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464815301856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S1050464815301856"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2015.10.008","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Function analysis of fish Tollip gene in response to virus infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2015.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}