{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:27:11Z","timestamp":1767918431459,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31272662"],"award-info":[{"award-number":["31272662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31302214"],"award-info":[{"award-number":["31302214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology","award":["2011BAD13B01"],"award-info":[{"award-number":["2011BAD13B01"]}]},{"DOI":"10.13039\/501100011223","name":"State Key Laboratory of Freshwater Ecology and Biotechnology","doi-asserted-by":"crossref","award":["2014FB02"],"award-info":[{"award-number":["2014FB02"]}],"id":[{"id":"10.13039\/501100011223","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008682","name":"Shanghai Ocean University","doi-asserted-by":"crossref","award":["A-0209-13-0105392"],"award-info":[{"award-number":["A-0209-13-0105392"]}],"id":[{"id":"10.13039\/501100008682","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.fsi.2016.01.038","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T04:24:55Z","timestamp":1454387095000},"page":"191-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in\u00a0vitro"],"prefix":"10.1016","volume":"50","author":[{"given":"Lang","family":"Gui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2016.01.038_bib1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.fsi.2009.11.020","article-title":"Antimicrobial peptides (AMP) with antiviral activity against fish nodavirus","volume":"28","author":"Chia","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.gene.2008.02.016","article-title":"Molecular evolution and characterization of hepcidin gene products in vertebrates","volume":"415","author":"Hilton","year":"2008","journal-title":"Gene"},{"key":"10.1016\/j.fsi.2016.01.038_bib3","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1074\/jbc.M008922200","article-title":"Hepcidin, a urinary antimicrobial peptide synthesized in the liver","volume":"276","author":"Park","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2016.01.038_bib4","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.fsi.2016.01.038_bib5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.peptides.2010.11.005","article-title":"Applications of antimicrobial peptides from fish and perspectives for the future","volume":"32","author":"Rajanbabu","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2016.01.038_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.fsi.2009.10.001","article-title":"Inactivation of nervous necrosis virus infecting grouper (Epinephelus coioides) by epinecidin-1 and hepcidin 1\u20135 antimicrobial peptides, and downregulation of Mx2 and Mx3 gene expressions","volume":"28","author":"Wang","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib7","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.peptides.2010.02.025","article-title":"Antiviral activity by fish antimicrobial peptides of epinecidin-1 and hepcidin 1\u20135 against nervous necrosis virus in medaka","volume":"31","author":"Wang","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2016.01.038_bib8","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.peptides.2010.11.003","article-title":"Tilapia (Oreochromis mossambicus) antimicrobial peptide, hepcidin 1\u20135, shows antitumor activity in cancer cells","volume":"32","author":"Chang","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2016.01.038_bib9","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1016\/j.biomaterials.2011.05.053","article-title":"Modulation of the immune-related gene responses to protect mice against Japanese encephalitis virus using the antimicrobial peptide, tilapia hepcidin 1-5","volume":"32","author":"Huang","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.fsi.2016.01.038_bib10","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.molimm.2006.09.031","article-title":"Three different hepcidins from tilapia, Oreochromis mossambicus: analysis of their expressions and biological functions","volume":"44","author":"Huang","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib11","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.peptides.2009.06.009","article-title":"A\u00a0fish antimicrobial peptide, tilapia hepcidin TH2-3, shows potent antitumor activity against human fibrosarcoma cells","volume":"30","author":"Chen","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2016.01.038_bib12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.fsi.2010.05.001","article-title":"Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species","volume":"29","author":"Hsieh","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.fsi.2014.03.011","article-title":"Turbot (Scophthalmus maximus) hepcidin-1 and hepcidin-2 possess antimicrobial activity and promote resistance against bacterial and viral infection","volume":"38","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.fsi.2012.11.049","article-title":"Iron-metabolic function and potential antibacterial role of Hepcidin and its correlated genes (Ferroportin 1 and Transferrin Receptor) in Turbot (Scophthalmus maximus)","volume":"34","author":"Yang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cbpb.2010.11.003","article-title":"Molecular characterization of hepcidin AS-hepc2 and AS-hepc6 in black porgy (Acanthopagrus schlegelii): expression pattern responded to bacterial challenge and in\u00a0vitro antimicrobial activity","volume":"158","author":"Yang","year":"2011","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2016.01.038_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cbpb.2011.10.006","article-title":"Recombinant medaka (Oryzias melastigmus) pro-hepcidin: multifunctional characterization","volume":"161","author":"Cai","year":"2012","journal-title":"Comp. Biochem. Physiol. Part B Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2016.01.038_bib17","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.fsi.2010.11.021","article-title":"Molecular cloning and characterization of two novel hepcidins from orange-spotted grouper, Epinephelus coioides","volume":"30","author":"Zhou","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejbt.2015.03.003","article-title":"Molecular cloning and antibacterial activity of hepcidin from Chinese rare minnow (Gobiocypris rarus)","volume":"18","author":"Ke","year":"2015","journal-title":"Electron. J. Biotechnol."},{"key":"10.1016\/j.fsi.2016.01.038_bib19","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.molimm.2007.11.007","article-title":"The antimicrobial peptide hepcidin exerts an important role in the innate immunity against bacteria in the bony fish gilthead seabream","volume":"45","author":"Cuesta","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fsi.2014.04.013","article-title":"Antimicrobial activity of trout hepcidin","volume":"41","author":"\u00c1lvarez","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib21","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.fsi.2009.03.014","article-title":"Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea","volume":"26","author":"Zhang","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.peptides.2014.04.014","article-title":"Characterization and bioactivity of hepcidin-2 in zebrafish: dependence of antibacterial activity upon disulfide bridges","volume":"57","author":"Lin","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2016.01.038_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pep.2013.11.001","article-title":"Expression, purification and antibacterial activity of the channel catfish hepcidin mature peptide","volume":"94","author":"Tao","year":"2014","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.fsi.2016.01.038_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pep.2008.05.012","article-title":"Expression, purification and structural characterization of recombinant hepcidin, an antimicrobial peptide identified in Japanese flounder, Paralichthys olivaceus","volume":"61","author":"Srinivasulu","year":"2008","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.fsi.2016.01.038_bib25","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.fsi.2012.04.011","article-title":"Identification and characterization of a hepcidin from half-smooth tongue sole Cynoglossus semilaevis","volume":"33","author":"Wang","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib26","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.dci.2006.02.005","article-title":"Dual function of fish hepcidin: response to experimental iron overload and bacterial infection in sea bass (Dicentrarchus labrax)","volume":"30","author":"Rodrigues","year":"2006","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.fsi.2010.09.005","article-title":"Antiviral function of tilapia hepcidin 1\u20135 and its modulation of immune-related gene expressions against infectious pancreatic necrosis virus (IPNV) in Chinook salmon embryo (CHSE)-214 cells","volume":"30","author":"Rajanbabu","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetmic.2011.12.025","article-title":"The antiviral defense mechanisms in mandarin fish induced by DNA vaccination against a rhabdovirus","volume":"157","author":"Chen","year":"2012","journal-title":"Veterinary Microbiol."},{"key":"10.1016\/j.fsi.2016.01.038_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2006.09.030","article-title":"Isolation and characterization of a rhabdovirus from co-infection of two viruses in mandarin fish","volume":"262","author":"Tao","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.01.038_bib30","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.3390\/v7082820","article-title":"Whole-genome analysis of a novel fish reovirus (MsReV) discloses aquareovirus genomic structure relationship with host in saline environments","volume":"7","author":"Chen","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2016.01.038_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cbpb.2014.05.002","article-title":"Identification of fxyd genes from the spotted scat (Scatophagus argus): molecular cloning, tissue-specific expression, and response to acute hyposaline stress","volume":"174","author":"Hu","year":"2014","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2016.01.038_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ygcen.2014.09.017","article-title":"Comparative renal gene expression in response to abrupt hypoosmotic shock in spotted scat (Scatophagus argus)","volume":"215","author":"Mu","year":"2015","journal-title":"General Comp. Endocrinol."},{"key":"10.1016\/j.fsi.2016.01.038_bib33","doi-asserted-by":"crossref","first-page":"14893","DOI":"10.1016\/S0021-9258(18)82417-6","article-title":"A\u00a0novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution","volume":"268","author":"Bulet","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2016.01.038_bib34","first-page":"7","article-title":"Detection of grass carp hemorrhage virus (GCHV) from Vietnam and comparison with GCHV strain from China","volume":"9","author":"Zhang","year":"2003","journal-title":"High. Technol. Lett."},{"key":"10.1016\/j.fsi.2016.01.038_bib35","series-title":"Virology Methods Manual","first-page":"293","article-title":"14-Initial in\u00a0vitro screening of drug candidates for their potential antiviral activities","author":"Al-Jabri","year":"1996"},{"key":"10.1016\/j.fsi.2016.01.038_bib36","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.fsi.2009.03.023","article-title":"Identification of centrarchid hepcidins and evidence that 17\u03b2-estradiol disrupts constitutive expression of hepcidin-1 and inducible expression of hepcidin-2 in largemouth bass (Micropterus salmoides)","volume":"26","author":"Robertson","year":"2009","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.dci.2012.04.001","article-title":"Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts","volume":"39","author":"Zhu","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib38","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1111\/j.1742-4658.2005.04922.x","article-title":"Two different types of hepcidins from the Japanese flounder Paralichthys olivaceus","volume":"272","author":"Hirono","year":"2005","journal-title":"FEBS J."},{"issue":"Suppl.\u00a03","key":"10.1016\/j.fsi.2016.01.038_bib39","doi-asserted-by":"crossref","first-page":"S423","DOI":"10.1016\/j.bone.2010.09.245","article-title":"Effect of hepcidin on proliferation and gene expression in mice osteoblast-like cells","volume":"47","author":"Ma","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.fsi.2016.01.038_bib40","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0769-2617(83)80060-4","article-title":"Some properties of the Epithelioma papulosum cyprini (EPC) cell line from carp cyprinus carpio","volume":"134","author":"Fijan","year":"1983","journal-title":"Ann. l'Institut Pasteur Virol."},{"key":"10.1016\/j.fsi.2016.01.038_bib41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.critrevonc.2008.07.021","article-title":"Infections and cancer: Established associations and new hypotheses","volume":"70","author":"de Martel","year":"2009","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.fsi.2016.01.038_bib42","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nri1860","article-title":"Defensins in innate antiviral immunity","volume":"6","author":"Klotman","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2016.01.038_bib43","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.peptides.2010.02.025","article-title":"Antiviral activity by fish antimicrobial peptides of epinecidin-1 and hepcidin 1-5 against nervous necrosis virus in medaka","volume":"31","author":"Wang","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2016.01.038_bib44","first-page":"11","article-title":"Hepcidin and host defense against infectious diseases","author":"Michels","year":"2015","journal-title":"PLoS Pathog."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464816300419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464816300419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:21Z","timestamp":1654214421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464816300419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":44,"alternative-id":["S1050464816300419"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2016.01.038","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in\u00a0vitro","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2016.01.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}