{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:14:35Z","timestamp":1770815675410,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries, Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.fsi.2016.02.021","type":"journal-article","created":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T08:17:27Z","timestamp":1455697047000},"page":"41-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Effects of a broad-spectrum caspase inhibitor, Z-VAD(OMe)-FMK, on viral hemorrhagic septicemia virus (VHSV) infection-mediated apoptosis and viral replication"],"prefix":"10.1016","volume":"51","author":[{"given":"Min Sun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Ae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2016.02.021_bib1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev.micro.53.1.577","article-title":"Viruses and apoptosis","volume":"53","author":"Roulston","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2016.02.021_bib2","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1099\/0022-1317-83-7-1547","article-title":"A\u00a0time to kill: viral manipulation of the cell death program","volume":"83","author":"Hay","year":"2002","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.fsi.2016.02.021_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.virol.2003.11.025","article-title":"Caspase activation during virus infection: more than just the kiss of death?","volume":"320","author":"Best","year":"2004","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2016.02.021_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0959-8030(95)00002-X","article-title":"Viral hemorrhagic septicemia virus in North America","volume":"5","author":"Meyers","year":"1995","journal-title":"Ann. Rev. Fish. Dis."},{"key":"10.1016\/j.fsi.2016.02.021_bib5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2761.2005.00654.x","article-title":"Viral haemorrhagic septicaemia virus in marine fish and its implications for fish farming \u2013 a review","volume":"28","author":"Skall","year":"2005","journal-title":"J.\u00a0Fish. Dis."},{"key":"10.1016\/j.fsi.2016.02.021_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0168-1702(95)00026-M","article-title":"Induction of apoptotic DNA fragmentation by the infection of vesicular stomatitis virus","volume":"37","author":"Koyama","year":"1995","journal-title":"Virus Res."},{"key":"10.1016\/j.fsi.2016.02.021_bib7","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1128\/JVI.71.7.5658-5662.1997","article-title":"Rhabdovirus-induced apoptosis in a fish cell line is inhibited by a human endogenous acid cysteine proteinase inhibitor","volume":"71","author":"Bj\u00f6rklund","year":"1997","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.fsi.2016.02.021_bib8","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1128\/JVI.74.16.7619-7627.2000","article-title":"Infectious hematopoietic necrosis virus matrix protein inhibits host-directed gene expression and induces morphological changes of apoptosis in cell cultures","volume":"74","author":"Chiou","year":"2000","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.fsi.2016.02.021_bib9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1053\/jcpa.2001.0467","article-title":"Comparative study of in-situ cell death induced by the viruses of viral haemorrhagic septicaemia (VHS) and infectious pancreatic necrosis (IPN) in rainbow trout","volume":"124","author":"El\u00e9ou\u00ebt","year":"2001","journal-title":"J.\u00a0Comp. Pathol."},{"key":"10.1016\/j.fsi.2016.02.021_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.virusres.2003.12.034","article-title":"Induction of apoptosis in a carp leucocyte cell line infected with turbot (Scophthalmus maximus L.) rhabdovirus","volume":"101","author":"Du","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.fsi.2016.02.021_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.virusres.2011.01.006","article-title":"In situ apoptosis of adaptive immune cells and the cellular escape of rabies virus in CNS from patients with human rabies transmitted by Desmodus rotundus","volume":"156","author":"Fernandes","year":"2011","journal-title":"Virus Res."},{"key":"10.1016\/j.fsi.2016.02.021_bib12","doi-asserted-by":"crossref","first-page":"8393","DOI":"10.1128\/JVI.00597-11","article-title":"Nonvirgin protein of novirhabdovirus suppresses apoptosis at the early stage of virus infection","volume":"85","author":"Ammayappan","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.fsi.2016.02.021_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.aquaculture.2009.07.019","article-title":"An outbreak of VHSV (viral hemorrhagic septicemia virus) infection in farmed olive flounder Paralichthys olivaceus in Korea","volume":"296","author":"Kim","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.021_bib14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.fsi.2011.05.003","article-title":"Oral immunization of olive flounder (Paralichthys olivaceus) with recombinant live viral hemorrhagic septicemia virus (VHSV) induces protection against VHSV infection","volume":"31","author":"Kim","year":"2011","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.02.021_bib15","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1016\/j.vaccine.2013.07.036","article-title":"Inactivated vaccine against viral hemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder (Paralichthys olivaceus)","volume":"31","author":"Vinay","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2016.02.021_bib16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fsi.2016.02.021_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/imr.12284","article-title":"Caspase-8 functions as a key mediator of inflammation and pro-IL-1\u03b2 processing via both canonical and non-canonical pathways","volume":"265","author":"Monie","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2016.02.021_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.cdd.4402034","article-title":"Caspase inhibitors: viral, cellular and chemical","volume":"14","author":"Callus","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2016.02.021_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3354\/dao02394","article-title":"Generation and characterization of NV gene-knockout recombinant viral hemorrhagic septicemia virus (VHSV) genotype IVa","volume":"97","author":"Kim","year":"2011","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2016.02.021_bib20","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/AEM.39.4.872-876.1980","article-title":"Plaquing procedure for infectious hematopoietic necrosis virus","volume":"39","author":"Burke","year":"1980","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fsi.2016.02.021_bib21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.20506\/rst.24.1.1565","article-title":"DNA vaccines for aquaculture fish","volume":"24","author":"Lorenzen","year":"2005","journal-title":"Rev. Sci. Tech."},{"key":"10.1016\/j.fsi.2016.02.021_bib22","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.fsi.2013.10.021","article-title":"Leong JA. DNA vaccines against viral diseases of farmed fish","volume":"35","author":"Evensen","year":"2013","journal-title":"Fish. Shellfish Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481630064X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481630064X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T15:58:48Z","timestamp":1600185528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046481630064X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":22,"alternative-id":["S105046481630064X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2016.02.021","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of a broad-spectrum caspase inhibitor, Z-VAD(OMe)-FMK, on viral hemorrhagic septicemia virus (VHSV) infection-mediated apoptosis and viral replication","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2016.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}