{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:25:08Z","timestamp":1779333908295,"version":"3.51.4"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2014CB138600"],"award-info":[{"award-number":["2014CB138600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Department Public Benefit Research Foundation (Agriculture) of China","award":["201003020"],"award-info":[{"award-number":["201003020"]}]},{"name":"Science and Technology Support Program of Sichuan Province of China","award":["2014NZ0003"],"award-info":[{"award-number":["2014NZ0003"]}]},{"name":"Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China","award":["2012NC0007"],"award-info":[{"award-number":["2012NC0007"]}]},{"name":"Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China","award":["2013NC0045"],"award-info":[{"award-number":["2013NC0045"]}]},{"name":"Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China","award":["2015CC0011"],"award-info":[{"award-number":["2015CC0011"]}]},{"name":"Natural Science Foundation for Young Scientists of Sichuan Province","award":["2014JQ0007"],"award-info":[{"award-number":["2014JQ0007"]}]},{"name":"Sichuan Province Research Foundation for Basic Research","award":["2013JY0082"],"award-info":[{"award-number":["2013JY0082"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.fsi.2016.02.029","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T17:30:40Z","timestamp":1457458240000},"page":"405-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Immunity decreases, antioxidant system damages and tight junction changes in the intestine of grass carp ( Ctenopharyngodon idella ) during folic acid deficiency: Regulation of NF-\u03baB, Nrf2 and MLCK mRNA levels"],"prefix":"10.1016","volume":"51","author":[{"given":"Lei","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Dan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Yao","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu-Neng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-An","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Qiu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2016.02.029_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fsi.2015.09.023","article-title":"Folic acid deficiency impairs the gill health status associated with the NF-\u03baB, MLCK and Nrf2 signaling pathways in the gills of young grass carp (Ctenopharyngodon idella)","volume":"47","author":"Shi","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.02.029_bib2","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.fsi.2012.06.017","article-title":"Transcriptional regulation of cytokines in the intestine of Atlantic cod fed yeast derived mannan oligosaccharide or \u03b2-glucan and challenged with vibrio anguillarum","volume":"33","author":"Lokesh","year":"2012","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.fsi.2014.10.002","article-title":"Effect of dietary isoleucine on the immunity, antioxidant status, tight junctions and microflora in the intestine of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"41","author":"Zhao","year":"2014","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib4","first-page":"4855","article-title":"Mechanism for maintaining homeostasis in the immune system of the intestine","volume":"29","author":"Taniguchi","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fsi.2016.02.029_bib5","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.fsi.2011.09.011","article-title":"Disturbance of the intestinal mucosal immune system of farmed atlantic salmon (Salmo salar), in response to long-term hypoxic conditions","volume":"31","author":"Niklasson","year":"2011","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fsi.2014.07.003","article-title":"The impaired intestinal mucosal immune system by valine deficiency for young grass carp (Ctenopharyngodon idella) is associated with decreasing immune status and regulating tight junction proteins transcript abundance in the intestine","volume":"40","author":"Luo","year":"2014","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aquaculture.2013.03.005","article-title":"Dietary folic acid requirement of juvenile abalone Haliotis discus hannai Ino","volume":"400","author":"Miao","year":"2013","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.029_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.fsi.2014.07.004","article-title":"Dietary tryptophan modulates intestinal immune response, barrier function, antioxidant status and gene expression of TOR and Nrf2 in young grass carp (Ctenopharyngodon idella)","volume":"40","author":"Wen","year":"2014","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.02.029_bib9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.aquaculture.2015.04.005","article-title":"Dietary leucine regulates the intestinal immune status, immune-related signalling molecules and tight junction transcript abundance in grass carp (Ctenopharyngodon idella)","volume":"444","author":"Jiang","year":"2015","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.029_bib10","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.3945\/ajcn.2009.29002","article-title":"Folate and methionine metabolism in autism: a systematic review","volume":"91","author":"Main","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.fsi.2011.12.012","article-title":"Effects of graded levels of dietary methionine hydroxy analogue on immune response and antioxidant status of immune organs in juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"32","author":"Kuang","year":"2012","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1365-2095.2000.00129.x","article-title":"Feeding Atlantic salmon Salmo salar L. soybean products: effects on disease resistance (furunculosis), and lysozyme and IgM levels in the intestinal mucosa","volume":"6","author":"Krogdahl","year":"2000","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib13","first-page":"89","article-title":"Genomics of fish cytokines","volume":"1","author":"Savan","year":"2006","journal-title":"Com. Biochem. Phys. D."},{"key":"10.1016\/j.fsi.2016.02.029_bib14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.bjc.6605530","article-title":"TNF-\u03b1\/NF-\u03baB\/Snail pathway in cancer cell migration and invasion","volume":"102","author":"Wu","year":"2010","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/j.fsi.2016.02.029_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jnutbio.2005.05.008","article-title":"Decreased TGF-\u03b21 and IGF-1 protein expression in rat embryo skull bone in folic acid-restricted diet","volume":"17","author":"Santoso","year":"2006","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.fsi.2016.02.029_bib16","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1074\/jbc.M407517200","article-title":"Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase\/Akt\/mammalian target of rapamycin (PI3K\/Akt\/mTOR) pathway","volume":"280","author":"Latres","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2016.02.029_bib17","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.4049\/jimmunol.174.9.5823","article-title":"Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-\u03baB activation in endothelial cells","volume":"174","author":"Minhajuddin","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.fsi.2016.02.029_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00441-006-0323-0","article-title":"Histological changes in intestine of atlantic salmon (Salmo salar L.) following in\u00a0vitro exposure to pathogenic and probiotic bacterial strains","volume":"328","author":"Ring\u00f8","year":"2007","journal-title":"Cell. Tissue Res."},{"key":"10.1016\/j.fsi.2016.02.029_bib19","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1365-2095.2011.00853.x","article-title":"Methionine hydroxy analogue prevents oxidative damage and improves antioxidant status of intestine and hepatopancreas for juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"17","author":"Feng","year":"2011","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.fsi.2014.06.012","article-title":"Effect of dietary supplementation of probiotics and palm fruits extracts on the antioxidant enzyme gene expression in the mucosae of gilthead seabream (Sparus aurata L.)","volume":"39","author":"Esteban","year":"2014","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.aquatox.2014.07.003","article-title":"Copper exposure induces oxidative injury, disturbs the antioxidant system and changes the Nrf2\/ARE (CuZnSOD) signaling in the fish brain: Protective effects of myo-inositol","volume":"155","author":"Jiang","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2016.02.029_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10545-010-9177-4","article-title":"Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects","volume":"34","author":"Blom","year":"2011","journal-title":"J.\u00a0Inherit. Metab. Dis."},{"key":"10.1016\/j.fsi.2016.02.029_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2012.08.017","article-title":"Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection","volume":"200","author":"Elanchezhian","year":"2012","journal-title":"Chem Biol. Interact."},{"key":"10.1016\/j.fsi.2016.02.029_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5607\/en.2014.23.1.93","article-title":"Glutathione protects brain endothelial cells from hydrogen peroxide-induced oxidative stress by increasing nrf2 expression","volume":"23","author":"Song","year":"2014","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.fsi.2016.02.029_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.resp.2012.05.020","article-title":"Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: a review","volume":"184","author":"Chasiotis","year":"2012","journal-title":"Resp. Physiol. Neurobiol."},{"key":"10.1016\/j.fsi.2016.02.029_bib26","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1002\/cphy.c110045","article-title":"Claudins and other tight junction proteins","volume":"2","author":"G\u00fcnzel","year":"2012","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.fsi.2016.02.029_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/TA.0b013e318191bb1f","article-title":"Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase","volume":"66","author":"Costantini","year":"2009","journal-title":"J.\u00a0Trauma"},{"key":"10.1016\/j.fsi.2016.02.029_bib28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00011-011-0337-2","article-title":"Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264. 7 macrophages by suppressing MAPKs and NF-\u03baB activation","volume":"60","author":"Feng","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.fsi.2016.02.029_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jss.2009.03.066","article-title":"Role of p38 MAPK in burn-induced intestinal barrier breakdown","volume":"156","author":"Costantini","year":"2009","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.fsi.2016.02.029_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.fsi.2015.02.027","article-title":"Effect of dietary arginine on the immune response and gene expression in head kidney and spleen following infection of Jian carp with aeromonas hydrophila","volume":"44","author":"Chen","year":"2015","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.aquaculture.2005.03.014","article-title":"Acute stress alters intestinal function of rainbow trout, Oncorhynchus mykiss (Walbaum)","volume":"250","author":"Olsen","year":"2005","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.029_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.aquatox.2014.10.025","article-title":"Copper-induced tight junction mRNA expression changes, apoptosis and antioxidant responses via NF-\u03baB, TOR and Nrf2 signaling molecules in the gills of fish: preventive role of arginine","volume":"158","author":"Wang","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2016.02.029_bib33","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/j.1365-2109.2004.01150.x","article-title":"Growth, reproductive performance, muscle and egg composition in grass carp, Ctenopharyngodon idella (Valenciennes), fed hydrilla or formulated diets with varying protein levels","volume":"35","author":"Khan","year":"2004","journal-title":"Aquac. Res."},{"key":"10.1016\/j.fsi.2016.02.029_bib34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/chromsci\/15.7.262","article-title":"Analysis of water soluble vitamins by high pressure liquid chromatography","volume":"15","author":"Wills","year":"1977","journal-title":"J.\u00a0Chromatog. Sci."},{"key":"10.1016\/j.fsi.2016.02.029_bib35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.aquaculture.2011.04.010","article-title":"Dietary folic acid requirement of grouper, Epinephelus malabaricus, and its effects on non-specific immune responses","volume":"317","author":"Lin","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.029_bib36","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.fsi.2010.07.018","article-title":"Probiotic applications of two dominant gut Bacillus strains with antagonistic activity improved the growth performance and immune responses of grouper Epinephelus coioides","volume":"29","author":"Sun","year":"2010","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib37","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s12011-013-9785-6","article-title":"Effects of dietary copper on growth, digestive, and brush border enzyme activities and antioxidant defense of hepatopancreas and intestine for young grass carp (Ctenopharyngodon idella)","volume":"155","author":"Tang","year":"2013","journal-title":"Bio. Trace Elem. Res."},{"key":"10.1016\/j.fsi.2016.02.029_bib38","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10499-005-9029-7","article-title":"The influence of feeding rate on growth, feed efficiency and body composition of juvenile grass carp (Ctenopharyngodon idella)","volume":"14","author":"Du","year":"2006","journal-title":"Aquacult. Int."},{"key":"10.1016\/j.fsi.2016.02.029_bib39","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.aquaculture.2004.03.011","article-title":"Growth, feed efficiency and digestibility in salmon (Salmo salar L.) fed different dietary proportions of vegetable protein sources in combination with two fish meal qualities","volume":"237","author":"Mundheim","year":"2004","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.029_bib40","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.fct.2006.10.020","article-title":"Hepatic metabolism, phase I and II biotransformation enzymes in atlantic salmon (Salmo Salar, L) during a 12 week feeding period with graded levels of the synthetic antioxidant, ethoxyquin","volume":"45","author":"Berdikova Bohne","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fsi.2016.02.029_bib41","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.aquatox.2011.06.013","article-title":"Effects of dietary methylmercury on growth performance and tissue burden in juvenile green (Acipenser medirostris) and white sturgeon (A.\u00a0transmontanus)","volume":"105","author":"Lee","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2016.02.029_bib42","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10695-012-9719-9","article-title":"Effects of dietary histidine on antioxidant capacity in juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"39","author":"Feng","year":"2013","journal-title":"Fish. Physio Biochem."},{"key":"10.1016\/j.fsi.2016.02.029_bib43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fsi.2016.02.029_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0007114511005459","article-title":"Effect of dietary arginine on growth, intestinal enzyme activities and gene expression in muscle, hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"108","author":"Chen","year":"2012","journal-title":"Brit. J. Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib45","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10695-010-9454-z","article-title":"Mitochondrion-rich cells distribution, Na+\/K+-ATPase activity and gill morphometry of the Amazonian freshwater stingrays (Chondrichthyes: potamotrygonidae)","volume":"37","author":"Duncan","year":"2011","journal-title":"Fish. Physio Biochem."},{"key":"10.1016\/j.fsi.2016.02.029_bib46","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1016\/S0021-9258(18)69649-8","article-title":"Creatine and creatine kinase measurement","volume":"234","author":"Tanzer","year":"1959","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.fsi.2016.02.029_bib47","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1471-2261-6-16","article-title":"Estrogen-induced DNA synthesis in vascular endothelial cells is mediated by ROS signaling, BMC","volume":"6","author":"Felty","year":"2006","journal-title":"Cardiovasc Disord."},{"key":"10.1016\/j.fsi.2016.02.029_bib48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.fsi.2010.02.018","article-title":"Effects of anthraquinone extract from Rheum officinale bail on the growth performance and physiological responses of macrobrachium rosenbergii under high temperature stress","volume":"29","author":"Liu","year":"2010","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.02.029_bib49","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.foodchem.2009.10.062","article-title":"Lipid peroxidation, protein oxidant and antioxidant status of muscle, intestine and hepatopancreas for juvenile Jian carp (Cyprinus carpio var. Jian) fed graded levels of myo-inositol","volume":"120","author":"Jiang","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.fsi.2016.02.029_bib50","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.fsi.2013.01.008","article-title":"Dietary lipid requirement on non-specific immune responses in juvenile grass carp (Ctenopharyngodon idella)","volume":"34","author":"Jin","year":"2013","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.02.029_bib51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2095.2011.00934.x","article-title":"Effects of myo-inositol on proliferation, differentiation, oxidative status and antioxidant capacity of carp enterocytes in primary culture","volume":"19","author":"Jiang","year":"2013","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib52","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.freeradbiomed.2004.10.009","article-title":"Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration","volume":"38","author":"G\u00f3mez","year":"2005","journal-title":"Free. Radic. Bio. Med."},{"key":"10.1016\/j.fsi.2016.02.029_bib53","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.aquaculture.2012.09.019","article-title":"Effects of dietary isoleucine on growth, the digestion and absorption capacity and gene expression in hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"368","author":"Zhao","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.029_bib54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.aquaculture.2013.04.032","article-title":"Analysis of transcripts in gilthead seabream sperm and zebrafish testicular cells: mRNA profile as a predictor of gamete quality","volume":"406","author":"Guerra","year":"2013","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2016.02.029_bib55","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.fsi.2015.07.015","article-title":"The acute modulation of norepinephrine on immune responses and genes expressions via adrenergic receptors in the giant freshwater prawn, Macrobrachium rosenbergii","volume":"46","author":"Chang","year":"2015","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib56","doi-asserted-by":"crossref","first-page":"8403","DOI":"10.1007\/s00253-015-6702-2","article-title":"Modulation of the intestinal microbiota and morphology of tilapia, Oreochromis niloticus, following the application of a multi-species probiotic","volume":"99","author":"Standen","year":"2015","journal-title":"Appl. Microbiol. Biot."},{"key":"10.1016\/j.fsi.2016.02.029_bib57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.fsi.2015.01.027","article-title":"Effects of a phytogenic feed additive on growth performance, susceptibility of channel catfish to Edwardsiella ictaluri and levels of mannose binding lectin","volume":"44","author":"Peterson","year":"2015","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib58","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2095.2011.00898.x","article-title":"Effects of dietary histidine levels on growth performance, body composition and intestinal enzymes activities of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"18","author":"Zhao","year":"2012","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0891-5520(05)70086-6","article-title":"The gut's role in metabolism, mucosal barrier function, and gut immunology","volume":"13","author":"DeWitt","year":"1999","journal-title":"Infect. Dis. Clin. North. Am."},{"key":"10.1016\/j.fsi.2016.02.029_bib60","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.fsi.2005.03.010","article-title":"Ontogeny of humoral immune parameters in fish","volume":"19","author":"Magnad\u00f3ttir","year":"2005","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib61","first-page":"16","article-title":"Anti-inflammatory function of arctiin by inhibiting COX-2 expression via NF-kB pathways","volume":"8","author":"Lee","year":"2011","journal-title":"J.\u00a0Inflamm. Lond."},{"key":"10.1016\/j.fsi.2016.02.029_bib62","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3945\/jn.110.136176","article-title":"Prebiotic oligosaccharides reduce proinflammatory cytokines in intestinal Caco-2 cells via activation of PPAR\u03b3 and peptidoglycan recognition protein 3","volume":"141","author":"Zenhom","year":"2011","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2004.08.007","article-title":"Cloning and characterization of a homologue of the alpha inhibitor of NF-\u03baB in Rainbow trout (Oncorhynchus mykiss)","volume":"103","author":"Sangrador-Vegas","year":"2005","journal-title":"Vet. Immunol. Immunop."},{"key":"10.1016\/j.fsi.2016.02.029_bib64","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0026-895X(24)12615-6","article-title":"The green tea polyphenol (\u2212)-epigallocatechin-3-gallate blocks nuclear factor-\u03baB activation by inhibiting I\u03baB kinase activity in the intestinal epithelial cell line IEC-6","volume":"60","author":"Yang","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.fsi.2016.02.029_bib65","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1101\/gad.1662308","article-title":"Akt-dependent regulation of NF-\u03baB is controlled by mTOR and Raptor in association with IKK","volume":"22","author":"Dan","year":"2008","journal-title":"Gene. Dev."},{"key":"10.1016\/j.fsi.2016.02.029_bib66","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jn\/136.1.189","article-title":"Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women","volume":"136","author":"Troen","year":"2006","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.fsi.2016.02.029_bib67","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0022-4731(87)90030-6","article-title":"Inhibition by cortisol of human natural killer (NK) cell activity","volume":"26","author":"Gatti","year":"1987","journal-title":"J.\u00a0Steroid Biochem."},{"key":"10.1016\/j.fsi.2016.02.029_bib68","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/humrep\/dep349","article-title":"Detailed analysis of peripheral blood natural killer (NK) cells in women with recurrent miscarriage","volume":"25","author":"King","year":"2009","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.fsi.2016.02.029_bib69","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1139\/y05-093","article-title":"Impaired NK cell cytotoxicity by high level of interferon-\u03b3 in concanavalin a-induced hepatitis","volume":"83","author":"Dong","year":"2005","journal-title":"Can. J. Physiol. Pharm."},{"key":"10.1016\/j.fsi.2016.02.029_bib70","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.fsi.2015.03.030","article-title":"Effect of copper nanoparticles and copper sulphate on oxidation stress, cell apoptosis and immune responses in the intestines of juvenile Epinephelus coioides","volume":"44","author":"Wang","year":"2015","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib71","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.fsi.2014.06.032","article-title":"Dietary administration of microalgae alone or supplemented with Lactobacillus sakei affects immune response and intestinal morphology of Pacific red snapper (Lutjanus peru)","volume":"40","author":"Reyes-Becerril","year":"2014","journal-title":"Fish. Shellfish Immun."},{"key":"10.1016\/j.fsi.2016.02.029_bib72","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.aquatox.2013.02.005","article-title":"In\u00a0vitro interceptive and reparative effects of myo-inositol against copper-induced oxidative damage and antioxidant system disturbance in primary cultured fish enterocytes","volume":"132","author":"Jiang","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2016.02.029_bib73","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.foodchem.2014.06.091","article-title":"Effects of dietary arginine supplementation on growth performance, flesh quality, muscle antioxidant capacity and antioxidant-related signalling molecule expression in young grass carp (Ctenopharyngodon idella)","volume":"167","author":"Wang","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.fsi.2016.02.029_bib74","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11160-005-7846-4","article-title":"Antioxidant defenses in fish: biotic and abiotic factors","volume":"15","author":"Martinez-Alvarez","year":"2005","journal-title":"Rev. Fish. Biol. Fish."},{"key":"10.1016\/j.fsi.2016.02.029_bib75","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1128\/MCB.01080-08","article-title":"The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds","volume":"29","author":"Kobayashi","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2016.02.029_bib76","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/toxsci\/kfp038","article-title":"Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish","volume":"109","author":"Timme-Laragy","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fsi.2016.02.029_bib77","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/BJ20090471","article-title":"Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1","volume":"422","author":"Eggler","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.fsi.2016.02.029_bib78","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s11481-008-9131-5","article-title":"Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature","volume":"3","author":"Chen","year":"2008","journal-title":"J.\u00a0Neuroimmune Pharm."},{"key":"10.1016\/j.fsi.2016.02.029_bib79","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1242\/jcs.144550","article-title":"Nonmuscle myosin light chain kinase is required for b-catenin\/FoxO1-dependent downregulation of claudin-5 in interleukin-1\u03b2-mediated brain endothelial cell barrier dysfunction","volume":"127","author":"Beard","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.fsi.2016.02.029_bib80","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-physiol-021909-135725","article-title":"The physiological significance of the cardiotonic steroid\/ouabain-binding site of the Na, K-ATPase","volume":"72","author":"Lingrel","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.fsi.2016.02.029_bib81","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2010.08.006","article-title":"Loss of claudin-15, but not claudin-2, causes Na+ deficiency and glucose malabsorption in mouse small intestine","volume":"140","author":"Tamura","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.fsi.2016.02.029_bib82","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1146\/annurev.biochem.71.102201.141218","article-title":"Biochemistry of Na, K-ATPase","volume":"71","author":"Kaplan","year":"2002","journal-title":"Annu. Rev Biochem."},{"key":"10.1016\/j.fsi.2016.02.029_bib83","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aquaculture.2011.03.042","article-title":"Effect of dietary choline on growth, intestinal enzyme activities and relative expressions of target of rapamycin and eIF4E-binding protein2 gene in muscle, hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"317","author":"Wu","year":"2011","journal-title":"Aquaculture"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464816300730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464816300730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T17:50:10Z","timestamp":1748800210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464816300730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":83,"alternative-id":["S1050464816300730"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2016.02.029","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunity decreases, antioxidant system damages and tight junction changes in the intestine of grass carp (Ctenopharyngodon idella) during folic acid deficiency: Regulation of NF-\u03baB, Nrf2 and MLCK mRNA levels","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2016.02.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}