{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:06:41Z","timestamp":1789898801812,"version":"4.0.1"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministerio de Econom\u00eda y Competitividad (MINECO)","award":["AGL2014-53167-C3-1-R"],"award-info":[{"award-number":["AGL2014-53167-C3-1-R"]}]},{"name":"Ministerio de Econom\u00eda y Competitividad (MINECO)","award":["AGL2014-53167-C3-2-R"],"award-info":[{"award-number":["AGL2014-53167-C3-2-R"]}]},{"name":"European Commission (FEDER\/ERDF)"},{"name":"Fundaci\u00f3n S\u00e9neca, CARM","award":["19883\/GERM\/15"],"award-info":[{"award-number":["19883\/GERM\/15"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.fsi.2016.03.041","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T07:33:41Z","timestamp":1458545621000},"page":"189-197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Selective estrogen receptor modulators differentially alter the immune response of gilthead seabream juveniles"],"prefix":"10.1016","volume":"52","author":[{"given":"M.C.","family":"Rodenas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Cabas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garc\u00eda-Alc\u00e1zar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Meseguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Mulero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Garc\u00eda-Ayala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2016.03.041_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4067\/S0716-97602012000100002","article-title":"The effects of 4-nonylphenol contamination on livers of Tilapia fish (Oreochromus spilurs) in Jeddah","volume":"45","author":"Abdulla Bin-Dohaish el","year":"2012","journal-title":"Biol. Res."},{"key":"10.1016\/j.fsi.2016.03.041_bib2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10565-008-9069-7","article-title":"Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc)-regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish","volume":"24","author":"Arukwe","year":"2008","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.fsi.2016.03.041_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.taap.2014.04.025","article-title":"Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17alpha-ethinylestradiol","volume":"278","author":"Baumann","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fsi.2016.03.041_bib4","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1021\/es0629965","article-title":"Distributions of pharmaceuticals in an urban estuary during both dry- and wet-weather conditions","volume":"41","author":"Benotti","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fsi.2016.03.041_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/iid3.37","article-title":"Effects of lasofoxifene and bazedoxifene on B cell development and function","volume":"2","author":"Bernardi","year":"2014","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.fsi.2016.03.041_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ygcen.2014.09.014","article-title":"Effects of the environmental estrogenic contaminants bisphenol A and 17alpha-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species","volume":"214","author":"Bhandari","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jneuroim.2009.06.023","article-title":"Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis","volume":"214","author":"Blasko","year":"2009","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nchembio775","article-title":"Virtual and biomolecular screening converge on a selective agonist for GPR30","volume":"2","author":"Bologa","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.fsi.2016.03.041_bib9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0145-305X(01)00040-4","article-title":"Ecotoxicology and innate immunity in fish","volume":"25","author":"Bols","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib10","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.molimm.2011.07.001","article-title":"Dietary intake of 17alpha-ethinylestradiol promotes leukocytes infiltration in the gonad of the hermaphrodite gilthead seabream","volume":"48","author":"Cabas","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.dci.2011.09.011","article-title":"17alpha-Ethynylestradiol alters the immune response of the teleost gilthead seabream (Sparus aurata L.) both in\u00a0vivo and in\u00a0vitro","volume":"36","author":"Cabas","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib12","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.4049\/jimmunol.1301613","article-title":"Estrogen signaling through the G protein-coupled estrogen receptor regulates granulocyte activation in fish","volume":"191","author":"Cabas","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib13","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.3390\/md11124973","article-title":"The effect of 17alpha-ethynylestradiol on steroidogenesis and gonadal cytokine gene expression is related to the reproductive stage in marine hermaphrodite fish","volume":"11","author":"Cabas","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fsi.2016.03.041_bib14","series-title":"Characterization of IgM+B Lymphocytes in Gilthead Seabream and Impact of Estrogens on Their Functions","author":"Cabas","year":"2015"},{"key":"10.1016\/j.fsi.2016.03.041_bib15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/bjc.1995.59","article-title":"Interaction of tamoxifen with the multidrug resistance P-glycoprotein","volume":"71","author":"Callaghan","year":"1995","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.fsi.2016.03.041_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1095\/biolreprod.105.049494","volume":"75","author":"Campbell","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.fsi.2016.03.041_bib17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.marpolbul.2011.05.007","article-title":"Endocrine disrupting compounds: can they target the immune system of fish?","volume":"63","author":"Casanova-Nakayama","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.fsi.2016.03.041_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1677\/joe.0.1790165","article-title":"A\u00a0role for acidophilic granulocytes in the testis of the gilthead seabream (Sparus aurata L., Teleostei)","volume":"179","author":"Chaves-Pozo","year":"2003","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00441-004-1063-7","article-title":"Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum","volume":"320","author":"Chaves-Pozo","year":"2005","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.fsi.2016.03.041_bib20","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1161\/01.CIR.103.11.1497","article-title":"Tamoxifen effects on endothelial function and cardiovascular risk factors in men with advanced atherosclerosis","volume":"103","author":"Clarke","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.fsi.2016.03.041_bib21","first-page":"317","article-title":"Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth","volume":"42","author":"Coezy","year":"1982","journal-title":"Cancer Res."},{"key":"10.1016\/j.fsi.2016.03.041_bib22","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jsbmb.2011.07.002","article-title":"Identification of a GPER\/GPR30 antagonist with improved estrogen receptor counterselectivity","volume":"127","author":"Dennis","year":"2011","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2016.03.041_bib23","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1021\/es9707973","article-title":"Identification of estrogenic chemicals in STW effluent. Chemical fractionation and in\u00a0vitro biological screening","volume":"32","author":"Desbrow","year":"1988","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fsi.2016.03.041_bib24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1677\/joe.0.1750319","article-title":"Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice","volume":"175","author":"Erlandsson","year":"2002","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cbpc.2015.09.005","article-title":"Tamoxifen disrupts the reproductive process in gilthead seabream males and modulates the effects promoted by 17\u03b1-ethynylestradiol","volume":"179","author":"Garc\u00eda-Hern\u00e1ndez","year":"2016","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2016.03.041_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.aquatox.2010.08.014","article-title":"Behavioral and genomic impacts of a wastewater effluent on the fathead minnow","volume":"101","author":"Garc\u00eda-Reyero","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2016.03.041_bib27","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1016\/j.watres.2006.04.028","article-title":"Field study using two immunoassays for the determination of estradiol and ethinylestradiol in the aquatic environment","volume":"40","author":"Hinteman","year":"2006","journal-title":"Water Res."},{"key":"10.1016\/j.fsi.2016.03.041_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fsi.2014.06.021","article-title":"Channel catfish (Ictalurus punctatus) leukocytes express estrogen receptor isoforms ERalpha and ERbeta2 and are functionally modulated by estrogens","volume":"40","author":"Iwanowicz","year":"2014","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.watres.2004.07.025","article-title":"Comparing steroid estrogen, and nonylphenol content across a range of European sewage plants with different treatment and management practices","volume":"39","author":"Johnson","year":"2005","journal-title":"Water Res."},{"key":"10.1016\/j.fsi.2016.03.041_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-2964(75)90119-X","article-title":"Tamoxifen (ICI 46,474) and the human carcinoma 8S oestrogen receptor","volume":"11","author":"Jordan","year":"1975","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.fsi.2016.03.041_bib31","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/tox.20585","article-title":"Effects of 17alpha-ethynylestradiol and nonylphenol on liver and gonadal apoptosis and histopathology in Chalcalburnus tarichi","volume":"26","author":"Kaptaner","year":"2011","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.fsi.2016.03.041_bib32","doi-asserted-by":"crossref","first-page":"8897","DOI":"10.1073\/pnas.0609568104","article-title":"Collapse of a fish population after exposure to a synthetic estrogen","volume":"104","author":"Kidd","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2016.03.041_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1749-6632.2009.04453.x","article-title":"Endocrine disruption in aquatic vertebrates","volume":"1163","author":"Kloas","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fsi.2016.03.041_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.scitotenv.2004.01.015","article-title":"Urban contribution of pharmaceuticals and other organic wastewater contaminants to streams during differing flow conditions","volume":"328","author":"Kolpin","year":"2004","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2016.03.041_bib35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0048-9697(01)01036-1","article-title":"Prediction of the bioaccumulation factors and body burden of natural and synthetic estrogens in aquatic organisms in the river systems","volume":"289","author":"Lai","year":"2002","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2016.03.041_bib36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.taap.2007.06.017","article-title":"Functional characterization of estrogen receptor subtypes, ERalpha and ERbeta, mediating vitellogenin production in the liver of rainbow trout","volume":"224","author":"Lea\u00f1os-Casta\u00f1eda","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fsi.2016.03.041_bib37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jat.1682","article-title":"A\u00a0review of studies on androgen and estrogen exposure in fish early life stages: effects on gene and hormonal control of sexual differentiation","volume":"31","author":"Leet","year":"2011","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.fsi.2016.03.041_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.dci.2010.07.007","article-title":"17beta-Estradiol regulates gilthead seabream professional phagocyte responses through macrophage activation","volume":"35","author":"Liarte","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.steroids.2004.10.009","article-title":"Effects of sex steroids and their inhibitors on endocrine parameters and gender growth differences in Eurasian perch (Perca fluviatilis) juveniles","volume":"70","author":"Mandiki","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.fsi.2016.03.041_bib40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.envint.2013.11.011","article-title":"In\u00a0vitro tests aiding ecological risk assessment of ciprofloxacin, tamoxifen and cyclophosphamide in range of concentrations released in hospital wastewater and surface water","volume":"63","author":"Mater","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.fsi.2016.03.041_bib41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10646-010-0588-7","article-title":"The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review","volume":"20","author":"Milla","year":"2011","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.fsi.2016.03.041_bib42","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/j.molimm.2008.01.017","article-title":"Vaccination of larvae of the bony fish gilthead seabream reveals a lack of correlation between lymphocyte development and adaptive immunocompetence","volume":"45","author":"Mulero","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/485441a","article-title":"Environmental science: The hidden costs of flexible fertility","volume":"485","author":"Owen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2016.03.041_bib44","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1292\/jvms.65.1155","article-title":"Tamoxifen induces vasorelaxation via inhibition of mitogen-activated protein kinase in rat aortic smooth muscle","volume":"65","author":"Park","year":"2003","journal-title":"J.\u00a0Vet. Med. Sci."},{"key":"10.1016\/j.fsi.2016.03.041_bib45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/eesa.1998.1725","article-title":"Apoptosis in dab (Limanda limanda) as possible new biomarker for anthropogenic stress","volume":"42","author":"Piechotta","year":"1999","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fsi.2016.03.041_bib46","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.aquatox.2012.09.002","article-title":"The stress response of three-spined sticklebacks is modified in proportion to effluent exposure downstream of wastewater treatment works","volume":"126","author":"Pottinger","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2016.03.041_bib47","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrendo.2011.122","article-title":"The G-protein-coupled estrogen receptor GPER in health and disease","volume":"7","author":"Prossnitz","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2010.07.017","article-title":"GPR30\/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages","volume":"328","author":"Rettew","year":"2010","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib49","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A\u00a0transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.fsi.2016.03.041_bib50","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.dci.2015.06.014","article-title":"Tamoxifen persistently disrupts the humoral adaptive immune response of gilthead seabream (Sparus aurata L.)","volume":"53","author":"Rodenas","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib51","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.molimm.2012.09.013","article-title":"Review: Endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms","volume":"53","author":"Rogers","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib52","doi-asserted-by":"crossref","first-page":"12927","DOI":"10.3390\/ijerph111212927","article-title":"Histological changes in gills of two fish species as indicators of water quality in Jansen Lagoon (Sao Luis, Maranhao State, Brazil)","volume":"11","author":"Santos","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.fsi.2016.03.041_bib53","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.chemosphere.2011.07.048","article-title":"Rapid-behaviour responses as a reliable indicator of estrogenic chemical toxicity in zebrafish juveniles","volume":"85","author":"Sarria","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2016.03.041_bib54","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000223078","article-title":"Effects of endocrine disrupters on sexual, gonadal development in fish","volume":"3","author":"Scholz","year":"2009","journal-title":"Sex. Dev."},{"key":"10.1016\/j.fsi.2016.03.041_bib55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ygcen.2012.09.014","article-title":"Alteration of immune function endpoints and differential expression of estrogen receptor isoforms in leukocytes from 17beta-estradiol exposed rainbow trout (Oncorhynchus mykiss)","volume":"180","author":"Shelley","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib56","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/toxsci\/kfn150","article-title":"Environmentally relevant concentrations of 17alpha-ethinylestradiol (EE2) interfere with the growth hormone (GH)\/insulin-like growth factor (IGF)-I system in developing bony fish","volume":"106","author":"Shved","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.fsi.2016.03.041_bib57","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1677\/JOE-07-0295","article-title":"Ethinylestradiol differentially interferes with IGF-I in liver and extrahepatic sites during development of male and female bony fish","volume":"195","author":"Shved","year":"2007","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib58","first-page":"447","article-title":"Effect of dietary administration of letrozole and tamoxifen on gonadal development, sex differentiation and biochemical changes in common carp (Cyprinus carpio L.)","volume":"27","author":"Singh","year":"2014","journal-title":"Reprod. Fertil. Dev."},{"issue":"Suppl 7","key":"10.1016\/j.fsi.2016.03.041_bib59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1289\/ehp.95103s7173","article-title":"Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment","volume":"103","author":"Sumpter","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.fsi.2016.03.041_bib60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.etap.2007.01.003","article-title":"Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)","volume":"24","author":"Sun","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2016.03.041_bib61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0048-9697(98)00334-9","article-title":"Behavior and occurrence of estrogens in municipal sewage treatment plants\u2013I. Investigations in Germany, Canada and Brazil","volume":"225","author":"Ternes","year":"1999","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2016.03.041_bib62","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1021\/es0201348","article-title":"Relative potencies and combination effects of steroidal estrogens in fish","volume":"37","author":"Thorpe","year":"2003","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fsi.2016.03.041_bib63","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0013-9351(03)00033-1","article-title":"The bioaccumulation of nonyphenol and its adverse effect on the liver of rainbow trout (Onchorynchus mykiss)","volume":"92","author":"Uguz","year":"2003","journal-title":"Environ. Res."},{"key":"10.1016\/j.fsi.2016.03.041_bib64","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/me.2005-0280","article-title":"The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells","volume":"20","author":"Vivacqua","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib65","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1210\/me.2007-0359","article-title":"GPR30 contributes to estrogen-induced thymic atrophy","volume":"22","author":"Wang","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.fsi.2016.03.041_bib66","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1897\/02-570","article-title":"Increased kidney, liver, and testicular cell death after chronic exposure to 17alpha-ethinylestradiol in medaka (Oryzias latipes)","volume":"23","author":"Weber","year":"2004","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.fsi.2016.03.041_bib67","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.scitotenv.2005.04.038","article-title":"Acute and early life stage toxicity of industrial effluent on Japanese medaka (Oryzias latipes)","volume":"357","author":"Zha","year":"2006","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2016.03.041_bib68","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.chemosphere.2006.05.071","article-title":"Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol","volume":"66","author":"Zha","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2016.03.041_bib69","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.taap.2007.10.006","article-title":"Assessment of 17alpha-ethinylestradiol effects and underlying mechanisms in a continuous, multigeneration exposure of the Chinese rare minnow (Gobiocypris rarus)","volume":"226","author":"Zha","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fsi.2016.03.041_bib70","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0145-305X(01)00025-8","article-title":"A fish cell surface receptor defined by a mAb mediates leukocyte aggregation and deactivation","volume":"25","author":"Mulero","year":"2001","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2016.03.041_bib71","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.molimm.2010.12.010","article-title":"TLR agonists extend the functional lifespan of professional phagocytic granulocytes in the bony fish gilthead seabream and direct precursor differentiation towards the production of granulocytes","volume":"48","author":"Sepulcre","year":"2011","journal-title":"Mol. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481630119X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481630119X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T05:57:21Z","timestamp":1536904641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046481630119X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":71,"alternative-id":["S105046481630119X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2016.03.041","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective estrogen receptor modulators differentially alter the immune response of gilthead seabream juveniles","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2016.03.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}