{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:04:02Z","timestamp":1785269042039,"version":"3.55.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"am","delay-in-days":308,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"National Basic Research Program of China (973 Program)","award":["2014CB138600"],"award-info":[{"award-number":["2014CB138600"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["31502184"],"award-info":[{"award-number":["31502184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004573","name":"Outstanding Talents and Innovative Team of Agricultural Scientific Research (Ministry of Agriculture)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004573","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Department Public Benefit Research Foundation (Agriculture) of China","award":["201003020"],"award-info":[{"award-number":["201003020"]}]},{"name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","award":["20135103110001"],"award-info":[{"award-number":["20135103110001"]}]},{"name":"Science and Technology Support Program of Sichuan Province of China","award":["2014NZ0003"],"award-info":[{"award-number":["2014NZ0003"]}]},{"name":"Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China","award":["2012NC0007"],"award-info":[{"award-number":["2012NC0007"]}]},{"name":"Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China","award":["2013NC0045"],"award-info":[{"award-number":["2013NC0045"]}]},{"name":"Demonstration of Major Scientific and Technological Achievement Transformation Project of Sichuan Province of China","award":["2015CC0011"],"award-info":[{"award-number":["2015CC0011"]}]},{"name":"Natural Science Foundation for Young Scientists of Sichuan Province","award":["2014JQ0007"],"award-info":[{"award-number":["2014JQ0007"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.fsi.2017.03.053","type":"journal-article","created":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T16:21:15Z","timestamp":1490890875000},"page":"34-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Intestinal immune responses of Jian carp against Aeromonas hydrophila depressed by choline deficiency: Varied change patterns of mRNA levels of cytokines, tight junction proteins and related signaling molecules among three intestinal segments"],"prefix":"10.1016","volume":"65","author":[{"given":"Pei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Dan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-An","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2017.03.053_bib1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.dci.2012.07.004","article-title":"Immunogenicity and protective effects of inactivated Singapore grouper iridovirus (SGIV) vaccines in orange-spotted grouper, Epinephelus coioides","volume":"38","author":"Ou-yang","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aquaculture.2012.02.011","article-title":"Antibiograms and the estimation of epidemiological cut off values for Vibrio ichthyoenteri isolated from larval olive flounder, Paralichthys olivaceus","volume":"342\u2013343","author":"Lee","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2017.03.053_bib3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1365-2109.2011.02805.x","article-title":"Seasonal variations in the intestinal microbiota of farmed Atlantic salmon (Salmo salar L.)","volume":"43","author":"Hovda","year":"2012","journal-title":"Aquac. Res."},{"key":"10.1016\/j.fsi.2017.03.053_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.aquaculture.2014.08.015","article-title":"Aeromonas hydrophila induces intestinal inflammation in grass carp (Ctenopharyngodon idella): an experimental model","volume":"434","author":"Song","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2017.03.053_bib5","doi-asserted-by":"crossref","first-page":"e30440","DOI":"10.1371\/journal.pone.0030440","article-title":"Composition, diversity, and origin of the bacterial community in grass carp intestine","volume":"7","author":"Wu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2017.03.053_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2011.02.015","article-title":"Effects of anthraquinone extract from Rheum officinale Bail on the physiological responses and HSP70 gene expression of Megalobrama amblycephala under Aeromonas hydrophila infection","volume":"32","author":"Liu","year":"2012","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.dci.2015.03.007","article-title":"Immunomodulatory effect of cathelicidins in response to a \u03b2-glucan in intestinal epithelial cells from rainbow trout","volume":"51","author":"Schmitt","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fsi.2016.04.011","article-title":"Importance of prebiotics in aquaculture as immunostimulants. Effects on immune system of Sparus aurata and Dicentrarchus labrax","volume":"54","author":"Carbone","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.fsi.2016.03.152","article-title":"Impact of date palm fruits extracts and probiotic enriched diet onantioxidant status, innate immune response and immune-related gene expression of European seabass (Dicentrarchus labrax)","volume":"52","author":"Guardiola","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib10","first-page":"794","article-title":"Oral administration of Gum Arabic: effects on haematological parameters and oxidative stress markers in Mugil cephalus","volume":"126","author":"Faggio","year":"2015","journal-title":"Iran. J. Fish. Sci."},{"key":"10.1016\/j.fsi.2017.03.053_bib11","series-title":"Nutrient Requirements of Fish and Shrimp","author":"NRC","year":"2011"},{"key":"10.1016\/j.fsi.2017.03.053_bib12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.fsi.2013.05.030","article-title":"Dietary choline modulates immune responses, and gene expressions of TOR and eIF4E-binding protein2 in immune organs of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"35","author":"Wu","year":"2013","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aquaculture.2011.03.042","article-title":"Effect of dietary choline on growth, intestinal enzyme activities and relative expressions of target of rapamycin and eIF4E-binding protein2 gene in muscle, hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"317","author":"Wu","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2017.03.053_bib14","first-page":"e169888","article-title":"A\u00a0comparative study on antioxidant system in fish hepatopancreas and intestine affected by choline deficiency: different change patterns of varied antioxidant enzyme genes and Nrf2 signaling factors","volume":"12","author":"Wu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2017.03.053_bib15","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.fsi.2016.11.003","article-title":"Immunohistochemical characterization of Toll-like receptor 2 in gut epithelial cells and macrophages of goldfish Carassius auratus fed with a high-cholesterol diet","volume":"59","author":"Lauriano","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.dci.2008.09.012","article-title":"Expression profiles of cytokines released in intestinal epithelial cells of the rainbow trout, Oncorhynchus mykiss, in response to bacterial infection","volume":"33","author":"Komatsu","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cbpa.2008.06.008","article-title":"Gossypol affects ion transport in the isolated intestine of the seawater adapted eel, Anguilla anguilla","volume":"151","author":"Trischitta","year":"2008","journal-title":"Comp. Biochem. Phys. A"},{"key":"10.1016\/j.fsi.2017.03.053_bib18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.fsi.2012.11.010","article-title":"Intestinal barrier of carp (Cyprinus carpio L.) during a cyprinid herpesvirus 3-infection: molecular identification and regulation of the mRNA expression of claudin encoding genes","volume":"34","author":"Syakuri","year":"2013","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib19","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/sj.bjp.0707264","article-title":"The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation","volume":"151","author":"de Jonge","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fsi.2017.03.053_bib20","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fsi.2016.09.006","article-title":"Estrogen regulation of gene expression in the teleost fish immune system","volume":"58","author":"Burgos-Aceves","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jb\/mvu002","article-title":"AMPK-sensitive cellular transport","volume":"155","author":"D\u00ebrmaku-Sopjani","year":"2014","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.fsi.2017.03.053_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fsi.2016.08.013","article-title":"Transcriptome signatures in common carp spleen in response to Aeromonas hydrophila infection","volume":"57","author":"Jiang","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib23","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2119\/2008-00079.Parrish","article-title":"Modulation of TNF release by choline requires \u03b17 subunit nicotinic acetylcholine receptor-mediated signaling","volume":"14","author":"Parrish","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.fsi.2017.03.053_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1159\/000329982","article-title":"Nicotine reduces TNF-\u03b1 expression through a \u03b17 nAChR\/MyD88\/NF-\u03baB pathway in HBE16 airway epithelial cells","volume":"27","author":"Li","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.fsi.2017.03.053_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.dci.2012.04.001","article-title":"Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts","volume":"39","author":"Zhu","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib26","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.bbadis.2013.06.009","article-title":"Acetylcholine leads to signal transducer and activator of transcription 1 (STAT-1) mediated oxidative\/nitrosative stress in human bronchial epithelial cell line","volume":"1832","author":"Profita","year":"2013","journal-title":"BBA-Mol. Basis Dis."},{"key":"10.1016\/j.fsi.2017.03.053_bib27","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fsi.2010.09.001","article-title":"Teleost intestinal immunology","volume":"31","author":"Rombout","year":"2011","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.fsi.2009.03.007","article-title":"Immunological differences in intestine and rectum of Atlantic cod (Gadus morhua L.)","volume":"26","author":"Inami","year":"2009","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0145-305X(93)90015-I","article-title":"The gut-associated lymphoid tissue (GALT) of carp (Cyprinus carpio L.): an immunocytochemical analysis","volume":"17","author":"Rombout","year":"1993","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev.nu.01.070181.000523","article-title":"Dietary choline: biochemistry, physiology, and pharmacology","volume":"1","author":"Zeisel","year":"1981","journal-title":"Ann. Rev. Nutr."},{"key":"10.1016\/j.fsi.2017.03.053_bib31","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/jn\/119.5.800","article-title":"Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship","volume":"119","author":"Zeisel","year":"1989","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.fsi.2017.03.053_bib32","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.fsi.2016.09.055","article-title":"Dietary choline deficiency and excess induced intestinal inflammation and alteration of intestinal tight junction protein transcription potentially by modulating NF-\u03baB, STAT and p38 MAPK signaling molecules in juvenile Jian carp","volume":"58","author":"Wu","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib33","series-title":"Methods of Vitamin Assay","first-page":"555","article-title":"Choline","author":"Venugopal","year":"1985"},{"key":"10.1016\/j.fsi.2017.03.053_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye-binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.fsi.2017.03.053_bib35","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.fsi.2010.01.017","article-title":"Immunomodulatory effect of dietary Saccharomyces cerevisiae, \u03b2-glucan and laminaran in mercuric chloride treated Nile tilapia (Oreochromis niloticus) and experimentally infected with Aeromonas hydrophila","volume":"28","author":"El-Boshy","year":"2010","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib36","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/10.6.741","article-title":"Histochemical methods for acid phosphatase using hexazonium pararosanalin as coupler","volume":"10","author":"Barka","year":"1962","journal-title":"J.\u00a0Histochem. Cytochem"},{"key":"10.1016\/j.fsi.2017.03.053_bib37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.aquaculture.2006.09.036","article-title":"Growth, immune function, and disease and stress resistance of juvenile Nile tilapia (Oreochromis niloticus) fed graded levels of bovine lactoferrin","volume":"262","author":"Welker","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2017.03.053_bib38","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0044-8486(93)90139-P","article-title":"Changes in an immunoglobulin M (IgM)-like protein during larval stages in tilapia, Oreochromis mossambicus","volume":"115","author":"Takemura","year":"1993","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2017.03.053_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u25b3\u25b3CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2017.03.053_bib40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.dci.2016.07.007","article-title":"Transcriptomic profiling revealed the signatures of intestinal barrier alteration and pathogen entry in turbot (Scophthalmus maximus) following Vibrio anguillarum challenge","volume":"65","author":"Gao","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.fsi.2015.01.020","article-title":"Dietary vegetable oils: effects on the expression of immune-related genes in Senegalese sole (Solea senegalensis) intestine","volume":"44","author":"Montero","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib42","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.fsi.2013.07.001","article-title":"Molecular characterization of hepcidin gene in common carp (Cyprinus carpio L.) and its expression pattern responding to bacterial challenge","volume":"35","author":"Li","year":"2013","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib43","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fsi.2012.11.009","article-title":"Immune responses and gene expression in hepatopancreas from Macrobrachium rosenbergii challenged by a novel pathogen spiroplasma MR-1008","volume":"34","author":"Du","year":"2013","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.exppara.2015.04.010","article-title":"Immunological, ionic and biochemical responses in blood serum of the marine fish Trachinotus ovatus to poly-infection by Cryptocaryon irritans","volume":"154","author":"Yin","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.fsi.2017.03.053_bib45","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.fsi.2011.02.023","article-title":"Transcriptomic responses to functional feeds in Atlantic salmon (Salmo salar)","volume":"31","author":"Tacchi","year":"2011","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib46","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1017\/S0007114515003256","article-title":"Vitamin D inhibits lipopolysaccharide-induced inflammatory response potentially through the Toll-like receptor 4 signalling pathway in the intestine and enterocytes of juvenile Jian carp (Cyprinus carpio var. Jian)","volume":"114","author":"Jiang","year":"2015","journal-title":"Brit. J. Nutr."},{"key":"10.1016\/j.fsi.2017.03.053_bib47","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.fsi.2014.05.003","article-title":"Dietary supplementation of Pediococcus pentosaceus enhances innate immunity, physiological health and resistance to Vibrio anguillarum in orange-spotted grouper (Epinephelus coioides)","volume":"39","author":"Huang","year":"2014","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib48","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.fsi.2015.11.037","article-title":"Dietary administration of a commercial mixed-species probiotic improves growth performance and modulates the intestinal immunity of tilapia, Oreochromis niloticus","volume":"49","author":"Standen","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib49","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.3748\/wjg.v12.i46.7451","article-title":"Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases","volume":"12","author":"Scott","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.fsi.2017.03.053_bib50","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.0801755","article-title":"Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-\u03baB activation","volume":"182","author":"Sepulcre","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.fsi.2017.03.022","article-title":"Intestinal transcriptome modulation by functional diets in rainbow trout: a high-throughput sequencing appraisal to highlight GALT immunomodulation","volume":"64","author":"Gon\u00e7alves","year":"2017","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2013.06.007","article-title":"Involvement of JAK\/STAT signaling in the pathogenesis of inflammatory bowel disease","volume":"76","author":"Coskun","year":"2013","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.fsi.2017.03.053_bib53","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.fsi.2017.03.053_bib54","doi-asserted-by":"crossref","first-page":"4368","DOI":"10.1182\/blood-2006-11-055756","article-title":"Nonredundant roles for Stat5a\/b in directly regulating Foxp3","volume":"109","author":"Yao","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.fsi.2017.03.053_bib55","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib56","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/liv.12271","article-title":"Intestinal epithelial barrier function in liver cirrhosis: an extensive review of the literature","volume":"33","author":"Pijls","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.fsi.2017.03.053_bib57","doi-asserted-by":"crossref","first-page":"C1412","DOI":"10.1152\/ajpcell.00007.2004","article-title":"Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoforms","volume":"287","author":"McLaughlin","year":"2004","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.fsi.2017.03.053_bib58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1748-1716.2010.02148.x","article-title":"Claudins of intestine and nephron-a correlation of molecular tight junction structure and barrier function","volume":"201","author":"Amasheh","year":"2011","journal-title":"Acta Physiol."},{"key":"10.1016\/j.fsi.2017.03.053_bib59","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1091\/mbc.11.12.4131","article-title":"Complex phenotype of mice lacking occludin, a component of tight junction strands","volume":"11","author":"Saitou","year":"2000","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.fsi.2017.03.053_bib60","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.fsi.2015.01.039","article-title":"Effects of dietary NEXT ENHANCE\u00ae150 on growth performance and expression of immune and intestinal integrity related genes in gilthead sea bream (Sparus aurata L.)","volume":"44","author":"P\u00e9rez-S\u00e1nchez","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.tox.2012.11.020","article-title":"Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation","volume":"304","author":"Wu","year":"2013","journal-title":"Toxicology"},{"key":"10.1016\/j.fsi.2017.03.053_bib62","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF00495024","article-title":"Regional functional differentiation in the gut of the grasscarp, Ctenopharyngodon idella (Val.)","volume":"64","author":"Stroband","year":"1979","journal-title":"Histochemistry"},{"key":"10.1016\/j.fsi.2017.03.053_bib63","first-page":"1","article-title":"Multiwall carbon nanotube-induced apoptosis and antioxidant gene expression in the gills, liver, and intestine of Oryzias latipes","volume":"2015","author":"Lee","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.fsi.2017.03.053_bib64","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1194\/jlr.R700019-JLR200","article-title":"Phosphatidylcholine and choline homeostasis","volume":"49","author":"Li","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.fsi.2017.03.053_bib65","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10409239509083487","article-title":"New insight into the biochemical pathology of liver in choline deficiency","volume":"30","author":"Ghoshal","year":"1995","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2017.03.053_bib66","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.fsi.2005.12.010","article-title":"Pre- and post-challenge immuno-haematological changes in Labeo rohita juveniles fed gelatinised or non-gelatinised carbohydrate with n-3 PUFA","volume":"21","author":"Misra","year":"2006","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.03.053_bib67","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1163\/15693910260698320","article-title":"Expression of acetylcholine in lymphocytes and modulation of an independent lymphocytic cholinergic activity by immunological stimulation","volume":"17","author":"Fujii","year":"2003","journal-title":"Biog. Amines"},{"key":"10.1016\/j.fsi.2017.03.053_bib68","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0163-7258(99)00071-6","article-title":"Extraneuronal cholinergic system in lymphocytes","volume":"86","author":"Kawashima","year":"2000","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.fsi.2017.03.053_bib69","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1254\/jjp.85.11","article-title":"An independent non-neuronal cholinergic system in lymphocytes","volume":"85","author":"Fujii","year":"2001","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.fsi.2017.03.053_bib70","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/A:1022840416292","article-title":"Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses","volume":"28","author":"Fujii","year":"2003","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.fsi.2017.03.053_bib71","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0024-3205(03)00072-9","article-title":"Expression of multiple mRNA species for choline acetyltransferase in human T-lymphocytes","volume":"72","author":"Ogawa","year":"2003","journal-title":"Life Sci."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481730181X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481730181X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:07:35Z","timestamp":1760936855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046481730181X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":71,"alternative-id":["S105046481730181X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2017.03.053","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intestinal immune responses of Jian carp against Aeromonas hydrophila depressed by choline deficiency: Varied change patterns of mRNA levels of cytokines, tight junction proteins and related signaling molecules among three intestinal segments","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2017.03.053","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}