{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:20:28Z","timestamp":1787887228864,"version":"build-2784847793"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31172437"],"award-info":[{"award-number":["31172437"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31372566"],"award-info":[{"award-number":["31372566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472309"],"award-info":[{"award-number":["31472309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["KF2015No10"],"award-info":[{"award-number":["KF2015No10"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology and industrial development Marine fishery Project of Guangdong Province, China","award":["A201501C01"],"award-info":[{"award-number":["A201501C01"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.fsi.2017.08.019","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T10:01:32Z","timestamp":1503050492000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Fish TRIM35 negatively regulates the interferon signaling pathway in response to grouper nodavirus infection"],"prefix":"10.1016","volume":"69","author":[{"given":"Youhua","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingcheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songwei","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yepin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.fsi.2017.08.019_bib1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/nrc3139","article-title":"TRIM proteins and cancer","volume":"11","author":"Hatakeyama","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.fsi.2017.08.019_bib2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri3043","article-title":"Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?","volume":"11","author":"Jefferies","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"27","key":"10.1016\/j.fsi.2017.08.019_bib3","doi-asserted-by":"crossref","first-page":"25046","DOI":"10.1074\/jbc.M303438200","article-title":"Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function","volume":"278","author":"Kimura","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"issue":"9","key":"10.1016\/j.fsi.2017.08.019_bib4","doi-asserted-by":"crossref","first-page":"8181","DOI":"10.1074\/jbc.M306751200","article-title":"HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor","volume":"279","author":"Lalonde","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"issue":"30","key":"10.1016\/j.fsi.2017.08.019_bib5","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1038\/onc.2014.325","article-title":"TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma","volume":"34","author":"Chen","year":"2015","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.fsi.2017.08.019_bib6","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.febslet.2015.04.019","article-title":"TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7","volume":"89","author":"Wang","year":"2015","journal-title":"FEBS Lett."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2017.08.019_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.vetmic.2010.03.016","article-title":"Mass mortality of hatchery-produced larvae of Asian seabass, Lates calcarifer (Bloch), associated with viral nervous necrosis in Sabah, Malaysia","volume":"145","author":"Ransangan","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fsi.2017.08.019_bib8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1746-6148-9-20","article-title":"Viral Encephalopathy and Retinopathy in groupers (Epinephelus spp.) in southern Italy: a threat for wild endangered species?","volume":"9","author":"Vendramin","year":"2013","journal-title":"BMC Vet. Res."},{"issue":"9","key":"10.1016\/j.fsi.2017.08.019_bib9","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/jfd.12440","article-title":"Betanodavirus ability to infect juvenile European sea bass, Dicentrarchus labrax, at different water salinity","volume":"39","author":"Pascoli","year":"2016","journal-title":"J.\u00a0Fish. Dis."},{"issue":"5","key":"10.1016\/j.fsi.2017.08.019_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/jfd.12541","article-title":"Viral encephalopathy and retinopathy in aquaculture: a review","volume":"40","author":"Doan","year":"2017","journal-title":"J.\u00a0Fish. Dis."},{"issue":"10","key":"10.1016\/j.fsi.2017.08.019_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1365-2761.2004.00581.x","article-title":"Characterization of nodavirus and viral encephalopathy and retinopathy in farmed turbot, Scophthalmus maximus (L.)","volume":"27","author":"Johansen","year":"2004","journal-title":"J.\u00a0Fish. Dis."},{"issue":"2","key":"10.1016\/j.fsi.2017.08.019_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3354\/dao073123","article-title":"Viral nerve necrosis in hatchery-produced fry of Asian seabass Lates calcarifer: sequential microscopic analysis of histopathology","volume":"73","author":"Azad","year":"2006","journal-title":"Dis. Aquat. Organ"},{"issue":"1","key":"10.1016\/j.fsi.2017.08.019_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.rvsc.2009.01.004","article-title":"Nodavirus associated with pathological changes in adult spotted coral groupers (Plectropomus maculatus) in Thailand with viral nervous necrosis","volume":"87","author":"Nopadon","year":"2009","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.fsi.2017.08.019_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0044-8486(02)00092-3","article-title":"Characterization, pathogenicity and neutralization studies of a nervous necrosis virus isolated from grouper, Epinephelus tauvina, in Singapore","volume":"213","author":"Hegde","year":"2002","journal-title":"Aquaculture"},{"issue":"3","key":"10.1016\/j.fsi.2017.08.019_bib15","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/jfd.12020","article-title":"Betanodavirus-associated mortalities of adult wild groupers Epinephelus marginatus (Lowe) and Epinephelus costae (Steindachner) in Algeria","volume":"37","author":"Kara","year":"2014","journal-title":"J.\u00a0Fish. Dis."},{"key":"10.1016\/j.fsi.2017.08.019_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fsi.2016.11.036","article-title":"Fish TRIM32 functions as a critical antiviral molecule against iridovirus and nodavirus","volume":"60","author":"Yu","year":"2017","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fsi.2016.08.035","article-title":"Negative regulation of the innate antiviral immune response by TRIM62 from orange spotted grouper","volume":"57","author":"Yang","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.fsi.2016.07.015","article-title":"Negative regulation of the antiviral response by grouper LGP2 against fish viruses","volume":"56","author":"Yu","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib19","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.fsi.2016.04.001","article-title":"Antiviral function of grouper MDA5 against iridovirus and nodavirus","volume":"54","author":"Huang","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2017.08.019_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.fsi.2014.12.031","article-title":"Involvement of fish signal transducer and activator of transcription 3 (STAT3) in nodavirus infection induced cell death","volume":"43","author":"Huang","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2017.08.019_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.fsi.2014.11.025","article-title":"Identification of orange-spotted grouper (Epinephelus coioides) interferon regulatory factor 3 involved in antiviral immune response against fish RNA virus","volume":"42","author":"Huang","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2017.08.019_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.dci.2014.04.004","article-title":"Functional analysis of an orange-spotted grouper (Epinephelus coioides) interferon gene and characterisation of its expression in response to nodavirus infection","volume":"46","author":"Chen","year":"2014","journal-title":"Dev. Comp. Immunol."},{"issue":"4\u20135","key":"10.1016\/j.fsi.2017.08.019_bib23","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.fsi.2011.02.003","article-title":"Anti-viral effects of interferon administration on sevenband grouper, Epinephelus septemfasciatus","volume":"30","author":"Ohta","year":"2011","journal-title":"Fish. Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2017.08.019_bib24","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.fsi.2013.01.010","article-title":"Molecular cloning, expression and functional analysis of ISG15 in orange-spotted grouper, Epinephelus coioides","volume":"34","author":"Huang","year":"2013","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2016.01.016","article-title":"Fish TRIM39 regulates cell cycle progression and exerts its antiviral function against iridovirus and nodavirus","volume":"50","author":"Wang","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.fsi.2016.04.138","article-title":"Fish TRIM8 exerts antiviral roles through regulation of the proinflammatory factors and interferon signaling","volume":"54","author":"Huang","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.fsi.2016.06.005","article-title":"RING domain is essential for the antiviral activity of TRIM25 from orange spotted grouper","volume":"55","author":"Yang","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib28","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.fsi.2016.10.044","article-title":"Fish TRIM16L exerts negative regulation on antiviral immune response against grouper iridoviruses","volume":"59","author":"Yu","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2017.08.019_bib29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquaculture.2009.04.019","article-title":"Characterization of two grouper Epinephelus akaara cell lines: application to studies of Singapore grouper iridovirus (SGIV) propagation and virus-host interaction","volume":"292","author":"Huang","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2017.08.019_bib30","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1186\/1471-2164-12-556","article-title":"Transcriptome analysis of orange-spotted grouper (Epinephelus coioides) spleen in response to Sin-gapore grouper iridovirus","volume":"12","author":"Huang","year":"2011","journal-title":"BMC Genomics"},{"issue":"3","key":"10.1016\/j.fsi.2017.08.019_bib31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bbrc.2014.09.139","article-title":"Molecular characterization of a CpTRIM35-like protein and its splice variants from whitespotted bamboo shark (Chiloscyllium plagiosum)","volume":"453","author":"Zhang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.fsi.2017.08.019_bib32","doi-asserted-by":"crossref","first-page":"e22022","DOI":"10.1371\/journal.pone.0022022","article-title":"Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish","volume":"6","author":"Boudinot","year":"2011","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.fsi.2017.08.019_bib33","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1093\/emboj\/20.9.2140","article-title":"The tripartite motif family identifies cell compartments","volume":"20","author":"Reymond","year":"2001","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.fsi.2017.08.019_bib34","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.4049\/jimmunol.0803126","article-title":"TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response","volume":"182","author":"Yang","year":"2009","journal-title":"J.\u00a0Immunol."},{"issue":"16","key":"10.1016\/j.fsi.2017.08.019_bib35","doi-asserted-by":"crossref","first-page":"8116","DOI":"10.1128\/JVI.00341-11","article-title":"Role of TRIM5\u03b1 RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus","volume":"85","author":"Kim","year":"2011","journal-title":"J.\u00a0Virol."},{"issue":"7138","key":"10.1016\/j.fsi.2017.08.019_bib36","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","article-title":"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity","volume":"446","author":"Gack","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2017.08.019_bib37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fsi.2016.04.002","article-title":"TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway","volume":"54","author":"Zhang","year":"2016","journal-title":"Fish. Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2017.08.019_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.fsi.2015.09.014","article-title":"Antiviral role of grouper STING against iridovirus infection","volume":"47","author":"Huang","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2017.08.019_bib39","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.fsi.2010.08.012","article-title":"Molecular cloning and antiviral activity of IFN-\u03b2 promoter stimulator-1 (IPS-1) gene in Japanese flounder, Paralichthys olivaceus","volume":"29","author":"Simora","year":"2010","journal-title":"Fish. Shellfish Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464817304825?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464817304825?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T12:58:49Z","timestamp":1535461129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464817304825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":39,"alternative-id":["S1050464817304825"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2017.08.019","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fish TRIM35 negatively regulates the interferon signaling pathway in response to grouper nodavirus infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2017.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}