{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:44:42Z","timestamp":1791819882405,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Major State Basic Research Development Program of China (973 Program)","award":["2014CB138600"],"award-info":[{"award-number":["2014CB138600"]}]},{"DOI":"10.13039\/501100005693","name":"Hainan University for R & D","doi-asserted-by":"publisher","award":["KYQD(ZR)1736"],"award-info":[{"award-number":["KYQD(ZR)1736"]}],"id":[{"id":"10.13039\/501100005693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.fsi.2018.02.041","type":"journal-article","created":{"date-parts":[[2018,2,24]],"date-time":"2018-02-24T17:56:46Z","timestamp":1519495006000},"page":"48-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"C","title":["Histological and transcriptomic responses of two immune organs, the spleen and head kidney, in Nile tilapia (Oreochromis niloticus) to long-term hypersaline stress"],"prefix":"10.1016","volume":"76","author":[{"given":"Chang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-6369","authenticated-orcid":false,"given":"Erchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantong","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian G.","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fsi.2004.09.005","article-title":"Ontogeny of the immune system of fish","volume":"20","author":"Zapata","year":"2006","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jmor.10385","article-title":"Cytomorphological alterations of the thymus, spleen, head-kidney, and liver in cardinal fish (Apogonidae, Teleostei) as bioindicators of stress","volume":"267","author":"Fishelson","year":"2006","journal-title":"J. Morphol."},{"issue":"10","key":"10.1016\/j.fsi.2018.02.041_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.17221\/3294-VETMED","article-title":"Innate and adaptive immunity in teleost fish: a review","volume":"56","author":"Uribe","year":"2011","journal-title":"Vet. Med."},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1542\/peds.37.1.111","article-title":"The role of the spleen in immunity","volume":"37","author":"Ellis","year":"1966","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.fsi.2018.02.041_bib5","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0301-472X(02)00881-0","article-title":"Roles of spleen and liver in development of the murine hematopoietic system","volume":"30","author":"Wolber","year":"2002","journal-title":"Exp. Hematol."},{"issue":"4","key":"10.1016\/j.fsi.2018.02.041_bib6","first-page":"505","article-title":"Effect of cadmium chloride on liver, spleen and kidney melano macrophage centres in Tilapia mossambica","volume":"30","author":"Suresh","year":"2009","journal-title":"J. Environ. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib7","first-page":"1","article-title":"Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish","volume":"72","author":"Jiang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"5\u20136","key":"10.1016\/j.fsi.2018.02.041_bib8","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.fsi.2010.02.012","article-title":"Spleen immune status is affected after acute handling stress but not regulated by cortisol in Eurasian perch, Perca fluviatilis","volume":"28","author":"Milla","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.fsi.2008.11.002","article-title":"Oxidative stress in macrophages from spleen of Nile tilapia (Oreochromis niloticus) exposed to sublethal concentration of endosulfan","volume":"27","author":"TellezBa\u00f1uelos","year":"2009","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2018.02.041_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1515\/bmc-2012-0001","article-title":"Vasilis Vasiliou, the role of hyperosmotic stress in inflammation and disease","volume":"3","author":"Chad Brocker","year":"2012","journal-title":"Biomol. Concepts"},{"issue":"6","key":"10.1016\/j.fsi.2018.02.041_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.fsi.2008.09.006","article-title":"Acute osmotic stress affects Tilapia (Oreochromis mossambicus) innate immune responses","volume":"25","author":"Jiang","year":"2008","journal-title":"Fish Shellfish Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2018.02.041_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jprot.2017.08.005","article-title":"Salinity stress, enhancing basal and induced immune responses in striped catfish Pangasianodon hypophthalmus (Sauvage)","volume":"167","author":"Schmitz","year":"2017","journal-title":"J. Proteomics"},{"key":"10.1016\/j.fsi.2018.02.041_bib13","first-page":"590","article-title":"Haemotological analysis of 'cachara' Pseudoplatystoma fasciatum in captivity","volume":"28","author":"Ranzani Paiva","year":"2000","journal-title":"Acta Sci."},{"issue":"3","key":"10.1016\/j.fsi.2018.02.041_bib14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s10695-009-9339-1","article-title":"Hematology of great sturgeon (Huso huso Linnaeus, 1758) juvenile exposed to brackish water environment","volume":"36","author":"Zarejabad","year":"2010","journal-title":"Fish Physiol. Biochem."},{"issue":"6","key":"10.1016\/j.fsi.2018.02.041_bib15","first-page":"602","article-title":"Effect of salinity on hematology and gill Na+-K+ ATPase activity of juvenile cobia, Rachycentron canadum Linnaeus","volume":"27","author":"Xu","year":"2008","journal-title":"Mar. Environ. Sci."},{"key":"10.1016\/j.fsi.2018.02.041_bib16","first-page":"49","article-title":"Hematology and serum biochemical changes in response to change in saline concentration in fresh water fish Notopterus notopterus","volume":"32","author":"Kavya","year":"2016","journal-title":"World Scientific News"},{"issue":"1\u20134","key":"10.1016\/j.fsi.2018.02.041_bib17","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0044-8486(03)00063-2","article-title":"Metabolic responses to salinity acclimation in juvenile shortnose sturgeon Acipenser brevirostrum","volume":"219","author":"Jarvis","year":"2003","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2018.02.041_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jprot.2016.04.046","article-title":"Synergic stress in striped catfish (Pangasianodon hypophthalmus, S.) exposed to chronic salinity and bacterial infection: effects on kidney protein expression profile","volume":"142","author":"Schmitz","year":"2016","journal-title":"J. Proteomics"},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1300\/J028v06n01_04","article-title":"Effects of salinity on Streptococcus infection of Nile Tilapia, Oreochromis niloticus","volume":"6","author":"Chang","year":"1996","journal-title":"J. Appl. Aquacult."},{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/jai.12997","article-title":"Effects of salinity on growth, body composition, muscle fatty acid composition, and antioxidant status of juvenile Nile Tilapia Oreochromis niloticus (Linnaeus, 1758)","volume":"32","author":"Gan","year":"2016","journal-title":"J. Appl. Ichthyol."},{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib21","first-page":"146","article-title":"Alterations in the hematological parameters of Juvenile Nile Tilapia (Oreochromis niloticus) submitted to different salinities","volume":"12","author":"Bosisio","year":"2017","journal-title":"Pan Am. J. Aquat. Sci."},{"issue":"5","key":"10.1016\/j.fsi.2018.02.041_bib22","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1023\/A:1026156222685","article-title":"The biology of Oreochromis niloticus in a polluted canal","volume":"12","author":"Khallaf","year":"2003","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.fsi.2018.02.041_bib23","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1095-8649.2008.02144.x","article-title":"Erratum: metabolic depression and spleen and liver enlargement in juvenile Arctic charr Salvelinus alpinus exposed to chronic parasite infection","volume":"74","author":"Seppanen","year":"2009","journal-title":"J. Fish. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1749-7345.2006.00010.x","article-title":"Bowser PR, Infection of tilapia Oreochromis sp. by Vibrio vulnificus in freshwater and low salinity, environments","volume":"37","author":"Chen","year":"2006","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.fsi.2018.02.041_bib25","series-title":"Fish Kill of Mullet liza Klunzingeri in kuwait Bay: the Role of Streptococcus Agalactiae and the Influence of Temperature","first-page":"143","volume":"vol.5","author":"Al-Marzouk","year":"2002"},{"issue":"3","key":"10.1016\/j.fsi.2018.02.041_bib26","first-page":"116","article-title":"Parasitism influence on the hepato, splenosomatic and weight\/length relation and relative condition factor of Prochilodus lineatus (Valenciennes, 1836) (Prochilodontidae) of the upper paran\u00e1 river floodplain","volume":"15","author":"Lizama","year":"2006","journal-title":"Brazil Rev Bras Parasitol Vet"},{"key":"10.1016\/j.fsi.2018.02.041_bib27","series-title":"Basic Haematology and Serology for Fish Health Programs","first-page":"185","author":"Anderson","year":"1995"},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1095-8649.1988.tb05341.x","article-title":"Normal ranges of some blood chemistry parameters in adult farmed Atlantic salmon, Salmo salar","volume":"32","author":"Sandnes","year":"1988","journal-title":"J. Fish. Biol."},{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.fsi.2015.03.025","article-title":"Effects of dietary administration of stinging nettle (Urtica dioica) on the growth performance, biochemical, hematological and immunological parameters in juvenile and adult Victoria Labeo (Labeo victorianus) challenged with Aeromonas hydrophila","volume":"44","author":"Ngugi","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00281-011-0280-x","article-title":"Interactions between coagulation and complement-their role in inflammation","volume":"34","author":"Oikonomopoulou","year":"2012","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.fsi.2018.02.041_bib31","series-title":"Hematology: Basic Principles and Practice, Transfusion","first-page":"1722","volume":"vol.41","author":"Toby Simon","year":"2001"},{"issue":"4","key":"10.1016\/j.fsi.2018.02.041_bib32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1055\/s-2004-833481","article-title":"Platelet coagulation-protein interactions","volume":"30","author":"Walsh","year":"2004","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.fsi.2018.02.041_bib33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.fsi.2016.06.031","article-title":"Chronic hyperosmotic stress interferes with immune homeostasis in striped catfish (Pangasianodon hypophthalmus, S.) and leads to excessive inflammatory response during bacterial infection","volume":"55","author":"Schmitz","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2018.02.041_bib34","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1095-8649.1992.tb02643.x","article-title":"Melanomacrophage centres in white mouth croaker Micropogoniasfuerney, as biological indicators of environmental changes","volume":"40","author":"Macchi","year":"2006","journal-title":"J. Fish. Biol."},{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1095-8649.1981.tb05820.x","article-title":"Effects of starvation on the melano-macrophage centres of fish","volume":"19","author":"Agius","year":"1981","journal-title":"J. Fish. Biol."},{"issue":"8","key":"10.1016\/j.fsi.2018.02.041_bib36","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1365-2109.2006.01498.x","article-title":"Effects of starvation on kidney melano-macrophage centre in olive flounder, Paralichthys olivaceus (Temminck and Schlegel)","volume":"37","author":"Hur","year":"2006","journal-title":"Aquacult. Res."},{"issue":"1\u20134","key":"10.1016\/j.fsi.2018.02.041_bib37","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-2427(86)90116-9","article-title":"Structure and function of the melano-macrophage centres of the goldfish Carassius auratus","volume":"12","author":"Herr\u00e1ez","year":"1986","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.fsi.2018.02.041_bib38","first-page":"1","article-title":"Melano-macrophages of the seawater teleosts, sea bass (Dicentrarchus labrax) and gilthead seabream (Sparus aurata): morphology, formation and possible function","volume":"277","author":"Meseguer","year":"1994","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.fsi.2018.02.041_bib39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2761.1992.tb00656.x","article-title":"Mortalities in Atlantic salmon, Salmo salar L., associated with pathology of the melano-macrophage and haemopoietic systems","volume":"15","author":"Palmer","year":"1992","journal-title":"J. Fish. Dis."},{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1095-8649.1990.tb05851.x","article-title":"A quantitative and histochemical study on melano-macrophage centres in the spleen of the teleost fish Diplodus annularis L","volume":"37","author":"Micale","year":"1990","journal-title":"J. Fish. Biol."},{"issue":"9","key":"10.1016\/j.fsi.2018.02.041_bib41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-2761.2003.00485.x","article-title":"Melano-macrophage centres and their role in fish pathology","volume":"26","author":"Agius","year":"2003","journal-title":"J. Fish. Dis."},{"issue":"69","key":"10.1016\/j.fsi.2018.02.041_bib42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annu. Rev. Biochem."},{"issue":"6","key":"10.1016\/j.fsi.2018.02.041_bib43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1359-6101(02)00028-X","article-title":"Evolution of interleukin-1\u03b2","volume":"13","author":"Bird","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"issue":"4","key":"10.1016\/j.fsi.2018.02.041_bib44","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1095-8649.1984.tb04818.x","article-title":"An electron microscopical study on the genesis of lipofuscin, melanin and haemosiderin in the haemopoietic tissues of fish","volume":"24","author":"Agius","year":"1984","journal-title":"J. Fish. Biol."},{"issue":"6","key":"10.1016\/j.fsi.2018.02.041_bib45","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1095-8649.1995.tb01410.x","article-title":"Changes in some endocrinological and non-specific immunological parameters during seawater exposure in the brown trout","volume":"46","author":"Marc","year":"1995","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2018.02.041_bib46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0959-8030(92)90060-B","article-title":"Fish granulocytes: morphology, distribution, and function","volume":"2","author":"Ainsworth","year":"1992","journal-title":"Annu. Rev. Fish Dis."},{"issue":"5","key":"10.1016\/j.fsi.2018.02.041_bib47","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","article-title":"Neutrophils, from marrow to microbes","volume":"33","author":"Borregaard","year":"2010","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.fsi.2018.02.041_bib48","first-page":"484","article-title":"Effect of time, temperature and anticoagulants on in vitro complement activation: consequences for collection and preservation of samples to be examined for complement activation","volume":"73","author":"Mollnes","year":"1988","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2018.02.041_bib49","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0167-5699(91)90012-I","article-title":"The response of human platelets to activated components of the complement system","volume":"12","author":"Sims","year":"1991","journal-title":"Immunol. Today"},{"issue":"5","key":"10.1016\/j.fsi.2018.02.041_bib50","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.fsi.2009.03.005","article-title":"Effects of serum on phagocytic activity and proteomic analysis of tilapia (Oreochromis mossambicus) serum after acute osmotic stress","volume":"26","author":"Kumar","year":"2009","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2018.02.041_bib51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.fsi.2004.07.009","article-title":"Esteban M\u00c1, Salinity influences the humoral immune parameters of gilthead seabream (Sparus aurata L.)","volume":"18","author":"Cuesta","year":"2005","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.02.041_bib52","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1042\/bj1870909","article-title":"Fluorometric assays for cathepsin B and cathepsin H with methyl courmaryl amide substrates","volume":"187","author":"Barrett","year":"1980","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.fsi.2018.02.041_bib53","first-page":"3","article-title":"Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting","volume":"70","author":"Ciechanover","year":"2010","journal-title":"Medicina"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818301037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818301037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T21:30:00Z","timestamp":1660512600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464818301037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":53,"alternative-id":["S1050464818301037"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2018.02.041","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histological and transcriptomic responses of two immune organs, the spleen and head kidney, in Nile tilapia (Oreochromis niloticus) to long-term hypersaline stress","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2018.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}