{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:14:16Z","timestamp":1788412456395,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST106-3114-B-019-001"],"award-info":[{"award-number":["MOST106-3114-B-019-001"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST106-3114-8-019-001"],"award-info":[{"award-number":["MOST106-3114-8-019-001"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST106-3114-B-020-001"],"award-info":[{"award-number":["MOST106-3114-B-020-001"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.fsi.2018.03.009","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T18:24:11Z","timestamp":1520101451000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Transcriptome profiling analysis of grouper during nervous necrosis virus persistent infection"],"prefix":"10.1016","volume":"76","author":[{"given":"Chun-Hsi","family":"Tso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3249-5311","authenticated-orcid":false,"given":"Ming-Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fsi.2018.03.009_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3354\/dao029085","article-title":"Vacuolating encephalopathy and retinopathy associated with a nodavirus-like agent: a probable cause of mass mortality of cultured larval and juvenile Atlantic halibut Hippoglossus hippoglossus","volume":"29","author":"Grotmol","year":"1997","journal-title":"Dis. Aquat. Org."},{"issue":"1\u20134","key":"10.1016\/j.fsi.2018.03.009_bib2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquaculture.2005.04.076","article-title":"Immunolocalisation of nervous necrosis virus indicates vertical transmission in hatchery produced Asian sea bass (Lates calcarifer Bloch)\u2014A case study","volume":"255","author":"Azad","year":"2006","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2018.03.009_bib3","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.molimm.2007.07.018","article-title":"The interferon response is involved in nervous necrosis virus acute and persistent infection in zebrafish infection model","volume":"45","author":"Lu","year":"2008","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2018.03.009_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2761.1988.tb00532.x","article-title":"Studies on the Carrier state of infectious pancreatic necrosis virus infections in rainbow trout, Salmo gairdneri Richardson","volume":"11","author":"Mangunwiryo","year":"1988","journal-title":"J. Fish. Dis."},{"issue":"5","key":"10.1016\/j.fsi.2018.03.009_bib5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.fsi.2010.02.001","article-title":"Differentially expressed genes following persistent infection with infectious pancreatic necrosis virus in vitro and in vivo","volume":"28","author":"Marjara","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2018.03.009_bib6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fsi.2014.08.029","article-title":"Induction of anti-inflammatory cytokine expression by IPNV in persistent infection","volume":"41","author":"Reyes-Cerpa","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"1\u201310","key":"10.1016\/j.fsi.2018.03.009_bib7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1439-0450.1986.tb00058.x","article-title":"Demonstration of persistent viral haemorrhagic septicaemia (VHS) virus in rainbow trout after experimental waterborne infection","volume":"33","author":"Neukirch","year":"1986","journal-title":"J. Vet. Med. Ser. B"},{"issue":"1","key":"10.1016\/j.fsi.2018.03.009_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3354\/dao02283","article-title":"Chronic and persistent viral hemorrhagic septicemia virus infections in Pacific herring","volume":"93","author":"Hershberger","year":"2010","journal-title":"Dis. Aquat. Org."},{"issue":"1","key":"10.1016\/j.fsi.2018.03.009_bib9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1186\/1471-2164-13-651","article-title":"Transcriptome characterization and gene expression of Epinephelus spp in endoplasmic reticulum stress-related pathway during betanodavirus infection in vitro","volume":"13","author":"Lu","year":"2012","journal-title":"BMC Genom."},{"issue":"11","key":"10.1016\/j.fsi.2018.03.009_bib10","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.vaccine.2007.12.043","article-title":"Efficacies of inactivated vaccines against betanodavirus in grouper larvae (Epinephelus coioides) by bath immunization","volume":"26","author":"Kai","year":"2008","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.fsi.2018.03.009_bib11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Full-length transcriptome assembly from RNA-Seq data without a reference genome","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.fsi.2018.03.009_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"Camacho","year":"2009","journal-title":"BMC Bioinf."},{"issue":"9","key":"10.1016\/j.fsi.2018.03.009_bib13","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/ng2082","article-title":"C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy","volume":"39","author":"Richards","year":"2007","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.fsi.2018.03.009_bib14","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2007.10.017","article-title":"Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease","volume":"131","author":"Yang","year":"2007","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.fsi.2018.03.009_bib15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ni.1941","article-title":"The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1","volume":"11","author":"Yan","year":"2010","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2018.03.009_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.immuni.2005.02.010","article-title":"CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells","volume":"22","author":"Marsland","year":"2005","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.fsi.2018.03.009_bib17","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/1521-4141(200208)32:8<2133::AID-IMMU2133>3.0.CO;2-W","volume":"32","author":"Alt","year":"2002","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2018.03.009_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00005-015-0339-9","article-title":"Central nervous system and peripheral expression of CCL19, CCL21 and their receptor CCR7 in experimental model of multiple sclerosis","volume":"63","author":"Bielecki","year":"2015","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"2","key":"10.1016\/j.fsi.2018.03.009_bib19","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1152\/physiolgenomics.00168.2009","article-title":"Impact of asymptomatic nodavirus Carrier state and intraperitoneal viral mimic injection on brain transcript expression in Atlantic cod (<span class=\"named-content genus-species\">Gadus morhua<\/span>)","volume":"42","author":"Rise","year":"2010","journal-title":"Physiol. Genom."},{"issue":"2","key":"10.1016\/j.fsi.2018.03.009_bib20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/72769","article-title":"ARSACS, a spastic ataxia common in northeastern Quebec, is caused by mutations in a new gene encoding an 11.5-kb ORF","volume":"24","author":"Engert","year":"2000","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.fsi.2018.03.009_bib21","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jmb.2011.06.016","article-title":"The neurodegenerative-disease-related protein sacsin is a molecular chaperone","volume":"411","author":"Anderson","year":"2011","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2018.03.009_bib22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1186\/1471-2164-13-651","article-title":"Transcriptome characterization and gene expression of Epinephelus spp in endoplasmic reticulum stress-related pathway during betanodavirus infection in vitro","volume":"13","author":"Lu","year":"2012","journal-title":"BMC Genom."},{"issue":"7","key":"10.1016\/j.fsi.2018.03.009_bib23","doi-asserted-by":"crossref","first-page":"e22542","DOI":"10.1371\/journal.pone.0022542","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.fsi.2018.03.009_bib24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","article-title":"Cerebrovascular \"moyamoya\" disease: disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki","year":"1969","journal-title":"Arch. Neurol."},{"issue":"Supplement C","key":"10.1016\/j.fsi.2018.03.009_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2016.03.009","article-title":"Temporal profile of magnetic resonance angiography and decreased ratio of regulatory T cells after immunological adjuvant administration to mice lacking RNF213, a susceptibility gene for moyamoya disease","volume":"1642","author":"Kanoke","year":"2016","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.fsi.2018.03.009_bib26","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1084\/jem.180.5.1763","article-title":"A novel cysteine-rich sequence-specific DNA-binding protein interacts with the conserved X-box motif of the human major histocompatibility complex class II genes via a repeated Cys-His domain and functions as a transcriptional repressor","volume":"180","author":"Song","year":"1994","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.fsi.2018.03.009_bib27","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.4049\/jimmunol.171.3.1255","article-title":"A Giant GTPase, Very large inducible GTPase-1, is inducible by IFNs","volume":"171","author":"Klamp","year":"2003","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2018.03.009_bib28","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.chom.2012.09.007","article-title":"IFN-inducible GTPases in host cell defense","volume":"12","author":"Kim","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.fsi.2018.03.009_bib29","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.fsi.2013.07.035","article-title":"Identification of the STAT1 gene and the characterisation of its immune response to immunostimulants, including nervous necrosis virus (NNV) infection, in Malabar grouper (Epinephelus malabaricus)","volume":"35","author":"Tso","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2018.03.009_bib30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jnc.12816","article-title":"The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function","volume":"131","author":"Beesley","year":"2014","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.fsi.2018.03.009_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1523\/JNEUROSCI.1808-15.2016","article-title":"Absence of Neuroplastin-65 affects synaptogenesis in mouse inner hair cells and causes profound hearing loss","volume":"36","author":"Carrott","year":"2016","journal-title":"J. Neurosci."},{"issue":"35","key":"10.1016\/j.fsi.2018.03.009_bib32","doi-asserted-by":"crossref","first-page":"9201","DOI":"10.1523\/JNEUROSCI.0093-16.2016","article-title":"Neuroplastin isoform Np55 is expressed in the stereocilia of outer hair cells and required for normal outer hair cell function","volume":"36","author":"Zeng","year":"2016","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.fsi.2018.03.009_bib33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.1032","article-title":"Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia","volume":"44","author":"Quesada","year":"2012","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.fsi.2018.03.009_bib34","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.ccell.2016.10.005","article-title":"Transcriptomic characterization of SF3B1 mutation reveals its pleiotropic effects in chronic lymphocytic leukemia","volume":"30","author":"Wang","year":"2016","journal-title":"Canc. Cell"},{"issue":"3","key":"10.1016\/j.fsi.2018.03.009_bib35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molcel.2011.05.035","article-title":"The Ewing sarcoma protein regulates DNA damage-induced alternative splicing","volume":"43","author":"Paronetto","year":"2011","journal-title":"Mol. Cell"},{"issue":"12","key":"10.1016\/j.fsi.2018.03.009_bib36","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1128\/JVI.01006-12","article-title":"EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient viral replication","volume":"87","author":"Oakland","year":"2013","journal-title":"J. Virol."},{"issue":"7178","key":"10.1016\/j.fsi.2018.03.009_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature06501","article-title":"NLRX1 is a regulator of mitochondrial antiviral immunity","volume":"451","author":"Moore","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.fsi.2018.03.009_bib38","doi-asserted-by":"crossref","first-page":"e1006398","DOI":"10.1371\/journal.ppat.1006398","article-title":"FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1","volume":"13","author":"Kim","year":"2017","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.fsi.2018.03.009_bib39","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.immuni.2011.03.026","article-title":"NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-\u03bab signaling pathways","volume":"34","author":"Allen","year":"2011","journal-title":"Immunity"},{"issue":"7077","key":"10.1016\/j.fsi.2018.03.009_bib40","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"Barber","year":"2006","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.fsi.2018.03.009_bib41","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1182\/blood-2010-11-318675","article-title":"LAG-3, TGF-\u03b2, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L","volume":"117","author":"Lucas","year":"2011","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.fsi.2018.03.009_bib42","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1128\/IAI.00278-16","article-title":"Cooperation of PD-1 and LAG-3 contributes to t-cell exhaustion in anaplasma marginale-infected cattle","volume":"84","author":"Okagawa","year":"2016","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.fsi.2018.03.009_bib43","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/imm.12665","article-title":"Functional exhaustion of CD4(+) T cells induced by co-stimulatory signals from myeloid leukaemia cells","volume":"149","author":"Ozkazanc","year":"2016","journal-title":"Immunology"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818301268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818301268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T01:37:32Z","timestamp":1565314652000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464818301268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":43,"alternative-id":["S1050464818301268"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2018.03.009","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome profiling analysis of grouper during nervous necrosis virus persistent infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2018.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}