{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:57:43Z","timestamp":1778839063336,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["APP1099912"],"award-info":[{"award-number":["APP1099912"]}]},{"name":"Australian National Health and Medical Research Council","award":["APP1053407"],"award-info":[{"award-number":["APP1053407"]}]},{"DOI":"10.13039\/501100001054","name":"Meat and Livestock Australia","doi-asserted-by":"publisher","award":["P.PSH. 0813"],"award-info":[{"award-number":["P.PSH. 0813"]}],"id":[{"id":"10.13039\/501100001054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity"},{"DOI":"10.13039\/100001711","name":"Kenyon Family Foundation Inflammation Award","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010556","name":"Conseller\u00eda de Econom\u00eda, Emprego e Industria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["IN607B 2016\/12"],"award-info":[{"award-number":["IN607B 2016\/12"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.fsi.2018.09.037","type":"journal-article","created":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T04:32:35Z","timestamp":1536813155000},"page":"238-242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility"],"prefix":"10.1016","volume":"83","author":[{"given":"Matt D.","family":"Johansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elinor","family":"Hortle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua A.","family":"Kasparian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Novoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Figueras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warwick J.","family":"Britton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumudika","family":"de Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-6658","authenticated-orcid":false,"given":"Auriol C.","family":"Purdie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-672X","authenticated-orcid":false,"given":"Stefan H.","family":"Oehlers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2018.09.037_bib1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni.1781","article-title":"Foamy macrophages and the progression of the human tuberculosis granuloma","volume":"10","author":"Cardona","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2018.09.037_bib2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.immuni.2016.09.014","article-title":"Macrophage epithelial reprogramming underlies mycobacterial granuloma formation and promotes infection","volume":"45","author":"Cronan","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2018.09.037_bib3","series-title":"Hemostasis and Lipoprotein Indices Signify Exacerbated Lung Injury in Tuberculosis with Diabetes Comorbidity","author":"Dong","year":"2017"},{"key":"10.1016\/j.fsi.2018.09.037_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.vetimm.2018.07.009","article-title":"Sheep and cattle exposed to Mycobacterium avium subspecies paratuberculosis exhibit altered total serum cholesterol profiles during the early stages of infection","volume":"202","author":"Johansen","year":"2018","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2018.09.037_bib5","series-title":"Mycobacterium avium Subspecies Paratuberculosis Is Able to Manipulate Host Lipid Metabolism and Accumulate Cholesterol within Macrophages","author":"Johansen","year":"2018"},{"key":"10.1016\/j.fsi.2018.09.037_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.dci.2018.07.022","article-title":"Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models","volume":"88","author":"Johansen","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2018.09.037_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/emmm.201000079","article-title":"Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism","volume":"2","author":"Kim","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.fsi.2018.09.037_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1194\/jlr.D081521","article-title":"Modeling hypercholesterolemia and vascular lipid accumulation in LDL receptor mutant zebrafish","volume":"59","author":"Liu","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.fsi.2018.09.037_bib9","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.3389\/fmicb.2016.01086","article-title":"Plasma membrane profiling reveals upregulation of ABCA1 by infected macrophages leading to restriction of mycobacterial growth","volume":"7","author":"Long","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2018.09.037_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mib.2015.10.002","article-title":"Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection","volume":"29","author":"Lovewell","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.fsi.2018.09.037_bib11","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1128\/IAI.00037-08","article-title":"Hypercholesterolemia impairs immunity to tuberculosis","volume":"76","author":"Martens","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fsi.2018.09.037_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-4939-3771-4_14","article-title":"Live imaging of host-pathogen interactions in zebrafish larvae","volume":"1451","author":"Matty","year":"2016","journal-title":"Meth. Mol. Biol."},{"key":"10.1016\/j.fsi.2018.09.037_bib13","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1194\/jlr.M046540","article-title":"Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia","volume":"55","author":"O'Hare","year":"2014","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.fsi.2018.09.037_bib14","first-page":"813","article-title":"Infection-induced vascular permeability aids mycobacterial growth","volume":"215","author":"Oehlers","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.fsi.2018.09.037_bib15","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature13967","article-title":"Interception of host angiogenic signalling limits mycobacterial growth","volume":"517","author":"Oehlers","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2018.09.037_bib16","doi-asserted-by":"crossref","first-page":"4376","DOI":"10.1073\/pnas.0711159105","article-title":"Mycobacterial persistence requires the utilization of host cholesterol","volume":"105","author":"Pandey","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2018.09.037_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/hep.22667","article-title":"Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation","volume":"49","author":"Passeri","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.fsi.2018.09.037_bib18","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni.1781","article-title":"Foamy macrophages and the progression of the human tuberculosis granuloma","volume":"10","author":"Russell","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2018.09.037_bib19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1101\/gr.075069.107","article-title":"Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis","volume":"18","author":"Stinear","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.fsi.2018.09.037_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.vetimm.2008.02.021","article-title":"Toll-like receptor genes are differentially expressed at the sites of infection during the progression of Johne's disease in outbred sheep","volume":"124","author":"Taylor","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2018.09.037_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/1040841X.2014.932327","article-title":"Role of host- and pathogen-associated lipids in directing the immune response in mycobacterial infections, with emphasis on Mycobacterium avium subsp. paratuberculosis","author":"Thirunavukkarasu","year":"2014","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2018.09.037_bib22","first-page":"253","article-title":"The zebrafish as a model organism to study development of the immune system","volume":"81","author":"Traver","year":"2003","journal-title":"Adv. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818305813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818305813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T18:03:52Z","timestamp":1545329032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464818305813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":22,"alternative-id":["S1050464818305813"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2018.09.037","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/250548","asserted-by":"object"}]},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2018.09.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}