{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:38:53Z","timestamp":1781789933645,"version":"3.54.5"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation, China","doi-asserted-by":"publisher","award":["ZR2017BD026"],"award-info":[{"award-number":["ZR2017BD026"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yantai University Doctoral Start-up Fund","award":["HX15B14"],"award-info":[{"award-number":["HX15B14"]}]},{"name":"Innovative Development of Marine Economy Fund","award":["YHCX-SW- P201701"],"award-info":[{"award-number":["YHCX-SW- P201701"]}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["KFZD-SW-106"],"award-info":[{"award-number":["KFZD-SW-106"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.fsi.2018.10.022","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T04:37:37Z","timestamp":1539059857000},"page":"434-440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["The influence of three antibiotics on the growth, intestinal enzyme activities, and immune response of the juvenile sea cucumber Apostichopus japonicus selenka"],"prefix":"10.1016","volume":"84","author":[{"given":"Ye","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.fsi.2018.10.022_bib1","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1021\/es048550a","article-title":"Occurrence and sorption behavior of sulfonamides, macrolides, and trimethoprim in activated sludge treatment","volume":"39","author":"G\u00f6bel","year":"2005","journal-title":"Environ. Sci. Technol."},{"issue":"24","key":"10.1016\/j.fsi.2018.10.022_bib2","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1021\/es034368i","article-title":"Occurrence and fate of macrolide antibiotics in wastewater treatment plants and in the Glatt Valley watershed, Switzerland","volume":"37","author":"McArdell","year":"2003","journal-title":"Environ. Sci. Technol."},{"issue":"10","key":"10.1016\/j.fsi.2018.10.022_bib3","doi-asserted-by":"crossref","first-page":"8978","DOI":"10.1007\/s11356-015-5607-z","article-title":"Application of veterinary antibiotics in China's aquaculture industry and their potential human health risks","volume":"24","author":"Mo","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fsi.2018.10.022_bib4","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.scitotenv.2014.05.068","article-title":"Occurrence and ecological potential of pharmaceuticals and personal care products in groundwater and reservoirs in the vicinity of municipal landfills in China","volume":"490","author":"Peng","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2018.10.022_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.scitotenv.2013.09.092","article-title":"Potential environmental implications of emerging organic contaminants in Taihu lake, China: comparison of two ecotoxicological assessment approaches","volume":"470\u2013471","author":"Yan","year":"2014","journal-title":"Sci. Total Environ."},{"issue":"1","key":"10.1016\/j.fsi.2018.10.022_bib6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.marpolbul.2013.05.007","article-title":"Fate of antibiotics during wastewater treatment and antibiotic distribution in the effluent-receiving waters of the Yellow Sea, northern China","volume":"73","author":"Zhang","year":"2013","journal-title":"Mar. Pollut. Bull."},{"issue":"11","key":"10.1016\/j.fsi.2018.10.022_bib7","doi-asserted-by":"crossref","first-page":"6772","DOI":"10.1021\/acs.est.5b00729","article-title":"Comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modeling, and linkage to bacterial resistance","volume":"49","author":"Zhang","year":"2015","journal-title":"Environ. Sci. Technol."},{"issue":"24","key":"10.1016\/j.fsi.2018.10.022_bib8","doi-asserted-by":"crossref","first-page":"14317","DOI":"10.1021\/es503700j","article-title":"Occurrences of three classes of antibiotics in a natural river basin: association with antibiotic-resistant Escherichia coli","volume":"48","author":"Zhang","year":"2014","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.fsi.2018.10.022_bib9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.etap.2014.07.020","article-title":"Integrated biomarker responses in zebrafish exposed to sulfonamides","volume":"38","author":"Lin","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.fsi.2018.10.022_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2761.1989.tb00279.x","article-title":"An investigation into oxytetracycline residues in Atlantic salmon, Salmo salar L","volume":"12","author":"Bruno","year":"2010","journal-title":"J. Fish. Dis."},{"issue":"5","key":"10.1016\/j.fsi.2018.10.022_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/fsim.1999.0247","article-title":"The influence of in vitro, and in vivo, exposure to antibiotics on mitogen-induced proliferation of lymphoid cells in rainbow trout (Oncorhynchus mykiss)","volume":"10","author":"Lund\u00e9n","year":"2000","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.10.022_bib12","series-title":"Fauna Sinica: Phylum Enchinodermata Class Holothuroidea","first-page":"148","author":"Liao","year":"1997"},{"issue":"1","key":"10.1016\/j.fsi.2018.10.022_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jip.2007.03.001","article-title":"Acute peristome edema disease in juvenile and adult sea cucumbers Apostichopus japonicus (selenka) reared in north China","volume":"96","author":"Wang","year":"2007","journal-title":"J. Invertebr. Pathol."},{"issue":"5","key":"10.1016\/j.fsi.2018.10.022_bib14","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.fsi.2018.10.022_bib15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.fsi.2014.12.028","article-title":"Effect of potential probiotic Rhodotorula benthica, D30 on the growth performance, digestive enzyme activity and immunity in juvenile sea cucumber Apostichopus japonicas","volume":"43","author":"Wang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2018.10.022_bib16","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1093\/clinchem\/17.12.1150","article-title":"Simplified turbidimetric assay for lipase activity","volume":"17","author":"Shihabi","year":"1971","journal-title":"Clin. Chem."},{"key":"10.1016\/j.fsi.2018.10.022_bib17","doi-asserted-by":"crossref","first-page":"40247","DOI":"10.1038\/srep40247","article-title":"Identification and functional characterisation of 5-HT4 receptor in sea cucumber Apostichopus japonicus (Selenka)","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.fsi.2018.10.022_bib18","first-page":"57","article-title":"Effects of dietary supplementation of commercial human probiotic and antibiotic on the growth rate and content of intestinal microflora in ornamental fishes","volume":"11","author":"Abraham","year":"2007","journal-title":"Bangladesh J. Fish. Res."},{"issue":"5","key":"10.1016\/j.fsi.2018.10.022_bib19","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1749-7345.2008.00195.x","article-title":"A preliminary study on the effects on growth, condition, and feeding indexes in Channel Catfish, Ictalurus punctatus, after the prophylactic use of potassium permanganate and oxytetracycline","volume":"39","author":"Sanchez\u2010Mart\u00ednez","year":"2008","journal-title":"J. World Aquacult. Soc."},{"issue":"4","key":"10.1016\/j.fsi.2018.10.022_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejar.2013.12.001","article-title":"Effect of oxytetracycline and florfenicol as growth promoters on the health status of cultured Oreochromis niloticus","volume":"39","author":"Reda","year":"2013","journal-title":"Egypt J. Aquat. Res."},{"issue":"1","key":"10.1016\/j.fsi.2018.10.022_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1577\/1548-8659(1954)84[86:TEOSSO]2.0.CO;2","article-title":"The effect of some sulfonamides on the growth of brook trout, brown trout, and rainbow trout","volume":"84","author":"Snieszko","year":"1955","journal-title":"Trans. Am. Fish. Soc."},{"issue":"18","key":"10.1016\/j.fsi.2018.10.022_bib22","doi-asserted-by":"crossref","first-page":"18222","DOI":"10.1007\/s11356-016-7018-1","article-title":"Long-term effects of antibiotics, norfloxacin, and sulfamethoxazole, in a partial life-cycle study with zebrafish (Danio rerio): effects on growth, development, and reproduction","volume":"23","author":"Yan","year":"2016","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.fsi.2018.10.022_bib23","first-page":"1","article-title":"Influence of long-term feeding antibiotics on the gut health of zebrafish","volume":"00","author":"Zhou","year":"2018","journal-title":"Zebrafish"},{"issue":"1","key":"10.1016\/j.fsi.2018.10.022_bib24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.aquaculture.2008.10.015","article-title":"Isolation and pathogenicity of pathogens from skin ulceration disease and viscera ejection syndrome of the sea cucumber Apostichopus japonicas","volume":"287","author":"Deng","year":"2009","journal-title":"Aquaculture"},{"issue":"3","key":"10.1016\/j.fsi.2018.10.022_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/fsim.1998.0142","article-title":"Influence of oxytetracycline and oxolinic acid on the immune response of rainbow trout (Oncorhynchus mykiss)","volume":"8","author":"Lund\u00e9n","year":"1998","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.10.022_bib26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.physbeh.2014.11.051","article-title":"Feeding behavior and digestive physiology in sea cucumber Apostichopus japonicus","volume":"139","author":"Sun","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.fsi.2018.10.022_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.aquaculture.2013.07.002","article-title":"Effect of tryptophan on growth, intestinal enzyme activities and TOR gene expression in juvenile Jian carp (Cyprinus carpio var. Jian): studies in vivo and in vitro","volume":"412","author":"Tang","year":"2013","journal-title":"Aquaculture"},{"issue":"5","key":"10.1016\/j.fsi.2018.10.022_bib28","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s10499-017-0148-8","article-title":"Alteration of growth, intestinal Lactobacillus, selected immune and digestive enzyme activities in juvenile sea cucumber Apostichopus japonicus, fed dietary multiple probiotics","volume":"25","author":"Bao","year":"2017","journal-title":"Aquac. Int."},{"issue":"4","key":"10.1016\/j.fsi.2018.10.022_bib29","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s00343-009-9202-3","article-title":"Effect of water temperature on digestive enzyme activity and gut mass in sea cucumber Apostichopus japonicus (Selenka), with special reference to aestivation","volume":"27","author":"Gao","year":"2009","journal-title":"Chin. J. Oceanol. Limnol."},{"key":"10.1016\/j.fsi.2018.10.022_bib30","first-page":"006","article-title":"Activities of four digestive enzymes in various developmental larvae and in alimentary canals at various sizes of Apostichopus japonicus","volume":"5","author":"Tang","year":"2007","journal-title":"Fish. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2018.10.022_bib31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1079\/BJN19900009","article-title":"The influence of inclusion of either an antibiotic or a probiotic in the diet on the development of digestive enzyme activity in the pig","volume":"64","author":"Collington","year":"1990","journal-title":"Br. J. Nutr."},{"issue":"6","key":"10.1016\/j.fsi.2018.10.022_bib32","first-page":"2","article-title":"Histological and histochemical studies on the digestive system of Apostichopus japonicas","volume":"35","author":"Cui","year":"2000","journal-title":"Chin. J. Zool."},{"key":"10.1016\/j.fsi.2018.10.022_bib33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aquaculture.2012.06.007","article-title":"Growth, metabolism and immune responses to evisceration and the regeneration of viscera in sea cucumber, Apostichopus japonicas","volume":"358","author":"Zang","year":"2012","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2018.10.022_bib34","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aquaculture.2013.10.045","article-title":"Growth performance, immune response, and disease resistance against Vibrio splendidus infection in juvenile sea cucumber Apostichopus japonicus fed a supplementary diet of the potential probiotic Paracoccus marcusii DB11","volume":"420","author":"Yan","year":"2014","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2018.10.022_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s004410050517","article-title":"Defensive mechanisms of holothuroids (Echinodermata): formation, role, and fate of intracoelomic brown bodies in the sea cucumber Holothuria tubulosa","volume":"283","author":"Jans","year":"1995","journal-title":"Cell Tissue Res."},{"issue":"2\u20133","key":"10.1016\/j.fsi.2018.10.022_bib36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2004.02.005","article-title":"Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases","volume":"93","author":"Tlaskalov\u00e1hogenov\u00e1","year":"2004","journal-title":"Immunol. Lett."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2018.10.022_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0165-2427(89)90122-0","article-title":"Comparisons of nonspecific and specific immunomodulation by oxolinic acid, oxytetracycline and levamisole in salmonids","volume":"23","author":"Siwicki","year":"1989","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"2","key":"10.1016\/j.fsi.2018.10.022_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0044-8486(80)90018-6","article-title":"The immune system of cyprinid fish. The immunosuppressive effect of the antibiotic oxytetracycline in carp (Cyprinus carpio L.)","volume":"19","author":"Rijkers","year":"1980","journal-title":"Aquaculture"},{"issue":"3","key":"10.1016\/j.fsi.2018.10.022_bib39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0165-2427(81)90029-5","article-title":"The immune system of cyprinid fish. Oxytetracycline and the regulation of humoral immunity in carp (Cyprinus carpio)","volume":"2","author":"Rijkers","year":"1981","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"4","key":"10.1016\/j.fsi.2018.10.022_bib40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0165-2427(98)00232-3","article-title":"Effect of florfenicol on the immune response of rainbow trout (Oncorhynchus mykiss)","volume":"67","author":"Lund\u00e9n","year":"1999","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"6","key":"10.1016\/j.fsi.2018.10.022_bib41","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1080\/01926230290166724","article-title":"Invited review: oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification","volume":"30","author":"Kohen","year":"2002","journal-title":"Toxicol. Pathol."},{"issue":"2","key":"10.1016\/j.fsi.2018.10.022_bib42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1382-6689(02)00126-6","article-title":"Fish bioaccumulation and biomarkers in environmental risk assessment: a review","volume":"13","author":"Van","year":"2003","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"6","key":"10.1016\/j.fsi.2018.10.022_bib43","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.fsi.2012.02.012","article-title":"The effect of lycopene on oxytetracycline-induced oxidative stress and immunosuppression in rainbow trout (Oncorhynchus mykiss W.)","volume":"32","author":"Yonar","year":"2012","journal-title":"Fish Shellfish Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818306521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818306521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T10:05:13Z","timestamp":1605175513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464818306521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":43,"alternative-id":["S1050464818306521"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2018.10.022","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The influence of three antibiotics on the growth, intestinal enzyme activities, and immune response of the juvenile sea cucumber Apostichopus japonicus selenka","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2018.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}