{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:37:57Z","timestamp":1790455077585,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772873"],"award-info":[{"award-number":["31772873"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.fsi.2018.11.035","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T12:13:55Z","timestamp":1542284035000},"page":"116-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Cytokine gene expression profiles in goldfish (Carassius auratus) during Gyrodactylus kobayashii infection"],"prefix":"10.1016","volume":"86","author":[{"given":"Xiao","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoxue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2018.11.035_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/B:SYPA.0000038447.52015.e4","article-title":"Nominal species of the genus Gyrodactylus von Nordmann 1832 (Monogenea: Gyrodactylidae), with a list of principal host species","volume":"59","author":"Harris","year":"2004","journal-title":"Syst. Parasitol."},{"key":"10.1016\/j.fsi.2018.11.035_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0065-308X(06)64003-7","article-title":"The biology of gyrodactylid monogeneans: the \"Russian-doll killers\"","volume":"64","author":"Bakke","year":"2007","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.fsi.2018.11.035_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1014555904968","article-title":"Parasites of fish from the Salton sea, California, U.S.A","volume":"466","author":"Kuperman","year":"2001","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.fsi.2018.11.035_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.vetpar.2015.03.002","article-title":"Efficacy of ginger-based treatments against infection with Gyrodactylus turnbulli in the guppy (Poecilia reticulata (Peters))","volume":"209","author":"Levy","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.fsi.2018.11.035_bib5","first-page":"54","article-title":"Treatments for parasitic diseases of aquarium and ornamental fish, Semin","volume":"5","author":"Harms","year":"1996"},{"key":"10.1016\/j.fsi.2018.11.035_bib6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.aquaculture.2018.06.064","article-title":"Arctigenin: an emerging candidate against infections of Gyrodactylus","volume":"495","author":"Tu","year":"2018","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2018.11.035_bib7","first-page":"441","article-title":"Monogeneans of fishes near G\u00f6k\u00e7eada, in Turkey","volume":"37","author":"Akmirza","year":"2013","journal-title":"Turk. J. Zool."},{"key":"10.1016\/j.fsi.2018.11.035_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.aquaculture.2016.09.048","article-title":"Anthelmintic efficacies of three common disinfectants and extracts of four traditional Chinese medicinal plants against Gyrodactylus kobayashii (Monogenea) in goldfish (Carassius auratus)","volume":"466","author":"Zhou","year":"2017","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2018.11.035_bib9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1017\/S003118209800287X","article-title":"Killing of Gyrodactylus salaris (Platyhelminthes, Monogenea) mediated by host complement","volume":"117","author":"Harris","year":"1998","journal-title":"Parasitology"},{"key":"10.1016\/j.fsi.2018.11.035_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3354\/dao032195","article-title":"Binding and lethal effect of complement from Oncorhynchus mykiss on Gyrodactylus derjavini (Platyhelminthes: Monogenea)","volume":"32","author":"Buchmann","year":"1998","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2018.11.035_bib11","first-page":"227","article-title":"Lectins in fish skin: do they play a role in host-monogenean interactions?","volume":"75","author":"Buchmann","year":"2001","journal-title":"J. Helminthol."},{"key":"10.1016\/j.fsi.2018.11.035_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1050-4648(02)00142-0","article-title":"Gyrodactylus derjavini infection elicits IL-1beta expression in rainbow trout skin","volume":"15","author":"Lindenstr\u00f8m","year":"2003","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fsi.2018.05.060","article-title":"Expression of immune-related genes of Nile tilapia Oreochromis niloticus after Gyrodactylus cichlidarum and Cichlidogyrus sclerosus infections demonstrating immunosupression in coinfection","volume":"80","author":"Zhi","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.fsi.2018.03.033","article-title":"Expression analysis of immune genes in goldfish (Carassius auratus) infected with the monogenean parasite Gyrodactylus kobayashii","volume":"77","author":"Zhou","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.fsi.2011.11.018","article-title":"IPNV modulation of pro and anti-inflammatory cytokine expression in Atlantic salmon might help the establishment of infection and persistence","volume":"32","author":"Reyes-Cerpa","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pt.2008.03.012","article-title":"What are the respective host and parasite contributions to toxoplasmosis?","volume":"24","author":"Maubon","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.fsi.2018.11.035_bib17","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1007\/s00436-015-4474-3","article-title":"The first report of Dactylogyrus formosus Kulwiec, 1927 (Monogenea: Dactylogyridae) from goldfish (Carassius auratus) in central China","volume":"114","author":"Tu","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.fsi.2018.11.035_bib18","article-title":"Origin of Chinese goldfish and sequential loss of genetic diversityaccompanies new breeds","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2018.11.035_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.dci.2016.05.019","article-title":"Characterization of Toll-like receptor gene expression in goldfish (Carassius auratus) during Dactylogyrus intermedius infection","volume":"63","author":"Tu","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00436-014-4241-x","article-title":"An infection of Gyrodactylus kobayashii Hukuda, 1940 (Monogenea) associated with the mortality of goldfish (Carassius auratus) from central China","volume":"114","author":"Tu","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.fsi.2018.11.035_bib21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fsi.2017.10.060","article-title":"Display of GCRV vp7 protein on the surface of Escherichia coli and its immunoprotective effects in grass carp (Ctenopharyngodon idella)","volume":"72","author":"Hao","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib22","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.dci.2013.01.014","article-title":"Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish","volume":"40","author":"Yang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib23","series-title":"Fish Disease: Diagnosis and Treatment","author":"Noga","year":"2010"},{"key":"10.1016\/j.fsi.2018.11.035_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-9-75","article-title":"Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress","volume":"9","author":"Peng","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.fsi.2018.11.035_bib25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.fsi.2017.11.038","article-title":"A teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus","volume":"72","author":"He","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"10","key":"10.1016\/j.fsi.2018.11.035_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078909","article-title":"Reproductive trade-offs may moderate the impact of Gyrodactylus salaris in warmer climates","volume":"8","author":"Denholm","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2018.11.035_bib28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0020-7519(01)00188-6","article-title":"The susceptibility of grayling (Thymallus thymallus) to experimental infections with the monogenean Gyrodactylus salaris","volume":"31","author":"Soleng","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.fsi.2018.11.035_bib29","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1095-8312.2006.00755.x","article-title":"The role of innate and acquired resistance in two natural populations of guppies (Poecilia reticulata) infected with the ectoparasite Gyrodactylus turnbulli","volume":"90","author":"Cable","year":"2010","journal-title":"Biol. J. Linn. Soc."},{"key":"10.1016\/j.fsi.2018.11.035_bib30","doi-asserted-by":"crossref","first-page":"A13","DOI":"10.1016\/S0167-5699(05)80005-2","article-title":"The involvement of TNF, IL-1 and IL-6 in the immune response to protozoan parasites","volume":"12","author":"Titus","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1016\/j.fsi.2018.11.035_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.fsi.2003.12.005","article-title":"Expression of pro-inflammatory cytokines in rainbow trout (Oncorhynchus mykiss) during an infection with Ichthyophthirius multifiliis","volume":"17","author":"Sigh","year":"2004","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib32","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3354\/dao035013","article-title":"Rainbow trout leucocyte activity: influence on the ectoparasitic monogenean Gyrodactylus derjavini","volume":"35","author":"Buchmann","year":"1999","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2018.11.035_bib33","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3354\/dao032195","article-title":"Binding and lethal effect of complement from Oncorhynchus mykiss on Gyrodactylus derjavini (Platyhelminthes: Monogenea)","volume":"32","author":"Buchmann","year":"1998","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2018.11.035_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-065X.2000.17706.x","article-title":"The neutrophil as a cellular source of chemokines","volume":"177","author":"Scapini","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2018.11.035_bib35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.vetimm.2003.08.016","article-title":"Expression of immune response genes in rainbow trout skin induced by Gyrodactylus derjavini infections","volume":"97","author":"Lindenstr\u00f8m","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2018.11.035_bib36","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1002\/eji.1830221006","article-title":"The microbicidal activity of interferon-\u03b3 treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by IL-10 and transforming growth factor-\u03b2","volume":"22","author":"Gazzinelli","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib37","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.fsi.2011.07.008","article-title":"The expression analysis of inflammatory and antimicrobial genes in the goldfish (Carassius auratus L.) infected with Trypanosoma carassii","volume":"31","author":"Oladiran","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/expr.1996.0109","article-title":"Trypanosoma cruzi: IL-10, TNF, IFN-\u03b3, and IL-12 regulate innate and acquired immunity to infection","volume":"84","author":"Abrahamsohn","year":"1996","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.fsi.2018.11.035_bib39","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.lfs.2003.10.042","article-title":"iNOS-mediated nitric oxide production and its regulation","volume":"75","author":"Aktan","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.fsi.2018.11.035_bib40","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S1567-5769(01)00090-X","article-title":"Nitric oxide in parasitic infections","volume":"1","author":"Brunet","year":"2001","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.fsi.2018.11.035_bib41","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1359-6101(02)00026-6","article-title":"Regulation of cytokine signaling and inflammation","volume":"13","author":"Hanada","year":"2002","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.fsi.2018.11.035_bib42","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0002-9440(10)63853-9","article-title":"Transforming growth factor-\u03b2 mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells","volume":"162","author":"Beck","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fsi.2018.11.035_bib43","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.fsi.2012.11.004","article-title":"Expression of immune-related genes in goldfish gills induced by Dactylogyrus intermedius infections","volume":"34","author":"Lu","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib44","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.fsi.2008.02.011","article-title":"Dynamic expression of immune response genes in the sea bass, Dicentrarchus labrax, experimentally infected with the monogenean Diplectanum aequans","volume":"24","author":"Faliex","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0169-4758(99)01562-8","article-title":"Maintaining the immunological balance in parasitic infections: a role for TGF-beta?","volume":"16","author":"Omer","year":"2000","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.fsi.2018.11.035_bib46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","article-title":"Interleukin-10","volume":"11","author":"Moore","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib48","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","article-title":"Regulation and functions of IL-10 family cytokines in inflammation and diseases","volume":"29","author":"Ouyang","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","article-title":"Regulation and functions of the IL-10 family of cytokines in inflammation and disease","volume":"29","author":"Ouyang","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib50","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1473-3099(06)70577-1","article-title":"The two faces of interleukin 10 in human infectious diseases","volume":"6","author":"Mege","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.fsi.2018.11.035_bib51","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.fsi.2014.08.029","article-title":"Induction of anti-inflammatory cytokine expression by IPNV in persistent infection","volume":"41","author":"Reyescerpa","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.11.035_bib52","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1084\/jem.20030026","article-title":"Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1","volume":"198","author":"Liu","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2018.11.035_bib53","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481830754X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481830754X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T09:43:30Z","timestamp":1565257410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046481830754X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":53,"alternative-id":["S105046481830754X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2018.11.035","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine gene expression profiles in goldfish (Carassius auratus) during Gyrodactylus kobayashii infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2018.11.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}