{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:00:11Z","timestamp":1778349611481,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160444"],"award-info":[{"award-number":["BK20160444"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31640074"],"award-info":[{"award-number":["31640074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY19B020012"],"award-info":[{"award-number":["LY19B020012"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY19H160015"],"award-info":[{"award-number":["LY19H160015"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007540","name":"Jiangsu Agriculture Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["CX(18)3027"],"award-info":[{"award-number":["CX(18)3027"]}],"id":[{"id":"10.13039\/100007540","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qing Lan Project of Jiangsu Province"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.fsi.2018.12.055","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T12:02:32Z","timestamp":1545652952000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Transcriptome-wide identification of differentially expressed genes in Procambarus clarkii in response to chromium challenge"],"prefix":"10.1016","volume":"87","author":[{"given":"Xun","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Hua","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai-Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Lian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Ping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Fei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2018.12.055_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02784599","article-title":"Toxic effects of chromium and its compounds","volume":"32","author":"Baruthio","year":"1992","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib2","series-title":"Molecular, Clinical and Environmental Toxicology","first-page":"133","article-title":"Heavy metal toxicity and environment","volume":"32","author":"Tchounwou","year":"2012"},{"key":"10.1016\/j.fsi.2018.12.055_bib3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0891-5849(94)00159-H","article-title":"Oxidative mechanisms in the toxicity of metal ions","volume":"18","author":"Stoh","year":"1995","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fsi.2018.12.055_bib4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02784599","article-title":"Toxic effects of chromium and its compounds","volume":"32","author":"Baruthio","year":"1992","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib5","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1093\/humrep\/dei148","article-title":"Chronic chromium exposure-induced changes in testicular histoarchitecture are associated with oxidative stress: study in a non-human primate (Macaca radiata Geoffroy)","volume":"20","author":"Aruldhas","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.fsi.2018.12.055_bib6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.fsi.2017.12.056","article-title":"Identification of a clip domain serine proteinase involved in immune defense in Chinese mitten crab Eriocheir sinensis","volume":"74","author":"Jia","year":"2018","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.fsi.2018.12.055_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10126-008-9146-1","article-title":"Functional annotation and analysis of expressed sequence tags from the hepatopancreas of mitten crab (Eriocheir sinensis)","volume":"11","author":"Jiang","year":"2009","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.fsi.2018.12.055_bib8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.dci.2009.02.003","article-title":"Two thymosin-repeated molecules with structural and functional diversity coexist in Chinese mitten crab Eriocheir sinensis","volume":"33","author":"Gai","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2018.12.055_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1744-7917.2009.00249.x","article-title":"Molecular mechanisms of heavy metal tolerance and evolution in invertebrates","volume":"16","author":"Janssens","year":"2009","journal-title":"Insect Sci."},{"key":"10.1016\/j.fsi.2018.12.055_bib10","doi-asserted-by":"crossref","first-page":"9305","DOI":"10.1021\/acs.jafc.7b03391","article-title":"Transcriptome-wide identification of differentially expressed genes in Chinese oak silkworm Antheraea pernyi in response to Lead challenge","volume":"65","author":"Xin","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fsi.2018.12.055_bib11","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1101\/gr.079558.108","article-title":"RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays","volume":"18","author":"Marioni","year":"2008","journal-title":"Genome. Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.dci.2017.12.030","article-title":"Transcriptome sequencing reveals the involvement of reactive oxygen species in the hematopoiesis from Chinese mitten crab Eriocheir sinensis","volume":"82","author":"Jia","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2018.12.055_bib13","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1126\/science.1158441","article-title":"The transcriptional landscape of the yeast genome defined by RNA sequencing","volume":"320","author":"Nagalakshmi","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.fsi.2018.12.055_bib14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.gdata.2015.12.010","article-title":"Transcriptome response to copper heavy metal stress in hard-shelled mussel (Mytilus coruscus)","volume":"7","author":"Xu","year":"2016","journal-title":"Genomics Data"},{"key":"10.1016\/j.fsi.2018.12.055_bib15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.fsi.2015.05.022","article-title":"The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)","volume":"46","author":"Meng","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.12.055_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.fsi.2017.02.025","article-title":"A ferritin gene from Procambarus clarkii, molecular characterization and in response to heavy metal stress and lipopolysaccharide challenge","volume":"63","author":"Liu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.12.055_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110548","article-title":"In-depth transcriptome analysis of the red swamp crayfish Procambarus clarkii","volume":"9","author":"Shen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2018.12.055_bib18","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Full-length transcriptome assembly from RNA-Seq data without a reference genome","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.fsi.2018.12.055_bib19","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic. Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib20","first-page":"71","article-title":"Integrated nr database in protein annotation system and its localization","volume":"32","author":"Deng","year":"2006","journal-title":"Computer Engineering Italic"},{"key":"10.1016\/j.fsi.2018.12.055_bib21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the universal protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.fsi.2018.12.055_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/nar\/28.1.33","article-title":"The COG database: a tool for genome scale analysis of protein functions and evolution","volume":"28","author":"Tatusov","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib24","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1186\/gb-2004-5-2-r7","article-title":"A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes","volume":"5","author":"Koonin","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.fsi.2018.12.055_bib25","first-page":"1248","article-title":"eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences","volume":"35","author":"Huerta-Cepas","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/nar\/gkh063","article-title":"The KEGG resource for deciphering the genome","volume":"32","author":"Kanehisa","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib28","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/bioinformatics\/14.9.755","article-title":"Profile hidden Markov models","volume":"14","author":"Eddy","year":"1998","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fsi.2018.12.055_bib29","first-page":"1223","article-title":"Pfam: the protein family database","volume":"56","author":"Finn","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.fsi.2018.12.055_bib31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.fsi.2017.10.010","article-title":"Transcriptome analysis of hepatopancraes of Procambarus clarkii challenged with polyriboinosinic polyribocytidylic acid (poly I:C)","volume":"71","author":"Dai","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.12.055_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.fsi.2018.12.055_bib33","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.fsi.2017.10.030","article-title":"Transcriptome profiling of red swamp P. clarkii (Procambarus clarkii) hepatopancreas in response to lipolysaccharide (LPS) infection","volume":"71","author":"Zhou","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2018.12.055_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.fsi.2018.12.055_bib35","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1214\/aos\/1074290335","article-title":"The positive false discovery rate: a Bayesian interpretation and the q-value","volume":"31","author":"Storey","year":"2003","journal-title":"Ann. Stat."},{"key":"10.1016\/j.fsi.2018.12.055_bib36","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00343-012-1252-2","article-title":"EST-derived SNP discovery and selective pressure analysis in Pacific white shrimp (Litopenaeus vannamei)","volume":"30","author":"Liu","year":"2012","journal-title":"Chin. J. Oceanol. Limnol."},{"key":"10.1016\/j.fsi.2018.12.055_bib37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2018.12.055_bib38","article-title":"From FastQ data to high confidence variant calls: the genome analysis toolkit best practices pipeline","volume":"63","author":"Auwera","year":"2013","journal-title":"Curr. Protocols Bioinforma."},{"key":"10.1016\/j.fsi.2018.12.055_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fsi.2018.12.055_bib40","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using realtime quantitative PCR and the 2(-Delta Delta C (T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2018.12.055_bib41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.tibs.2006.11.003","article-title":"Mammalian catalase: a venerable enzyme with new mysteries","volume":"32","author":"Kirkman","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fsi.2018.12.055_bib42","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1111\/j.1600-0854.2009.00966.x","article-title":"Hitchhiking of Cu\/Zn superoxide dismutase to peroxisomes-evidence for a natural piggyback import mechanism in mammals","volume":"10","author":"Islinger","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.fsi.2018.12.055_bib43","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1021\/acs.jafc.8b01645","article-title":"Transcriptome analysis reveals potential antioxidant defense mechanisms in Antheraea pernyi in response to Zinc stress","volume":"66","author":"Liu","year":"2018","journal-title":"J. Agric. Food Chem."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818308611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464818308611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T11:41:47Z","timestamp":1576496507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464818308611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":43,"alternative-id":["S1050464818308611"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2018.12.055","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome-wide identification of differentially expressed genes in Procambarus clarkii in response to chromium challenge","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2018.12.055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}