{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:33:00Z","timestamp":1777905180504,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2018YFD0900400"],"award-info":[{"award-number":["2018YFD0900400"]}]},{"name":"Guangdong Provincial Oceanic Fisheries Science and Technology Project","award":["A201601C04"],"award-info":[{"award-number":["A201601C04"]}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2018A030313222"],"award-info":[{"award-number":["2018A030313222"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2016A030313447"],"award-info":[{"award-number":["2016A030313447"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.fsi.2019.02.031","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T11:07:09Z","timestamp":1550315229000},"page":"126-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Effects of dietary dandelion extracts on growth performance, liver histology, immune-related gene expression and CCl4 resistance of hybrid grouper (Epinephelus lanceolatus\u2642 \u00d7 Epinephelus fuscoguttatus\u2640)"],"prefix":"10.1016","volume":"88","author":[{"given":"Zhenzhu","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaqun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuiyun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoxia","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2019.02.031_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.fsi.2017.05.028","article-title":"Effects of dietary dandelion extracts on growth performance, body composition, plasma biochemical parameters, immune responses and disease resistance of juvenile golden pompano, Trachinotus ovatus","volume":"66","author":"Tan","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.fsi.2016.10.039","article-title":"Plant polysaccharides used as immunostimulants enhance innate immune response and disease resistance against Aeromonas hydrophila infection in fish","volume":"59","author":"Wang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.fsi.2014.12.025","article-title":"Effects of curcumin on antioxidative activities and cytokine production in Jian carp (Cyprinus carpio var. Jian) with CCl4-induced liver damage","volume":"43","author":"Cao","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.fsi.2018.08.047","article-title":"The hepatoprotective effects of Radix Bupleuri extracts against D-galactosamine\/lipopolysaccharide induced liver injury in hybrid grouper (Epinephelus lanceolatus\u2642 \u00d7 Epinephelus fuscoguttatus\u2640)","volume":"83","author":"Zou","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00244-012-9835-7","article-title":"Effects of Waterborne Chronic Copper Exposure on Hepatic Lipid Metabolism and Metal-Element Composition in Synechogobius hasta","volume":"64","author":"Chen","year":"2013","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.fsi.2019.02.031_bib6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.fsi.2017.03.007","article-title":"Anti-inflammatory and hepatoprotective effects of glycyrrhetinic acidon CCl4 -induced damage in precision-cut liver slices from Jian carp (Cyprinus carpio var. jian) through inhibition of the nf-k\u0181 pathway","author":"Cao","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.intimp.2015.06.036","article-title":"Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2\/4 and MAPK\/NF-\u03baB pathway","volume":"28","author":"Ma","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fsi.2019.02.031_bib8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.intimp.2014.05.014","article-title":"Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin","volume":"21","author":"Al-Harbi","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fsi.2019.02.031_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.intimp.2014.05.022","article-title":"Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-\u03baB activities","volume":"21","author":"Ma","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fsi.2019.02.031_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.fsi.2017.10.022","volume":"72","author":"Tan","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jep.2011.09.025","article-title":"Traditional phytotherapy remedies used in Southern Rwanda for the treatment of liver diseases","volume":"138","author":"Mukazayire","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fsi.2019.02.031_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.aquaculture.2014.05.048","article-title":"Use of plant extracts in fish aquaculture as an alternative to chemotherapy: current status and future perspectives","volume":"433","author":"Reverter","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2019.02.031_bib13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1753-4887.2012.00509.x","article-title":"Diverse biological activities of dandelion","volume":"70","author":"Gonz\u00e1lez Castej\u00f3n","year":"2012","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.fsi.2019.02.031_bib14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jff.2016.11.032","article-title":"Dandelion extract suppresses reactive oxidative species and inflammasome in intestinal epithelial cells","volume":"29","author":"Xue","year":"2017","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.fsi.2019.02.031_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.fsi.2017.12.020","article-title":"Effects of dietary dandelion extract on intestinal morphology, antioxidant status, immune function and physical barrier function of juvenile golden pompano, Trachinotus ovatus","volume":"73","author":"Tan","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.carbpol.2013.12.029","article-title":"Cellulase-assisted extraction and antibacterial activity of polysaccharides from the dandelion, Taraxacum officinale","volume":"103","author":"Wang","year":"2014","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.fsi.2019.02.031_bib17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.fitote.2009.12.004","article-title":"Sesquiterpenoids and phenolics from roots of Taraxacum udum","volume":"81","author":"Michalska","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.fsi.2019.02.031_bib18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ijbiomac.2013.12.031","article-title":"Preparation and antibacterial activity of oligosaccharides derived from dandelion","volume":"64","author":"Qian","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2019.02.031_bib19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.indcrop.2017.10.017","article-title":"Skin-care effects of dandelion leaf extract and stem extract: antioxidant properties, tyrosinase inhibitory and molecular docking simulations","volume":"111","author":"Xie","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.fsi.2019.02.031_bib20","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.foodres.2018.03.012","article-title":"Assessment of effects of phenolic fractions from leaves and petals of dandelion in selected components of hemostasis","volume":"107","author":"Lis","year":"2018","journal-title":"Food Res. Int."},{"key":"10.1016\/j.fsi.2019.02.031_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cbi.2016.12.003","article-title":"Evaluation of antioxidant activity of phenolic fractions from the leaves and petals of dandelion in human plasma treated with H2O2 and H2O2\/Fe","volume":"262","author":"J\u0119drejek","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fsi.2019.02.031_bib22","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.phymed.2003.12.012","article-title":"Dandelion (Taraxacum officinale) flower extract suppresses both reactive oxygen species and nitric oxide and prevents lipid oxidation in vitro","volume":"12","author":"Hu","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.fsi.2019.02.031_bib23","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.fct.2012.04.003","article-title":"Spirulina or dandelion-enriched diet of mothers alleviates lead-induced damages in brain and cerebellum of newborn rats","volume":"50","author":"Gargouri","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fsi.2019.02.031_bib24","doi-asserted-by":"crossref","first-page":"336","DOI":"10.12816\/0013792","article-title":"Comparative protective effect of moringa and dandelion extracts against hepatic disorders and oxidative stress associated with prolonged use of brufendrug in rats","volume":"60","author":"Hassan","year":"2015","journal-title":"Egypt. J. Hosp. Med."},{"key":"10.1016\/j.fsi.2019.02.031_bib25","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/ptr.3121","article-title":"Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in sprague-dawley rats","volume":"24","author":"Park","year":"2010","journal-title":"Phytother Res."},{"key":"10.1016\/j.fsi.2019.02.031_bib26","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.toxrep.2018.10.013","article-title":"Consolidating probiotic with dandelion, coriander and date palm seeds extracts against mercury neurotoxicity and for maintaining normal testosterone levels in male rats","volume":"5","author":"Abdel-Salam","year":"2018","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.fsi.2019.02.031_bib27","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.fsi.2017.11.007","article-title":"Effects of dietary Panax notoginseng extract on growth performance, fish composition, immune responses, intestinal histology and immune related genes expression of hybrid grouper ( Epinephelus lanceolatus\u2642 \u00d7 Epinephelus fuscoguttatus\u2640) fed high lipid diets","volume":"73","author":"Sun","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2019.02.031_bib29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.aquaculture.2018.08.051","article-title":"Physiological, immune responses and liver lipid metabolism of orange-spotted grouper (Epinephelus coioides) under cold stress","volume":"498","author":"Sun","year":"2019","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2019.02.031_bib30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fsi.2017.03.003","article-title":"Immune and physiological responses of pufferfish (Takifugu obscurus) under cold stress","volume":"64","author":"Cheng","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib31","first-page":"17","article-title":"Protective effect of extract from dandelion flowers on hematopoietic function in radiation injured mice","volume":"33","author":"Wang","year":"2018","journal-title":"Chin J Ctrl Endem Dis"},{"key":"10.1016\/j.fsi.2019.02.031_bib32","series-title":"Study on the Anti - Inflammatory Effect of Dandelion Extract, Vol","first-page":"42","author":"Ping","year":"2010"},{"key":"10.1016\/j.fsi.2019.02.031_bib33","first-page":"167","article-title":"Content analysis of total flavone and amylose in extract from Taraxacum mogonon (ETM)","volume":"10","author":"Wu","year":"2010","journal-title":"J. Trop. Med."},{"key":"10.1016\/j.fsi.2019.02.031_bib34","series-title":"Protective Effect of Dandelion Extract on Acute Lung Injury Induced by Lipopolysaccharide in Mice, Vol","first-page":"51","author":"Liu","year":"2011"},{"key":"10.1016\/j.fsi.2019.02.031_bib35","first-page":"64","article-title":"Anti-inflammatory effect of Dandelion different extracts","volume":"53","author":"Hou","year":"2017","journal-title":"Chin. J. Vet. Med."},{"key":"10.1016\/j.fsi.2019.02.031_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.fct.2013.04.023","article-title":"Taraxacum official (dandelion) leaf extract alleviates high-fat diet-induced nonalcoholic fatty liver","volume":"58","author":"Davaatseren","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.fsi.2019.02.031_bib37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0009-8981(01)00762-8","article-title":"Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract","volume":"317","author":"Cho","year":"2002","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.fsi.2019.02.031_bib38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1095-8649.1990.tb03519.x","article-title":"Hepatocyte nuclear size and nutritional condition of larval pejerrey, Odontesthes bonariensis (Cuvier et Valenciennes)","volume":"36","author":"Strussmann","year":"1990","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2019.02.031_bib39","first-page":"1494","article-title":"Hepatoprotective effect of dandelion (Taraxacum officinale) against induced chronic liver cirrhosis","volume":"20","author":"Al-Malki","year":"2013","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.fsi.2019.02.031_bib40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.aquaculture.2014.10.004","article-title":"Effects of Rehmannia glutinosa on growth performance, immunological parameters and disease resistance to Aeromonas hydrophila in common carp (Cyprinus carpio L.)","volume":"435","author":"Wang","year":"2015","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2019.02.031_bib41","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fsi.2016.03.163","article-title":"Dietary low or excess levels of lipids reduced growth performance, and impaired immune function and structure of head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella) under the infection of Aeromonas hydrophila","volume":"55","author":"Ni","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib42","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.fsi.2015.09.037","article-title":"Intestinal immune function, antioxidant status and tight junction proteins mRNA expression in young grass carp (Ctenopharyngodon idella) fed riboflavin deficient diet","volume":"47","author":"Chen","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.fsi.2014.09.027","article-title":"Dietary administration of laminarin improves the growth performance and immune responses in Epinephelus coioides","volume":"41","author":"Yin","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.fsi.2015.05.051","article-title":"Effect of guava leaves on the growth performance and cytokine gene expression of Labeo rohita and its susceptibility to Aeromonas hydrophila infection","volume":"46","author":"Giri","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib45","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.fsi.2013.12.005","article-title":"\u03b2-Glucan-supplemented diets increase poly(I:C)-induced gene expression of Mx, possibly via Tlr3-mediated recognition mechanism in common carp (Cyprinus carpio)","volume":"36","author":"Falco","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib46","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/jf0258858","article-title":"Antioxidant, prooxidant, and cytotoxic activities of solvent-fractionated dandelion (Taraxacum officinale) flower extracts in vitro","volume":"51","author":"Hu","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.fsi.2019.02.031_bib47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aquatox.2015.04.004","article-title":"Effects of ammonia exposure on apoptosis, oxidative stress and immune response in pufferfish (Takifugu obscurus)","volume":"164","author":"Cheng","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2019.02.031_bib48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.fsi.2010.02.016","article-title":"Molecular cloning of sea bass (Dicentrarchus labrax L.) caspase-8 gene and its involvement in Photobacterium damselae ssp. piscicida triggered apoptosis","volume":"29","author":"Reis","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.02.031_bib49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.intimp.2014.02.009","article-title":"Protective effect of tormentic acid from Potentilla chinensis against lipopolysaccharide\/d-galactosamine induced fulminant hepatic failure in mice","volume":"19","author":"Lin","year":"2014","journal-title":"Int. Immunopharmacol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819301056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819301056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T13:46:14Z","timestamp":1565185574000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464819301056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":49,"alternative-id":["S1050464819301056"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2019.02.031","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of dietary dandelion extracts on growth performance, liver histology, immune-related gene expression and CCl4 resistance of hybrid grouper (Epinephelus lanceolatus\u2642 \u00d7 Epinephelus fuscoguttatus\u2640)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2019.02.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}