{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:28:54Z","timestamp":1781846934340,"version":"3.54.5"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 106-2321-B-006-010"],"award-info":[{"award-number":["MOST 106-2321-B-006-010"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 107-2313-B-006-006-MY3"],"award-info":[{"award-number":["MOST 107-2313-B-006-006-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 107-3017-F-006-001"],"award-info":[{"award-number":["MOST 107-3017-F-006-001"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.fsi.2019.02.035","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T17:08:57Z","timestamp":1550596137000},"page":"150-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["LvRas and LvRap are both important for WSSV replication in Litopenaeus vannamei"],"prefix":"10.1016","volume":"88","author":[{"given":"Yi-Ting","family":"Tseng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Ching","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2019.02.035_bib1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jip.2010.09.012","article-title":"Virus diseases of farmed shrimp in the Western Hemisphere (the Americas): a review","volume":"106","author":"Lightner","year":"2011","journal-title":"J. Invertebr. Pathol."},{"key":"10.1016\/j.fsi.2019.02.035_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3354\/dao027131","article-title":"Identification of white spot syndrome associated baculovirus (WSBV) target organs in the shrimp Penaeus monodon by in situ hybridization","volume":"27","author":"Chang","year":"1996","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2019.02.035_bib3","doi-asserted-by":"crossref","first-page":"12919","DOI":"10.1128\/JVI.05385-11","article-title":"White spot syndrome virus induces metabolic changes resembling the Warburg effect in shrimp hemocytes in the early stage of infection","volume":"24","author":"Chen","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2019.02.035_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004196","article-title":"An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway","volume":"10","author":"Su","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2019.02.035_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.dci.2015.06.001","article-title":"To complete its replication cycle, a shrimp virus changes the population of long chain fatty acids during infection via the PI3K-Akt-mTOR-HIF1\u03b1 pathway","volume":"53","author":"Hsieh","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.02.035_bib6","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm2438","article-title":"Ras oncogenes: split personalities","volume":"9","author":"Karnoub","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2019.02.035_bib7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation","volume":"36","author":"Mendoza","year":"2011","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fsi.2019.02.035_bib8","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.2174\/0929867321666140414101528","article-title":"Four major factors regulate phosphatidylinositol 3-kinase signaling pathway in cancers induced by infection of human papillomaviruses","volume":"21","author":"Wu","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.fsi.2019.02.035_bib9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/07853890.2014.912836","article-title":"PI3K\/AKT signaling pathway and cancer: an updated review","volume":"46","author":"Martini","year":"2014","journal-title":"Ann. Med."},{"key":"10.1016\/j.fsi.2019.02.035_bib10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1947601911408079","article-title":"RAS interaction with PI3K: more than just another effector pathway","volume":"2","author":"Castellano","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.fsi.2019.02.035_bib11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2016.01.012","article-title":"PI3K\/Akt\/mTOR and Ras\/Raf\/MEK\/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives","volume":"109","author":"Asati","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.fsi.2019.02.035_bib12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10147-017-1156-4","article-title":"Targeting metabolic reprogramming in KRAS-driven cancers","volume":"22","author":"Kawada","year":"2017","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.fsi.2019.02.035_bib13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/bj3510289","article-title":"Meaningful relationships: the regulation of the Ras\/Raf\/MEK\/ERK pathway by protein interactions","volume":"351","author":"Kolch","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.fsi.2019.02.035_bib14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/cr.2011.145","article-title":"K-rasG12V transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis","volume":"22","author":"Hu","year":"2012","journal-title":"Cell Res."},{"key":"10.1016\/j.fsi.2019.02.035_bib15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/msb.2011.56","article-title":"Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth","volume":"7","author":"Gaglio","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.fsi.2019.02.035_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/1389201011314030002","article-title":"Regulation of glycolytic and mitochondrial metabolism by ras","volume":"14","author":"Chesney","year":"2013","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.fsi.2019.02.035_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tibs.2013.12.004","article-title":"KRAS: feeding pancreatic cancer proliferation","volume":"39","author":"Bryant","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fsi.2019.02.035_bib18","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s11033-015-3858-x","article-title":"Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K","volume":"42","author":"Courtnay","year":"2015","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.fsi.2019.02.035_bib19","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature12040","article-title":"Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway","volume":"496","author":"Son","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2019.02.035_bib20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","article-title":"Glutamine addiction: a new therapeutic target in cancer","volume":"35","author":"Wise","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fsi.2019.02.035_bib21","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2012.01.058","article-title":"Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism","volume":"149","author":"Ying","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2019.02.035_bib22","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3892\/ol.2012.928","article-title":"Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (Review)","volume":"4","author":"Zheng","year":"2012","journal-title":"Oncol Lett"},{"key":"10.1016\/j.fsi.2019.02.035_bib23","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.2337\/db07-1313","article-title":"Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling","volume":"57","author":"Wang","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.fsi.2019.02.035_bib24","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nrc2960","article-title":"Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?","volume":"10","author":"Vigil","year":"2010","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.fsi.2019.02.035_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-62703-791-4_1","article-title":"The Ras superfamily of small GTPases: the unlocked secrets","volume":"1120","author":"Goitre","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.fsi.2019.02.035_bib26","doi-asserted-by":"crossref","first-page":"RE13","DOI":"10.1126\/stke.2502004re13","article-title":"Human RAS superfamily proteins and related GTPases","volume":"2004","author":"Colicelli","year":"2004","journal-title":"Sci. STKE"},{"key":"10.1016\/j.fsi.2019.02.035_bib27","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/stem.1990","article-title":"Activated K-ras, but not H-ras or N-ras, regulates brain neural stem cell proliferation in a Raf\/Rb-dependent manner","volume":"33","author":"Bender","year":"2015","journal-title":"Stem Cell."},{"key":"10.1016\/j.fsi.2019.02.035_bib28","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1101\/gad.261677.115","article-title":"Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways","volume":"29","author":"Chen","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2019.02.035_bib29","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1515\/hsz-2014-0257","article-title":"Ras activation revisited: role of GEF and GAP systems","volume":"396","author":"Hennig","year":"2015","journal-title":"Biol. Chem."},{"key":"10.1016\/j.fsi.2019.02.035_bib30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.6026\/97320630013174","article-title":"Analysis of correlated mutations in Ras G-domain","volume":"13","author":"Pathak","year":"2017","journal-title":"Bioinformation"},{"key":"10.1016\/j.fsi.2019.02.035_bib31","article-title":"Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling","volume":"7","author":"Song","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2019.02.035_bib32","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1242\/jcs.182873","article-title":"RAS isoforms and mutations in cancer at a glance","volume":"129","author":"Hobbs","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.fsi.2019.02.035_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-416749-0.00001-4","article-title":"The Ras superfamily G-proteins","volume":"33","author":"Tetlow","year":"2013","journal-title":"Enzymes"},{"key":"10.1016\/j.fsi.2019.02.035_bib34","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/310583a0","article-title":"The p21 ras C-terminus is required for transformation and membrane association","volume":"310","author":"Willumsen","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2019.02.035_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrm1105","article-title":"Ras proteins: different signals from different locations","volume":"4","author":"Hancock","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2019.02.035_bib36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrm3255","article-title":"Regulating the regulator: post-translational modification of RAS","volume":"13","author":"Ahearn","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2019.02.035_bib37","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nrd4389","article-title":"Drugging the undruggable RAS: mission possible?","volume":"13","author":"Cox","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.fsi.2019.02.035_bib38","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1242\/jcs.131789","article-title":"Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells","volume":"126","author":"K\u00f6the","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.fsi.2019.02.035_bib39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0076-6879(07)00432-6","article-title":"The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer","volume":"439","author":"Rotblat","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.fsi.2019.02.035_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12849","article-title":"The Rho signalling pathway mediates the pathogenicity of AHPND-causing V. parahaemolyticus in shrimp","volume":"20","author":"Ng","year":"2018","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.fsi.2019.02.035_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3354\/dao074179","article-title":"Identification of icp11, the most highly expressed gene of shrimp white spot syndrome virus (WSSV)","volume":"74","author":"Wang","year":"2007","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2019.02.035_bib42","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1158\/1078-0432.CCR-14-3214","article-title":"Targeting RAS membrane association: back to the future for anti-RAS drug discovery?","volume":"21","author":"Cox","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.fsi.2019.02.035_bib43","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"10.1016\/j.fsi.2019.02.035_bib44","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.canlet.2014.04.001","article-title":"The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism","volume":"356","author":"Lu","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fsi.2019.02.035_bib45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1158\/1535-7163.MCT-11-0517","article-title":"Oncogenic viruses and tumor glucose metabolism: like kids in a candy store","volume":"11","author":"Noch","year":"2012","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.fsi.2019.02.035_bib46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.fsi.2019.02.035_bib47","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.fsi.2019.02.035_bib48","doi-asserted-by":"crossref","first-page":"17495","DOI":"10.1074\/jbc.M115.660498","article-title":"Signaling through the phosphatidylinositol 3-kinase (PI3K)\/Mammalian target of rapamycin (mTOR) Axis is responsible for aerobic glycolysis mediated by glucose transporter in epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma","volume":"290","author":"Makinoshima","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2019.02.035_bib49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.molmed.2014.12.007","article-title":"Molecular drivers of cellular metabolic reprogramming in melanoma","volume":"21","author":"Abildgaard","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fsi.2019.02.035_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ygyno.2015.02.003","article-title":"The PI3K\/AKT\/mTOR pathway as a therapeutic target in ovarian cancer","volume":"137","author":"Mabuchi","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.fsi.2019.02.035_bib51","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1634\/theoncologist.2015-0084","article-title":"Targeting the KRAS pathway in non-small cell lung cancer","volume":"21","author":"Tomasini","year":"2016","journal-title":"Oncol."},{"key":"10.1016\/j.fsi.2019.02.035_bib52","doi-asserted-by":"crossref","first-page":"4296","DOI":"10.1242\/jcs.134015","article-title":"Two distinct functions for PI3-kinases in micropinocytosis","volume":"126","author":"Hoeller","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.fsi.2019.02.035_bib53","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1158\/0008-5472.CAN-11-1457","article-title":"Lactate: a metabolic key player in cancer","volume":"71","author":"Hirschhaeuser","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.fsi.2019.02.035_bib54","first-page":"119","article-title":"Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect","volume":"38","author":"San-Mill\u00e1n","year":"2017","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.fsi.2019.02.035_bib55","doi-asserted-by":"crossref","first-page":"9837","DOI":"10.1073\/pnas.1004110107","article-title":"Inhibition of host translation by virus infection in vivo","volume":"107","author":"Toribio","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2019.02.035_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005288","article-title":"The transcription and translation landscapes during human cytomegalovirus infection reveal novel host-pathogen interactions","volume":"11","author":"Tirosh","year":"2015","journal-title":"PLoS Pathog."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819301093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819301093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T03:19:16Z","timestamp":1662952756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464819301093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":56,"alternative-id":["S1050464819301093"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2019.02.035","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LvRas and LvRap are both important for WSSV replication in Litopenaeus vannamei","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2019.02.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}