{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:00:34Z","timestamp":1776078034745,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31760764"],"award-info":[{"award-number":["31760764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31460146"],"award-info":[{"award-number":["31460146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.fsi.2019.04.026","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T19:05:29Z","timestamp":1555009529000},"page":"727-735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Molecular characterization of caspase-8-like and its expression induced by microcystin-LR in grass carp (Ctenopharygodon idella)"],"prefix":"10.1016","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-3231","authenticated-orcid":false,"given":"LiLi","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiming","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiwang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2019.04.026_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/imr.12541","article-title":"Caspase-8: regulating life and death","volume":"277","author":"Tummers","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2019.04.026_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/sj.cdd.4400989","article-title":"Alice in caspase land. A phylogenetic analysis of caspases from worm to man","volume":"9","author":"Lamkanfi","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2019.04.026_bib3","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/emboj\/16.10.2794","article-title":"FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)","volume":"16","author":"Medema","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2019.04.026_bib4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0092-8674(00)81266-0","article-title":"FLICE, a novel FADD-homologous ICE\/CED-3-like protease, is recruited to the CD95 (Fas\/APO-1) death--inducing signaling complex","volume":"85","author":"Muzio","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2019.04.026_bib5","doi-asserted-by":"crossref","first-page":"14486","DOI":"10.1073\/pnas.93.25.14486","article-title":"Molecular ordering of the Fas-apoptotic pathway: the Fas\/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3\/ICE-like cysteine proteases","volume":"93","author":"Srinivasula","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2019.04.026_bib6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/jcp.22276","article-title":"From procaspase-8 to caspase-8: revisiting structural functions of caspase-8","volume":"225","author":"Zhao","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fsi.2019.04.026_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1042\/bst0280051","article-title":"Role of the BH3 (Bcl-2 homology 3) domain in the regulation of apoptosis and Bcl-2-related proteins","volume":"28","author":"Lutz","year":"2000","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.fsi.2019.04.026_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/cdd.2011.121","article-title":"Fas death receptor signalling: roles of Bid and XIAP","volume":"19","author":"Kaufmann","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2019.04.026_bib9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bbabio.2011.03.010","article-title":"Recent advances in apoptosis, mitochondria and drug resistance in cancer cells","volume":"1807","author":"Indran","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fsi.2019.04.026_bib10","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.3390\/md12115372","article-title":"High levels of structural diversity observed in microcystins from Microcystis CAWBG11 and characterization of six new microcystin congeners","volume":"12","author":"Puddick","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fsi.2019.04.026_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10408440701749454","article-title":"Human health risk assessment related to cyanotoxins exposure","volume":"38","author":"Funari","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.fsi.2019.04.026_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0005-2736(90)90190-Y","article-title":"Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin","volume":"1025","author":"Eriksson","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fsi.2019.04.026_bib13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0009-2797(92)90033-H","article-title":"Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins","volume":"81","author":"Falconer","year":"1992","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fsi.2019.04.026_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1620\/tjem.224.235","article-title":"A cyanobacterial toxin, microcystin-LR, induces apoptosis of sertoli cells by changing the expression levels of apoptosis-related proteins","volume":"224","author":"Zhang","year":"2011","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.fsi.2019.04.026_bib15","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.2174\/1389557516666160219130407","article-title":"Mechanisms of microcystin-induced cytotoxicity and apoptosis","volume":"16","author":"Chen","year":"2016","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.fsi.2019.04.026_bib16","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3892\/etm.2016.3423","article-title":"Microcystin-LR induces mitochondria-mediated apoptosis in human bronchial epithelial cells","volume":"12","author":"Li","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.fsi.2019.04.026_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.chemosphere.2016.05.051","article-title":"PUMA and survivin are involved in the apoptosis of HepG2 cells induced by microcystin-LR via mitochondria-mediated pathway","volume":"157","author":"Ma","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2019.04.026_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2016.00397","article-title":"Microcystin-lr induced apoptosis in rat sertoli cells via the mitochondrial caspase-dependent pathway: role of reactive oxygen species","volume":"7","author":"Huang","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.fsi.2019.04.026_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.fsi.2010.02.016","article-title":"Molecular cloning of sea bass (Dicentrarchus labrax L.) caspase-8 gene and its involvement in Photobacterium damselae ssp. piscicida triggered apoptosis","volume":"29","author":"Reis","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.gene.2007.03.010","article-title":"Conserved function of caspase-8 in apoptosis during bony fish evolution","volume":"396","author":"Sakata","year":"2007","journal-title":"Gene"},{"key":"10.1016\/j.fsi.2019.04.026_bib21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.dci.2013.08.004","article-title":"Cadmium triggers kidney cell apoptosis of purse red common carp (Cyprinus carpio) without caspase-8 activation","volume":"41","author":"Gao","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib22","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.fsi.2016.10.015","article-title":"Molecular and functional characterization of caspase-8 from the big-belly seahorse (Hippocampus abdominalis), Fish","volume":"58","author":"Oh","year":"2016","journal-title":"Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib23","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.fsi.2015.10.016","article-title":"Molecular cloning, immunohistochemical localization, characterization and expression analysis of caspase-8 from the blunt snout bream (Megalobrama amblycephala) exposed to ammonia","volume":"47","author":"Sun","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib24","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.fsi.2013.08.026","article-title":"Cloning, characterization and expression analysis of a caspase-8 like gene from the Hong Kong oyster, Crassostrea hongkongensis","volume":"35","author":"Xiang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.fsi.2015.06.035","article-title":"Cloning and characterization of a novel caspase-8-like gene in Crassostrea gigas, Fish","volume":"46","author":"Li","year":"2015","journal-title":"Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.aquaculture.2018.01.016","article-title":"Transcriptome analysis of grass carp provides insights into the immune-related genes and pathways in response to MC-LR induction","volume":"448","author":"Wei","year":"2018","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2019.04.026_bib27","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1745-7270.2005.00108.x","article-title":"Caspase family proteases and apoptosis","volume":"37","author":"Fan","year":"2005","journal-title":"Acta. Biochbioph. Sin."},{"key":"10.1016\/j.fsi.2019.04.026_bib28","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fsi.2009.12.016","article-title":"First molecular cloning of a molluscan caspase from variously colored abalone (Haliotis diversicolor) and gene expression analysis with bacterial challenge","volume":"28","author":"Huang","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib29","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.dci.2007.10.010","article-title":"Requirement for shrimp caspase in apoptosis against virus infection","volume":"32","author":"Wang","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib30","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ni0503-404","article-title":"The death effector domain protein family: regulators of cellular homeostasis","volume":"4","author":"Tibbetts","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1006\/bbrc.2001.6055","article-title":"Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes","volume":"289","author":"Eckhart","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2019.04.026_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fsi.2018.08.060","article-title":"Impaired immune function and structural integrity in the gills of common carp (Cyprinus carpio L.) caused by chlorpyrifos exposure: through oxidative stress and apoptosis","volume":"86","author":"Jiao","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.fsi.2018.10.029","article-title":"Atrazine exposure triggers common carp neutrophil apoptosis via the CYP450s\/ROS pathway","volume":"84","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.04.026_bib34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chemosphere.2018.04.020","article-title":"N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes","volume":"204","author":"Zhao","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2019.04.026_bib35","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/jat.2735","article-title":"Apoptotic responses of zebrafish (Danio rerio) after exposure with microcystin-LR under different ambient temperatures","volume":"33","author":"Ji","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.fsi.2019.04.026_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.aquatox.2014.01.021","article-title":"The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos","volume":"149","author":"Zeng","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2019.04.026_bib37","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.etap.2011.12.015","article-title":"Microcystin-LR causes cytotoxicity effects in rat testicular Sertoli cells","volume":"33","author":"Li","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2019.04.026_bib38","doi-asserted-by":"crossref","first-page":"16105","DOI":"10.1074\/jbc.M611115200","article-title":"Caspase inhibition sensitizes inhibitor of NF-kappaB kinase beta-deficient fibroblasts to caspase-independent cell death via the generation of reactive oxygen species","volume":"282","author":"May","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2019.04.026_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0092-8674(95)90422-0","article-title":"Protease activation during apoptosis: death by a thousand cuts","volume":"82","author":"Martin","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2019.04.026_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s001090000099","article-title":"Bid, a critical mediator for apoptosis induced by the activation of Fas\/TNF-R1 death receptors in hepatocytes","volume":"78","author":"Yin","year":"2000","journal-title":"J. Mol. Med. (Berl.)"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819302645?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819302645?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:49:58Z","timestamp":1565138998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464819302645"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":40,"alternative-id":["S1050464819302645"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2019.04.026","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization of caspase-8-like and its expression induced by microcystin-LR in grass carp (Ctenopharygodon idella)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2019.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}