{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:33:17Z","timestamp":1768401197382,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2018YFD0900501"],"award-info":[{"award-number":["2018YFD0900501"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31572651"],"award-info":[{"award-number":["31572651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31302226"],"award-info":[{"award-number":["31302226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2015A020209181"],"award-info":[{"award-number":["2015A020209181"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.fsi.2019.05.061","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T22:42:26Z","timestamp":1559256146000},"page":"216-223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Characterization of a tandem-repeat galectin-9 from Nile tilapia (Oreochromis niloticus) involved in the immune response against bacterial infection"],"prefix":"10.1016","volume":"92","author":[{"given":"Jinzhong","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jufen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jichang","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fsi.2019.05.061_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1749-6632.2009.05131.x","article-title":"Galectins: regulators of acute and chronic inflammation","volume":"1183","author":"Liu","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fsi.2019.05.061_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fimmu.2013.00248","article-title":"Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology","volume":"4","author":"Mahla","year":"2013","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2019.05.061_bib3","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1007\/s00018-005-5032-4","article-title":"Innate and acquired plasticity of the intestinal immune system","volume":"62","author":"Didierlaurent","year":"2005","journal-title":"Cell. Mol. Life Sci. CMLS"},{"issue":"1","key":"10.1016\/j.fsi.2019.05.061_bib4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0304-4165(99)00177-4","article-title":"Secretion of the galectin family of mammalian carbohydrate-binding proteins","volume":"1473","author":"Hughes","year":"1999","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"9","key":"10.1016\/j.fsi.2019.05.061_bib5","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1074\/jbc.272.9.6078","article-title":"Identification and characterization of galectin-9, a novel \u03b2-galactoside-binding mammalian lectin","volume":"272","author":"Wada","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2019.05.061_bib6","first-page":"1200990","article-title":"The Tim3\u2013galectin 9 pathway induces antibacterial activity in human macrophages infected with Mycobacterium tuberculosis","author":"Ovalle","year":"2012","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2019.05.061_bib7","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.7314\/APJCP.2012.13.6.2503","article-title":"Galectin-9 acts as a prognostic factor with antimetastatic potential in hepatocellular carcinoma","volume":"13","author":"Zhang","year":"2012","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"issue":"3","key":"10.1016\/j.fsi.2019.05.061_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/fsim.2000.0307","article-title":"Cloning and characterisation of tandem-repeat type galectin in rainbow trout (Oncorhynchus mykiss)","volume":"11","author":"Inagawa","year":"2001","journal-title":"Fish Shellfish Immunol."},{"issue":"8\u20139","key":"10.1016\/j.fsi.2019.05.061_bib9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10719-004-5541-7","article-title":"Galectins in teleost fish: Zebrafish (Danio rerio) as a model species to address their biological roles in development and innate immunity","volume":"21","author":"Vasta","year":"2004","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.fsi.2019.05.061_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.fsi.2016.03.032","article-title":"Characterization and functional analysis of a tandem-repeat galectin-9 in large yellow croaker Larimichthys crocea","volume":"52","author":"Zhang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fsi.2016.02.018","article-title":"A tandem-repeat galectin-9 involved in immune response of yellow catfish, Pelteobagrus fulvidraco, against Aeromonas hydrophila","volume":"51","author":"Wang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2017.10.008","article-title":"Conservation of structural and interactional features of CD28 and CD80\/86 molecules from Nile tilapia (Oreochromis niloticus)","volume":"72","author":"Huang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2019.05.061_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.gene.2014.07.032","article-title":"Molecular characterization and expression of CD2BP2 in Nile tilapia (Oreochromis niloticus) in response to Streptococcus agalactiae stimulus","volume":"548","author":"Gan","year":"2014","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.fsi.2019.05.061_bib14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.fsi.2014.05.028","article-title":"Immunostimulatory effects of artificial feed supplemented with a Chinese herbal mixture on Oreochromis niloticus against Aeromonas hydrophila","volume":"39","author":"Tang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.fsi.2018.09.072","article-title":"Identification and characterization of a B-type mannose-binding lectin from Nile tilapia (Oreochromis niloticus) in response to bacterial infection","volume":"84","author":"Yin","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.fsi.2017.06.016","article-title":"Identification and characterization of a mannose-binding lectin from Nile tilapia (Oreochromis niloticus)","volume":"67","author":"Mu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2019.05.061_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111084","article-title":"Early immune responses in rainbow trout liver upon viral hemorrhagic septicemia virus (VHSV) infection","volume":"9","author":"Castro","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.fsi.2019.05.061_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/bioinformatics\/10.2.189","article-title":"MEGA: molecular evolutionary genetics analysis software for microcomputers","volume":"10","author":"Kumar","year":"1994","journal-title":"Bioinformatics"},{"key":"10.1016\/j.fsi.2019.05.061_bib19","series-title":"Evolutionary Divergence and Convergence in Proteins, Evolving Genes and Proteins","first-page":"97","author":"Zuckerkandl","year":"1965"},{"issue":"4","key":"10.1016\/j.fsi.2019.05.061_bib20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2019.05.061_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2018.05.041","article-title":"Identification of a novel galectin in Sinonovacula constricta and its role in recognition of Gram-negative bacteria","volume":"80","author":"Bai","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib22","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.fsi.2018.01.023","article-title":"Expression and functional characterization of transferrin in Nile tilapia (Oreochromis niloticus) in response to bacterial infection","volume":"74","author":"Yin","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.fsi.2017.11.002","article-title":"NK-lysin from Oreochromis niloticus improves antimicrobial defence against bacterial pathogens","volume":"72","author":"Huang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.fsi.2016.03.032","article-title":"Characterization and functional analysis of a tandem-repeat galectin-9 in large yellow croaker Larimichthys crocea","volume":"52","author":"Zhang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.fsi.2018.02.037","article-title":"Molecular cloning, characterization and expression profiling of galectin-9 gene from Labeo rohita (Hamilton, 1822)","volume":"76","author":"Mushtaq","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib26","series-title":"Fish Mucosal Immunity: Skin, Mucosal Health in Aquaculture","first-page":"67","author":"Esteban","year":"2015"},{"key":"10.1016\/j.fsi.2019.05.061_bib27","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.fsi.2018.12.036","article-title":"Characterization and expression of galectin-3 after Streptococcus agalactiae and Aeromonas hydrophila challenge in GIFT strain Nile tilapia (Oreochromis niloticus)","volume":"86","author":"Zhu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2019.05.061_bib28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.molimm.2015.09.012","article-title":"Molecular characterization of Galectin-8 from Nile tilapia (Oreochromis niloticus Linn.) and its response to bacterial infection","volume":"68","author":"Unajak","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.dci.2018.02.015","article-title":"A C-type lectin (CL11X1-like) from Nile tilapia (Oreochromis niloticus) is involved in host defense against bacterial infection","volume":"84","author":"Mu","year":"2018","journal-title":"Dev. Comp. Immunol."},{"issue":"6721","key":"10.1016\/j.fsi.2019.05.061_bib30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/17812","article-title":"Development of peripheral lymphoid organs and natural killer cells depends on the helix\u2013loop\u2013helix inhibitor Id2","volume":"397","author":"Yokota","year":"1999","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.fsi.2019.05.061_bib31","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4049\/jimmunol.136.1.152","article-title":"Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer's patches, mesenteric lymph nodes, and spleen","volume":"136","author":"Stanisz","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2019.05.061_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2016.03.158","article-title":"Molecular and functional characterization of peptidoglycan-recognition protein SC2 (PGRP-SC2) from Nile tilapia (Oreochromis niloticus) involved in the immune response to Streptococcus agalactiae","volume":"54","author":"Gan","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2019.05.061_bib33","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.bbagen.2005.12.008","article-title":"Carbohydrates as future anti-adhesion drugs for infectious diseases","volume":"1760","author":"Sharon","year":"2006","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"6","key":"10.1016\/j.fsi.2019.05.061_bib34","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.febslet.2006.02.006","article-title":"Carbohydrate-induced modulation of cell membrane. VIII. Agglutination with mammalian lectin galectin-1 increases osmofragility and membrane fluidity of trypsinized erythrocytes","volume":"580","author":"Gupta","year":"2006","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.fsi.2019.05.061_bib35","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.fsi.2015.03.017","article-title":"A galectin from shrimp Litopenaeus vannamei is involved in immune recognition and bacteria phagocytosis","volume":"44","author":"Hou","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2019.05.061_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091794","article-title":"A galectin from the kuruma shrimp (Marsupenaeus japonicus) functions as an opsonin and promotes bacterial clearance from hemolymph","volume":"9","author":"Shi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2019.05.061_bib37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fsi.2016.01.010","article-title":"Antimicrobial response of galectin-1 from rock bream Oplegnathus fasciatus: molecular, transcriptional, and biological characterization","volume":"50","author":"Thulasitha","year":"2016","journal-title":"Fish Shellfish Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819306291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819306291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:11:53Z","timestamp":1760937113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464819306291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":37,"alternative-id":["S1050464819306291"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2019.05.061","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of a tandem-repeat galectin-9 from Nile tilapia (Oreochromis niloticus) involved in the immune response against bacterial infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2019.05.061","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}