{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:22:18Z","timestamp":1784308938553,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010012","name":"National Aerospace Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31602193"],"award-info":[{"award-number":["31602193"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.fsi.2019.07.038","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T08:14:27Z","timestamp":1563178467000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Characterization and initial functional analysis of cathepsin K in turbot (Scophthalmus maximus L.)"],"prefix":"10.1016","volume":"93","author":[{"given":"Mengyu","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2019.07.038_bib1","doi-asserted-by":"crossref","first-page":"w13042","DOI":"10.4414\/smw.2010.13042","article-title":"Cathepsins and their involvement in immune responses","volume":"140","author":"Conus","year":"2010","journal-title":"Swiss Med. Wkly."},{"issue":"17","key":"10.1016\/j.fsi.2019.07.038_bib2","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1093\/emboj\/20.17.4629","article-title":"Lysosomal cysteine proteases: facts and opportunities","volume":"20","author":"Turk","year":"2001","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.fsi.2019.07.038_bib3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1515\/BC.2004.040","article-title":"Comprehensive search for cysteine cathepsins in the human genome","volume":"385","author":"Rossi","year":"2004","journal-title":"Biol. Chem."},{"issue":"Pt 3","key":"10.1016\/j.fsi.2019.07.038_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1042\/bj3310727","article-title":"Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix","volume":"331","author":"Kafienah","year":"1998","journal-title":"Biochem. J."},{"issue":"48","key":"10.1016\/j.fsi.2019.07.038_bib5","doi-asserted-by":"crossref","first-page":"32347","DOI":"10.1074\/jbc.273.48.32347","article-title":"The collagenolytic activity of cathepsin K is unique among mammalian proteinases","volume":"273","author":"Garnero","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.fsi.2019.07.038_bib6","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1515\/hsz-2013-0134","article-title":"Cathepsin K: a unique collagenolytic cysteine peptidase","volume":"394","author":"Novinec","year":"2013","journal-title":"Biol. Chem."},{"issue":"5863","key":"10.1016\/j.fsi.2019.07.038_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1126\/science.1150110","article-title":"Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis","volume":"319","author":"Asagiri","year":"2008","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.fsi.2019.07.038_bib8","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.addr.2004.12.013","article-title":"The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics","volume":"57","author":"Yasuda","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.fsi.2019.07.038_bib9","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1515\/BC.2007.144","article-title":"Cysteine proteases: destruction ability versus immunomodulation capacity in immune cells","volume":"388","author":"Zavasnik-Bergant","year":"2007","journal-title":"Biol. Chem."},{"issue":"5","key":"10.1016\/j.fsi.2019.07.038_bib10","first-page":"619","article-title":"Recent developments in cathepsin K inhibitor design","volume":"8","author":"Grabowskal","year":"2005","journal-title":"Curr. Opin. Drug Discov. Dev"},{"issue":"23","key":"10.1016\/j.fsi.2019.07.038_bib11","doi-asserted-by":"crossref","first-page":"13453","DOI":"10.1073\/pnas.95.23.13453","article-title":"Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice","volume":"95","author":"Saftig","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.fsi.2019.07.038_bib12","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ecl.2012.05.003","article-title":"Future directions in osteoporosis therapeutics","volume":"41","author":"Bone","year":"2012","journal-title":"Endocrinol Metab. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11914-011-0085-9","article-title":"Inhibition of cathepsin K for treatment of osteoporosis","volume":"10","author":"Boonen","year":"2012","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.fsi.2019.07.038_bib14","doi-asserted-by":"crossref","first-page":"w13624","DOI":"10.4414\/smw.2012.13624","article-title":"The future of osteoporosis treatment - a research update","volume":"142","author":"Lippuner","year":"2012","journal-title":"Swiss Med. Wkly."},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib15","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.atherosclerosis.2007.12.047","article-title":"Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice","volume":"200","author":"Samokhin","year":"2008","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.fsi.2019.07.038_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jcp.10253","article-title":"Identification of cathepsin K as a novel marker of adiposity in white adipose tissue","volume":"195","author":"Chiellini","year":"2003","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib17","doi-asserted-by":"crossref","first-page":"L66","DOI":"10.1002\/mc.20362","article-title":"Cathepsins and osteosarcoma: expression analysis identifies cathepsin K as an indicator of metastasis","volume":"47","author":"Husmann","year":"2008","journal-title":"Mol. Carcinog."},{"issue":"4","key":"10.1016\/j.fsi.2019.07.038_bib18","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1136\/gutjnl-2011-300076","article-title":"Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice","volume":"62","author":"Sina","year":"2013","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.fsi.2019.07.038_bib19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1574-695X.2007.00343.x","article-title":"A review on the interactions between gut microbiota and innate immunity of fish","volume":"52","author":"G\u00f3mez","year":"2010","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"4","key":"10.1016\/j.fsi.2019.07.038_bib20","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2015.1068907","article-title":"Physiology and immunology of mucosal barriers in catfish (Ictalurus spp.)","volume":"3","author":"Peatman","year":"2015","journal-title":"Tissue Barriers"},{"issue":"4","key":"10.1016\/j.fsi.2019.07.038_bib21","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cbpa.2009.07.024","article-title":"Molecular cloning, expression analysis and enzymatic characterization of cathepsin K from olive flounder (Paralichthys olivaceus)","volume":"154","author":"Je","year":"2009","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."},{"issue":"2","key":"10.1016\/j.fsi.2019.07.038_bib22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S8756-3282(96)00351-1","article-title":"Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry","volume":"20","author":"Littlewood-Evans","year":"1997","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/bbrc.1995.1013","article-title":"Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone","volume":"206","author":"Inaoka","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.fsi.2019.07.038_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-5793(94)01349-6","article-title":"Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2","volume":"357","author":"Shi","year":"1995","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.fsi.2019.07.038_bib25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fsi.2009.12.005","article-title":"Immune response and expression analysis of cathepsin K in goldfish during Aeromonas hydrophila infection","volume":"28","author":"Harikrishnan","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"6 Pt 1","key":"10.1016\/j.fsi.2019.07.038_bib26","first-page":"G1033","article-title":"Macromolecular transport by rat gastric mucosa","volume":"262","author":"Curtis","year":"1992","journal-title":"Am. J. Physiol."},{"issue":"5","key":"10.1016\/j.fsi.2019.07.038_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00251-003-0580-y","article-title":"Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish, Fugu rubripes","volume":"55","author":"Zou","year":"2003","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2019.07.038_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.fsi.2018.04.025","article-title":"Expression profiling and microbial ligand binding analysis of high-mobility group box-1 (HMGB1) in turbot (Scophthalmus maximus L.)","volume":"78","author":"Cai","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.07.038_bib29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.fsi.2017.07.032","article-title":"Identification and expression analysis of fetuin B (FETUB) in turbot (Scophthalmus maximus L.) mucosal barriers following bacterial challenge","volume":"68","author":"Li","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.07.038_bib30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.fsi.2018.06.008","article-title":"l-rhamnose-binding lectins (RBLs) in turbot (Scophthalmus maximus L.): characterization and expression profiling in mucosal tissues","volume":"80","author":"Gao","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.micpath.2004.03.001","article-title":"Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum","volume":"37","author":"O'Toole","year":"2004","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fsi.2014.06.030","article-title":"Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarum vaccine","volume":"40","author":"Liu","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2019.07.038_bib33","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF00123437","article-title":"An oral challenge for turbot larvae with Vibrio anguillarum","volume":"2","author":"Chair","year":"1994","journal-title":"Aquacult. Int."},{"issue":"3","key":"10.1016\/j.fsi.2019.07.038_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2761.1996.tb00129.x","article-title":"Is turbot, Scophthalmus maximus (L.), intestine a portal of entry for the fish pathogen Vibrio anguillarum?","volume":"19","author":"Oisson","year":"2010","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.fsi.2019.07.038_bib35","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.fsi.2017.01.023","article-title":"Transcriptomic profiling analysis of tilapia (Oreochromis niloticus) following Streptococcus agalactiae challenge","volume":"62","author":"Zhu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.07.038_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.fsi.2018.07.002","article-title":"Characterization, expression signatures and microbial binding analysis of cathepsin A in turbot, Scophthalmus maximus L. (SmCTSA)","volume":"81","author":"Fu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.07.038_bib37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.fsi.2018.10.046","article-title":"Characterization, expression profiling and functional characterization of cathepsin Z (CTSZ) in turbot (Scophthalmus maximus L.)","volume":"84","author":"Cai","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2019.07.038_bib38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/jmbi.1994.0083","article-title":"Alignment\/phylogeny of the papain superfamily of cysteine proteases","volume":"246","author":"Berti","year":"1995","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0305-0491(90)90262-R","article-title":"High activities of cathepsins B, D, H, and L in the white muscle of chum salmon in spawning migration","volume":"95","author":"Yamashita","year":"1990","journal-title":"Comp. Biochem. Physiol. B"},{"issue":"4","key":"10.1016\/j.fsi.2019.07.038_bib40","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1046\/j.1365-3083.2003.01322.x","article-title":"Phylogeny of antigen-processing enzymes: cathepsins of a cephalochordate, an agnathan and a bony fish","volume":"58","author":"Uinuk-Ool","year":"2003","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2019.07.038_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/A:1007763711158","article-title":"Lysis of pathogenic bacteria by epidermal cathepsins L and B in the Japanese eel","volume":"20","author":"Aranishi","year":"1999","journal-title":"Fish Physiol. Biochem."},{"issue":"3","key":"10.1016\/j.fsi.2019.07.038_bib42","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.bbrc.2007.08.010","article-title":"Two osteoclastic markers expressed in multinucleate osteoclasts of goldfish scales","volume":"362","author":"Azuma","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"14","key":"10.1016\/j.fsi.2019.07.038_bib43","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1242\/dev.127.14.3031","article-title":"An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio","volume":"127","author":"Parichy","year":"2000","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.fsi.2019.07.038_bib44","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bone.2006.08.019","article-title":"Multinucleate osteoclasts in medaka as evidence of active bone remodeling","volume":"40","author":"Nemoto","year":"2007","journal-title":"Bone"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819307478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819307478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:10:55Z","timestamp":1778584255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464819307478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":44,"alternative-id":["S1050464819307478"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2019.07.038","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization and initial functional analysis of cathepsin K in turbot (Scophthalmus maximus L.)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2019.07.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}