{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:03:48Z","timestamp":1793480628390,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.fsi.2019.10.023","type":"journal-article","created":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T01:22:29Z","timestamp":1570929749000},"page":"93-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection"],"prefix":"10.1016","volume":"95","author":[{"given":"Xue-peng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2019.10.023_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.iy.11.040193.001121","article-title":"Interleukin-10","volume":"11","author":"Moore","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0896-8411(03)00044-1","article-title":"The complex role of interleukin-10 in autoimmunity","volume":"20","author":"Groux","year":"2003","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.fsi.2019.10.023_bib3","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.dci.2011.05.001","article-title":"The interleukins of fish","volume":"35","author":"Secombes","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib4","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1073\/pnas.97.4.1695","article-title":"Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)","volume":"97","author":"Kotenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2019.10.023_bib5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1128\/JVI.76.3.1285-1292.2002","article-title":"Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10","volume":"76","author":"Spencer","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2019.10.023_bib6","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1084\/jem.170.6.2081","article-title":"Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones","volume":"170","author":"Fiorentino","year":"1989","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2019.10.023_bib7","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib8","doi-asserted-by":"crossref","first-page":"12906","DOI":"10.1074\/jbc.270.21.12906","article-title":"Characterization of recombinant extracellular domain of human interleukin-10 receptor","volume":"270","author":"Tan","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2019.10.023_bib9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1615\/CritRevImmunol.2016017480","article-title":"IL10, a tale of an evolutionarily conserved cytokine across vertebrates","volume":"36","author":"Piazzon","year":"2016","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cytogfr.2003.11.001","article-title":"The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle","volume":"15","author":"Mocellin","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.fsi.2019.10.023_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jlb.61.4.389","article-title":"Studies with IL-10-\/- mice: an overview","volume":"61","author":"Rennick","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.fsi.2019.10.023_bib13","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1128\/iai.61.7.3093-3097.1993","article-title":"Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice","volume":"61","author":"Bermudez","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fsi.2019.10.023_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00251-003-0580-y","article-title":"Characterisation, expression and promoter analysis of an interleukin 10 homologue in the puffer fish","volume":"55","author":"Zou","year":"2003","journal-title":"Fugu rubripes, Immunogenetics."},{"key":"10.1016\/j.fsi.2019.10.023_bib15","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.fsi.2004.08.004","article-title":"Molecular cloning and expression analysis of rainbow trout (Oncorhynchus mykiss) interleukin-10 cDNAs","volume":"18","author":"Inoue","year":"2005","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib16","first-page":"571","article-title":"Cloning, characterization and expression analysis of interleukin-10 from the zebrafish (Danio rerion)","volume":"38","author":"Zhang","year":"2005","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2019.10.023_bib17","doi-asserted-by":"crossref","first-page":"10360","DOI":"10.1038\/s41598-018-28511-w","article-title":"Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection","volume":"8","author":"Harjula","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2019.10.023_bib18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.molimm.2010.10.013","article-title":"Characterization and functional analysis of goldfish (Carassius auratus L.) interleukin-10","volume":"48","author":"Grayfer","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molimm.2012.08.021","article-title":"Functional expression and characterization of grass carp IL-10: an;essential mediator of TGF-beta 1 immune regulation in peripheral blood;lymphocytes","volume":"53","author":"Wei","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.fsi.2015.03.023","article-title":"Dual-parallel inhibition of IL-10 and TGF-\u03b21 controls LPS-induced inflammatory response via NF-\u03baB signaling in grass carp monocytes\/macrophages","volume":"44","author":"Wei","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib21","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1365-2109.2011.02904.x","article-title":"Molecular characterization, inductive expression and mechanism of interleukin-10 gene induction in the Indian major carp, catla (Catla catla)","volume":"43","author":"Swain","year":"2012","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsi.2019.10.023_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3962596","article-title":"Structural and functional characterization of recombinant interleukin-10 from Indian major carp Labeo rohita","volume":"2016","author":"Karan","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.fsi.2019.10.023_bib23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.aquaculture.2007.05.040","article-title":"Interleukin-10 expression by real-time PCR and homology modelling analysis in the European sea bass (Dicentrarchus labrax L.)","volume":"270","author":"Buonocore","year":"2007","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2019.10.023_bib24","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.molimm.2006.09.014","article-title":"Molecular characterization, 3D modelling and expression analysis of sea bass (Dicentrarchus labrax L.) interleukin-10","volume":"44","author":"Pinto","year":"2007","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib25","first-page":"774","article-title":"Conserved gene structure and function of interleukin-10 in teleost fish","author":"Nam","year":"2014","journal-title":"J. Anim. Vet. Adv."},{"key":"10.1016\/j.fsi.2019.10.023_bib26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.dci.2019.03.017","article-title":"Functional characterization of IL-10 and its receptor subunits in a perciform fish, the Mandarin fish, Siniperca chuatsi","volume":"97","author":"Huo","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib27","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1046\/j.1432-1033.2003.03854.x","article-title":"Cloning, characterization and expression analysis of interleukin-10 from the common carp, Cyprinus carpio L","volume":"270","author":"Savan","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.fsi.2019.10.023_bib28","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.molimm.2007.08.003","article-title":"Characterisation and expression analysis of the interleukin genes, IL-1beta, IL-8 and IL-10, in Atlantic cod (Gadus morhua L.)","volume":"45","author":"Seppola","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4049\/jimmunol.1402093","article-title":"Carp Il10 has anti-inflammatory activities on phagocytes, promotes proliferation of memory T cells, and regulates B cell differentiation and antibody secretion","volume":"194","author":"Piazzon","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib30","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s12562-018-1223-4","article-title":"Amberjack Seriola dumerili interleukin-10 negatively suppresses host cell-mediated immunity","volume":"84","author":"Matsumoto","year":"2018","journal-title":"Fish. Sci."},{"key":"10.1016\/j.fsi.2019.10.023_bib31","doi-asserted-by":"crossref","first-page":"39287","DOI":"10.1038\/srep39287","article-title":"CsMAP34, a teleost MAP with dual role: a promoter of MASP-assisted complement activation and a regulator of immune cell activity","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2019.10.023_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112918","article-title":"Poly (I: C) induces antiviral immune responses in Japanese flounder (Paralichthys olivaceus) that require TLR3 and MDA5 and is negatively regulated by Myd88","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2019.10.023_bib33","article-title":"CsBAFF, a teleost B cell activating factor, promotes pathogen-induced innate immunity and vaccine-induced adaptive immunity","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2019.10.023_bib34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.dci.2015.10.002","article-title":"CsSAP, a teleost serum amyloid P component, interacts with bacteria, promotes phagocytosis, and enhances host resistance against bacterial and viral infection","volume":"55","author":"Wang","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib35","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/j.vaccine.2009.03.012","article-title":"Immunoprotective analysis of VhhP2, a Vibrio harveyi vaccine candidate","volume":"27","author":"Sun","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2019.10.023_bib36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.vetmic.2015.03.030","article-title":"Edwardsiella tarda Sip1: a serum-induced zinc metalloprotease that is essential to serum resistance and host infection","volume":"177","author":"Zhou","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fsi.2019.10.023_bib37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fsi.2014.01.013","article-title":"Antibacterial and antiviral properties of tongue sole (Cynoglossus semilaevis) high mobility group B2 protein are largely independent on the acidic C-terminal domain","volume":"37","author":"Long","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib38","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1128\/AEM.02872-06","article-title":"Cloning, characterization, and molecular application of a beta-agarase gene from Vibrio sp. strain V134","volume":"73","author":"Zhang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fsi.2019.10.023_bib39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.dci.2015.07.004","article-title":"Tongue sole (Cynoglossus semilaevis) prothymosin alpha: cytokine-like activities associated with the intact protein and the C-terminal region that lead to antiviral immunity via Myd88-dependent and-independent pathways respectively","volume":"53","author":"Zhang","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib40","series-title":"Total Protein Extraction with TCA-Acetone. Plant Proteomics","first-page":"1","author":"M\u00e9chin","year":"2007"},{"key":"10.1016\/j.fsi.2019.10.023_bib41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.dci.2017.01.021","article-title":"A teleost complement factor Ba possesses antimicrobial activity and inhibits bacterial infection in fish","volume":"71","author":"Li","year":"2017","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib42","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1016\/j.vaccine.2009.04.023","article-title":"Construction of an attenuated Pseudomonas fluorescens strain and evaluation of its potential as a cross-protective vaccine","volume":"27","author":"Wang","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2019.10.023_bib43","article-title":"Streptococcus iniae SF1: complete genome sequence, proteomic profile, and immunoprotective antigens","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2019.10.023_bib44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.fsi.2016.03.001","article-title":"Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: signaling pathway and involvement in bacterial infection","volume":"51","author":"Li","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib45","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fimmu.2017.00290","article-title":"Neutrophil extracellular traps of Cynoglossus semilaevis: production characteristics and antibacterial effect","volume":"8","author":"Zhao","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.dci.2014.11.018","article-title":"Immune effects of R848: evidences that suggest an essential role of TLR7\/8-induced, Myd88-and NF-\u03baB-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus)","volume":"49","author":"Zhou","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1472-6750-9-22","article-title":"Viral and murine interleukin-10 are correctly processed and retain their biological activity when produced in tobacco","volume":"9","author":"Bortesi","year":"2009","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.fsi.2019.10.023_bib48","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4049\/jimmunol.158.2.604","article-title":"The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor","volume":"158","author":"Liu","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib49","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.dci.2011.08.006","article-title":"Identification and molecular characterization of the interleukin-10 receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius auratus L.)","volume":"36","author":"Grayfer","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib50","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.dci.2014.03.012","article-title":"Identification of grass carp IL-10 receptor subunits: functional evidence for IL-10 signaling in teleost immunity","volume":"45","author":"Wei","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib51","first-page":"393","article-title":"Human blood platelets, PMN leukocytes and their interactions in vitro. Responses to selective and non-selective stimuli","volume":"19","author":"Dr\u00e1bikov\u00e1","year":"2000","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.fsi.2019.10.023_bib52","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1084\/jem.174.6.1549","article-title":"Macrophage deactivation by interleukin 10","volume":"174","author":"Bogdan","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2019.10.023_bib53","doi-asserted-by":"crossref","first-page":"8676","DOI":"10.1073\/pnas.89.18.8676","article-title":"Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation","volume":"89","author":"Oswald","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2019.10.023_bib54","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1574-695X.1996.tb00084.x","article-title":"Interleukin-10 inhibits neutrophil phagocytic and bactericidal activity","volume":"15","author":"Laichalk","year":"1996","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.fsi.2019.10.023_bib55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1165\/ajrcmb.15.1.8679223","article-title":"Apoptosis in human alveolar macrophages is induced by endotoxin and is modulated by cytokines","volume":"15","author":"Bingisser","year":"1996","journal-title":"Am. J. Resp. Cell Mol."},{"key":"10.1016\/j.fsi.2019.10.023_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2567.1997.00348.x","article-title":"Interleukin\u201010 rescues T cells from apoptotic cell death: association with an upregulation of Bcl\u20102","volume":"92","author":"Cohen","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.fsi.2019.10.023_bib57","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1006\/bbrc.1995.2174","article-title":"Endogenous interleukin 10 prevents apoptosis in macrophages during Salmonella infection","volume":"213","author":"Arai","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2019.10.023_bib58","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of reactive oxygen species (ROS) in apoptosis induction","volume":"5","author":"Simon","year":"2000","journal-title":"Apoptosis"},{"key":"10.1016\/j.fsi.2019.10.023_bib59","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.4049\/jimmunol.150.12.5501","article-title":"Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy","volume":"150","author":"Sieling","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2019.10.023_bib60","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.155.2.722","article-title":"Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia","volume":"155","author":"Greenberger","year":"1995","journal-title":"J. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819309829?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464819309829?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:11:04Z","timestamp":1760937064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464819309829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":60,"alternative-id":["S1050464819309829"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2019.10.023","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2019.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}