{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:09:27Z","timestamp":1790474967863,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560109"],"award-info":[{"award-number":["81560109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771606"],"award-info":[{"award-number":["31771606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation Project of Jiangxi Province","award":["2018ACB21033"],"award-info":[{"award-number":["2018ACB21033"]}]},{"name":"Science and Technology Foundation of the Education Department of Jiangxi Province","award":["GJJ150759"],"award-info":[{"award-number":["GJJ150759"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Foundation","doi-asserted-by":"crossref","award":["2019M652269"],"award-info":[{"award-number":["2019M652269"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014769","name":"Jinggangshan University","doi-asserted-by":"crossref","award":["JZB15006"],"award-info":[{"award-number":["JZB15006"]}],"id":[{"id":"10.13039\/501100014769","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014769","name":"Jinggangshan University","doi-asserted-by":"crossref","award":["JFD1802"],"award-info":[{"award-number":["JFD1802"]}],"id":[{"id":"10.13039\/501100014769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.fsi.2019.11.066","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T20:12:56Z","timestamp":1574971976000},"page":"114-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish"],"prefix":"10.1016","volume":"96","author":[{"given":"Bo","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zigang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1032-5218","authenticated-orcid":false,"given":"Guanghua","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3987-6742","authenticated-orcid":false,"given":"Huiqiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.fsi.2019.11.066_bib1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/1526-4998(200008)56:8<696::AID-PS182>3.0.CO;2-5","article-title":"Spinosad \u2013 a case study: an example from a natural products discovery programme","volume":"56","author":"Thompson","year":"2000","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.fsi.2019.11.066_bib2","first-page":"185","article-title":"biotechnology, Natural product derived insecticides: discovery and development of spinetoram","volume":"43","author":"Galm","year":"2016","journal-title":"J. Ind. Microbiol."},{"key":"10.1016\/j.fsi.2019.11.066_bib3","series-title":"Spinetoram: How Artificial Intelligence Combined Natural Fermentation with Synthetic Chemistry to Produce a New Spinosyn Insecticide","author":"James","year":"2008"},{"issue":"1","key":"10.1016\/j.fsi.2019.11.066_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/amt\/tsv199","article-title":"Toxicity of selected insecticides (spinosad, spinetoram, and isoclast active [Sulfoxaflor]) to bed bugs","volume":"40","author":"Hamm","year":"2015","journal-title":"Arthropod Manag. Tests"},{"issue":"1","key":"10.1016\/j.fsi.2019.11.066_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/ps.4348","article-title":"Toxicities and effects of insecticidal toxic baits to control Drosophila suzukii and Zaprionus indianus (Diptera: Drosophilidae)","volume":"73","author":"Andreazza","year":"2017","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.fsi.2019.11.066_bib6","first-page":"1","article-title":"Registered have been, Wdg Diana\u00ae, development of the novel insecticide spinetoram (DIANA\u00ae)","author":"Diana\u00ae","year":"2012","journal-title":"Sumitomo Kagaku"},{"issue":"4","key":"10.1016\/j.fsi.2019.11.066_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/jisesa\/iey082","article-title":"Spinosad versus spinetoram effects on kill and oviposition of rhagoletis indifferens (Diptera: Tephritidae) at differing fly ages and temperatures","volume":"18","author":"Yee","year":"2018","journal-title":"J. Insect Sci."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00128-012-0885-3","article-title":"Simultaneous determination of spinetoram residues in tomato by high performance liquid chromatography combined with QuEChERS method","volume":"90","author":"Malhat","year":"2013","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"10","key":"10.1016\/j.fsi.2019.11.066_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/bmc.1577","article-title":"Determination of spinetoram in leafy vegetable crops using liquid chromatography and confirmation via tandem mass spectrometry","volume":"25","author":"Liu","year":"2011","journal-title":"Biomed. Chromatogr. : BMC"},{"issue":"4","key":"10.1016\/j.fsi.2019.11.066_bib10","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1016\/j.foodchem.2012.04.066","article-title":"Determination of spinetoram and its metabolites in amaranth and parsley using QuEChERS-based extraction and liquid chromatography-tandem mass spectrometry","volume":"134","author":"Park","year":"2012","journal-title":"Food Chem."},{"issue":"3","key":"10.1016\/j.fsi.2019.11.066_bib11","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1093\/jee\/toz032","article-title":"Monitoring onion thrips (Thysanoptera: Thripidae) susceptibility to spinetoram in New York onion fields","volume":"112","author":"Moretti","year":"2019","journal-title":"J. Econ. Entomol."},{"issue":"7","key":"10.1016\/j.fsi.2019.11.066_bib12","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/ps.4887","article-title":"Resistance development, stability, cross-resistance potential, biological fitness and biochemical mechanisms of spinetoram resistance in Thrips hawaiiensis (Thysanoptera: Thripidae)","volume":"74","author":"Fu","year":"2018","journal-title":"Pest Manag. Sci."},{"issue":"9","key":"10.1016\/j.fsi.2019.11.066_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204154","article-title":"Assessment of the lethal and sublethal effects by spinetoram on cotton bollworm","volume":"13","author":"Wei","year":"2018","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.fsi.2019.11.066_bib14","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/ps.4639","article-title":"Lethal effects of selected novel pesticides on immature stages of Trichogramma pretiosum (Hymenoptera: Trichogrammatidae)","volume":"73","author":"Khan","year":"2017","journal-title":"Pest Manag. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2019.11.066_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1242\/dmm.007138","article-title":"A model 450 million years in the making: zebrafish and vertebrate immunity","volume":"5","author":"Renshaw","year":"2012","journal-title":"Dis. Models Mech."},{"issue":"7446","key":"10.1016\/j.fsi.2019.11.066_bib16","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2019.11.066_bib17","first-page":"549","article-title":"Clethodim exposure induces developmental immunotoxicity and neurobehavioral dysfunction in zebrafish embryos","volume":"86","author":"Xiong","year":"2019"},{"issue":"3","key":"10.1016\/j.fsi.2019.11.066_bib18","first-page":"217","article-title":"Vers une solution durable au probl\u00e8me du criquet p\u00e8lerin?","volume":"15","author":"Lecoq","year":"2004","journal-title":"Secheresse"},{"key":"10.1016\/j.fsi.2019.11.066_bib19","first-page":"139","article-title":"Acute pesticide poisoning: a major global health problem","volume":"43","author":"Jeyaratnam","year":"1990","journal-title":"World Health Stat. Q."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/(SICI)1098-2280(1996)28:2<112::AID-EM7>3.0.CO;2-H","article-title":"Alkaline single\u2010cell gel (comet) assay and genotoxicity monitoring using two species of tadpoles","volume":"28","author":"Ralph","year":"2015","journal-title":"Environ. Mol. Mutagen."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib21","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11356-011-0588-z","article-title":"Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication","volume":"19","author":"Ayed-Boussema","year":"2012","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib22","first-page":"37","article-title":"Beyond pest control: a closer look at the health implication of pesticides usage","volume":"4","author":"Salako","year":"2011","journal-title":"J. Toxicol. Environ. Health Sci."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.taap.2013.01.025","article-title":"Abdollahi Mohammad Pesticides and human chronic diseases: evidences, mechanisms, and perspectives","volume":"268","author":"Mostafalou","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.etap.2015.08.005","article-title":"Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish","volume":"40","author":"Jiang","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2019.11.066_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ecoenv.2012.11.031","article-title":"Embryonic exposure to butachlor in zebrafish (Danio rerio): endocrine disruption, developmental toxicity and immunotoxicity","volume":"89","author":"Tu","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"8","key":"10.1016\/j.fsi.2019.11.066_bib26","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0025-326X(01)00060-1","article-title":"Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms","volume":"42","author":"Livingstone","year":"2001","journal-title":"Mar. Pollut. Bull."},{"issue":"1","key":"10.1016\/j.fsi.2019.11.066_bib27","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/humrep\/dei286","article-title":"Adverse effects of retinoic acid on embryo development and the selective expression of retinoic acid receptors in mouse blastocysts","volume":"21","author":"Huang","year":"2006","journal-title":"Hum. Reprod."},{"issue":"3","key":"10.1016\/j.fsi.2019.11.066_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11270-018-3739-8","article-title":"Developmental toxicity of diethylnitrosamine in zebrafish embryos\/juveniles related to excessive oxidative stress","volume":"229","author":"Huang","year":"2018","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.fsi.2019.11.066_bib29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.envpol.2015.03.044","article-title":"Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio)","volume":"203","author":"Zhu","year":"2015","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib30","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.fsi.2015.01.010","article-title":"The toxicity of chlorpyrifos on the early life stage of zebrafish: a survey on the endpoints at development, locomotor behavior, oxidative stress and immunotoxicity","volume":"43","author":"Jin","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2019.11.066_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0145-305X(03)00103-4","article-title":"Development and maturation of the immune system in zebrafish, Danio rerio: a gene expression profiling, in situ hybridization and immunological study","volume":"28","author":"Lam","year":"2004","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2019.11.066_bib32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1074-7613(04)00084-6","article-title":"The use of zebrafish to understand immunity","volume":"20","author":"Trede","year":"2004","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.fsi.2015.04.033","article-title":"Assessment of immunotoxicity of dibutyl phthalate using live zebrafish embryos","volume":"45","author":"Xu","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2019.11.066_bib34","first-page":"100","article-title":"Oxidative stress: mechanistic insights into inherited mitochondrial disorders and Parkinson's Disease","volume":"6","author":"Al Shahrani","year":"2017"},{"issue":"3","key":"10.1016\/j.fsi.2019.11.066_bib35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.aquatox.2004.05.011","article-title":"Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress","volume":"69","author":"Risso-de Faverney","year":"2004","journal-title":"Aquat. Toxicol."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ecoenv.2005.03.013","article-title":"Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants","volume":"64","author":"Valavanidis","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.fsi.2019.11.066_bib37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib38","first-page":"141","article-title":"Oxidative stress biomarkers in the freshwater characid fish, Brycon cephalus, exposed to organophosphorus insecticide Folisuper 600 (methyl parathion), Comparative biochemistry and physiology","volume":"143","author":"Monteiro","year":"2006","journal-title":"Toxicol. Pharmacol.: CBP"},{"issue":"1","key":"10.1016\/j.fsi.2019.11.066_bib39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chemosphere.2011.02.087","article-title":"Dimethoate-induced oxidative stress and DNA damage in Oncorhynchus mykiss","volume":"84","author":"Dogan","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2019.11.066_bib40","series-title":"Molecular Mechanisms of Pesticide Toxicity, Pesticides in the Modern World-Pests Control and Pesticides Exposure and Toxicity Assessment","author":"Tebourbi","year":"2011"},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib41","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.fsi.2012.11.046","article-title":"Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio)","volume":"34","author":"Jin","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2019.11.066_bib42","first-page":"1049","article-title":"Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in","volume":"30","author":"Jin","year":"2011","journal-title":"Zebrafish"},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/toxsci\/kfq066","article-title":"The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos","volume":"115","author":"Shi","year":"2010","journal-title":"Toxicol. Sci.: Off. J. Soc. Toxicol."},{"key":"10.1016\/j.fsi.2019.11.066_bib44","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1191\/074823399678846637","article-title":"Immunotoxicity of pesticides: a review","volume":"15","author":"Voccia","year":"1999","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.fsi.2019.11.066_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.aquatox.2014.12.006","article-title":"Enantioselective developmental toxicity and immunotoxicity of pyraclofos toward zebrafish (Danio rerio)","volume":"159","author":"Zhuang","year":"2015","journal-title":"Aquat. Toxicol."},{"issue":"2","key":"10.1016\/j.fsi.2019.11.066_bib46","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.intimp.2014.02.006","article-title":"Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1-AMPK signaling pathway in mice","volume":"19","author":"Bai","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.fsi.2019.11.066_bib47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cbi.2018.05.015","article-title":"Venlafaxine mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats","volume":"290","author":"El-Kashef","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.fsi.2019.11.066_bib48","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.chemosphere.2017.10.158","article-title":"Chronic exposure of nanomolar MC-LR caused oxidative stress and inflammatory responses in HepG2 cells","volume":"192","author":"Ma","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2019.11.066_bib49","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ecoenv.2018.10.110","article-title":"Hepatotoxicity and immunotoxicity of MC-LR on silver carp","volume":"169","author":"Li","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481931109X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046481931109X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:11:26Z","timestamp":1760937086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046481931109X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":49,"alternative-id":["S105046481931109X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2019.11.066","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2019.11.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}