{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:21:58Z","timestamp":1790083318273,"version":"4.0.1"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SFI-Sea Lice Research Centre","award":["203516\/O30"],"award-info":[{"award-number":["203516\/O30"]}]},{"name":"SFI-Sea Lice Research Centre","award":["268100"],"award-info":[{"award-number":["268100"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.fsi.2020.05.014","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T17:21:11Z","timestamp":1589563271000},"page":"200-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Rainbow trout Oncorhynchus mykiss skin responses to salmon louse Lepeophtheirus salmonis: From copepodid to adult stage"],"prefix":"10.1016","volume":"103","author":[{"given":"Sussie","family":"Dalvin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise v.G.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per W.","family":"Kania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindre","family":"Grotmol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Buchmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina-Cathrine","family":"\u00d8verg\u00e5rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2020.05.014_bib1","series-title":"Fiskehelserapporten 2018","author":"Hjeltnes","year":"2019"},{"key":"10.1016\/j.fsi.2020.05.014_bib2","first-page":"201","article-title":"Sea reared rainbow trout Oncorhynchus mykiss need fewer sea lice treatments than farmed Atlantic salmon Salmo salar","volume":"36","author":"O'Donohoe","year":"2016","journal-title":"Bull. Eur. Assoc. Fish Pathol."},{"key":"10.1016\/j.fsi.2020.05.014_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aquaculture.2009.03.006","article-title":"Susceptibility of Atlantic salmon and rainbow trout to the salmon lice Lepeophtheirus salmonis","volume":"291","author":"Gjerde","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.05.014_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3354\/dao052057","article-title":"Susceptibility of rainbow trout Oncorhynchus mykiss, Atlantic salmon Salmo salar and coho salmon Oncorhynchus kisutch to experimental infection with sea lice Lepeophtheirus salmonis","volume":"52","author":"Fast","year":"2002","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2020.05.014_bib5","first-page":"1179","article-title":"The physiological effects of salmon lice infection on post-smolt of Atlantic salmon","volume":"48","author":"Grimnes","year":"1996","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2020.05.014_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1365-2761.2000.00235.x","article-title":"Enhanced susceptibility of seawater cultured rainbow trout, Oncorhynchus mykiss (Walbaum), to the microsporidian Loma salmonae during a primary infection with the sea louse, Lepeophtheirus salmonis","volume":"23","author":"Mustafa","year":"2000","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209178","article-title":"Sea lice, Lepeophtheirus salmonis (Kr\u00f8yer 1837), infected Atlantic salmon (Salmo salar L.) are more susceptible to infectious salmon anemia virus","volume":"14","author":"Barker","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2020.05.014_bib8","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/jfd.12749","article-title":"Sea trout adapt their migratory behaviour in response to high salmon lice concentrations","volume":"41","author":"Halttunen","year":"2018","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aquaculture.2004.12.027","article-title":"A review of the Norwegian 'national action plan against salmon lice on salmonids': the effect on wild salmonids","volume":"246","author":"Heuch","year":"2005","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.05.014_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/jfd.12061","article-title":"Salmon lice - impact on wild salmonids and salmon aquaculture","volume":"36","author":"Torrissen","year":"2013","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib11","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pt.2014.12.006","article-title":"Drug resistance in sea lice: a threat to salmonid aquaculture","volume":"31","author":"Aaen","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.fsi.2020.05.014_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073539","article-title":"The salmon louse Lepeophtheirus salmonis (Copepoda: caligidae) life cycle has only two chalimus stages","volume":"8","author":"Hamre","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2020.05.014_bib13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1139\/z91-138","article-title":"The developmental stages of lepeophtheirus-salmonis (kr\u00f8yer, 1837) (copepoda, caligidae)","volume":"69","author":"Johnson","year":"1991","journal-title":"Can. J. Zool."},{"key":"10.1016\/j.fsi.2020.05.014_bib14","series-title":"Pathogens of Wild and Farmed Fish: Sea Lice","first-page":"30","article-title":"Supplementary descriptions of the developmental stages of Lepeophtheirus salmonis (kr\u00f8yer, 1837) (Copepoda:Caligidae)","author":"Schram","year":"1993"},{"key":"10.1016\/j.fsi.2020.05.014_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1469-7998.1991.tb04799.x","article-title":"The settlement and attachment of early stages of the salmon louse, Lepeophtheirus salmonis (Copepoda, Caligidae) on the salmon host, Salmo salar","volume":"224","author":"Bron","year":"1991","journal-title":"J. Zool."},{"key":"10.1016\/j.fsi.2020.05.014_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(08)60265-1","article-title":"Copepoda (Crustacea) parasitic on fishes - problems and perspectives","volume":"19","author":"Kabata","year":"1982","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.fsi.2020.05.014_bib17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2761.1990.tb00786.x","article-title":"The histopathology associated with the juvenile stages of Lepeophtheirus salmonis on the Atlantic salmon, Salmo salar L","volume":"13","author":"Jones","year":"1990","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib18","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1139\/z98-003","article-title":"The development of salmon lice (Lepeophtheirus salmonis) on artificially infected post smolts of sea trout (Salmo trutta)","volume":"76","author":"Bj\u00f8rn","year":"1998","journal-title":"Can. J. Zool."},{"key":"10.1016\/j.fsi.2020.05.014_bib19","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1365-2761.2000.00225.x","article-title":"The physiological response of Atlantic salmon, Salmo salar L., to a single experimental challenge with sea lice, Lepeophtheirus salmonis","volume":"23","author":"Bowers","year":"2000","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.exppara.2015.09.001","article-title":"Molecular characterization and knock-down of salmon louse (Lepeophtheirus salmonis) prostaglandin E synthase","volume":"159","author":"Eichner","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.fsi.2020.05.014_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1645\/0022-3395(2003)089[0007:ERFLSI]2.0.CO;2","article-title":"Enzymes released from Lepeophtheirus salmonis in response to mucus from different salmonids","volume":"89","author":"Fast","year":"2003","journal-title":"J. Parasitol."},{"key":"10.1016\/j.fsi.2020.05.014_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-3024.2007.00932.x","article-title":"Lepeophtheirus salmonis secretory\/excretory products and their effects on Atlantic salmon immune gene regulation","volume":"29","author":"Fast","year":"2007","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.exppara.2004.04.001","article-title":"Lepeophtheirus salmonis: characterization of prostaglandin E2 in secretory products of the salmon louse by RP-HPLC and mass spectrometry","volume":"107","author":"Fast","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.fsi.2020.05.014_bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1095-6433(02)00109-5","article-title":"Skin morphology and humoral non-specific defence parameters of mucus and plasma in rainbow trout, coho and Atlantic salmon","volume":"132","author":"Fast","year":"2002","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.fsi.2020.05.014_bib25","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1645\/0022-3395(2000)086[1199:COPITS]2.0.CO;2","article-title":"Characterization of proteases in the skin mucus of Atlantic salmon (Salmo salar) infected with the salmon louse (Lepeophtheirus salmonis) and in whole-body louse homogenate","volume":"86","author":"Firth","year":"2000","journal-title":"J. Parasitol."},{"key":"10.1016\/j.fsi.2020.05.014_bib26","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/jmor.20611","article-title":"Exocrine glands of Lepeophtheirus salmonis (Copepoda: caligidae): distribution, developmental appearance, and site of secretion","volume":"277","author":"\u00d8verg\u00e5rd","year":"2016","journal-title":"J. Morphol."},{"key":"10.1016\/j.fsi.2020.05.014_bib27","article-title":"Mechanisms of resistance among salmon to the parasitic copepod Lepeophtheirus salmon","volume":"S2","author":"Jones","year":"2011","journal-title":"J. Aquacult. Res. Dev."},{"key":"10.1016\/j.fsi.2020.05.014_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-15-200","article-title":"Comparative transcriptomics of Atlantic Salmo salar, chum Oncorhynchus keta and pink salmon O. gorbuscha during infections with salmon lice Lepeophtheirus salmonis","volume":"15","author":"Sutherland","year":"2014","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2020.05.014_bib29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.dci.2014.09.015","article-title":"Signatures of resistance to Lepeophtheirus salmonis include a T(H)2-type response at the louse-salmon interface","volume":"48","author":"Braden","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.dci.2016.10.008","article-title":"Contrasting expression of immune genes in scaled and scaleless skin of Atlantic salmon infected with young stages of Lepeophtheirus salmonis","volume":"67","author":"Holm","year":"2017","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/aah.10053","article-title":"Differential effects of adult salmon lice Lepeophtheirus salmonis on physiological responses of sockeye salmon and atlantic salmon","volume":"31","author":"Long","year":"2019","journal-title":"J. Aquat. Anim. Health"},{"key":"10.1016\/j.fsi.2020.05.014_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-9-498","article-title":"Local and systemic gene expression responses of Atlantic salmon (Salmo salar L.) to infection with the salmon louse (Lepeophtheirus salmonis)","volume":"9","author":"Skugor","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2020.05.014_bib33","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.dci.2018.04.023","article-title":"Salmon louse rhabdoviruses: impact on louse development and transcription of selected Atlantic salmon immune genes","volume":"86","author":"\u00d8verg\u00e5rd","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.fsi.2005.11.010","article-title":"The effects of Lepeophtheirus salmonis infections on the stress response and immunological status of Atlantic salmon (Salmo salar)","volume":"21","author":"Fast","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.fsi.2006.06.012","article-title":"Differential expression of the pro-inflammatory cytokines IL-1beta-1, TNFalpha-1 and IL-8 in vaccinated pink (Oncorhynchus gorbuscha) and chum (Oncorhynchus keta) salmon juveniles","volume":"22","author":"Fast","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib36","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.fsi.2014.10.038","article-title":"Difference in skin immune responses to infection with salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar L.) of families selected for resistance and susceptibility","volume":"42","author":"Holm","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3354\/dao075229","article-title":"Differential rejection of salmon lice by pink and chum salmon: disease consequences and expression of proinflammatory genes","volume":"75","author":"Jones","year":"2007","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2020.05.014_bib38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1471-2164-13-130","article-title":"Gene expression in Atlantic salmon skin in response to infection with the parasitic copepod Lepeophtheirus salmonis, cortisol implant, and their combination","volume":"13","author":"Krasnov","year":"2012","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2020.05.014_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.vetimm.2010.07.024","article-title":"Molecular cloning of IgT from Atlantic salmon, and analysis of the relative expression of tau, mu, and delta in different tissues","volume":"139","author":"Tadiso","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2020.05.014_bib40","first-page":"100","article-title":"Comparative defense-associated responses in salmon skin elicited by the ectoparasite Lepeophtheirus salmonis","volume":"7","author":"Braden","year":"2012","journal-title":"Comp. Biochem. Physiol. D"},{"key":"10.1016\/j.fsi.2020.05.014_bib41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.parint.2009.08.009","article-title":"Establishment and characterisation of salmon louse (Lepeophtheirus salmonis (Kr\u00f8yer 1837)) laboratory strains","volume":"58","author":"Hamre","year":"2009","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.fsi.2020.05.014_bib42","series-title":"Innate Immune Response Dynamics in Rainbow Trout","author":"Chettri","year":"2011"},{"key":"10.1016\/j.fsi.2020.05.014_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-\u0394\u0394C) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2020.05.014_bib44","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Canc. Res."},{"key":"10.1016\/j.fsi.2020.05.014_bib45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3354\/aei00320","article-title":"Development of the salmon louse Lepeophtheirus salmonis parasitic stages in temperatures ranging from 3 to 24\u00b0C","volume":"11","author":"Hamre","year":"2019","journal-title":"Aquacult. Environ. Interac."},{"key":"10.1016\/j.fsi.2020.05.014_bib46","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.dci.2007.10.005","article-title":"The biological effects of rainbow trout (Oncorhynchus mykiss) recombinant interleukin-8","volume":"32","author":"Harun","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib47","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.dci.2008.05.004","article-title":"Interleukin 8 and CK-6 chemokines specifically attract rainbow trout (Oncorhynchus mykiss) RTS11 monocyte-macrophage cells and have variable effects on their immune functions","volume":"32","author":"Montero","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012384","article-title":"CXCL8 chemokines in teleost fish: two lineages with distinct expression profiles during early phases of inflammation","volume":"5","author":"van der Aa","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2020.05.014_bib49","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.fsi.2013.08.006","article-title":"Molecular characterization, expression analysis, and biological effects of interleukin-8 in grass carp Ctenopharyngodon idellus","volume":"35","author":"Wang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2172-9-66","article-title":"Cloning and bioactivity analysis of a CXC ligand in black seabream Acanthopagrus schlegeli: the evolutionary clues of ELR+CXC chemokines","volume":"9","author":"Zhonghua","year":"2008","journal-title":"BMC Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib51","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3354\/dao014179","article-title":"Comparative susceptibility and histopathology of the response of naive Atlantic, Chinook and Coho salmon to experimental infection with Lepeophtheirus salmonis (Copepoda, Caligidae)","volume":"14","author":"Johnson","year":"1992","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2020.05.014_bib52","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/sj.jidsp.5640205","article-title":"The roles of keratinocyte-derived cytokines in the epidermis and their possible responses to UVA-Irradiation","volume":"4","author":"Kondo","year":"1999","journal-title":"J. Invest. Dermatol. Symp. Proc."},{"key":"10.1016\/j.fsi.2020.05.014_bib53","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1084\/jem.164.6.2095","article-title":"Human keratinocytes contain mRNA indistinguishable from monocyte Interleukin 1 \u03b1 and \u03b2 mRNA","volume":"164","author":"Kupper","year":"1986","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2020.05.014_bib54","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/jfd.12169","article-title":"Epidermal response of rainbow trout to Ichthyobodo necator: immunohistochemical and gene expression studies indicate a Th1-\/Th2-like switch","volume":"37","author":"Chettri","year":"2014","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib55","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4049\/jimmunol.158.1.384","article-title":"Acute phase proteins in salmonids - evolutionary analyses and acute phase response","volume":"158","author":"Jensen","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib56","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3354\/dao01935","article-title":"Immune-relevant genes expressed in rainbow trout following immunisation with a live vaccine against Ichthyophthirius multifiliis","volume":"80","author":"J\u00f8rgensen","year":"2008","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2020.05.014_bib57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.vetimm.2009.03.006","article-title":"Characterization of two key molecules of teleost innate immunity from rainbow trout (Oncorhynchus mykiss): MyD88 and SAA","volume":"131","author":"Rebl","year":"2009","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2020.05.014_bib58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.dci.2010.08.012","article-title":"Salmonid Tollip and MyD88 factors can functionally replace their mammalian orthologues in TLR-mediated trout SAA promoter activation","volume":"35","author":"Rebl","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib59","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/jid.2012.503","article-title":"Antimicrobial peptides (AMPs) from fish epidermis: perspectives for investigative dermatology","volume":"133","author":"Rakers","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.fsi.2020.05.014_bib60","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.molimm.2011.05.027","article-title":"Bioactivity studies of rainbow trout (Oncorhynchus mykiss) interleukin-6: effects on macrophage growth and antimicrobial peptide gene expression","volume":"48","author":"Costa","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023417","article-title":"Evidence of an antimicrobial-immunomodulatory role of Atlantic salmon cathelicidins during infection with Yersinia ruckeri","volume":"6","author":"Bridle","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2020.05.014_bib62","article-title":"The Atlantic salmon (Salmo salar) antimicrobial peptide cathelicidin-2 is a molecular host-associated cue for the salmon louse (Lepeophtheirus salmonis)","volume":"8","author":"Nunez-Acuna","year":"2018","journal-title":"Sci. Rep.-Uk"},{"key":"10.1016\/j.fsi.2020.05.014_bib63","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.aquaculture.2016.06.023","article-title":"Antimicrobial peptides from Salmon salar skin induce frontal filament development and olfactory\/cuticle-related genes in the sea louse Caligus rogercresseyi","volume":"464","author":"Nunez-Acuna","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.05.014_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01105","article-title":"Mechanisms of fish macrophage antimicrobial immunity","volume":"9","author":"Grayfer","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib65","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/mi.2017.106","article-title":"iNOS- and NOX1-dependent ROS production maintains bacterial homeostasis in the ileum of mice","volume":"11","author":"Matziouridou","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib66","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cellbi.2006.11.029","article-title":"Effect of nitric oxide on phagocytic activity of lipopolysaccharide-induced macrophages: possible role of exogenous L-arginine","volume":"31","author":"Tumer","year":"2007","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.fsi.2020.05.014_bib67","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/fsim.1999.0229","article-title":"Effects of sea lice (Lepeophtheirus salmonis Kr\u00f8yer, 1837) infestation on macrophage functions in Atlantic salmon (Salmo salar L.)","volume":"10","author":"Mustafa","year":"2000","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib68","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.vetimm.2003.08.016","article-title":"Expression of immune response genes in rainbow trout skin induced by Gyrodactylus derjavini infections","volume":"97","author":"Lindenstr\u00f8m","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2020.05.014_bib69","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev.immunol.23.021704.115821","article-title":"Regulation of Th2 differentiation and Il4 locus accessibility","volume":"24","author":"Ansel","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib70","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00251-008-0299-x","article-title":"Comprehensive clarification of two paralogous interleukin 4\/13 loci in teleost fish","volume":"60","author":"Ohtani","year":"2008","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2020.05.014_bib71","doi-asserted-by":"crossref","first-page":"10917","DOI":"10.18632\/oncotarget.7295","article-title":"First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.fsi.2020.05.014_bib72","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.4049\/jimmunol.1102259","article-title":"Essential role of IL-4 and IL-4R alpha interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates","volume":"188","author":"Zhu","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib73","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.molimm.2011.02.014","article-title":"Constitutive high expression of interleukin-4\/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments","volume":"48","author":"Takizawa","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib74","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajpath.2011.04.025","article-title":"Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis","volume":"179","author":"Piehler","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.fsi.2020.05.014_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00716","article-title":"The hunt for the source of primary interleukin-4: how we discovered that natural killer T cells and basophils determine T helper type 2 cell differentiation in vivo","volume":"9","author":"Yoshimoto","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib76","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2761.1992.tb00684.x","article-title":"The histopathology associated with the preadult and adult stages of lepeophtheirus-salmonis on the atlantic salmon, salmo-salar L","volume":"15","author":"Jonsdottir","year":"1992","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib77","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.fsi.2015.08.008","article-title":"Differential modulation of resistance biomarkers in skin of juvenile and mature pink salmon, Oncorhynchus gorbuscha by the salmon louse, Lepeophtheirus salmonis","volume":"47","author":"Braden","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.05.014_bib78","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2761.2003.00519.x","article-title":"Effects of formalin treatments on epithelial structure and mucous cell densities in rainbow trout, Oncorhynchus mykiss (Walbaum), skin","volume":"27","author":"Buchmann","year":"2004","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib79","article-title":"Host gill attachment enables blood-feeding by the salmon louse (Lepeophtheirus salmonis) chalimus larvae and alters parasite development and transcriptome","author":"Heggland","year":"2019","journal-title":"BMC Parasites Vectors"},{"key":"10.1016\/j.fsi.2020.05.014_bib80","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3354\/dao02397","article-title":"Individual fish tank arrays in studies of Lepeophtheirus salmonis and lice loss variability","volume":"97","author":"Hamre","year":"2011","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2020.05.014_bib81","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S1054-3139(97)80018-5","article-title":"Comparison of the susceptibility of sea trout (Salmo trutta L.) and Atlantic salmon (Salmo salar L.) to sea lice (Lepeophtheirus salmonis (Kroyer, 1837)) infections","volume":"54","author":"Dawson","year":"1997","journal-title":"ICES J. Mar. Sci."},{"key":"10.1016\/j.fsi.2020.05.014_bib82","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3354\/aei00184","article-title":"Effect of ectoparasite infestation density and life-history stages on the swimming performance of Atlantic salmon Salmo salar","volume":"8","author":"Bui","year":"2016","journal-title":"Aquacult. Environ. Interac."},{"key":"10.1016\/j.fsi.2020.05.014_bib83","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/jfd.12707","article-title":"Susceptibility, behaviour, and retention of the parasitic salmon louse (Lepeophtheirus salmonis) differ with Atlantic salmon population origin","volume":"41","author":"Bui","year":"2018","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2020.05.014_bib84","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.dci.2011.07.002","article-title":"Stress and immune modulation in fish","volume":"35","author":"Tort","year":"2011","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464820303405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464820303405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:23:19Z","timestamp":1760937799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464820303405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":84,"alternative-id":["S1050464820303405"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2020.05.014","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rainbow trout Oncorhynchus mykiss skin responses to salmon louse Lepeophtheirus salmonis: From copepodid to adult stage","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2020.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}