{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:06:59Z","timestamp":1774580819595,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.fsi.2020.10.016","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T03:28:06Z","timestamp":1602646086000},"page":"346-356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"PA","title":["Dietary vitamin A deficiency reduces growth performance, immune function of intestine, and alters tight junction proteins of intestine for juvenile hybrid grouper (Epinephelus fuscoguttatus \u2640\u00a0\u00d7\u00a0Epinephelus lanceolatus \u2642)"],"prefix":"10.1016","volume":"107","author":[{"given":"Dazhi","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiping","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyan","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2020.10.016_bib1","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s10695-017-0400-1","article-title":"Supplementation of enzyme-treated soy protein saves dietary protein and promotes digestive and absorptive ability referring to TOR signaling in juvenile fish","volume":"43","author":"Xiao","year":"2017","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fsi.2020.10.016_bib2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.fsi.2016.09.055","article-title":"Dietary choline deficiency and excess induced intestinal inflammation and alteration of intestinal tight junction protein transcription potentially by modulating NF-\u03baB, STAT and p38 MAPK signaling molecules in juvenile Jian carp","volume":"58","author":"Wu","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1079\/BJN20051421","article-title":"Dietary levels of all- trans retinol affect retinoid nuclear receptor expression and skeletal development in European sea bass larvae","volume":"93","author":"Villeneuve","year":"2005","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fsi.2020.10.016_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.aquaculture.2004.01.031","article-title":"Vitamin A metabolism and early biological responses in juvenile sunshine bass (Morone chrysops\u00d7M. saxatilis) fed graded levels of vitamin A","volume":"235","author":"Hemre","year":"2004","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.dci.2012.04.001","article-title":"Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts","volume":"39","author":"Zhu","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cbd.2005.08.005","article-title":"Genomics of fish cytokines","volume":"1","author":"Savan","year":"2006","journal-title":"Comp. Biochem. Physiol. Genom. Proteonomics"},{"key":"10.1016\/j.fsi.2020.10.016_bib7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","article-title":"Molecular basis of NF-\u03baB signaling","volume":"42","author":"Napetschnig","year":"2013","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.fsi.2020.10.016_bib8","doi-asserted-by":"crossref","first-page":"13372","DOI":"10.3390\/ijms150813372","article-title":"\u03b2-defensin 2 ameliorates lung injury caused by pseudomonas infection and regulates proinflammatory and anti-Inflammatory cytokines in rat","volume":"15","author":"Shen","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2020.10.016_bib9","series-title":"Cell-Cell Interact. Heal. Dis.","first-page":"185","article-title":"Tight junctions and cell-cell interactions","author":"Utech","year":"2006"},{"key":"10.1016\/j.fsi.2020.10.016_bib10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.semcdb.2014.09.002","article-title":"Tight junction, selective permeability, and related diseases","volume":"36","author":"Krug","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.fsi.2020.10.016_bib11","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1091\/mbc.e12-09-0688","article-title":"Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux","volume":"24","author":"Buschmann","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.fsi.2020.10.016_bib12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/00004836-200204000-00003","article-title":"Intestinal permeation and gastrointestinal disease","volume":"34","author":"DeMeo","year":"2002","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.fsi.2020.10.016_bib13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.20506\/rst.10.3.576","article-title":"Environmental problems of aquaculture in Asia and their solutions","volume":"10","author":"Chen","year":"1991","journal-title":"Rev. Sci. Tech. l\u2019OIE."},{"key":"10.1016\/j.fsi.2020.10.016_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.aquaculture.2010.11.025","article-title":"The effect of vitamin A on flatfish development and skeletogenesis: a review","volume":"315","author":"Fern\u00e1ndez","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.aquaculture.2015.06.042","article-title":"Dietary vitamin A requirement of juvenile Wuchang bream (Megalobrama amblycephala) determined by growth and disease resistance","volume":"450","author":"Liu","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib16","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.aquaculture.2017.06.024","article-title":"Effects of dietary vitamin A on growth, feed utilization, lipid metabolism enzyme activities, and fatty acid synthase and hepatic lipase mRNA expression levels in the liver of juvenile orange spotted grouper","volume":"479","author":"Yang","year":"2017","journal-title":"Epinephelus coioides, Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fsi.2020.02.019","article-title":"Inconsistently impairment of immune function and structural integrity of head kidney and spleen by vitamin A deficiency in grass carp (Ctenopharyngodon idella)","volume":"99","author":"Jiang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib18","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1111\/are.13725","article-title":"Dietary vitamin A requirement of Sillago sihama Forsk\u00e1l","volume":"49","author":"Huang","year":"2018","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsi.2020.10.016_bib19","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.fsi.2019.01.056","article-title":"Vitamin A deficiency impairs intestinal physical barrier function of fish","volume":"87","author":"Jiang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1017\/S0007114516003342","article-title":"Vitamin A deficiency suppresses fish immune function with differences in different intestinal segments: the role of transcriptional factor NF-\u03baB and p38 mitogen-activated protein kinase signalling pathways","volume":"117","author":"Zhang","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.fsi.2020.10.016_bib21","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/are.13474","article-title":"Soy protein concentrate as an alternative in replacement of fish meal in the feeds of hybrid grouper, brown-marbled grouper (Epinephelus fuscoguttatus) \u00d7 giant grouper (E. lanceolatus) juvenile","volume":"49","author":"Mohd Faudzi","year":"2018","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsi.2020.10.016_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.fsi.2015.04.004","article-title":"Dietary riboflavin deficiency decreases immunity and antioxidant capacity, and changes tight junction proteins and related signaling molecules mRNA expression in the gills of young grass carp (Ctenopharyngodon idella)","volume":"45","author":"Chen","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib23","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.fsi.2019.10.025","article-title":"The effect of partial replacement of fish meal by soy protein concentrate on growth performance, immune responses, gut morphology and intestinal inflammation for juvenile hybrid grouper (Epinephelus fuscoguttatus \u2640 \u00d7 Epinephelus lanceolatus \u2642)","volume":"98","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib24","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.fsi.2018.07.038","article-title":"Cottonseed protein concentrate (CPC) suppresses immune function in different intestinal segments of hybrid grouper \u2640Epinephelus fuscoguttatus\u00d7\u2642Epinephelus lanceolatu via TLR-2\/MyD88 signaling pathways","volume":"81","author":"Yin","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib25","series-title":"Official Methods of Analysis of AOAC International","author":"Lee","year":"1995"},{"key":"10.1016\/j.fsi.2020.10.016_bib26","first-page":"420","article-title":"Growth performance, immune response, and disease resistance against Vibrio splendidus infection in juvenile sea cucumber Apostichopus japonicus fed a supplementary diet of the potential probiotic Paracoccus marcusii DB11","author":"Yan","year":"2014","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/1440-1681.12550","article-title":"Aliskiren improves endothelium-dependent relaxation of thoracic aorta by activating PI3K\/Akt\/eNOS signal pathway in SHR","volume":"43","author":"Gu","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.fsi.2020.10.016_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2020.10.016_bib29","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1124\/mol.116.103697","article-title":"All-trans -retinoic acid enhances mitochondrial function in models of human liver","volume":"89","author":"Tripathy","year":"2016","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.fsi.2020.10.016_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0044-8486(02)00665-8","article-title":"Dietary vitamin A requirement of juvenile greasy grouper (Epinephelus tauvina)","volume":"219","author":"Shaik Mohamed","year":"2003","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib31","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2095.2012.00977.x","article-title":"Dietary vitamin E could improve growth performance, lipid peroxidation and non-specific immune responses for juvenile cobia (Rachycentron canadum)","volume":"19","author":"Zhou","year":"2013","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2020.10.016_bib32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.fsi.2018.02.046","article-title":"Serum immune responses in common carp (Cyprinus carpio L.) to paraquat exposure: the traditional parameters and circulating microRNAs","volume":"76","author":"Ma","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.fsi.2020.01.032","article-title":"Ginger (Zingiber officinale) extract affects growth performance, body composition, haematology, serum and mucosal immune parameters in common carp (Cyprinus carpio)","volume":"99","author":"Mohammadi","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib34","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/S0015-0282(16)57870-4","article-title":"Total antioxidant capacity of seminal plasma is different in fertile and infertile men","volume":"64","author":"Lewis","year":"1995","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.fsi.2020.10.016_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aquaculture.2016.03.054","article-title":"Effects of dietary vitamin A on growth, hematology, digestion and lipometabolism of on-growing gibel carp (Carassius auratus gibelio var. CAS III)","volume":"460","author":"Shao","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10646-011-0785-z","article-title":"Acute toxicity and responses of antioxidant systems to 1-methyl-3-octylimidazolium bromide at different developmental stages of goldfish","volume":"21","author":"Li","year":"2012","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.fsi.2020.10.016_bib37","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0891-5849(98)00266-4","article-title":"Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease","volume":"26","author":"Palace","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.fsi.2020.10.016_bib38","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.aquaculture.2005.05.029","article-title":"Development of the digestive tract, trypsin activity and gene expression in eggs and larvae of the bullseye puffer fish Sphoeroides annulatus","volume":"251","author":"Garc\u00eda-Gasca","year":"2006","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2020.10.016_bib39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.fsi.2004.09.006","article-title":"Innate immunity of fish (overview)","volume":"20","author":"Magnad\u00f3ttir","year":"2006","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib40","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature09674","article-title":"Reduction of disulphide bonds unmasks potent antimicrobial activity of human \u03b2-defensin 1","volume":"469","author":"Schroeder","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2020.10.016_bib41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.fsi.2009.10.001","article-title":"Inactivation of nervous necrosis virus infecting grouper (Epinephelus coioides) by epinecidin-1 and hepcidin 1\u20135 antimicrobial peptides, and downregulation of Mx2 and Mx3 gene expressions","volume":"28","author":"Wang","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib42","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V124.21.2723.2723","article-title":"Cellular labile iron activates NLRP3 inflammasome","volume":"124","author":"Nakamura","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.fsi.2020.10.016_bib43","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2005.10.010","article-title":"A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression","volume":"2","author":"Wang","year":"2005","journal-title":"Cell Metabol."},{"key":"10.1016\/j.fsi.2020.10.016_bib44","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.fsi.2015.08.007","article-title":"Vitamin A supplementation enhances Senegalese sole (Solea senegalensis) early juvenile's immunocompetence: new insights on potential underlying pathways","volume":"46","author":"Fern\u00e1ndez","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.10.016_bib45","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.immuni.2008.03.003","article-title":"Contextual regulation of inflammation: a duet by transforming growth factor-\u03b2 and interleukin-10","volume":"28","author":"Li","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2020.10.016_bib46","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/jhered\/esm025","article-title":"Comparison of the human and canine cytokines IL-1(\u03b1\/\u03b2) and TNF-\u03b1 to orthologous other mammalians","volume":"98","author":"Soller","year":"2007","journal-title":"J. Hered."},{"key":"10.1016\/j.fsi.2020.10.016_bib47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/anu.12041","article-title":"Differences between intestinal segments and soybean meal-induced changes in intestinal mucus composition of common carp Cyprinus carpio L","volume":"20","author":"van der Marel","year":"2014","journal-title":"Aquacult. Nutr."},{"key":"10.1016\/j.fsi.2020.10.016_bib48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1172\/JCI12821","article-title":"Blocking Smad7 restores TGF-\u03b21 signaling in chronic inflammatory bowel disease","volume":"108","author":"Monteleone","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fsi.2020.10.016_bib49","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3945\/jn.110.135657","article-title":"Regulation of tight junction permeability by intestinal bacteria and dietary components","volume":"141","author":"Ulluwishewa","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.fsi.2020.10.016_bib50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.resp.2012.05.020","article-title":"Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: a review","volume":"184","author":"Chasiotis","year":"2012","journal-title":"Respir. Physiol. Neurobiol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464820306884?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464820306884?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:27:00Z","timestamp":1760938020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464820306884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":50,"alternative-id":["S1050464820306884"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2020.10.016","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary vitamin A deficiency reduces growth performance, immune function of intestine, and alters tight junction proteins of intestine for juvenile hybrid grouper (Epinephelus fuscoguttatus \u2640\u00a0\u00d7\u00a0Epinephelus lanceolatus \u2642)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2020.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}