{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:45:09Z","timestamp":1792813509244,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.fsi.2020.11.024","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T02:02:52Z","timestamp":1609293772000},"page":"6-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Identification, expression and pro-inflammatory effect of interleukin-17\u00a0N in common carp (Cyprinus carpio L.)"],"prefix":"10.1016","volume":"111","author":[{"given":"Hongxia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkai","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fsi.2020.11.024_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fsi.2014.02.020","article-title":"Characterization and mucosal responses of interleukin 17 family ligand and receptor genes in channel catfish Ictalurus punctatus","volume":"38","author":"Wang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2020.11.024_bib2","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.dci.2011.05.001","article-title":"The interleukins of fish","volume":"35","author":"Secombes","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2020.11.024_bib3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2567.2011.03465.x","article-title":"The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases","volume":"134","author":"Pappu","year":"2011","journal-title":"Immunology"},{"issue":"12","key":"10.1016\/j.fsi.2020.11.024_bib4","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.autrev.2014.08.019","article-title":"Th17 cells in inflammation and autoimmunity","volume":"13","author":"Singh","year":"2014","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.fsi.2020.11.024_bib5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cyto.2013.07.022","article-title":"IL-17 family: cytokines, receptors and signaling","volume":"64","author":"Gu","year":"2013","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.fsi.2020.11.024_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional specialization of interleukin-17 family members","volume":"34","author":"Iwakura","year":"2011","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.fsi.2020.11.024_bib7","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/cr.2008.320","article-title":"IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling","volume":"19","author":"Rong","year":"2009","journal-title":"Cell Res."},{"key":"10.1016\/j.fsi.2020.11.024_bib8","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/ncomms2127","article-title":"Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia","volume":"3","author":"Mellett","year":"2012","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.fsi.2020.11.024_bib9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.dci.2008.02.006","article-title":"Rapid accumulation of an interleukin 17 homolog transcript in crassostreagigashemocytes following bacterial exposure","volume":"32","author":"Roberts","year":"2008","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.11.024_bib10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.fsi.2014.07.026","article-title":"Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas","volume":"40","author":"Li","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2020.11.024_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.dci.2014.09.014","article-title":"Cionaintestinalis, interleukin 17-like genes expression is upregulated by LPS challenge","volume":"48","author":"Vizzini","year":"2015","journal-title":"Dev. Comp. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2020.11.024_bib12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00251-007-0254-2","article-title":"Lamprey (Lethenteron japonicum) IL-17 upregulated by LPS-stimulation in the skin cells","volume":"59","author":"Tsutsui","year":"2007","journal-title":"Immunogenetics"},{"issue":"4","key":"10.1016\/j.fsi.2020.11.024_bib13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fsi.2006.01.004","article-title":"Identification, cloning and characterization of interleukin-17 and its family from zebrafish","volume":"21","author":"Gunimaladevi","year":"2006","journal-title":"Fish Shellfish Immunol."},{"issue":"28","key":"10.1016\/j.fsi.2020.11.024_bib14","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.fsi.2010.01.016","article-title":"Isolation of seven IL-17 family genes from the Japanese puffer fish Takifugu rubripes","volume":"28","author":"Korenaga","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2020.11.024_bib15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.fsi.2009.08.009","article-title":"Interleukin-17D in Atlantic salmon (Salmo salar): molecular characterization, 3D modelling and promoter analysis","volume":"27","author":"Kumari","year":"2009","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2020.11.024_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.dci.2009.11.011","article-title":"Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated","volume":"34","author":"Wang","year":"2010","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2020.11.024_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1128\/IAI.00599-12","article-title":"Cloning and characterization of rainbow trout interleukin-17a\/F2 (IL-17A\/F2) and IL-17 receptor A: expression during infection and bioactivity of recombinant IL-17a\/F2","volume":"81","author":"Monte","year":"2013","journal-title":"Infect. Immun."},{"issue":"7","key":"10.1016\/j.fsi.2020.11.024_bib18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00251-015-0838-1","article-title":"Identification of the salmonid IL-17A\/F1a\/b, IL-17A\/F2b, IL-17A\/F3 and IL-17N genes and analysis of their expression following in vitro stimulation and infection","volume":"67","author":"Wang","year":"2015","journal-title":"Immunogenetics"},{"issue":"2","key":"10.1016\/j.fsi.2020.11.024_bib19","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.dci.2013.09.015","article-title":"Characterization of grass carp (Ctenopharyngodon idella) IL-17D: molecular cloning, functional implication and signal transduction","volume":"42","author":"Du","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2020.11.024_bib20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fsi.2016.01.042","article-title":"Cloning and characterization of two duplicated interleukin-17A\/F2 genes in common carp (Cyprinus carpio, L.): transcripts expression and bioactivity of recombinant IL-17A\/F2","volume":"51","author":"Li","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2020.11.024_bib21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.fsi.2010.11.028","article-title":"Genomics of fish IL-17 ligand and receptors: a review","volume":"31","author":"Kono","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2020.11.024_bib22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ng.3280","article-title":"The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation","volume":"47","author":"Wang","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.fsi.2020.11.024_bib23","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/nar\/gks1156","article-title":"Genomicus: five genome browsers for comparative genomics in eukaryote","volume":"41","author":"Louis","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2020.11.024_bib24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fsi.2020.11.024_bib25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using clustal omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.fsi.2020.11.024_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2105-4-29","article-title":"MatGAT: an application that generates similarity\/identity matrices using protein or DNA sequences","volume":"4","author":"Campanella","year":"2003","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.fsi.2020.11.024_bib27","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2020.11.024_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.fsi.2017.04.021","article-title":"Cloning, expression analysis, and antibacterial properties of three serum amyloid A in common carp (Cyprinus carpio)","volume":"65","author":"Yu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2020.11.024_bib29","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.fsi.2020.11.024_bib30","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.fsi.2012.06.027","article-title":"Identification of housekeeping genes suitable for gene expression analysis in Jian carp (Cyprinus carpio var. jian)","volume":"33","author":"Tang","year":"2012","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2020.11.024_bib31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ng.3526","article-title":"The spotted gar genome illuminates vertebrate evolution and facilitates human-to-teleost comparisons","volume":"48","author":"Braasch","year":"2016","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.fsi.2020.11.024_bib32","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.molimm.2013.04.014","article-title":"Basal polarization of the mucosal compartment in Flavobacterium columnare susceptible and resistant channel catfish (Ictalurus punctatus)","volume":"56","author":"Peatman","year":"2013","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2020.11.024_bib33","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.dci.2015.03.014","article-title":"Identification and functional characterization of grass carp IL-17A\/F1: an evaluation of the immunoregulatory role of teleost IL-17A\/F1[J]","volume":"51","author":"Du","year":"2015","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464820307348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464820307348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:24:37Z","timestamp":1760937877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464820307348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":33,"alternative-id":["S1050464820307348"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2020.11.024","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification, expression and pro-inflammatory effect of interleukin-17\u00a0N in common carp (Cyprinus carpio L.)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2020.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}