{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:22:43Z","timestamp":1792855363786,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.fsi.2021.01.002","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T14:22:47Z","timestamp":1610634167000},"page":"116-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Cadmium exposure induces inflammation through the canonical NF-\u03ba\u0392 pathway in monocytes\/macrophages of Channa punctatus Bloch"],"prefix":"10.1016","volume":"110","author":[{"given":"Chohelee","family":"Choudhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritwik","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajib","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahuya","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2021.01.002_bib1","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.3390\/ijerph17113782","article-title":"The effects of cadmium toxicity","volume":"17","author":"Genchi","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.fsi.2021.01.002_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.fsi.2020.02.015","article-title":"Cadmium exposure induces apoptosis, inflammation and immunosuppression through CYPs activation and antioxidant dysfunction in common carp neutrophils","volume":"99","author":"Jiaxin","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib3","series-title":"StatPearls. StatPearls Publishing Copyright \u00a9 2020","article-title":"Cadmium toxicity","author":"Koons","year":"2020"},{"key":"10.1016\/j.fsi.2021.01.002_bib4","first-page":"84","article-title":"Environmental toxicity of cadmium and health effect","volume":"10","author":"D\u00f6kmeci","year":"2009","journal-title":"J. Environ. Protect. Ecol."},{"key":"10.1016\/j.fsi.2021.01.002_bib5","first-page":"1195","article-title":"Overview of cadmium toxicity in fish","volume":"7","author":"Okocha","year":"2011","journal-title":"J. Appl. Sci. Res."},{"key":"10.1016\/j.fsi.2021.01.002_bib6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.aquatox.2004.05.011","article-title":"Cadmium-induced apoptosis through the mitochondrial pathway in rainbow trout hepatocytes: involvement of oxidative stress","volume":"69","author":"Risso-de Faverney","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib7","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.aquatox.2017.09.022","article-title":"Effect of cadmium on oxidative stress and immune function of common carp (Cyprinus carpio L.) by transcriptome analysis","volume":"192","author":"Zhang","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib8","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1089\/ars.2009.2637","article-title":"Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases","volume":"11","author":"Leto","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.fsi.2021.01.002_bib9","first-page":"427","article-title":"Oxidative stress in aquatic organisms in relation to pollution and aquaculture","volume":"154","author":"Livingstone","year":"2003","journal-title":"Rev. Med. Vet. (Toulouse)"},{"key":"10.1016\/j.fsi.2021.01.002_bib10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ecoenv.2005.03.013","article-title":"Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants","volume":"64","author":"Valavanidis","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fsi.2021.01.002_bib11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bbagen.2013.10.024","article-title":"Quercetin modulates OTA-induced oxidative stress and redox signalling in HepG2 cells - up regulation of Nrf2 expression and down regulation of NF-kappaB and COX-2","volume":"1840","author":"Ramyaa","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.fsi.2021.01.002_bib12","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.fsi.2015.07.024","article-title":"Characterization of interleukin-1beta as a proinflammatory cytokine in grass carp (Ctenopharyngodon idella)","volume":"46","author":"Bo","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.fsi.2010.11.006","article-title":"Gene expression and TNF-alpha secretion profile in rainbow trout macrophages following exposures to copper and bacterial lipopolysaccharide","volume":"30","author":"Teles","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib14","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.fsi.2012.08.029","article-title":"Functional characterization of TNF-alpha in grass carp head kidney leukocytes: induction and involvement in the regulation of NF-kappaB signaling","volume":"33","author":"Zhang","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.aquatox.2016.09.012","article-title":"Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio)","volume":"180","author":"Zheng","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.fsi.2014.12.026","article-title":"Cloning and characterization of the proximal promoter region of rainbow trout (Oncorhynchus mykiss) interleukin-6 gene","volume":"43","author":"Zante","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib17","first-page":"9","article-title":"Embryonic exposure to cadmium (II) and chromium (VI) induce behavioral alterations, oxidative stress and immunotoxicity in zebrafish (Danio rerio) Neurotoxicology and teratology","volume":"48","author":"Jin","year":"2015"},{"key":"10.1016\/j.fsi.2021.01.002_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.aquatox.2016.11.017","article-title":"Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish","volume":"182","author":"Zheng","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.aquatox.2017.04.014","article-title":"Immunosuppressive effects and associated compensatory responses in zebrafish after full life-cycle exposure to environmentally relevant concentrations of cadmium","volume":"188","author":"Guo","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib20","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/tox.22156","article-title":"Fresh water fish, Channa punctatus, as a model for pendimethalin genotoxicity testing: a new approach toward aquatic environmental contaminants","volume":"31","author":"Ahmad","year":"2016","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.dci.2016.06.025","article-title":"The teleost head kidney: integrating thyroid and immune signalling","volume":"66","author":"Geven","year":"2017","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib22","first-page":"395","article-title":"Bioaccumulation of Zn, Cu and Cd in Channa punctatus","volume":"28","author":"Shukla","year":"2007","journal-title":"J. Environ. Biol."},{"key":"10.1016\/j.fsi.2021.01.002_bib23","first-page":"137","article-title":"Isolation of salmoid macrophages and analysis of their killing activity","author":"Secombes","year":"1990","journal-title":"Tech. Fish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.fsi.2015.04.017","article-title":"Immunomodulation of intestinal macrophages by mercury involves oxidative damage and rise of pro-inflammatory cytokine release in the fresh water fish Channa punctatus","volume":"45","author":"Begam","year":"2015","journal-title":"Bloch Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib25","series-title":"Handbook of Experimental Immunology","article-title":"In vitro determination of phagocytosis and intracellular killing of polymorphonuclear neutrophils and mononuclear phagocytes","author":"Leigh","year":"1986"},{"key":"10.1016\/j.fsi.2021.01.002_bib26","doi-asserted-by":"crossref","first-page":"8617","DOI":"10.1073\/pnas.97.15.8617","article-title":"Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism","volume":"97","author":"Sasaki","year":"2000","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.fsi.2021.01.002_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1021\/tx00026a012","article-title":"Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress","volume":"5","author":"LeBel","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib28","series-title":"Studies on the Alterations in Haematological Indices, Micronuclei Induction and Pathological Marker Enzyme Activities in Channa punctatus (spotted snakehead) perciformes, channidae Exposed to Thermal Power Plant Effluent","first-page":"761","volume":"5","author":"Javed","year":"2016"},{"key":"10.1016\/j.fsi.2021.01.002_bib29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.aquatox.2017.09.006","article-title":"Chronic fluoride exposure exacerbates headkidney pathology and causes immune commotion in Clarias gariepinus","volume":"192","author":"Singh","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib30","first-page":"59","article-title":"Toxic effects of heavy metals (Cu, Ni, Fe Co, Mn, Cr, Zn) to the haematology of Mastacembelus armatus thriving in Harduaganj Reservoir, Aligarh, India","volume":"12","author":"Javed","year":"2012","journal-title":"Global J. Med. Res."},{"key":"10.1016\/j.fsi.2021.01.002_bib31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.etap.2007.05.006","article-title":"Acute intoxication of deltamethrin in monosex Nile tilapia, Oreochromis niloticus with special reference to the clinical, biochemical and haematological effects","volume":"24","author":"El-Sayed","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2021.01.002_bib32","series-title":"Phagocytosis in Teleosts. Implications of the New Cells Involved Biology (Basel)","first-page":"907","volume":"4","author":"Esteban","year":"2015"},{"key":"10.1016\/j.fsi.2021.01.002_bib33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aquatox.2014.03.017","article-title":"Lead toxicity on non-specific immune mechanisms of freshwater fish Channa punctatus","volume":"152","author":"Paul","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2021.01.002_bib34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2019.02.022","article-title":"Myeloperoxidase - a bridge linking inflammation and oxidative stress with cardiovascular disease","volume":"493","author":"Ndrepepa","year":"2019","journal-title":"Clin. Chim. Acta; Int. J. Clin. Chem."},{"key":"10.1016\/j.fsi.2021.01.002_bib35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1574-695X.2007.00329.x","article-title":"The role of nitric oxide in inflammatory reactions","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.fsi.2021.01.002_bib36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.taap.2005.09.006","article-title":"Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats","volume":"210","author":"Morales","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fsi.2021.01.002_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-4274(03)00237-6","article-title":"Induction of redox changes, inducible nitric oxide synthase and cyclooxygenase-2 by chronic cadmium exposure in mouse peritoneal macrophages","volume":"145","author":"Ramirez","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.fsi.2021.01.002_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.taap.2014.01.020","article-title":"Subneurotoxic copper(II)-induced NF-kappaB-dependent microglial activation is associated with mitochondrial ROS","volume":"276","author":"Hu","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.fsi.2021.01.002_bib39","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.4049\/jimmunol.1301584","article-title":"Two types of TNF-alpha exist in teleost fish: phylogeny, expression, and bioactivity analysis of type-II TNF-alpha3 in rainbow trout Oncorhynchus mykiss","volume":"191","author":"Hong","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib40","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.fsi.2017.08.013","article-title":"Effects of exposure to multiple heavy metals on biochemical and histopathological alterations in common carp, Cyprinus carpio L","volume":"70","author":"Rajeshkumar","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib41","first-page":"9512743","article-title":"Proinflammatory and anti-inflammatory cytokines mediated by NF-kappaB factor as prognostic markers in mammary tumors","author":"Martins","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.fsi.2021.01.002_bib42","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.scitotenv.2017.09.264","article-title":"Effects of heat and cadmium exposure on stress-related responses in the liver of female zebrafish: heat increases cadmium toxicity","volume":"618","author":"Guo","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2021.01.002_bib43","doi-asserted-by":"crossref","first-page":"103608","DOI":"10.1016\/j.dci.2020.103608","article-title":"The proinflammatory cytokines TNF-alpha and IL-6 in lumpfish (Cyclopterus lumpus L.) -identification, molecular characterization, phylogeny and gene expression analyses","volume":"105","author":"Eggestol","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2021.01.002_bib44","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.3390\/nu10111618","article-title":"The immunomodulatory and anti-inflammatory role of polyphenols","volume":"10","author":"Yahfoufi","year":"2018","journal-title":"Nutrients"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821000103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821000103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:25:59Z","timestamp":1760937959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464821000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":44,"alternative-id":["S1050464821000103"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2021.01.002","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium exposure induces inflammation through the canonical NF-\u03ba\u0392 pathway in monocytes\/macrophages of Channa punctatus Bloch","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2021.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}