{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:58:00Z","timestamp":1790873880260,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.fsi.2021.01.009","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T18:07:54Z","timestamp":1611684474000},"page":"102-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Identification and functional characterization of CD154 in T cell-dependent immune response in Nile tilapia (Oreochromis niloticus)"],"prefix":"10.1016","volume":"111","author":[{"given":"Bingxi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2021.01.009_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.iy.07.040189.000515","article-title":"Microanatomy of lymphoid tissue during humoral immune responses: structure function relationships","volume":"7","author":"Szakal","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev.iy.13.040195.003255","article-title":"T cell-independent antigens type 2","volume":"13","author":"Mond","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1146\/annurev.immunol.14.1.591","article-title":"Immune regulation by CD40 and its ligand GP39","volume":"14","author":"Foy","year":"1996","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2004.01775.x","article-title":"T lymphocyte dependence of the antibody response to 'T lymphocyte independent type 2' antigens","volume":"111","author":"Jeurissen","year":"2004","journal-title":"Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0065-2776(08)60854-8","article-title":"CD40 and its ligand","volume":"63","author":"Clark","year":"1996","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-065X.1996.tb00920.x","article-title":"CD80, CD86 and CD40 provide accessory signals in a multiple-step T-cell activation model","volume":"153","author":"van Gool","year":"1996","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2021.01.009_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.immunol.16.1.111","article-title":"CD40 and CD154 in cell-mediated immunity","volume":"16","author":"Grewal","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/357080a0","article-title":"Molecular and biological characterization of a murine ligand for CD40","volume":"357","author":"Armitage","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2021.01.009_bib9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.iy.12.040194.004313","article-title":"The CD40 antigen and its ligand","volume":"12","author":"Banchereau","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2009.00782.x","article-title":"Molecular mechanism and function of CD40\/CD40L engagement in the immune system","volume":"229","author":"Elgueta","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2021.01.009_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jlb.67.1.2","article-title":"CD40-CD40 ligand","volume":"67","author":"van Kooten","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.fsi.2021.01.009_bib12","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1084\/jem.185.12.2053","article-title":"A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction","volume":"185","author":"Carbone","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2021.01.009_bib13","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1073\/pnas.92.10.4342","article-title":"CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression","volume":"92","author":"Karmann","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2021.01.009_bib14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1084\/jem.184.1.173","article-title":"Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1","volume":"184","author":"Karmann","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2021.01.009_bib15","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1002\/eji.1830241235","article-title":"Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis","volume":"24","author":"Wagner","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib16","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0167-5699(96)10060-I","article-title":"The many roles of CD40 in cell-mediated inflammatory responses","volume":"17","author":"Stout","year":"1996","journal-title":"Immunol. Today"},{"key":"10.1016\/j.fsi.2021.01.009_bib17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.4049\/jimmunol.159.2.846","article-title":"IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-1beta synthesis and rescue from apoptosis","volume":"159","author":"Poe","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib18","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/BF02256091","article-title":"The role of CD40-CD154 interaction in cell immunoregulation","volume":"11","author":"Xu","year":"2004","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.fsi.2021.01.009_bib19","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.4049\/jimmunol.0804370","article-title":"CD154-CD40 interactions are essential for thymus-dependent antibody production in zebrafish: insights into the origin of costimulatory pathway in helper T cell-regulated adaptive immunity in early vertebrates","volume":"182","author":"Gong","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.fsi.2018.07.037","article-title":"Characterization of grass carp CD40 and CD154 genes and the association between their polymorphisms and resistance to grass carp reovirus","volume":"81","author":"Lu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib21","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.3389\/fimmu.2019.02902","article-title":"Rainbow trout IgM+ B cells preferentially respond to thymus-independent antigens but are activated by CD40L","volume":"10","author":"Granja","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.fsi.2016.12.014","article-title":"Identification and characterization of C1 inhibitor in Nile tilapia (Oreochromis niloticus) in response to pathogenic bacteria","volume":"61","author":"Ding","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fsi.2019.05.014","article-title":"Expression and functional characterization of a mannose-binding lectin-associated serine protease-1 (MASP-1) from Nile tilapia (Oreochromis niloticus) in host defense against bacterial infection","volume":"91","author":"Mu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.fsi.2017.09.015","article-title":"C1r and C1s from Nile tilapia (Oreochromis niloticus): molecular characterization, transcriptional profiling upon bacterial and IFN-gamma inductions and potential role in response to bacterial infection","volume":"70","author":"Zhong","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.dci.2018.08.012","article-title":"Interleukin-6 gets involved in response to bacterial infection and promotes antibody production in Nile tilapia (Oreochromis niloticus)","volume":"89","author":"Wei","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103515","article-title":"CD38 play roles in T cell-dependent response and B cell differentiation in nile tilapia (Oreochromis niloticus)","volume":"103","author":"Li","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib27","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/361494a0","article-title":"X-linked immunodeficiency. The fruits of cooperation","volume":"361","author":"Hill","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2021.01.009_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.immunol.22.012703.104533","article-title":"CD40\/CD154 interactions at the interface of tolerance and immunity","volume":"22","author":"Quezada","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib29","first-page":"61","article-title":"Antigen dose in the human immune response. Dose-relationships in the human immune response to Keyhole limpet hemocyanin","volume":"78","author":"Curtis","year":"1971","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.fsi.2021.01.009_bib30","first-page":"51","article-title":"Immunochemical and immunogenic properties of a purified keyhold limpet haemocyanin","volume":"22","author":"Herscowitz","year":"1972","journal-title":"Immunology"},{"key":"10.1016\/j.fsi.2021.01.009_bib31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0968-4328(99)00036-0","article-title":"Keyhole limpet hemocyanin (KLH): a biomedical review","volume":"30","author":"Harris","year":"1999","journal-title":"Micron"},{"key":"10.1016\/j.fsi.2021.01.009_bib32","first-page":"299","article-title":"Cells binding the antigen keyhole limpet haemocyanin in the peripheral blood and in the lymphocyte cultures of non-immune and immunized human subjects","volume":"17","author":"Hersh","year":"1974","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tox.2003.12.003","article-title":"Primary antibody response to keyhole limpet hemocyanin in rat as a model for immunotoxicity evaluation","volume":"197","author":"Gore","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.fsi.2021.01.009_bib34","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/bcp.12422","article-title":"Keyhole limpet haemocyanin - a model antigen for human immunotoxicological studies","volume":"78","author":"Swaminathan","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.fsi.2021.01.009_bib35","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1186\/s12864-018-5062-6","article-title":"A genome-wide association study for natural antibodies measured in blood of Canadian Holstein cows","volume":"19","author":"de Klerk","year":"2018","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2021.01.009_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12936-018-2219-3","article-title":"Avian malaria and bird humoral immune response","volume":"17","author":"Delhaye","year":"2018","journal-title":"Malar. J."},{"key":"10.1016\/j.fsi.2021.01.009_bib37","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.4049\/jimmunol.1701728","article-title":"Simultaneous presence of non- and highly mutated keyhole limpet hemocyanin (KLH)-specific plasmablasts early after primary KLH immunization suggests cross-reactive memory B cell activation","volume":"200","author":"Giesecke","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib38","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.3389\/fimmu.2018.02532","article-title":"Polymicrobial sepsis chronic immunoparalysis is defined by diminished Ag-specific T cell-dependent B cell responses","volume":"9","author":"Sjaastad","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2021.01.009_bib39","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.314668","article-title":"Monoclonal antibodies defining distinctive human T cell surface antigens","volume":"206","author":"Kung","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.fsi.2021.01.009_bib40","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1101\/gad.5.5.868","article-title":"Identification and characterization of a novel repressor of beta-interferon gene expression","volume":"5","author":"Keller","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2021.01.009_bib41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0092-8674(94)90321-2","article-title":"Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells","volume":"77","author":"Turner","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2021.01.009_bib42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1074-7613(02)00335-7","article-title":"Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program","volume":"17","author":"Shaffer","year":"2002","journal-title":"Immunity"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821000176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821000176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:25:37Z","timestamp":1760937937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464821000176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":42,"alternative-id":["S1050464821000176"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2021.01.009","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and functional characterization of CD154 in T cell-dependent immune response in Nile tilapia (Oreochromis niloticus)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2021.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}