{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:02:42Z","timestamp":1789153362217,"version":"build-2803163510"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.fsi.2021.05.023","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T02:45:08Z","timestamp":1622256308000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Grouper TRAF5 exerts negative regulation on antiviral immune response against iridovirus"],"prefix":"10.1016","volume":"115","author":[{"given":"Mengshi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingguang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2021.05.023_bib1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/jfd.12758","article-title":"The high prevalence of pathogenic Vibrio harveyi with multiple antibiotic resistance in scale drop and muscle necrosis disease of the hybrid grouper, Epinephelus fuscoguttatus (female symbol) x E. lanceolatus (male symbol), in China","volume":"41","author":"Zhu","year":"2018","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2021.05.023_bib2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.fsi.2019.02.052","article-title":"Dietary Radix Bupleuri extracts improves hepatic lipid accumulation and immune response of hybrid grouper (Epinephelus lanceolatusmale symbol x Epinephelus fuscoguttatusfemale symbol)","volume":"88","author":"Zou","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3354\/dao053001","article-title":"Characterization of a novel ranavirus isolated from grouper Epinephelus tauvina","volume":"53","author":"Qin","year":"2003","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2021.05.023_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.fsi.2014.04.022","article-title":"Isolation and characterization of tumor necrosis factor receptor-associated factor 6 (TRAF6) from grouper, Epinephelus tauvina","volume":"39","author":"Wei","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib5","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00705-019-04268-z","article-title":"Isolation and identification of Singapore grouper iridovirus Hainan strain (SGIV-HN) in China","volume":"164","author":"Wei","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.fsi.2021.05.023_bib6","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1016\/j.molimm.2009.05.178","article-title":"TRAF1 is involved in the classical NF-kappaB activation and CD30-induced alternative activity in Hodgkin's lymphoma cells","volume":"46","author":"Guo","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/v10060305","article-title":"Tumor necrosis factor receptor-associated factor 5 interacts with the NS3 protein and promotes classical swine fever virus replication","volume":"10","author":"Lv","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2021.05.023_bib8","doi-asserted-by":"crossref","first-page":"ra81","DOI":"10.1126\/scisignal.2003152","article-title":"Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5","volume":"5","author":"Zhang","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.fsi.2021.05.023_bib9","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/jcp.24011","article-title":"The seventh ring: exploring TRAF7 functions","volume":"227","author":"Zotti","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fsi.2021.05.023_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-2187-8-7","article-title":"TRAF molecules in cell signaling and in human diseases","volume":"8","author":"Xie","year":"2013","journal-title":"J. Mol. Signal."},{"key":"10.1016\/j.fsi.2021.05.023_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/978-0-387-70630-6_3","article-title":"Physiological roles and mechanisms of signaling by TRAF2 and TRAF5","volume":"597","author":"Au","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fsi.2021.05.023_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4049\/jimmunol.1301901","article-title":"TRAF5 negatively regulates TLR signaling in B lymphocytes","volume":"192","author":"Buchta","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009172","article-title":"TRAF5 is a downstream target of MAVS in antiviral innate immune signaling","volume":"5","author":"Tang","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2021.05.023_bib14","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.fsi.2019.07.052","article-title":"Expression and functional analysis of tumor necrosis factor receptor (TNFR)-associated factor 5 from Nile tilapia, Oreochromis niloticus","volume":"93","author":"Xia","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib15","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.fsi.2019.02.018","article-title":"Molecular characteristics and function study of TNF receptor-associated factor 5 from grouper (Epinephelus coioides)","volume":"87","author":"Yang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquaculture.2009.04.019","article-title":"Characterization of two grouper Epinephelus akaara cell lines: application to studies of Singapore grouper iridovirus (SGIV) propagation and virus-host interaction","volume":"292","author":"Huang","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2021.05.023_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3389\/fimmu.2019.00517","article-title":"Fish autophagy protein 5 exerts negative regulation on antiviral immune response against iridovirus and nodavirus","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib18","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/pro.2881","article-title":"Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5","volume":"25","author":"Foight","year":"2016","journal-title":"Protein Sci. : a publication of the Protein Society"},{"key":"10.1016\/j.fsi.2021.05.023_bib19","doi-asserted-by":"crossref","first-page":"9437","DOI":"10.1073\/pnas.93.18.9437","article-title":"TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling","volume":"93","author":"Ishida","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2021.05.023_bib20","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.4049\/jimmunol.165.9.5084","article-title":"TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies","volume":"165","author":"Zapata","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib21","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.fsi.2018.11.014","article-title":"The proliferation and clonal migration of B cells in the systemic and mucosal tissues of channel catfish suggests there is an interconnected mucosal immune system","volume":"84","author":"Lange","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.05.023_bib22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.dci.2017.02.010","article-title":"Omics in fish mucosal immunity","volume":"75","author":"Salinas","year":"2017","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821001510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821001510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:26:16Z","timestamp":1760937976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464821001510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":22,"alternative-id":["S1050464821001510"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2021.05.023","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Grouper TRAF5 exerts negative regulation on antiviral immune response against iridovirus","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2021.05.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}