{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T15:40:34Z","timestamp":1783179634067,"version":"3.54.6"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018735","name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","doi-asserted-by":"publisher","award":["1510027"],"award-info":[{"award-number":["1510027"]}],"id":[{"id":"10.13039\/501100018735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1210852"],"award-info":[{"award-number":["1210852"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006255","name":"Universidad de Concepci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006255","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.fsi.2021.08.005","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T03:18:29Z","timestamp":1628565509000},"page":"169-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Transcriptome and morphological analysis in Caligus rogercresseyi uncover the effects of Atlantic salmon vaccination with IPath\u00ae"],"prefix":"10.1016","volume":"117","author":[{"given":"Valentina","family":"Valenzuela-Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara P.","family":"Benavente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-1793","authenticated-orcid":false,"given":"Antonio","family":"Casuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-5314","authenticated-orcid":false,"given":"Yeny","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Valenzuela-Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"N\u00fa\u00f1ez-Acu\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"S\u00e1ez-Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Gallardo-Esc\u00e1rate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.fsi.2021.08.005_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.hgmx.2015.06.008","article-title":"Iron deficiency anaemia","volume":"79","author":"Barrag\u00e1n","year":"2016","journal-title":"Rev. M\u00e9d. Hosp. Gen. M\u00e9xico"},{"key":"10.1016\/j.fsi.2021.08.005_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-4939-2095-2_10","article-title":"A systems biology approach to iron metabolism","volume":"844","author":"Chifman","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"issue":"8","key":"10.1016\/j.fsi.2021.08.005_bib3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen-host interface","volume":"10","author":"Hood","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2021.08.005_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2728(96)00022-9","article-title":"The ferritins: molecular properties, iron storage function and cellular regulation","volume":"1275","author":"Harrison","year":"1996","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"7","key":"10.1016\/j.fsi.2021.08.005_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103729","article-title":"Cloning and characterisation of multiple ferritin isoforms in the Atlantic salmon (Salmo salar)","volume":"9","author":"Lee","year":"2014","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.fsi.2021.08.005_bib6","first-page":"48","article-title":"Conceptos actuales sobre fisiolog\u00eda y patolog\u00eda del hierro","volume":"14","author":"Rosolen","year":"2010","journal-title":"Hematologia"},{"issue":"10","key":"10.1016\/j.fsi.2021.08.005_bib7","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","article-title":"Regulation of ferritin genes and protein","volume":"99","author":"Torti","year":"2002","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.fsi.2021.08.005_bib8","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.dci.2006.02.005","article-title":"Dual function of fish hepcidin: response to experimental iron overload and bacterial infection in sea bass (Dicentrarchus labrax)","volume":"30","author":"Rodrigues","year":"2006","journal-title":"Dev. Comp. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2021.08.005_bib9","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.dci.2009.02.001","article-title":"Transferrin and ferritin response to bacterial infection: the role of the liver and brain in fish","volume":"33","author":"Neves","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2021.08.005_bib10","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/jfd.12592","article-title":"Uncovering iron regulation with species\u2010specific transcriptome patterns in Atlantic and coho salmon during a Caligus rogercresseyi infestation","volume":"40","author":"Valenzuela\u2010Mu\u00f1oz","year":"2017","journal-title":"J. Fish. Dis."},{"issue":"3","key":"10.1016\/j.fsi.2021.08.005_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cbpb.2010.03.012","article-title":"Identification and analysis of a Scophthalmus maximus ferritin that is regulated at transcription level by oxidative stress and bacterial infection","volume":"156","author":"Zheng","year":"2010","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.fsi.2021.08.005_bib12","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.fsi.2012.11.049","article-title":"Iron-metabolic function and potential antibacterial role of Hepcidin and its correlated genes (Ferroportin 1 and Transferrin Receptor) in turbot (Scophthalmus maximus)","volume":"34","author":"Yang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.fsi.2014.10.039","article-title":"Ferritin protect shrimp Litopenaeus vannamei from WSSV infection by inhibiting virus replication","volume":"42","author":"Ye","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.08.005_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.vetimm.2018.09.001","article-title":"Recombinant ferritin-H induces immunosuppression in European sea bass larvae (Dicentrarchus labrax) rather than immunostimulation and protection against a Vibrio anguillarum infection","volume":"204","author":"Yaacob","year":"2018","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"17","key":"10.1016\/j.fsi.2021.08.005_bib15","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1016\/j.vaccine.2010.02.008","article-title":"Characterization of ferritin 2 for the control of tick infestations","volume":"28","author":"Hajdusek","year":"2010","journal-title":"Vaccine"},{"issue":"10","key":"10.1016\/j.fsi.2021.08.005_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185504","article-title":"Secretome analysis of Trypanosoma cruzi by proteomics studies","volume":"12","author":"Brossas","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.fsi.2021.08.005_bib17","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M115.053934","article-title":"The extracellular vesicles of the helminth pathogen, Fasciola hepatica: biogenesis pathways and cargo molecules involved in parasite pathogenesis","author":"Cwiklinski","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"issue":"2","key":"10.1016\/j.fsi.2021.08.005_bib18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.fsi.2015.10.022","article-title":"Transcription expression of immune-related genes from Caligus rogercresseyi evidences host-dependent patterns on Atlantic and coho salmon","volume":"47","author":"Vera","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.08.005_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3390\/vaccines9040361","article-title":"Chimeric protein IPath\u00ae with chelating activity improves Atlantic Salmon's immunity against infectious diseases","volume":"9","author":"Valenzuela-Mu\u00f1oz","year":"2021","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2012.08.003","article-title":"Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms","volume":"148","author":"Rauta","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.fsi.2021.08.005_bib21","first-page":"1","article-title":"The Tps series of software","volume":"26","author":"Rohlf","year":"2015","journal-title":"Hystrix"},{"key":"10.1016\/j.fsi.2021.08.005_bib22","doi-asserted-by":"crossref","DOI":"10.2307\/2992207","article-title":"Extensions of the Procrustes method for the optimal Superimposition of landmarks","volume":"39","author":"Rohlf","year":"1990","journal-title":"Syst. Zool."},{"key":"10.1016\/j.fsi.2021.08.005_bib23","first-page":"15","article-title":"Visualizations in geometric morphometrics: how to read and how to make graphs showing shape changes","volume":"24","author":"Klingenberg","year":"2013","journal-title":"Hystrix"},{"key":"10.1016\/j.fsi.2021.08.005_bib24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1755-0998.2010.02924.x","article-title":"MorphoJ: an integrated software package for geometric morphometrics","volume":"11","author":"Klingenberg","year":"2011","journal-title":"Molecular Ecology Resources"},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41597-021-00842-w","article-title":"Chromosome-scale genome assembly of the sea louse Caligus rogercresseyi by SMRT sequencing and Hi-C analysis","volume":"8","author":"Gallardo-Escarate","year":"2021","journal-title":"Sci Data"},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/nar\/28.1.45","article-title":"The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000","volume":"28","author":"Bairoch","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2021.08.005_bib27","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1093\/bioinformatics\/bti610","article-title":"Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research","volume":"21","author":"Conesa","year":"2005","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib28","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2164-12-141","article-title":"Gene expression analyses of immune responses in Atlantic salmon during early stages of infection by salmon louse (Lepeophtheirus salmonis) revealed bi-phasic responses coinciding with the copepod-chalimus transition","volume":"12","author":"Tadiso","year":"2011","journal-title":"BMC Genom."},{"key":"10.1016\/j.fsi.2021.08.005_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.012809.104804","article-title":"Iron homeostasis and the inflammatory response","volume":"30","author":"Wessling-Resnick","year":"2010","journal-title":"Annu. Rev. Nutr."},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib30","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2180-10-64","article-title":"Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens","volume":"10","author":"Pan","year":"2010","journal-title":"BMC Microbiol."},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0008-8749(91)90336-A","article-title":"Role of iron in T cell activation: Th1 clones differ from TH2 clones in their sensitivity to inhibition of DNA synthesis caused by IGG mabs against the transferrin receptor and the iron chelator deferoxamine","volume":"134","author":"Thorson","year":"1991","journal-title":"Cell. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2021.08.005_bib32","first-page":"1","article-title":"Immune cell functions in iron overload","volume":"75","author":"De Sousa","year":"1989","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2021.08.005_bib33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1096\/fasebj.9.2.7540156","article-title":"Free radicals and phagocytic cells","volume":"9","author":"Rosen","year":"1995","journal-title":"Faseb. J."},{"issue":"5","key":"10.1016\/j.fsi.2021.08.005_bib34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression","volume":"38","author":"Babitt","year":"2006","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.fsi.2021.08.005_bib35","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1079\/BJN19940094","article-title":"The effects of iron deficiency and iron overload on cell-mediated immunity in the mouse","volume":"72","author":"Omara","year":"1994","journal-title":"Br. J. Nutr."},{"issue":"5","key":"10.1016\/j.fsi.2021.08.005_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1600-0609.1994.tb00097.x","article-title":"Haemochromatosis as a window into the study of the immunological system: a novel correlation between CD8+ lymphocytes and iron overload","volume":"52","author":"Porto","year":"1994","journal-title":"Eur. J. Haematol."},{"issue":"2","key":"10.1016\/j.fsi.2021.08.005_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.imbio.2013.08.011","article-title":"Suppression of immunoglobulin production in human peripheral blood mononuclear cells by monocytes via secretion of heavy-chain ferritin","volume":"219","author":"Yamashita","year":"2014","journal-title":"Immunobiology"},{"issue":"5\u20136","key":"10.1016\/j.fsi.2021.08.005_bib38","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.fsi.2010.01.013","article-title":"Cloning and analysis of a ferritin subunit from turbot (Scophthalmus maximus)","volume":"28","author":"Zheng","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2021.08.005_bib39","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.fsi.2018.02.023","article-title":"Hepcidin protects grass carp (Ctenopharyngodon idellus) against Flavobacterium columnare infection via regulating iron distribution and immune gene expression","volume":"75","author":"Wei","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"8","key":"10.1016\/j.fsi.2021.08.005_bib40","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen-host interface","volume":"10","author":"Hood","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2021.08.005_bib41","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.fsi.2016.11.045","article-title":"Iron metabolism modulation in Atlantic salmon infested with the sea lice Lepeophtheirus salmonis and Caligus rogercresseyi: a matter of nutritional immunity?","volume":"60","author":"Valenzuela-Mu\u00f1oz","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"1\/2","key":"10.1016\/j.fsi.2021.08.005_bib42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1163\/18759866-0690102015","article-title":"On the identity of the common Caligus (Copepoda: Siphonostomatoida: Caligidae) from salmonid netpen systems in southern Chile","volume":"69","author":"Boxshall","year":"2000","journal-title":"Contrib. Zool."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821002278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464821002278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:29:34Z","timestamp":1760938174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464821002278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":42,"alternative-id":["S1050464821002278"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2021.08.005","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome and morphological analysis in Caligus rogercresseyi uncover the effects of Atlantic salmon vaccination with IPath\u00ae","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2021.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}