{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:22:39Z","timestamp":1791537759583,"version":"4.3.4"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2019C02049"],"award-info":[{"award-number":["2019C02049"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2020C02014"],"award-info":[{"award-number":["2020C02014"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31172116"],"award-info":[{"award-number":["31172116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472015"],"award-info":[{"award-number":["31472015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ17C030001"],"award-info":[{"award-number":["LZ17C030001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017538","name":"Zhejiang Provincial Ten Thousand Plan for Young Top Talents","doi-asserted-by":"publisher","award":["2018R52028"],"award-info":[{"award-number":["2018R52028"]}],"id":[{"id":"10.13039\/501100017538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.fsi.2022.01.008","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T01:57:51Z","timestamp":1641866271000},"page":"305-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Transcriptome analysis of grass carp (Ctenopharyngodon idella) and Holland's spinibarbel (Spinibarbus hollandi) infected with Ichthyophthirius multifiliis"],"prefix":"10.1016","volume":"121","author":[{"given":"Minghao","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0816-5753","authenticated-orcid":false,"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanjian","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongquan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.fsi.2022.01.008_bib1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/gb-2011-12-10-r100","article-title":"Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control","volume":"12","author":"Coyne","year":"2011","journal-title":"Genome Biol."},{"issue":"3\u20134","key":"10.1016\/j.fsi.2022.01.008_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.vetimm.2008.07.013","article-title":"Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects","volume":"126","author":"Alvarez-Pellitero","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"7","key":"10.1016\/j.fsi.2022.01.008_bib3","first-page":"369","article-title":"Advances in studies on genetic resources of grass carp","volume":"27","author":"Shen","year":"2011","journal-title":"Chin. Agricult. Sci. Bull."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.fsi.2003.12.005","article-title":"Expression of pro-inflammatory cytokines in rainbow trout (Oncorhynchus mykiss) during an infection with Ichthyophthirius multifiliis","volume":"17","author":"Sigh","year":"2004","journal-title":"Fish Shellfish Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2022.01.008_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2761.2004.00558.x","article-title":"The parasitic ciliate Ichthyophthirius multifiliis induces expression of immune relevant genes in rainbow trout, Oncorhynchus mykiss (Walbaum)","volume":"27","author":"Sigh","year":"2004","journal-title":"J. Fish. Dis."},{"issue":"3","key":"10.1016\/j.fsi.2022.01.008_bib6","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.fsi.2011.01.010","article-title":"Cellular and humoral factors involved in the response of rainbow trout gills to Ichthyophthirius multifiliis infections: molecular and immunohistochemical studies","volume":"30","author":"Olsen","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"37","key":"10.1016\/j.fsi.2022.01.008_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3750\/AIP2007.37.1.04","article-title":"Stress response in rainbow trout during infection with Ichthyophthirius multifiliis and formalin bath treatment","volume":"1","author":"Jorgensen","year":"2007","journal-title":"Acta Ichthyol. Piscatoria"},{"issue":"10","key":"10.1016\/j.fsi.2022.01.008_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/j.1365-2761.2011.01291.x","article-title":"Experimental evidence for direct in situ binding of IgM and IgT to early trophonts of Ichthyophthirius multifiliis (Fouquet) in the gills of rainbow trout, Oncorhynchus mykiss (Walbaum)","volume":"34","author":"Jorgensen","year":"2011","journal-title":"J. Fish. Dis."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib9","first-page":"233","article-title":"Gene expression analysis in rainbow trout (Oncorhynchus mykiss) skin: immunological responses to radiovaccine against Ichthyophthirius multifiliis","volume":"166","author":"Heidarieh","year":"2015","journal-title":"Revue M\u00e9d V\u00e9t"},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrg2484","article-title":"RNA-Seq: a revolutionary tool for transcriptomics","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib11","first-page":"1","article-title":"Transcriptome analysis of the Larimichthys crocea liver in response to Cryptocaryon irritans","volume":"48","author":"Wang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.fsi.2016.01.022","article-title":"Transcriptome and analysis on the complement and coagulation cascades pathway of large yellow croaker (Larimichthys crocea) to ciliate ectoparasite Cryptocaryon irritans infection","volume":"50","author":"Yin","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib13","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.fsi.2017.05.042","article-title":"Transcriptomic variation of locally-infected skin of Epinephelus coioides reveals the mucosal immune mechanism against Cryptocaryon irritans","volume":"66","author":"Hu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fsi.2017.09.003","article-title":"Transcriptomic profiling of Tibetan highland fish (Gymnocypris przewalskii) in response to the infection of parasite ciliate Ichthyophthirius multifiliis","volume":"70","author":"Tian","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2022.01.008_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.fsi.2003.06.001","article-title":"The ontogeny of complement component C3 in Atlantic cod (Gadus morhua L.)-an immunohistochemical study","volume":"16","author":"Lange","year":"2004","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1186\/1471-2164-15-829","article-title":"Profiling of the embryonic Atlantic halibut (Hippoglossus hippoglossus L.) transcriptome reveals maternal transcripts as potential markers of embryo quality","volume":"15","author":"Mommens","year":"2014","journal-title":"BMC Genom."},{"issue":"2\u20133","key":"10.1016\/j.fsi.2022.01.008_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s00251-006-0096-3","article-title":"Maternal transfer of complement components C3-1, C3-3, C3-4, C4, C5, C7, Bf, and Df to offspring in rainbow trout (Oncorhynchus mykiss)","volume":"58","author":"Lvoll","year":"2006","journal-title":"Immunogenetics"},{"issue":"88","key":"10.1016\/j.fsi.2022.01.008_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.fsi.2019.02.061","article-title":"Complement component 3 (C3): an important role in grass carp (Ctenopharyngodon idella) experimentally exposed to Aeromonas hydrophila","author":"Meng","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2022.01.008_bib19","doi-asserted-by":"crossref","first-page":"1007251","DOI":"10.1371\/journal.ppat.1007251","article-title":"Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection","volume":"14","author":"Yu","year":"2018","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.fsi.2022.01.008_bib20","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Full-length transcriptome assembly from RNA-Seq data without a reference genome","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13104-020-05351-4","article-title":"De novo assembly of the Brown trout (Salmo trutta m. fario) brain and muscle transcriptome: transcript annotation, tissue differential expression profile and SNP discovery","volume":"13","author":"Fibla","year":"2020","journal-title":"BMC Res. Notes"},{"issue":"19","key":"10.1016\/j.fsi.2022.01.008_bib22","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/bioinformatics\/bti430","article-title":"Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary","volume":"21","author":"Mao","year":"2005","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.fsi.2022.01.008_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ng.3280","article-title":"The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation","volume":"47","author":"Wang","year":"2015","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib24","first-page":"480","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib25","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1186\/s12864-019-6345-2","article-title":"Transcriptional profiling of skeletal muscle reveals starvation response and compensatory growth in Spinibarbus hollandi","volume":"20","author":"Yang","year":"2019","journal-title":"BMC Genom."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib26","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/nmeth.1517","article-title":"De novo assembly and analysis of RNA-seq data","volume":"7","author":"Robertson","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fsi.2022.01.008_bib27","first-page":"2020","article-title":"CNSA: a data repository for archiving omics data","author":"Guo","year":"2020","journal-title":"Database"},{"key":"10.1016\/j.fsi.2022.01.008_bib28","first-page":"799","volume":"vol. 42","author":"Chen","year":"2020"},{"issue":"2","key":"10.1016\/j.fsi.2022.01.008_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMra1202117","article-title":"JAKs and STATs in immunity, immunodeficiency, and cancer","volume":"368","author":"O'Shea","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.fsi.2022.01.008_bib30","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"Mechanisms of disease - the many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.fsi.2022.01.008_bib31","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2893.2009.01130.x","article-title":"Association study of IFN-\u0391R2 and IL10RB genes with the susceptibility and interferon response in HBV infection","volume":"16","author":"Gong","year":"2009","journal-title":"J. Viral Hepat."},{"issue":"12","key":"10.1016\/j.fsi.2022.01.008_bib32","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1111\/liv.12859","article-title":"The interferon receptor\u20101 promoter polymorphisms affect the outcome of Caucasians with HBeAg\u2010negative chronic HBV infection","volume":"35","author":"Karamitros","year":"2016","journal-title":"Liver Int."},{"issue":"8","key":"10.1016\/j.fsi.2022.01.008_bib33","first-page":"182866","article-title":"IFN-\u0391R2-dependent gene expression profile induced by IFN-\u03b1 in Pteropus alecto bat cells and impact of IFN-\u0391R2 knockout on virus infection[J]","volume":"12","author":"Qian","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib34","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.dci.2011.07.001","article-title":"Teleost fish interferons and their role in immunity","volume":"35","author":"Zou","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.fsi.2017.03.054","article-title":"Two type II IFN- members, IFN-\u03b3 and IFN-\u03b3 related (rel), regulate differentially IRF1 and IRF11 in zebrafish","volume":"63","author":"Ruan","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib36","first-page":"22","article-title":"CD40\/CD40 ligand interactions and TNF alpha treatment reduce activity of P105 promoter of the human papilloma virus-18 in vitro","volume":"38","author":"Altenburg","year":"2016","journal-title":"Exp. Hematol. Oncol."},{"issue":"10","key":"10.1016\/j.fsi.2022.01.008_bib37","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1172\/JCI99005","article-title":"TLR-3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs","volume":"128","author":"Cheng","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molimm.2018.11.001","article-title":"Characterization of CD40+ leukocytes in flounder (Paralichthys olivaceus) and its response after Hirame novirhabdovirus infection and immunization","volume":"104","author":"Xing","year":"2018","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cbd.2005.08.005","article-title":"Genomics of fish cytokines","volume":"1","author":"Savan","year":"2006","journal-title":"Comp. Biochem. Physiol. Genom. Proteonomics"},{"issue":"90","key":"10.1016\/j.fsi.2022.01.008_bib40","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1099\/vir.0.012286-0","article-title":"Differential virulence mechanisms of infectious hematopoietic necrosis virus in rainbow trout (Oncorhynchus mykiss) include host entry and virus replication kinetics","author":"Penaranda","year":"2009","journal-title":"J. Gen. Virol."},{"issue":"9","key":"10.1016\/j.fsi.2022.01.008_bib41","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s00109-006-0084-y","article-title":"Toll-like receptors and innate immunity","volume":"84","author":"Uematsu","year":"2006","journal-title":"J. Mol. Med."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition[J]","volume":"20","author":"Charles","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.fsi.2022.01.008_bib43","first-page":"14","article-title":"Toll-like receptors","volume":"109","author":"Takeda","year":"2015","journal-title":"Curr. Protoc. Im."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib44","doi-asserted-by":"crossref","first-page":"40878","DOI":"10.1038\/srep40878","article-title":"A conserved TLR-5 binding and activation hot spot on flagellin","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib45","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial agellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"issue":"5663","key":"10.1016\/j.fsi.2022.01.008_bib46","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1093616","article-title":"Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA","volume":"303","author":"Diebold","year":"2004","journal-title":"Science"},{"issue":"6913","key":"10.1016\/j.fsi.2022.01.008_bib47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature01180","article-title":"The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors","volume":"420","author":"Horng","year":"2002","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.dci.2014.11.018","article-title":"Immune effects of R848: evidences that suggest an essential role of TLR7\/8-induced, Myd88- and NF-\u03baB-dependent signaling in the antiviral immunity of Japanese flounder (Paralichthys olivaceus)","volume":"49","author":"Zhou","year":"2015","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.fsi.2010.01.006","article-title":"A novel protein isolated from the serum of rabbitfish (Siganus oramin) is lethal to Cryptocaryon irritans","volume":"29","author":"Wang","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2008.01.061","article-title":"Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling","volume":"368","author":"Natsuko","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2022.01.008_bib51","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2006.03.047","article-title":"Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling","volume":"125","author":"Jonathan","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2022.01.008_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fsi.2017.08.009","article-title":"l-amino acid oxidase expression profile and biochemical responses of rabbitfish (Siganus oramin) after exposure to a high dose of Cryptocaryon irritans","volume":"69","author":"Jiang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2022.01.008_bib53","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Yniv","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2022.01.008_bib54","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1007\/s00436-018-6088-z","article-title":"The development of Cryptocaryon irritans in a less susceptible host rabbitfish, Siganus oramin","volume":"117","author":"Jiang","year":"2018","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.fsi.2022.01.008_bib55","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.0801755","article-title":"Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB, activation","volume":"182","author":"Sepulcre","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2022.01.008_bib56","first-page":"489","article-title":"Transcriptomic analysis of immunity in rainbow trout (Oncorhynchus mykiss) gills infected by Ichthyophthirius multifiliis","volume":"86","author":"Khairul","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"70","key":"10.1016\/j.fsi.2022.01.008_bib57","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fsi.2017.09.003","article-title":"Transcriptomic profiling of Tibetan highland fish (Gymnocypris przewalskii) in response to the infection of parasite ciliate Ichthyophthirius multifiliis","author":"Tian","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2022.01.008_bib58","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.fsi.2013.05.023","article-title":"Expression profiles of toll-like receptors in channel catfish (Ictalurus punctatus) after infection with Ichthyophthirius multifiliis","volume":"35","author":"Zhao","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2022.01.008_bib59","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.dci.2009.12.009","article-title":"Identification and expression analysis of the g-type and c-type lysozymes in grass carp Ctenopharyngodon idellus","volume":"34","author":"Ye","year":"2010","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2022.01.008_bib60","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s10695-012-9613-5","article-title":"Comparative analysis of innate immune parameters of the skin mucous secretions from certain freshwater teleosts, inhabiting different ecological niches","volume":"38","author":"Nigam","year":"2012","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fsi.2022.01.008_bib61","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.dci.2017.02.010","article-title":"Omics in fish mucosal immunity","volume":"75","author":"Salinas","year":"2017","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib62","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12038-010-0015-5","article-title":"Lysozymes in the animal kingdom","volume":"35","author":"Callewaert","year":"2010","journal-title":"J. Biosci."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.micpath.2017.11.039","article-title":"Fish antimicrobial peptides (AMP's) as essential and promising molecular therapeutic agents: a review","volume":"114","author":"Shabir","year":"2018","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib64","first-page":"322","article-title":"Characterization of the immune roles of cathepsin L in turbot (Scophthalmus maximus) mucosal immunity","volume":"97","author":"Chen","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2022.01.008_bib65","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.fsi.2012.12.011","article-title":"Immune responses and immune-related gene expression profile in orange-spotted grouper after immunization with Cryptocaryon irritans vaccine","volume":"34","author":"Dan","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib66","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.exppara.2015.04.010","article-title":"Immunological, ionic and biochemical responses in blood serum of the marine fish Trachinotus ovatus to poly-infection by Cryptocaryon irritans","volume":"154","author":"Yin","year":"2015","journal-title":"Exp. Parasitol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib67","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yexcr.2015.09.019","article-title":"The small chemical enzyme inhibitor 5-phenylnicotinic acid\/CD13 inhibits cell migration and invasion of tartrate-resistant acid phosphatase\/ACP5-overexpressing MDA-MB-231 breast cancer cells","volume":"339","author":"Michael","year":"2015","journal-title":"Exp. Cell Res."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib68","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fsi.2019.04.306","article-title":"Molecular cloning of the Rab7 effector RILP (Rab-interacting lysosomal protein) in Litopenaeus vannamei and preliminary analysis of its role in white spot syndrome virus infection","volume":"90","author":"Feng","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2022.01.008_bib69","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.dci.2012.04.001","article-title":"Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts","volume":"39","author":"Zhu","year":"2013","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2022.01.008_bib70","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.4049\/jimmunol.169.5.2488","article-title":"The IgH locus of the channel catfish, Ictalurus punctatus, contains multiple constant region gene sequences: different genes encode heavy chains of membrane and secreted IgD","volume":"169","author":"Bengten","year":"2002","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2022.01.008_bib71","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni1166","article-title":"The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z","volume":"6","author":"Danilova","year":"2005","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2022.01.008_bib72","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.molimm.2009.10.010","article-title":"Identification and characterization of a novel immunoglobulin Z isotype in zebrafish: implications for a distinct B cell receptor in lower vertebrates","volume":"47","author":"Hu","year":"2010","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2022.01.008_bib73","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.dci.2010.10.009","article-title":"Discovery of an unusual alternative splicing pathway of the immunoglobulin heavy chain in a teleost fish, Danio rerio","volume":"35","author":"Hu","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2022.01.008_bib74","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00251-005-0015-z","article-title":"Discovery of a novel immunoglobulin heavy chain gene chimera from common carp (Cyprinus carpio)","volume":"57","author":"Savan","year":"2005","journal-title":"Immunogenetics"},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib75","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0162-3109(00)80303-3","article-title":"Complement and innate immunity","volume":"49","author":"Song","year":"2000","journal-title":"Immunopharmacology"},{"issue":"2","key":"10.1016\/j.fsi.2022.01.008_bib76","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.fsi.2014.12.037","article-title":"Edwardsiella tarda evades serum killing by preventing complement activation via the alternative pathway","volume":"43","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol."},{"issue":"93","key":"10.1016\/j.fsi.2022.01.008_bib77","first-page":"87","article-title":"The phylogeny and evolution of the first component of complement, C1","volume":"93","author":"Dodds","year":"1993","journal-title":"Behring Inst. Mitteilungen"},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib78","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.fsi.2014.07.008","article-title":"Molecular cloning, sequencing and tissue-level expression of complement C3 of Labeo rohita (Hamilton, 1822)","volume":"40","author":"Pushpa","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib79","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-065X.1998.tb01252.x","article-title":"Molecular genetics of the complement C3 convertases in lower vertebrates","volume":"166","author":"Nonaka","year":"1998","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib80","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0167-5699(96)20028-F","article-title":"Expression of complement in the brain: role in heath and disease","volume":"17","author":"Morgan","year":"1996","journal-title":"Immunol. Today"},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib81","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/fsim.1999.0252","article-title":"Complement system of bony and cartilaginous fish","volume":"10","author":"Nonaka","year":"2000","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib82","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.fsi.2007.01.002","article-title":"The ontogeny and extrahepatic expression of complement factor C3 in Atlantic salmon (Salmo salar)","volume":"23","author":"L\u00f8voll","year":"2007","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib83","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.vetimm.2007.05.005","article-title":"Molecular cloning, promoter analysis and induced expression of the complement component C9 gene in the grass carp Ctenopharyngodon Idella","volume":"118","author":"Li","year":"2007","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib84","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.aquaculture.2019.03.046","article-title":"Molecular characterization and expression analysis of complement components C3 and C9 in largemouth bronze gudgeon (Coreius guichenoti) in response to Ichthyophthirius multifiliis infection","volume":"506","author":"Fu","year":"2019","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib85","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.dci.2003.10.006","article-title":"An immunohistochemical study on complement component C3 in juvenile Atlantic halibut (Hippoglossus hippoglossus)","volume":"28","author":"Lange","year":"2004","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib86","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.fsi.2017.11.022","article-title":"Molecular characterization and expression analysis of complement component 3 in dojo loach (Misgurnus anguillicaudatus)","volume":"72","author":"Xu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib87","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.fsi.2018.10.083","article-title":"Molecular characterization and expression analysis of complement component C3 in southern catfish (Silurus meridionalis) and a whole mount in situ hybridization study on its ontogeny","volume":"84","author":"Fu","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib88","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ni.1913","article-title":"IgT, a primitive immunoglobulin class specialized in mucosal immunity","volume":"11","author":"Zhang","year":"2010","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2022.01.008_bib89","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.dci.2011.03.003","article-title":"The complement system in teleost fish: progress of post-homolog-hunting researches","volume":"35","author":"Nakao","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.01.008_bib90","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1577\/1548-8667(1991)003<0016:EMOBEP>2.3.CO;2","article-title":"Electron microscopy of bactericidal effects produced by the alternative complement pathway of channel catfish","volume":"3","author":"Jenkins","year":"1991","journal-title":"J. Aquat. Anim. Health"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822000171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822000171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:32:04Z","timestamp":1760938324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822000171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":90,"alternative-id":["S1050464822000171"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.01.008","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptome analysis of grass carp (Ctenopharyngodon idella) and Holland's spinibarbel (Spinibarbus hollandi) infected with Ichthyophthirius multifiliis","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}