{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T09:51:41Z","timestamp":1783763501076,"version":"3.55.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002435"],"award-info":[{"award-number":["32002435"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M632733"],"award-info":[{"award-number":["2018M632733"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019BC102"],"award-info":[{"award-number":["ZR2019BC102"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2019GHY112043"],"award-info":[{"award-number":["2019GHY112043"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.fsi.2022.05.031","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T12:42:44Z","timestamp":1653309764000},"page":"131-140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Membrane orthologs of TLR5 of tongue sole Cynoglossus semilaevis: Expression patterns, signaling pathway and antibacterial property"],"prefix":"10.1016","volume":"126","author":[{"given":"Xue-peng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-qi","family":"sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hai","family":"sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-xing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.fsi.2022.05.031_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2183\/pjab.85.143","article-title":"Pathogen recognition by innate immunity and its signaling","volume":"85","author":"Akira","year":"2009","journal-title":"P JPN Acad. B-Phys."},{"issue":"6","key":"10.1016\/j.fsi.2022.05.031_bib2","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.bbamem.2014.01.020","article-title":"Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family","volume":"1838","author":"Reuven","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.fsi.2022.05.031_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.fsi.2022.05.031_bib4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.it.2008.12.001","article-title":"Variation matters: TLR structure and species-specific pathogen recognition","volume":"30","author":"Werling","year":"2009","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2022.05.031_bib5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/1753425912465661","article-title":"LRRfinder2.0: a webserver for the prediction of leucine-rich repeats","volume":"19","author":"Offord","year":"2013","journal-title":"Innate Immun."},{"issue":"4","key":"10.1016\/j.fsi.2022.05.031_bib6","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.167.4.1882","article-title":"Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression","volume":"167","author":"Gewirtz","year":"2001","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2022.05.031_bib7","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ni1011","article-title":"Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility","volume":"4","author":"Smith","year":"2003","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2022.05.031_bib8","doi-asserted-by":"crossref","first-page":"6922","DOI":"10.4049\/jimmunol.172.11.6922","article-title":"Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response","volume":"172","author":"Didierlaurent","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib9","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.fsi.2019.01.054","article-title":"Vibrio parahaemolyticus flagellin induces cytokines expression via toll-like receptor 5 pathway in orange-spotted grouper, Epinephelus coioides","volume":"87","author":"He","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2022.05.031_bib10","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.4049\/jimmunol.170.10.5165","article-title":"The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells","volume":"170","author":"Means","year":"2003","journal-title":"J. Immunol."},{"issue":"2 Pt A","key":"10.1016\/j.fsi.2022.05.031_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.imlet.2014.07.017","article-title":"Linking genetic variation in human Toll-like receptor 5 genes to the gut microbiome's potential to cause inflammation","volume":"162","author":"Leifer","year":"2014","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.031_bib12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.fsi.2014.09.022","article-title":"Toll-like receptor recognition of bacteria in fish: ligand specificity and signal pathways","volume":"41","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.fsi.2017.07.021","article-title":"Identification, characterization and expression analysis of TLR5 in the mucosal tissues of turbot (Scophthalmus maximus L.) following bacterial challenge","volume":"68","author":"Liu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2022.05.031_bib14","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.fsi.2007.06.002","article-title":"Divergent Toll-like receptors in catfish (Ictalurus punctatus): TLR5S, TLR20, TLR21","volume":"23","author":"Baoprasertkul","year":"2007","journal-title":"Fish Shellfish Immunol."},{"issue":"16","key":"10.1016\/j.fsi.2022.05.031_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165916","article-title":"Toll-like receptor 5 of golden pompano Trachinotus ovatus (Linnaeus 1758): characterization, promoter activity and functional analysis","volume":"21","author":"Zhu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"47","key":"10.1016\/j.fsi.2022.05.031_bib16","doi-asserted-by":"crossref","first-page":"48588","DOI":"10.1074\/jbc.M407634200","article-title":"Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss)","volume":"279","author":"Tsujita","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.fsi.2022.05.031_bib17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00251-002-0519-8","article-title":"Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome","volume":"54","author":"Oshiumi","year":"2003","journal-title":"Immunogenetics"},{"key":"10.1016\/j.fsi.2022.05.031_bib18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.fsi.2019.02.024","article-title":"Nonconservation of TLR5 activation site in Edwardsiella tarda flagellin decreases expression of interleukin-1\u03b2 and NF-\u03baB genes in Japanese flounder, Paralichthys olivaceus","volume":"87","author":"Morimoto","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.031_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.fsi.2011.10.031","article-title":"Inductive expression of toll-like receptor 5 (TLR5) and associated downstream signaling molecules following ligand exposure and bacterial infection in the Indian major carp, mrigal (Cirrhinus mrigala)","volume":"32","author":"Basu","year":"2012","journal-title":"Fish Shellfish Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2022.05.031_bib20","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1089\/dna.2013.2051","article-title":"Characterization and expression analysis of common carp Cyprinus carpio TLR5M","volume":"32","author":"Duan","year":"2013","journal-title":"DNA Cell Biol."},{"issue":"14","key":"10.1016\/j.fsi.2022.05.031_bib21","doi-asserted-by":"crossref","first-page":"E3221","DOI":"10.1073\/pnas.1719245115","article-title":"Duplicated TLR5 of zebrafish functions as a heterodimeric receptor","volume":"115","author":"Voogdt","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.031_bib22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.fsi.2015.01.024","article-title":"Isolation and expression of grass carp toll-like receptor 5a (CiTLR5a) and 5b (CiTLR5b) gene involved in the response to flagellin stimulation and grass carp reovirus infection","volume":"44","author":"Jiang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib23","article-title":"Detection of pathogenic Listonella anguillarum isolated from Cynoglossus semilaevis by duplex PCR","volume":"4","author":"Zhang","year":"2011","journal-title":"Mar. Sci. Bull."},{"key":"10.1016\/j.fsi.2022.05.031_bib24","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fsi.2017.10.057","article-title":"Two novel calreticulin-related molecules with microbial binding and phagocytosis enhancing capacity in the half-smooth tongue sole, Cynoglossus semilaevis","volume":"72","author":"Wang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2022.05.031_bib25","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1099\/mic.0.2008\/017343-0","article-title":"Regulation of autoinducer 2 production and luxS expression in a pathogenic Edwardsiella tarda strain","volume":"154","author":"Zhang","year":"2008","journal-title":"Microbiology"},{"issue":"30","key":"10.1016\/j.fsi.2022.05.031_bib26","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1016\/j.vaccine.2009.04.023","article-title":"Construction of an attenuated Pseudomonas fluorescens strain and evaluation of its potential as a cross-protective vaccine","volume":"27","author":"Wang","year":"2009","journal-title":"Vaccine"},{"issue":"21","key":"10.1016\/j.fsi.2022.05.031_bib27","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/j.vaccine.2009.03.012","article-title":"Immunoprotective analysis of VhhP2, a Vibrio harveyi vaccine candidate","volume":"27","author":"Sun","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.031_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.aquaculture.2013.08.016","article-title":"Development of a triplex loop-mediated isothermal amplification method for rapid on-site detection of three Vibrio species associated with fish diseases","volume":"414","author":"Yu","year":"2013","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2022.05.031_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.fsi.2018.10.066","article-title":"High mobility group box 2 of black rockfish Sebastes schlegelii: gene cloning, immunoregulatory properties and antibacterial effect","volume":"84","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.031_bib30","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fsi.2014.01.013","article-title":"Antibacterial and antiviral properties of tongue sole (Cynoglossus semilaevis) high mobility group B2 protein are largely independent on the acidic C-terminal domain","volume":"37","author":"Long","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib31","first-page":"1","article-title":"Immune gene expression in cyprinid herpesvirus-2 (CyHV-2)-sensitized peripheral blood leukocytes (PBLs) co-cultured with CyHV-2-infected goldfish fin cell line","author":"Das","year":"2021","journal-title":"Aquacult. Int."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.031_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/jfb.14722","article-title":"Characterization of TCR(+) and CD8(+) head kidney leucocytes in Japanese flounder (Paralichthys olivaceus) with antisera against TCR\u03b1 and CD8\u03b1","volume":"99","author":"Qiu","year":"2021","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2022.05.031_bib33","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.ijbiomac.2021.10.080","article-title":"CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense","volume":"192","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2022.05.031_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fsi.2019.10.023","article-title":"Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection","volume":"95","author":"Li","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.fsi.2016.03.001","article-title":"Toll-like receptor 2 of tongue sole Cynoglossus semilaevis: signaling pathway and involvement in bacterial infection","volume":"51","author":"Li","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2022.05.031_bib36","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jbiotec.2007.05.023","article-title":"Role of the plasma membrane ROS-generating NADPH oxidase in CD34+ progenitor cells preservation by hypoxia","volume":"130","author":"Fan","year":"2007","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.fsi.2022.05.031_bib37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.fsi.2016.06.055","article-title":"CsPTX1, a pentraxin of Cynoglossus semilaevis, is an innate immunity factor with antibacterial effects","volume":"56","author":"Wang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"6832","key":"10.1016\/j.fsi.2022.05.031_bib38","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2022.05.031_bib39","doi-asserted-by":"crossref","first-page":"19046","DOI":"10.1038\/srep19046","article-title":"Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition","volume":"6","author":"Voogdt","year":"2016","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.fsi.2022.05.031_bib40","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.molimm.2007.09.013","article-title":"Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin","volume":"45","author":"Keestra","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.theriogenology.2017.01.031","article-title":"Early pregnancy-related changes in toll-like receptors expression in ovine trophoblasts and peripheral blood leukocytes","volume":"93","author":"Kaya","year":"2017","journal-title":"Theriogenology"},{"issue":"3","key":"10.1016\/j.fsi.2022.05.031_bib42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/geno.2000.6115","article-title":"Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF\/Ei mice","volume":"64","author":"Sebastiani","year":"2000","journal-title":"Genomics"},{"key":"10.1016\/j.fsi.2022.05.031_bib43","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.fsi.2017.02.021","article-title":"Expression analysis of nine Toll-like receptors in yellow catfish (Pelteobagrus fulvidraco) responding to Aeromonas hydrophila challenge","volume":"63","author":"Zhang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"8","key":"10.1016\/j.fsi.2022.05.031_bib44","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.dci.2004.12.002","article-title":"Activation of TLR3 and TLR5 in channel catfish exposed to virulent Edwardsiella ictaluri","volume":"29","author":"Bilodeau","year":"2005","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib45","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.fsi.2017.01.020","article-title":"Identification of a gene encoding a membrane-anchored toll-like receptor 5 (TLR5M) in Oplegnathus fasciatus that responds to flagellin challenge and activates NF-\u03baB","volume":"62","author":"Umasuthan","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.fsi.2018.06.014","article-title":"Characterization of TLR5 and TLR9 from silver pomfret (Pampus argenteus) and expression profiling in response to bacterial components","volume":"80","author":"Gao","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104100","article-title":"Identification and expression analysis of sixteen Toll-like receptor genes, TLR1, TLR2a, TLR2b, TLR3, TLR5M, TLR5S, TLR7-9, TLR13a-c, TLR14, TLR21-23 in Mandarin fish Siniperca chuatsi","volume":"121","author":"Wang","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib48","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.fsi.2019.10.027","article-title":"Clone, identification and functional character of two toll-like receptor 5 molecules in Schizothorax prenanti","volume":"95","author":"Du","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2017.03.004","article-title":"Molecular characterization and expression analysis of toll-like receptors 5 and 22 from natural triploid Carassius auratus","volume":"64","author":"Zhang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.fsi.2017.07.022","article-title":"Molecular characterization and expression analyses of toll like receptor-5 induced by Vibrio parahaemolyticus antigens in Pacific red snapper","volume":"68","author":"Reyes-Becerril","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib51","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.fsi.2017.01.037","article-title":"Molecular identification and expression analysis of TLR5M and TLR5S from orange-spotted grouper (Epinepheluscoioides)","volume":"63","author":"Bai","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib52","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fsi.2017.01.041","article-title":"Studies on expression pattern of toll-like receptor 5 (TLR5) in Edwardsiella tarda infected Pangasianodon hypophthalmus","volume":"63","author":"Jayaramu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fsi.2016.07.012","article-title":"Molecular cloning, characterization and expression analysis of Toll-like receptor 5M gene in Japanese sea perch (Lateolabrax japonicas) after bacterial infection","volume":"56","author":"Wang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.031_bib54","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.fsi.2014.09.022","article-title":"Toll-like receptor recognition of bacteria in fish: ligand specificity and signal pathways","volume":"41","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2022.05.031_bib55","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/cmi.2017.122","article-title":"Beyond the recognition of flagellin","volume":"14","author":"Yang","year":"2017","journal-title":"Cell. Mol. Immunol."},{"issue":"25","key":"10.1016\/j.fsi.2022.05.031_bib56","doi-asserted-by":"crossref","first-page":"22414","DOI":"10.1074\/jbc.M201762200","article-title":"Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5","volume":"277","author":"Mizel","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2022.05.031_bib57","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jri.2017.08.004","article-title":"TLR3 and TLR5 regulation of pro-inflammatory and pro-labour mediators in human primary myometrial cells","volume":"122","author":"Lim","year":"2017","journal-title":"J. Reprod. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2022.05.031_bib58","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.fsi.2011.08.002","article-title":"Maximal transcriptional activation of piscine soluble Toll-like receptor 5 by the NF-\u03baB subunit p65 and flagellin","volume":"31","author":"Moon","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.031_bib59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13054-019-2408-7","article-title":"Flagellin attenuates experimental sepsis in a macrophage-dependent manner","volume":"23","author":"Yang","year":"2019","journal-title":"Crit. Care"},{"issue":"4","key":"10.1016\/j.fsi.2022.05.031_bib60","first-page":"393","article-title":"Human blood platelets, PMN leukocytes and their interactions in vitro. Responses to selective and non-selective stimuli","volume":"19","author":"Dr\u00e1bikov\u00e1","year":"2000","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.fsi.2022.05.031_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101080","article-title":"Particulate matter induces inflammatory cytokine production via activation of NF\u03baB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin","volume":"21","author":"Ryu","year":"2019","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.fsi.2022.05.031_bib62","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1073\/pnas.1108464109","article-title":"Toll-like receptor 5 (TLR5), IL-1\u03b2 secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing","volume":"109","author":"Descamps","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2022.05.031_bib63","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.fsi.2021.12.030","article-title":"Salmonid MyD88 is a key adapter protein that activates innate effector mechanisms through the TLR5M\/TLR5S signaling pathway and protects against Piscirickettsia salmonis infection","volume":"121","author":"Mu\u00f1oz-Flores","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.031_bib64","article-title":"MicroRNA-induced negative regulation of TLR-5 in grass carp, Ctenopharyngodon idella","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822002728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822002728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:33:50Z","timestamp":1760938430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822002728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":64,"alternative-id":["S1050464822002728"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.05.031","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane orthologs of TLR5 of tongue sole Cynoglossus semilaevis: Expression patterns, signaling pathway and antibacterial property","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}