{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:27:56Z","timestamp":1791520076959,"version":"4.3.4"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2313-B-019-010-MY3"],"award-info":[{"award-number":["110-2313-B-019-010-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.fsi.2022.05.032","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T02:12:53Z","timestamp":1652926373000},"page":"34-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["TLR23, a fish-specific TLR, recruits MyD88 and TRIF to activate expression of a range of effectors in melanomacrophages in Nile tilapia (Oreochromis niloticus)"],"prefix":"10.1016","volume":"126","author":[{"given":"Tan Phat","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao Trung","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Hua","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Chou","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Tsang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2022.05.032_bib1","article-title":"The state of world fisheries and aquaculture 2020","year":"2020","journal-title":"Sustainability in action"},{"issue":"12","key":"10.1016\/j.fsi.2022.05.032_bib2","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s12033-019-00217-y","article-title":"Structural characterization of open reading frame-encoded functional genes from tilapia lake virus (TiLV)","volume":"61","author":"Acharya","year":"2019","journal-title":"Mol. Biotechnol."},{"issue":"3","key":"10.1016\/j.fsi.2022.05.032_bib3","first-page":"4508","article-title":"The response of new-season Nile tilapia to Aeromonas hydrophila vaccine","volume":"8","author":"Aly","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.fsi.2022.05.032_bib4","first-page":"251","article-title":"Epidemiology of Streptococcus agalactiae and strepto-coccosis in tilapia fish (Oreochromissp.)","author":"Iregui","year":"2014","journal-title":"Epidemiology I: Theory, Research and Practice"},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.imlet.2012.08.003","article-title":"Immune system and immune responses in fish and their role in comparative immunity study: a model for higher organisms","volume":"148","author":"Rauta","year":"2012","journal-title":"Immunol. Lett."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2022.05.032_bib6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.dci.2012.04.001","article-title":"Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts","volume":"39","author":"Zhu","year":"2013","journal-title":"Dev. Comp. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2022.05.032_bib7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.fsi.2022.05.032_bib8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.fsi.2005.03.007","article-title":"Phylogeny and ontogeny of fish leucocytes","volume":"19","author":"Rombout","year":"2005","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ni0203-105","article-title":"Toll signaling: the TIReless quest for specificity","volume":"4","author":"Imler","year":"2003","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2022.05.032_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.molimm.2003.10.001","article-title":"Toll-like receptor gene family and TIR-domain adapters in Danio rerio","volume":"40","author":"Jault","year":"2004","journal-title":"Mol. Immunol."},{"issue":"6\u20137","key":"10.1016\/j.fsi.2022.05.032_bib11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.molimm.2004.04.006","article-title":"The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction","volume":"41","author":"McGettrick","year":"2004","journal-title":"Mol. Immunol."},{"issue":"27","key":"10.1016\/j.fsi.2022.05.032_bib12","doi-asserted-by":"crossref","first-page":"9577","DOI":"10.1073\/pnas.0502272102","article-title":"The evolution of vertebrate Toll-like receptors","volume":"102","author":"Roach","year":"2005","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"6","key":"10.1016\/j.fsi.2022.05.032_bib13","first-page":"2717","article-title":"Cutting edge: TLR13 is a receptor for bacterial","volume":"189","author":"Hidmark","year":"2012","journal-title":"RNA"},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.4049\/jimmunol.1701149","article-title":"Teleost-specific TLR19 localizes to endosome, recognizes dsRNA, recruits TRIF, triggers both IFN and NF-\u03baB pathways, and protects cells from grass carp reovirus infection","volume":"200","author":"Ji","year":"2018","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00251-013-0751-4","article-title":"Identification and functional characterization of nonmammalian Toll-like receptor 20","volume":"66","author":"Pietretti","year":"2014","journal-title":"Immunogenetics"},{"issue":"51","key":"10.1016\/j.fsi.2022.05.032_bib16","doi-asserted-by":"crossref","first-page":"20711","DOI":"10.1073\/pnas.1305273110","article-title":"Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish","volume":"110","author":"Yeh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2022.05.032_bib17","series-title":"Thoroughly Remold the Localization and Signaling Pathway of TLR22","first-page":"10","author":"Ji","year":"2020"},{"key":"10.1016\/j.fsi.2022.05.032_bib18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fimmu.2019.00343","article-title":"Paralogues from the expanded Tlr11 gene family in Mudskipper (Boleophthalmus pectinirostris) are under positive selection and respond differently to LPS\/Poly (I: C) challenge","volume":"10","author":"Qiu","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2022.05.032_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00251-007-0193-y","article-title":"Phylogenetic and expression analysis of amphibian Xenopus Toll-like receptors","volume":"59","author":"Ishii","year":"2007","journal-title":"Immunogenetics"},{"issue":"6","key":"10.1016\/j.fsi.2022.05.032_bib20","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1600-0854.2009.00899.x","article-title":"How location governs Toll\u2010like receptor signaling","volume":"10","author":"Chaturvedi","year":"2009","journal-title":"Traffic"},{"issue":"3","key":"10.1016\/j.fsi.2022.05.032_bib21","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.immuni.2010.03.012","article-title":"Intracellular toll-like receptors","volume":"32","author":"Blasius","year":"2010","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.fsi.2022.05.032_bib22","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1189\/jlb.2MR0316-117RR","article-title":"Molecular mechanisms of regulation of Toll\u2010like receptor signaling","volume":"100","author":"Leifer","year":"2016","journal-title":"J. Leukoc. Biol."},{"issue":"5","key":"10.1016\/j.fsi.2022.05.032_bib23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri2079","article-title":"The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling","volume":"7","author":"O'Neill","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2022.05.032_bib24","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2148-12-256","article-title":"Diversification of the expanded teleost-specific toll-like receptor family in Atlantic cod, Gadus morhua","volume":"12","author":"Sundaram","year":"2012","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.fsi.2022.05.032_bib26","doi-asserted-by":"crossref","first-page":"104100","DOI":"10.1016\/j.dci.2021.104100","article-title":"Identification and expression analysis of sixteen Toll-like receptor genes, TLR1, TLR2a, TLR2b, TLR3, TLR5M, TLR5S, TLR7\u22129, TLR13a\u2212c, TLR14, TLR21\u221223 in Mandarin fish Siniperca chuatsi","volume":"121","author":"Wang","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molimm.2021.01.020","article-title":"Structurally diverse genes encode TLR13 in Nile tilapia: the two receptors can recognize Streptococcus 23S RNA and conduct signal transduction through MyD88","volume":"132","author":"Gao","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib28","doi-asserted-by":"crossref","first-page":"110485","DOI":"10.1016\/j.cbpb.2020.110485","article-title":"Functional characterization of myeloid differentiation factor 88 in Nile tilapia (Oreochromis niloticus)","volume":"250","author":"Trung","year":"2020","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-8-124","article-title":"Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors","volume":"8","author":"Matsushima","year":"2007","journal-title":"BMC Genom."},{"issue":"W1","key":"10.1016\/j.fsi.2022.05.032_bib30","doi-asserted-by":"crossref","first-page":"W636","DOI":"10.1093\/nar\/gkz268","article-title":"The EMBL-EBI search and sequence analysis tools APIs in 2019","volume":"47","author":"Madeira","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.fsi.2022.05.032_bib31","doi-asserted-by":"crossref","first-page":"D700","DOI":"10.1093\/nar\/gks1156","article-title":"Genomicus: five genome browsers for comparative genomics in eukaryota","volume":"41","author":"Louis","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.fsi.2022.05.032_bib32","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2022.05.032_bib33","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.fsi.2016.01.013","article-title":"Development and characterization of a cell line from tilapia head kidney with melanomacrophage characteristics","volume":"49","author":"Wen","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib34","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.dci.2017.09.003","article-title":"In vitro immunostimulatory potential of fungal \u03b2-glucans in pacific red snapper (Lutjanus Peru) cells","volume":"77","author":"C\u00e1rdenas-Reyna","year":"2017","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib35","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fsi.2016.01.027","article-title":"Molecular characterization and immune response to lipopolysaccharide (LPS) of the suppressor of cytokine signaling (SOCS)-1, 2 and 3 genes in Nile tilapia (Oreochromis niloticus)","volume":"50","author":"Liu","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.antiviral.2017.08.003","article-title":"Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish","volume":"145","author":"Pereiro","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.fsi.2022.05.032_bib37","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.fsi.2018.06.022","article-title":"Gene expression analysis of isolated salmonid GALT leucocytes in response to PAMPs and recombinant cytokines","volume":"80","author":"Attaya","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib38","first-page":"708","article-title":"Functional characterization of a nonmammalian IL-21: rainbow trout <em>Oncorhynchus mykiss<\/em> IL-21 upregulates the expression of the Th cell signature cytokines IFN-\u03b3","volume":"186","author":"Wang","year":"2011","journal-title":"IL-10, and IL-22"},{"key":"10.1016\/j.fsi.2022.05.032_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.03054","article-title":"Studies on the use of flagellin as an immunostimulant and vaccine adjuvant in fish aquaculture","volume":"9","author":"Wangkahart","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fsi.2020.05.028","article-title":"Expression profile, subcellular localization and signaling pathway analysis of fish-specific TLR25 in Nile tilapia (Oreochromis niloticus)","volume":"104","author":"Lee","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib41","doi-asserted-by":"crossref","first-page":"103991","DOI":"10.1016\/j.dci.2020.103991","article-title":"Expression, signal transduction, and function analysis of TIRAP and TRIF in Nile tilapia (Oreochromis niloticus)","volume":"117","author":"Trung","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib42","doi-asserted-by":"crossref","first-page":"110485","DOI":"10.1016\/j.cbpb.2020.110485","article-title":"Functional characterization of myeloid differentiation factor 88 in Nile tilapia (Oreochromis niloticus)","volume":"250","author":"Trung","year":"2020","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib43","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4049\/jimmunol.1001203","article-title":"Functional characterization of a nonmammalian IL-21: rainbow trout Oncorhynchus mykiss IL-21 upregulates the expression of the Th cell signature cytokines IFN-\u03b3, IL-10, and IL-22","volume":"186","author":"Wang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib44","series-title":"Fly Development Genes Lead to Immune Find","author":"Vogel","year":"1998"},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib45","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/emmm.200900014","article-title":"Innate instruction of adaptive immunity revisited: the inflammasome","volume":"1","author":"Eisenbarth","year":"2009","journal-title":"EMBO Mol. Med."},{"issue":"6","key":"10.1016\/j.fsi.2022.05.032_bib46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/jez.b.22559","article-title":"A tetrapod\u2010like repertoire of innate immune receptors and effectors for coelacanths","volume":"322","author":"Boudinot","year":"2014","journal-title":"J. Exp. Zool. B Mol. Dev. Evol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep25211","article-title":"Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions","volume":"6","author":"Solbakken","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2022.05.032_bib48","series-title":"Genome-wide Characterization of Toll-like Receptors in Japanese Meagre Argyrosomus Japonicus and Their Response to Poly (I: C) Injection","first-page":"736907","author":"Han","year":"2021"},{"key":"10.1016\/j.fsi.2022.05.032_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.dci.2016.06.025","article-title":"The teleost head kidney: integrating thyroid and immune signalling","volume":"66","author":"Geven","year":"2017","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2022.05.032_bib50","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","article-title":"The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens","volume":"35","author":"Gomez","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.dci.2013.01.009","article-title":"Pathogen recognition receptors in channel catfish: III Phylogeny and expression analysis of Toll-like receptors","volume":"40","author":"Zhang","year":"2013","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1365-2567.1998.00402.x","article-title":"Group B streptococci persist inside macrophages","volume":"93","author":"Hunolstein","year":"1998","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087980","article-title":"Identification of genes preferentially expressed by highly virulent piscine Streptococcus agalactiae upon interaction with macrophages","volume":"9","author":"Guo","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.fsi.2022.05.032_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139733","article-title":"Endocytosis\u2012mediated invasion and pathogenicity of Streptococcus agalactiae in rat cardiomyocyte (H9C2)","volume":"10","author":"Pooja","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2022.05.032_bib55","first-page":"48","article-title":"Isolation and genotyping of Nile tilapia MHC IA gene","volume":"2","author":"Awadalla","year":"2019","journal-title":"Arabian Journal of Medical Sciences)"},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib56","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.fsi.2012.11.048","article-title":"Major histocompatibility complex class IIA and IIB genes of Nile tilapia Oreochromis niloticus: genomic structure, molecular polymorphism and expression patterns","volume":"34","author":"Pang","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib57","doi-asserted-by":"crossref","first-page":"104300","DOI":"10.1016\/j.dci.2021.104300","article-title":"TLR1 in Nile tilapia: the conserved receptor cannot interact with MyD88 and TIRAP but can activate NF-\u03baB in vitro","volume":"127","author":"Gao","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.05.032_bib58","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.fsi.2021.11.001","article-title":"Fish-specific TLR18 in Nile tilapia (Oreochromis niloticus) recruits MyD88 and TRIF to induce expression of effectors in NF-\u03baB and IFN pathways in melanomacrophages","volume":"119","author":"Trung","year":"2021","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2022.05.032_bib59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1177\/09680519060120050601","article-title":"Toll-like receptor-dependent discrimination of streptococci","volume":"12","author":"Santos-Sierra","year":"2006","journal-title":"J. Endotoxin Res."},{"issue":"12","key":"10.1016\/j.fsi.2022.05.032_bib60","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"10","key":"10.1016\/j.fsi.2022.05.032_bib61","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.4049\/jimmunol.174.10.6449","article-title":"Role of lipoteichoic acid in the phagocyte response to group B streptococcus","volume":"174","author":"Henneke","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.00039-09","article-title":"The genus Aeromonas: taxonomy, pathogenicity, and infection","volume":"23","author":"Janda","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1501\/Vetfak_0000002448","article-title":"Pathological findings of experimental Aeromonas hydrophila infection in Nile tilapia (Oreochromis niloticus)","volume":"58","author":"Yard\u0131mc\u0131","year":"2011","journal-title":"Ankara Univ. Vet. Fak. Derg."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib64","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1099\/00221287-144-2-299","article-title":"Internalization of Aeromonas hydrophila by fish epithelial cells can be inhibited with a tyrosine kinase inhibitor","volume":"144","author":"Tan","year":"1998","journal-title":"Microbiology"},{"issue":"1","key":"10.1016\/j.fsi.2022.05.032_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddiscovery.2017.67","article-title":"Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish","volume":"3","author":"Srivastava","year":"2017","journal-title":"Cell death discovery"},{"key":"10.1016\/j.fsi.2022.05.032_bib66","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2022.05.032_bib67","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1091\/mbc.6.5.587","article-title":"Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein","volume":"6","author":"Winans","year":"1995","journal-title":"Mol. Biol. Cell"},{"issue":"26","key":"10.1016\/j.fsi.2022.05.032_bib68","doi-asserted-by":"crossref","first-page":"23334","DOI":"10.1074\/jbc.M110.205419","article-title":"The ectodomain of the Toll-like receptor 4 prevents constitutive receptor activation","volume":"286","author":"Panter","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.fsi.2022.05.032_bib69","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1073\/pnas.1018135108","article-title":"Cleavage and activation of a Toll-like receptor by microbial proteases","volume":"108","author":"de Zoete","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.fsi.2022.05.032_bib70","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2249.1995.tb08340.x","article-title":"Beneficial effects of tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) blockade in rheumatoid arthritis (RA)","volume":"101","author":"Maini","year":"1995","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2022.05.032_bib71","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ni.2015","article-title":"Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk","volume":"12","author":"Liu","year":"2011","journal-title":"Nat. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482200273X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482200273X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:10:30Z","timestamp":1778584230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046482200273X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":71,"alternative-id":["S105046482200273X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.05.032","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR23, a fish-specific TLR, recruits MyD88 and TRIF to activate expression of a range of effectors in melanomacrophages in Nile tilapia (Oreochromis niloticus)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.05.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}