{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:58:42Z","timestamp":1786989522278,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.fsi.2022.05.044","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:19:39Z","timestamp":1653524379000},"page":"336-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Saponin and chitosan-based oral vaccine against viral haemorrhagic septicaemia virus (VHSV) provides protective immunity in olive flounder (Paralichthys olivaceus)"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-3804","authenticated-orcid":false,"given":"Myung-Hwa","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Ju","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2022.05.044_bib1","first-page":"1","article-title":"Genetic relationship of the VHSV (viral haemorrhagic septicemia virus) isolated from cultured olive flounder, Paralichthys olivaceus in Korea","volume":"16","author":"Kim","year":"2003","journal-title":"J. Fish. Pathol."},{"key":"10.1016\/j.fsi.2022.05.044_bib2","series-title":"Virus Taxonomy: Eight Report of the International Committee on Taxonomy of Viruses","first-page":"623","article-title":"Family Rhabdoviridae","author":"Trdo","year":"2005"},{"key":"10.1016\/j.fsi.2022.05.044_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.aquaculture.2009.07.019","article-title":"An outbreak of VHSV (viral haemorrhagic septicemia virus) infection in farmed olive flounder Paralichthys olivaceus in Korea","volume":"296","author":"Kim","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2022.05.044_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.fsi.2003.07.002","article-title":"Oral vaccination of African catfish with Vibrio anguillarum O2: effect on antigen uptake and immune response by absorption enhancers in lag time coated pellets","volume":"16","author":"Vervarcke","year":"2004","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.fsi.2004.06.008","article-title":"Use of a cDNA microarray to study immunity against viral haemorrhagic septicemia (VHS) in Japanese flounder (Paralichthys olivaceus) following DNA vaccination","volume":"18","author":"Byon","year":"2005","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3354\/dao02185","article-title":"Protection of Japanese flounder Paralichthys olivaceus from viral haemorrhagic septicemia (VHS) by Poly (I:C) immunization","volume":"89","author":"Takami","year":"2010","journal-title":"Dis. Aquat. Org."},{"key":"10.1016\/j.fsi.2022.05.044_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquaculture.2011.01.050","article-title":"Protection of olive flounder, Paralichthys olivaceus, against viral haemorrhagic septicemia virus (VHSV) by immunization with NV gene-knockout recombinant VHSV","volume":"314","author":"Kim","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2022.05.044_bib8","doi-asserted-by":"crossref","first-page":"8397","DOI":"10.1016\/j.vaccine.2011.08.032","article-title":"Live vaccine of viral haemorrhagic septicemia virus (VHSV) for Japanese flounder at fish rearing temperature of 21 \u00b0C instead of Poly (I:C) administration","volume":"29","author":"Nishizawa","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib9","doi-asserted-by":"crossref","first-page":"4603","DOI":"10.1016\/j.vaccine.2013.07.036","article-title":"Inactivated vaccine against viral haemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder (Paralichthys olivaceus)","volume":"31","author":"Vinay","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1095-8649.1989.tb03388.x","article-title":"Immunological importance of the second gut segment of carp. I. Uptake and processing of antigens by epithelial cells and macrophages","volume":"35","author":"Rombout","year":"1989","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2022.05.044_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0044-8486(72)90045-2","article-title":"Antibody production in the plaice (Pleuronectes platessa L.) after oral and parenteral immunization with Vibrio anguillarum antigens","volume":"1","author":"Fletcher","year":"1972","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2022.05.044_bib12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3147\/jsfp.15.257","article-title":"Mechanisms of protection in ayu orally vaccinated for vibriosis","volume":"15","author":"Kawai","year":"1981","journal-title":"Fish Pathol."},{"key":"10.1016\/j.fsi.2022.05.044_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0145-305X(86)90024-8","article-title":"Immunization of carp (Cyprinus carpio) with a Vibrio anguillarum bacterin: indications for a common mucosal immune system","volume":"10","author":"Rombout","year":"1986","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1095-8649.1989.tb02967.x","article-title":"Immunological importance of the second gut segment of carp. III. Systemic and\/or mucosal immune responses after immunization with soluble or particulate antigen","volume":"35","author":"Rombout","year":"1989","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2022.05.044_bib15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fimmu.2015.00354","article-title":"Mucosal immunity and B cells in teleosts: effect of vaccination and stress","volume":"6","author":"Parra","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib16","first-page":"2597","article-title":"Immunoglobulins, mucosal immunity and vaccination in teleost fish","author":"Yu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/fsim.1997.0100","article-title":"Oral vaccination of fish against Vibrio anguillarum using alginate microparticles","volume":"7","author":"Joosten","year":"1997","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.aquaculture.2004.02.028","article-title":"Oral immunization using alginate microparticles as a useful strategy for booster vaccination against fish lactoccocosis","volume":"236","author":"Romalde","year":"2004","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2022.05.044_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.vaccine.2007.11.065","article-title":"Development of an oral vaccine for immunisation of rainbow trout (Oncorhynchus mykiss) against viral haemorrhagic septicaemia","volume":"26","author":"Adelmann","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.vaccine.2015.12.044","article-title":"Oral vaccination of first-feeding Atlantic salmon, Salmo salar L., confers greater protection against yersiniosis than immersion vaccination","volume":"34","author":"Ghosh","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.fsi.2011.05.003","article-title":"Oral immunization of olive flounder (Paralichthys olivaceus) with recombinant live viral haemorrhagic septicemia virus (VHSV) induces protection against VHSV infection","volume":"31","author":"Kim","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2761.2011.01338.x","article-title":"Oral DNA vaccination of rainbow trout, Oncorhynchus mykiss (Walbaum), against infectious haematopoietic necrosis virus using PLGA [Poly (D, L\u2010Lactic\u2010Co\u2010Glycolic Acid)] nanoparticles","volume":"35","author":"Adomako","year":"2012","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2022.05.044_bib23","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.fsi.2009.12.006","article-title":"Immunogenic and protective effects of an oral DNA vaccine against infectious pancreatic necrosis virus in fish, Fish","volume":"28","author":"Ana","year":"2010","journal-title":"Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.fsi.2007.12.004","article-title":"Potential use of chitosan nanoparticles for oral delivery of DNA vaccine in Asian sea bass (Lates calcarifer) to protect from Vibrio (Listonella) anguillarum","volume":"25","author":"Kumar","year":"2008","journal-title":"Fish. Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.fsi.2017.10.044","article-title":"Efficacy of algal Ecklonia cava extract against viral haemorrhagic septicemia virus (VHSV)","volume":"72","author":"Yang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.vaccine.2018.12.063","article-title":"PLGA encapsulated inactivated-viral vaccine: formulation and evaluation of its protective efficacy against viral haemorrhagic septicaemia virus (VHSV) infection in olive flounder (Paralichthys olivaceus) vaccinated by mucosal delivery routes","volume":"37","author":"Kole","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fsi.2019.05.017","article-title":"Nanoencapsulation of inactivated-viral vaccine using chitosan nanoparticles: evaluation of its protective efficacy and immune modulatory effects in olive flounder (Paralichthys olivaceus) against viral haemorrhagic septicaemia virus (VHSV) infection","volume":"91","author":"Kole","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib28","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1016\/j.vaccine.2012.05.010","article-title":"Immunoprotective activity of a salmonid alphavirus vaccine: comparison of the immune responses induced by inactivated whole virus antigen formula-tions based on CpG class B oligonucleotides and poly I:C alone or combined with an oil adjuvant","volume":"30","author":"Thim","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib29","first-page":"177","article-title":"Development in fish vaccinology with focus on delivery methodologies, adjuvants and formulations","volume":"86","author":"Evensen","year":"2009","journal-title":"Options Mediterr."},{"key":"10.1016\/j.fsi.2022.05.044_bib30","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.fsi.2003.10.002","article-title":"Sequential study of antigen persistence and concomitant inflammatory reactions relative to side-effects and growth of Atlantic salmon (Salmo salar L.) following intraperitoneal injection with oil-adjuvanted vaccines","volume":"16","author":"Mutoloki","year":"2004","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0264-410X(96)00183-1","article-title":"Adjuvants\u2014a classification and review of their modes of action","volume":"15","author":"Cox","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib32","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.vaccine.2009.01.091","article-title":"Advances in saponin-based adjuvants","volume":"27","author":"Sun","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib33","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.fsi.2021.12.047","article-title":"Efficacy of saponin-based inactivated rock bream iridovirus (RBIV) vaccine in rock bream (Oplegnathus fasciatus)","volume":"121","author":"Jung","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib34","first-page":"1","article-title":"Saponins as vaccine adjuvants","volume":"13","author":"Kensil","year":"1996","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.fsi.2022.05.044_bib35","series-title":"Structural and Immunological Characterization of the Vaccine Adjuvant QS-21, Vaccine Design","first-page":"525","author":"Kensil","year":"1995"},{"key":"10.1016\/j.fsi.2022.05.044_bib36","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1016\/j.vaccine.2005.04.021","article-title":"Effective nasal influenza vaccine delivery using chitosan","volume":"23","author":"Read","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib37","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1128\/IAI.71.2.726-732.2003","article-title":"Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin A","volume":"71","author":"Mills","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fsi.2022.05.044_bib38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.vaccine.2003.09.012","article-title":"Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan","volume":"22","author":"McNeela","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib39","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1023\/A:1016085108889","article-title":"Gastrointestinal uptake of biodegradable microparticles: effect of particle size","volume":"13","author":"Desai","year":"1996","journal-title":"Pharmaceut. Res."},{"key":"10.1016\/j.fsi.2022.05.044_bib40","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0142-9612(00)00231-3","article-title":"Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches","volume":"22","author":"Van der Lubben","year":"2001","journal-title":"Biomaterials"},{"key":"10.1016\/j.fsi.2022.05.044_bib41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1389-1723(02)80121-9","article-title":"Polyethyleneimine\/chitosan hexamer-mediated gene transfection into intestinal epithelial cell cultured in serum-containing medium","volume":"94","author":"Ouji","year":"2002","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.fsi.2022.05.044_bib42","first-page":"447","article-title":"Potency testing of fish vaccines","volume":"49","author":"Amend","year":"1981"},{"key":"10.1016\/j.fsi.2022.05.044_bib43","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jep.2004.05.016","article-title":"Biological activities and distribution of plant saponins","volume":"94","author":"Sparg","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.fsi.2022.05.044_bib44","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1572-5995(05)80057-2","article-title":"Bioactive saponins with cancer related and immunomodulatory activity: recent developments","volume":"32","author":"Lacaille-Dubois","year":"2005","journal-title":"Stud. Nat. Prod. Chem."},{"key":"10.1016\/j.fsi.2022.05.044_bib45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.vetimm.2013.03.007","article-title":"Toxicity and dose determination of quillaja saponin, aluminum hydroxide and squalene in olive flounder (Paralichthys olivaceus)","volume":"158","author":"Vinay","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"Suppl. 69","key":"10.1016\/j.fsi.2022.05.044_bib46","first-page":"7","article-title":"A study of the isolation and characterization of the saponin Quil A. Evaluation of its adjuvant activity, with a special reference to the application in the vaccination of cattle foot-and-mouth disease","author":"Dalsgard","year":"1978","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.fsi.2022.05.044_bib47","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1211\/0022357011776441","article-title":"Chitosan: some pharmaceutical and biological aspects\u2010an update","volume":"53","author":"Singla","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.fsi.2022.05.044_bib48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1467-789X.2005.00158.x","article-title":"Effect of chitosan on weight loss in overweight and obese individuals: a systematic review of randomized controlled trials","volume":"6","author":"Mhurchu","year":"2005","journal-title":"Obes. Rev."},{"key":"10.1016\/j.fsi.2022.05.044_bib49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/ajcn\/79.4.529","article-title":"Dietary supplements for body-weight reduction: a systematic review","volume":"79","author":"Pittler","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.fsi.2022.05.044_bib50","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1016\/j.vaccine.2005.04.021","article-title":"Effective nasal influenza vaccine delivery using chitosan","volume":"23","author":"Read","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib51","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.vaccine.2003.09.012","article-title":"Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: enhancement of Th2 responses and toxin-neutralizing antibodies by formulation with chitosan","volume":"22","author":"McNeela","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib52","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.vaccine.2017.05.073","article-title":"Protective immunity against Megalocytivirus infection in rock bream (Oplegnathus fasciatus) following CpG ODN administration","volume":"35","author":"Jung","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2022.05.044_bib53","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.fsi.2017.06.026","article-title":"Protective immunity against rock bream iridovirus (RBIV) infection and TLR3-mediated type I interferon signaling pathway in rock bream (Oplegnathus fasciatus) following poly (I:C) administration","volume":"67","author":"Jung","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.05.044_bib54","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.vaccine.2017.12.077","article-title":"DNA vaccine encoding myristoylated membrane protein (MMP) of rock bream iridovirus (RBIV) induces protective immunity in rock bream (Oplegnathus fasciatus)","volume":"36","author":"Jung","year":"2018","journal-title":"Vaccine"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822002935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822002935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:36:07Z","timestamp":1760938567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822002935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":54,"alternative-id":["S1050464822002935"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.05.044","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Saponin and chitosan-based oral vaccine against viral haemorrhagic septicaemia virus (VHSV) provides protective immunity in olive flounder (Paralichthys olivaceus)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.05.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}