{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:19:20Z","timestamp":1785907160180,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.fsi.2022.08.035","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T12:18:52Z","timestamp":1660825132000},"page":"30-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Chitosan-polymer based nanovaccine as promising immersion vaccine against Aeromonas veronii challenge in red tilapia (Oreochromis sp.)"],"prefix":"10.1016","volume":"129","author":[{"given":"Pimwarang","family":"Sukkarun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirikorn","family":"Kitiyodom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakarwan","family":"Yostawornkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2892-1568","authenticated-orcid":false,"given":"Poowadon","family":"Chaiin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teerapong","family":"Yata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channarong","family":"Rodkhum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9550-939X","authenticated-orcid":false,"given":"Suwimon","family":"Boonrungsiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopadon","family":"Pirarat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2022.08.035_bib1","unstructured":"FAO, The State of World Fisheries and Aquaculture 2020, 2020."},{"issue":"10","key":"10.1016\/j.fsi.2022.08.035_bib2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/jfd.12617","article-title":"Aeromonas jandaei and Aeromonas veronii caused disease and mortality in Nile tilapia, Oreochromis niloticus (L.)","volume":"40","author":"Dong","year":"2017","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2022.08.035_bib3","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.aquaculture.2015.06.027","article-title":"Naturally concurrent infections of bacterial and viral pathogens in disease outbreaks in cultured Nile tilapia (Oreochromis niloticus) farms","volume":"448","author":"Dong","year":"2015","journal-title":"Aquaculture"},{"issue":"2","key":"10.1016\/j.fsi.2022.08.035_bib4","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1128\/AEM.68.2.650-655.2002","article-title":"Identification and characterization of pathogenic Aeromonas veronii biovar sobria associated with epizootic ulcerative syndrome in fish in Bangladesh","volume":"68","author":"Rahman","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"issue":"2","key":"10.1016\/j.fsi.2022.08.035_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejar.2017.06.001","article-title":"Molecular identification and epizootiology of Aeromonas veronii infection among farmed Oreochromis niloticus in Eastern Province, KSA","volume":"43","author":"Hassan","year":"2017","journal-title":"The Egyptian Journal of Aquatic Research"},{"issue":"6","key":"10.1016\/j.fsi.2022.08.035_bib6","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.fsi.2013.05.029","article-title":"Status and future perspectives of vaccines for industrialised fin-fish farming","volume":"35","author":"Brudeseth","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fsi.2019.04.066","article-title":"Progress, challenges and opportunities in fish vaccine development","volume":"90","author":"Adams","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.copbio.2015.03.014","article-title":"Nanoparticles as synthetic vaccines","volume":"34","author":"Smith","year":"2015","journal-title":"Curr. Opin. Biotechnol."},{"issue":"7","key":"10.1016\/j.fsi.2022.08.035_bib9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nri3694","article-title":"From empiricism to rational design: a personal perspective of the evolution of vaccine development","volume":"14","author":"De Gregorio","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2022.08.035_bib10","first-page":"327","volume":"32","author":"Zhao","year":"2014","journal-title":"Nanoparticle vaccines, Vaccine"},{"issue":"1","key":"10.1016\/j.fsi.2022.08.035_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/23308249.2017.1334625","article-title":"Recent advances in application of nanoparticles in fish vaccine delivery","volume":"26","author":"Vinay","year":"2018","journal-title":"Reviews in Fisheries Science & Aquaculture"},{"issue":"3","key":"10.1016\/j.fsi.2022.08.035_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.nano.2015.11.005","article-title":"Recent progress in applications of nanoparticles in fish medicine: a review","volume":"12","author":"Shaalan","year":"2016","journal-title":"Nanomedicine"},{"issue":"5","key":"10.1016\/j.fsi.2022.08.035_bib13","first-page":"227","article-title":"Nanotechnology and vaccine development","volume":"9","author":"Kim","year":"2014","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.fsi.2022.08.035_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2013.00013","article-title":"Vaccine delivery using nanoparticles","volume":"3","author":"Gregory","year":"2013","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"11","key":"10.1016\/j.fsi.2022.08.035_bib15","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri2868","article-title":"Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns","volume":"10","author":"Bachmann","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.fsi.2019.09.064","article-title":"Enhanced efficacy of immersion vaccination in tilapia against columnaris disease by chitosan-coated \u201cpathogen-like\u201d mucoadhesive nanovaccines","volume":"95","author":"Kitiyodom","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib17","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.fsi.2018.12.005","article-title":"The potential of mucoadhesive polymer in enhancing efficacy of direct immersion vaccination against Flavobacterium columnare infection in tilapia","volume":"86","author":"Kitiyodom","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.fsi.2021.02.017","article-title":"Modulation of the mucosal immune response of red tilapia (Oreochromis sp.) against columnaris disease using a biomimetic-mucoadhesive nanovaccine","volume":"112","author":"Kitiyodom","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fsi.2019.05.017","article-title":"Nanoencapsulation of inactivated-viral vaccine using chitosan nanoparticles: evaluation of its protective efficacy and immune modulatory effects in olive flounder (Paralichthys olivaceus) against viral haemorrhagic septicaemia virus (VHSV) infection","volume":"91","author":"Kole","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.08.035_bib20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.fsi.2013.11.015","article-title":"Vaccination of channel catfish with extracellular products of Aeromonas hydrophila provides protection against infection by the pathogen","volume":"36","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib21","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fimmu.2019.00256","article-title":"Comparative extracellular proteomics of Aeromonas hydrophila reveals iron-regulated secreted proteins as potential vaccine candidates","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fsi.2018.07.004","article-title":"Immunogenicity of extracellular products from an inactivated vaccine against Aeromonas veronii TH0426 in koi, Cyprinus carpio","volume":"81","author":"Song","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2022.08.035_bib23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2761.2005.00619.x","article-title":"Antigenicity of Streptococcus agalactiae extracellular products and vaccine efficacy","volume":"28","author":"Pasnik","year":"2005","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2022.08.035_bib24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.matpr.2019.11.267","article-title":"Nanoemulsions: a review on low energy formulation methods, characterization, applications and optimization technique","volume":"27","author":"Safaya","year":"2020","journal-title":"Mater. Today Proc."},{"issue":"4","key":"10.1016\/j.fsi.2022.08.035_bib25","article-title":"Stable chitosan-based nanoparticles using polyphosphoric acid or hexametaphosphate for tandem ionotropic\/covalent crosslinking and subsequent investigation as novel vehicles for drug delivery","volume":"8","author":"Saeed","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.fsi.2022.08.035_bib26","first-page":"34","article-title":"SEM study of ultrastructural changes in branchial architecture of Ctenopharyngodon idella (Cuvier & Valenciennes) exposed to chlorpyrifos","volume":"68","author":"Jindal","year":"2015","journal-title":"Arch. Biol. Sci."},{"issue":"5","key":"10.1016\/j.fsi.2022.08.035_bib27","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.sjbs.2015.08.004","article-title":"Ultrastructural effects on gill tissues induced in red tilapia Oreochromis sp. by a waterborne lead exposure","volume":"23","author":"Aldoghachi","year":"2016","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.fsi.2022.08.035_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103918","article-title":"Construction and immune efficacy of recombinant Lactobacillus casei strains expressing Malt from Aeromonas veronii","volume":"141","author":"Ju","year":"2020","journal-title":"Microb. Pathog."},{"issue":"2","key":"10.1016\/j.fsi.2022.08.035_bib29","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.fsi.2004.12.007","article-title":"Evaluation of DNA vaccination of spotted sand bass (Paralabrax maculatofasciatus) with two major outer-membrane protein-encoding genes from Aeromonas veronii","volume":"19","author":"Vazquez-Juarez","year":"2005","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.08.035_bib30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/fsim.2000.0299","article-title":"Mucosal immune response of spotted sand bass Paralabrax maculatofasciatus (Steindachner, 1868) orally immunised with an extracellular lectin of Aeromonas veronii","volume":"11","author":"Merino-Contreras","year":"2001","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.08.035_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/ijms21010033","article-title":"Oral administration of lactobacillus casei expressing flagellin A protein confers effective protection against Aeromonas veronii in common carp, Cyprinus carpio","volume":"21","author":"Tian","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2022.08.035_bib32","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.fsi.2019.01.032","article-title":"Oral immunization with recombinant Lactobacillus casei expressing flaB confers protection against Aeromonas veronii challenge in common carp, Cyprinus carpio","volume":"87","author":"Kong","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib33","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.fsi.2017.10.043","article-title":"Oral immunization with recombinant Lactobacillus casei expressing OmpAI confers protection against Aeromonas veronii challenge in common carp, Cyprinus carpio","volume":"72","author":"Zhang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.fsi.2020.05.027","article-title":"An effective live attenuated vaccine against Aeromonas veronii infection in the loach (Misgurnus anguillicaudatus)","volume":"104","author":"Zhang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.035_bib35","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/256261","article-title":"The main Aeromonas pathogenic factors","volume":"2012","author":"Tom\u00e1s","year":"2012","journal-title":"ISRN Microbiol"},{"issue":"1","key":"10.1016\/j.fsi.2022.08.035_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/vim.2017.0049","article-title":"Adjuvants for animal vaccines","volume":"31","author":"Burakova","year":"2018","journal-title":"Viral Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2022.08.035_bib37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13567-019-0712-5","article-title":"Nanoparticle-based vaccine development and evaluation against viral infections in pigs","volume":"50","author":"Dhakal","year":"2019","journal-title":"Vet. Res."},{"issue":"6","key":"10.1016\/j.fsi.2022.08.035_bib38","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.fsi.2013.09.032","article-title":"The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens","volume":"35","author":"Gomez","year":"2013","journal-title":"Fish Shellfish Immunol."},{"issue":"643","key":"10.1016\/j.fsi.2022.08.035_bib39","article-title":"Immunotherapies targeting fish mucosal immunity \u2013 current knowledge and future perspectives","volume":"6","author":"Koshio","year":"2016","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.08.035_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1165\/rcmb.2006-0291TR","article-title":"Mucin granule intraluminal organization","volume":"36","author":"Perez-Vilar","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.fsi.2022.08.035_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17040496","article-title":"Characterization of virulence properties of Aeromonas veronii isolated from diseased gibel carp (Carassius gibelio)","volume":"17","author":"Sun","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2022.08.035_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0959-8030(93)90028-A","article-title":"Pathogenesis of gram-negative bacterial infections in warmwater fish","volume":"3","author":"Thune","year":"1993","journal-title":"Annu. Rev. Fish Dis."},{"issue":"9","key":"10.1016\/j.fsi.2022.08.035_bib43","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1111\/1462-2920.14390","article-title":"Aeromonas veronii and aerolysin are important for the pathogenesis of motile aeromonad septicemia in cyprinid fish","volume":"20","author":"Ran","year":"2018","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.fsi.2022.08.035_bib44","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fsi.2020.01.005","article-title":"Mucosal delivery of fish vaccines: local and systemic immunity following mucosal immunisations","volume":"99","author":"Somamoto","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2022.08.035_bib45","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1016\/j.biomaterials.2012.11.066","article-title":"The effect of antigen encapsulation in chitosan particles on uptake, activation and presentation by antigen presenting cells","volume":"34","author":"Koppolu","year":"2013","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.fsi.2022.08.035_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0378-5173(99)00030-7","article-title":"Effect of chitosan on epithelial permeability and structure","volume":"182","author":"Dodane","year":"1999","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.fsi.2022.08.035_bib47","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1023\/A:1018967116988","article-title":"Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)","volume":"11","author":"Artursson","year":"1994","journal-title":"Pharmaceut. Res."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822005071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822005071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:35:36Z","timestamp":1760938536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822005071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":47,"alternative-id":["S1050464822005071"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.08.035","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan-polymer based nanovaccine as promising immersion vaccine against Aeromonas veronii challenge in red tilapia (Oreochromis sp.)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}