{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:34:44Z","timestamp":1773707684346,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.fsi.2022.08.057","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T11:47:24Z","timestamp":1661600844000},"page":"61-71","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Identification of a Yorkie homolog from Litopenaeus vannamei as a negative regulator in anti-WSSV immune response"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-0918","authenticated-orcid":false,"given":"Jie","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-7021","authenticated-orcid":false,"given":"Wenyang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-7947","authenticated-orcid":false,"given":"Yiwen","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingwei","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2022.08.057_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2761.2007.00877.x","article-title":"A review on the morphology, molecular characterization, morphogenesis and pathogenesis of white spot syndrome virus","volume":"31","author":"Escobedo-Bonilla","year":"2008","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2022.08.057_bib2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.dci.2017.07.003","article-title":"Characterization and function of a \u03b2-catenin homolog from Litopenaeus vannamei in WSSV infection","volume":"76","author":"Sun","year":"2017","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.08.057_bib3","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1128\/JVI.01880-06","article-title":"White spot syndrome virus annexes a shrimp STAT to enhance expression of the immediate-early gene ie1","volume":"81","author":"Liu","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.08.057_bib4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.virol.2010.06.046","article-title":"Shrimp NF-\u03baB binds to the immediate-early gene ie1 promoter of white spot syndrome virus and upregulates its activity","volume":"406","author":"Huang","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2022.08.057_bib5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.dci.2012.03.002","article-title":"A novel JNK from Litopenaeus vannamei involved in white spot syndrome virus infection","volume":"37","author":"Shi","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.08.057_bib6","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.fsi.2012.08.023","article-title":"Signaling pathways regulating innate immune responses in shrimp","volume":"34","author":"Li","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.057_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.fsi.2018.01.006","article-title":"Wnt5b regulates apoptosis in Litopenaeus vannamei against white spot syndrome virus","volume":"74","author":"Wang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.057_bib8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(03)00557-9","article-title":"The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis","volume":"114","author":"Harvey","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib9","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1101\/gad.1134003","article-title":"The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis","volume":"17","author":"Jia","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2022.08.057_bib10","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1534\/genetics.114.167346","article-title":"The Hippo pathway controls border cell migration through distinct mechanisms in outer border cells and polar cells of the Drosophila ovary","volume":"198","author":"Lin","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.fsi.2022.08.057_bib11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0092-8674(03)00549-X","article-title":"Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts","volume":"114","author":"Wu","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cell.2004.12.036","article-title":"Control of cell proliferation and apoptosis by mob as tumor suppressor, mats","volume":"120","author":"Lai","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib13","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1038\/onc.2009.43","article-title":"In vivo analysis of Yorkie phosphorylation sites","volume":"28","author":"Oh","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.fsi.2022.08.057_bib14","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib15","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/cr.2013.120","article-title":"A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity","volume":"23","author":"Guo","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.fsi.2022.08.057_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2008.01.006","article-title":"The TEAD\/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control","volume":"14","author":"Zhang","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cub.2008.02.034","article-title":"SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila","volume":"18","author":"Goulev","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.fsi.2022.08.057_bib18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.devcel.2008.01.007","article-title":"The TEAD\/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway","volume":"14","author":"Wu","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s13238-016-0258-5","article-title":"Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival","volume":"7","author":"Deng","year":"2016","journal-title":"Protein Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib20","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1101\/gad.1909210","article-title":"The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version","volume":"24","author":"Zhao","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2022.08.057_bib21","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.cell.2015.12.029","article-title":"Toll receptor-mediated hippo signaling controls innate immunity in Drosophila","volume":"164","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib22","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s12035-017-0388-7","article-title":"Yorkie regulates neurodegeneration through canonical pathway and innate immune response","volume":"55","author":"Dubey","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.fsi.2022.08.057_bib23","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1093\/cercor\/bhv292","article-title":"YAP is a critical inducer of SOCS3, preventing reactive Astrogliosis","volume":"26","author":"Huang","year":"2016","journal-title":"Cerebr. Cortex"},{"key":"10.1016\/j.fsi.2022.08.057_bib24","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/ncb3496","article-title":"Hippo signalling governs cytosolic nucleic acid sensing through YAP\/TAZ-mediated TBK1 blockade","volume":"19","author":"Zhang","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.fsi.2022.08.057_bib25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ni.3744","article-title":"YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKK\u03f5-mediated phosphorylation","volume":"18","author":"Wang","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.fsi.2022.08.057_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virusres.2004.08.002","article-title":"A simple and efficient method for purification of intact white spot syndrome virus (WSSV) viral particles","volume":"108","author":"Xie","year":"2005","journal-title":"Virus Res."},{"key":"10.1016\/j.fsi.2022.08.057_bib27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jviromet.2007.07.007","article-title":"Application of spectrophotometry to evaluate the concentration of purified white spot syndrome virus","volume":"146","author":"Zhou","year":"2007","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.fsi.2022.08.057_bib28","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41467-018-08197-4","article-title":"Penaeid shrimp genome provides insights into benthic adaptation and frequent molting","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fsi.2022.08.057_bib29","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/molbev\/msy096","article-title":"MEGA X: Molecular evolutionary Genetics analysis across computing platforms","volume":"35","author":"Kumar","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2022.08.057_bib30","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.fsi.2022.08.057_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/0471140864.ps1923s74","article-title":"BioID: a screen for protein-protein interactions","volume":"74","author":"Roux","year":"2013","journal-title":"Curr Protoc Protein Sci"},{"key":"10.1016\/j.fsi.2022.08.057_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dev.045500","article-title":"Hippo signaling: growth control and beyond","volume":"138","author":"Halder","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.fsi.2022.08.057_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.devcel.2010.09.011","article-title":"The hippo signaling pathway in development and cancer","volume":"19","author":"Pan","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib34","doi-asserted-by":"crossref","first-page":"14704","DOI":"10.1074\/jbc.RA119.009559","article-title":"Deleted in azoospermia-associated protein 2 regulates innate immunity by stimulating Hippo signaling in crab","volume":"294","author":"Yang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2022.08.057_bib35","article-title":"Yorkie negatively regulates the expression of antimicrobial proteins by inducing Cactus transcription in prawns Macrobrachium nipponense","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2022.08.057_bib36","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/molbev\/msr065","article-title":"The evolutionary history of YAP and the hippo\/YAP pathway","volume":"28","author":"Hilman","year":"2011","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2022.08.057_bib37","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.3389\/fmicb.2019.03033","article-title":"The hippo pathway and viral infections","volume":"10","author":"Wang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2022.08.057_bib38","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2001-1326-3-22","article-title":"The Hippo pathway in disease and therapy: cancer and beyond","volume":"3","author":"Gomez","year":"2014","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.fsi.2022.08.057_bib39","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.3892\/ol.2016.4885","article-title":"Hepatitis B virus X protein mediates yes-associated protein 1 upregulation in hepatocellular carcinoma","volume":"12","author":"Wu","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.fsi.2022.08.057_bib40","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.15252\/emmm.201404976","article-title":"The Hippo\/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression","volume":"7","author":"He","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.fsi.2022.08.057_bib41","doi-asserted-by":"crossref","first-page":"12055","DOI":"10.1128\/JVI.01399-14","article-title":"Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation","volume":"88","author":"Hwang","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.08.057_bib42","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2217\/epi-2018-0180","article-title":"Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells","volume":"11","author":"Kandilya","year":"2019","journal-title":"Epigenomics"},{"key":"10.1016\/j.fsi.2022.08.057_bib43","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fsi.2022.08.057_bib44","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.fsi.2007.11.017","article-title":"Knocking down caspase-3 by RNAi reduces mortality in Pacific white shrimp Penaeus (Litopenaeus) vannamei challenged with a low dose of white-spot syndrome virus","volume":"24","author":"Rijiravanich","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.08.057_bib45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2014.06.013","article-title":"YAP\/TAZ incorporation in the \u03b2-catenin destruction complex orchestrates the Wnt response","volume":"158","author":"Azzolin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2022.08.057_bib46","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.fsi.2022.08.057_bib47","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/emboj.2011.487","article-title":"A molecular mechanism that links Hippo signalling to the inhibition of Wnt\/\u03b2-catenin signaling","volume":"31","author":"Imajo","year":"2012","journal-title":"EMBO J."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822005332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822005332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:36:30Z","timestamp":1760938590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822005332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":47,"alternative-id":["S1050464822005332"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.08.057","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a Yorkie homolog from Litopenaeus vannamei as a negative regulator in anti-WSSV immune response","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.08.057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}