{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:05:48Z","timestamp":1792839948226,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.fsi.2022.09.001","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T12:29:37Z","timestamp":1662467377000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Zebrafish as an emerging tool for drug discovery and development for thyroid diseases"],"prefix":"10.1016","volume":"130","author":[{"given":"Poonam","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lopmudra P.","family":"Sarode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder Reddy","family":"Gaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasvinder Singh","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-5680","authenticated-orcid":false,"given":"Umashanker","family":"Navik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.fsi.2022.09.001_bib1","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1172\/JCI60047","article-title":"Mechanisms of thyroid hormone action","volume":"122","author":"Brent","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.fsi.2022.09.001_bib2","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrendo.2014.143","article-title":"Thyroid hormone receptors and resistance to thyroid hormone disorders","volume":"10","author":"Ortiga-Carvalho","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"issue":"3","key":"10.1016\/j.fsi.2022.09.001_bib3","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0889-8529(05)70349-2","article-title":"Effect of thyroid hormone on growth. Lessons from the syndrome of resistance to thyroid hormone","volume":"25","author":"Weiss","year":"1996","journal-title":"Endocrinol Metab. Clin. N. Am."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib4","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1530\/JOE-17-0708","article-title":"Thyroid hormone receptor localization in target tissues","volume":"237","author":"Anyetei-Anum","year":"2018","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.fsi.2022.09.001_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4939-7902-8_9","article-title":"Thyroid hormones and derivatives: endogenous thyroid hormones and their targets","volume":"1801","author":"K\u00f6hrle","year":"2018","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.fsi.2022.09.001_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.664557","article-title":"From endoderm to progenitors: an update on the early steps of thyroid morphogenesis in the zebrafish","volume":"12","author":"Marelli","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"15","key":"10.1016\/j.fsi.2022.09.001_bib7","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1242\/dev.129.15.3751","article-title":"Pax2.1 is required for the development of thyroid follicles in zebrafish","volume":"129","author":"Wendl","year":"2002","journal-title":"Development (Cambridge, England)"},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2009.12.008","article-title":"Morphogenesis of the thyroid gland","volume":"323","author":"Fagman","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib9","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1677\/JME-10-0084","article-title":"Morphogenetics of early thyroid development","volume":"46","author":"Fagman","year":"2011","journal-title":"J. Mol. Endocrinol."},{"issue":"7","key":"10.1016\/j.fsi.2022.09.001_bib10","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/dvdy.20831","article-title":"Analysis of origin and growth of the thyroid gland in zebrafish","volume":"235","author":"Alt","year":"2006","journal-title":"Dev. Dynam. : Off. Publ. Am. Assoc. Anatomists"},{"issue":"1\u20132","key":"10.1016\/j.fsi.2022.09.001_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0925-4773(00)00345-2","article-title":"Expression of nk2. 1a during early development of the thyroid gland in zebrafish","volume":"95","author":"Rohr","year":"2000","journal-title":"Mech Dev."},{"issue":"12","key":"10.1016\/j.fsi.2022.09.001_bib12","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1242\/dev.145615","article-title":"Development of the thyroid gland","volume":"144","author":"Nilsson","year":"2017","journal-title":"Development (Cambridge, England)"},{"issue":"9","key":"10.1016\/j.fsi.2022.09.001_bib13","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1210\/me.2011-0046","article-title":"TSH receptor function is required for normal thyroid differentiation in zebrafish","volume":"25","author":"Opitz","year":"2011","journal-title":"Mol. Endocrinol. (Baltimore, Md.)"},{"key":"10.1016\/j.fsi.2022.09.001_bib14","first-page":"3","volume":"2","author":"Larriv\u00e9e-Vanier","year":"2018","journal-title":"Zebrafish embryo: A new model for studying thyroid morphogenesis Curr. Opin. Endocr. Metabol. Res."},{"issue":"11","key":"10.1016\/j.fsi.2022.09.001_bib15","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1089\/thy.2019.0122","article-title":"Small-Molecule screening in zebrafish embryos identifies signaling pathways regulating early thyroid development","volume":"29","author":"Haerlingen","year":"2019","journal-title":"Thyroid : Off. J. Am. Thyroid Assoc."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0012-1606(03)00436-6","article-title":"Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors","volume":"263","author":"Elsalini","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.fsi.2022.09.001_bib17","doi-asserted-by":"crossref","unstructured":"U. Navik, P.S. Rawat, P. Allawadhi, A. Khurana, A.K. Banothu, K.K. Bharani, Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research, Zebrafish Model for Biomedical Research, Springer2022, pp. 93-141.","DOI":"10.1007\/978-981-16-5217-2_6"},{"key":"10.1016\/j.fsi.2022.09.001_bib18","doi-asserted-by":"crossref","unstructured":"A. Gadige, N.T. Gunturu, A. Khurana, P. Allawadhi, I. Khurana, A.K. Banothu, S. Thalugula, R.R. Naik, K.K. Bharani, Zebrafish as a Novel Pharmacological Screening Model for Drug Discovery and Development against Hematological Disorders, Zebrafish Model for Biomedical Research, Springer2022, pp. 259-287.","DOI":"10.1007\/978-981-16-5217-2_12"},{"key":"10.1016\/j.fsi.2022.09.001_bib19","doi-asserted-by":"crossref","unstructured":"V. Singh, A.P. Renushe, P. Allawadhi, S.K. Pasumarthi, I. Khurana, R. Weiskirchen, D. Neeradi, A.K. Banothu, K.K. Bharani, A. Khurana, Pharmacological Modeling of Gastrointestinal Disorders in Zebrafish for Drug Discovery and Development, Zebrafish Model for Biomedical Research, Springer2022, pp. 421-447.","DOI":"10.1007\/978-981-16-5217-2_19"},{"issue":"4","key":"10.1016\/j.fsi.2022.09.001_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000357079","article-title":"New model systems to illuminate thyroid organogenesis. Part I: an update on the zebrafish toolbox","volume":"2","author":"Opitz","year":"2013","journal-title":"Eur Thyroid J"},{"issue":"2","key":"10.1016\/j.fsi.2022.09.001_bib21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ydbio.2012.09.011","article-title":"Transgenic zebrafish illuminate the dynamics of thyroid morphogenesis and its relationship to cardiovascular development","volume":"372","author":"Opitz","year":"2012","journal-title":"Dev. Biol."},{"issue":"3","key":"10.1016\/j.fsi.2022.09.001_bib22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11154-005-3053-9","article-title":"Thyroid development and effect on the nervous system","volume":"6","author":"Santisteban","year":"2005","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"5","key":"10.1016\/j.fsi.2022.09.001_bib23","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1210\/er.2003-0028","article-title":"Thyroid development and its disorders: genetics and molecular mechanisms","volume":"25","author":"De Felice","year":"2004","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrendo.2014.186","article-title":"Thyroid transcription factors in development, differentiation and disease","volume":"11","author":"Fern\u00e1ndez","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.fsi.2022.09.001_bib25","doi-asserted-by":"crossref","first-page":"256","DOI":"10.30699\/ijp.13.2.256","article-title":"The expression of FOXE-1 and STIP-1 in papillary thyroid carcinoma and their relationship with patient prognosis","volume":"13","author":"E","year":"2018","journal-title":"Iran. J. Pathol."},{"key":"10.1016\/j.fsi.2022.09.001_bib26","series-title":"Zebrafish Pax8 Is Required for Otic Placode Induction and Plays a Redundant Role with Pax2 Genes in the Maintenance of the Otic Placode","author":"Mackereth","year":"2005"},{"issue":"13","key":"10.1016\/j.fsi.2022.09.001_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137410","article-title":"PAX8 in the junction between development and tumorigenesis","volume":"23","author":"Kakun","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrendo.2014.186","article-title":"Thyroid transcription factors in development, differentiation and disease","volume":"11","author":"Fern\u00e1ndez","year":"2015","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2022.09.001_bib29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0925-4773(00)00345-2","article-title":"Expression of nk2.1a during early development of the thyroid gland in zebrafish","volume":"95","author":"Rohr","year":"2000","journal-title":"Mech. Dev."},{"issue":"4","key":"10.1016\/j.fsi.2022.09.001_bib30","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/dev.113.4.1093","article-title":"The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain","volume":"113","author":"Lazzaro","year":"1991","journal-title":"Development (Cambridge, England)"},{"issue":"3","key":"10.1016\/j.fsi.2022.09.001_bib31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s004270050170","article-title":"Demarcation of ventral territories by the homeobox gene NKX2.1 during early chick development","volume":"208","author":"Pera","year":"1998","journal-title":"Dev. Gene. Evol."},{"issue":"11","key":"10.1016\/j.fsi.2022.09.001_bib32","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1631\/jzus.B1100382","article-title":"Nkx2-1: a novel tumor biomarker of lung cancer","volume":"13","author":"Yang","year":"2012","journal-title":"J. Zhejiang Univ. - Sci. B"},{"issue":"1\u20132","key":"10.1016\/j.fsi.2022.09.001_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2009.05.011","article-title":"Thyroid gland development and function in the zebrafish model","volume":"312","author":"Porazzi","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.fsi.2022.09.001_bib34","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1242\/dev.127.11.2433","article-title":"The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation","volume":"127","author":"Martinez Barbera","year":"2000","journal-title":"Development (Cambridge, England)"},{"issue":"16","key":"10.1016\/j.fsi.2022.09.001_bib35","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1242\/dev.125.16.3063","article-title":"Characterization of three novel members of the zebrafish Pax2\/5\/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function","volume":"125","author":"Pfeffer","year":"1998","journal-title":"Development (Cambridge, England)"},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ng0598-87","article-title":"Follicular cells of the thyroid gland require Pax8 gene function","volume":"19","author":"Mansouri","year":"1998","journal-title":"Nat. Genet."},{"issue":"16","key":"10.1016\/j.fsi.2022.09.001_bib37","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1242\/dev.125.16.3049","article-title":"A series of no isthmus (noi) alleles of the zebrafish pax2.1 gene reveals multiple signaling events in development of the midbrain-hindbrain boundary","volume":"125","author":"Lun","year":"1998","journal-title":"Development (Cambridge, England)"},{"issue":"8","key":"10.1016\/j.fsi.2022.09.001_bib38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/jez.b.21298","article-title":"Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish","volume":"312","author":"Nakada","year":"2009","journal-title":"J. Exp. Zool. B Mol. Dev. Evol."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.10.1.60","article-title":"The T\/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary","volume":"10","author":"Kimura","year":"1996","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1172\/JCI70038","article-title":"Embryonic exposure to excess thyroid hormone causes thyrotrope cell death","volume":"124","author":"Tonyushkina","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fsi.2022.09.001_bib41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.mod.2015.10.002","article-title":"Thyroid development in zebrafish lacking Taz","volume":"138 Pt 3","author":"Pappalardo","year":"2015","journal-title":"Mech. Dev."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib42","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1210\/en.2014-1628","article-title":"Functional zebrafish studies based on human genotyping point to netrin-1 as a link between aberrant cardiovascular development and thyroid dysgenesis","volume":"156","author":"Opitz","year":"2015","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.fsi.2022.09.001_bib43","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jc.2015-3403","article-title":"JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects","volume":"101","author":"de Filippis","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1586\/14737159.8.1.83","article-title":"Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis","volume":"8","author":"Nikiforova","year":"2008","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.fsi.2022.09.001_bib45","doi-asserted-by":"crossref","unstructured":"S. Jindal, P. Allawadhi, S. Sinha, A. Khurana, K.K. Bharani, P. Gopinath, Zebrafish as a Versatile Model for Cancer Research, Zebrafish Model for Biomedical Research, Springer 2022, pp. 143-180.","DOI":"10.1007\/978-981-16-5217-2_7"},{"issue":"2","key":"10.1016\/j.fsi.2022.09.001_bib46","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1677\/erc.1.0978","article-title":"BRAF mutation in thyroid cancer","volume":"12","author":"Xing","year":"2005","journal-title":"Endocr. Relat. Cancer"},{"issue":"7","key":"10.1016\/j.fsi.2022.09.001_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071529","article-title":"Current knowledge in thyroid cancer-from bench to bedside","volume":"18","author":"Grimm","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.fsi.2022.09.001_bib48","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00108-014-3637-0","article-title":"[Differentiated thyroid cancer]","volume":"56","author":"Tiedje","year":"2015","journal-title":"Der Internist"},{"issue":"9356","key":"10.1016\/j.fsi.2022.09.001_bib49","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0140-6736(03)12488-9","article-title":"Thyroid carcinoma","volume":"361","author":"Sherman","year":"2003","journal-title":"Lancet (London, England)"},{"issue":"5","key":"10.1016\/j.fsi.2022.09.001_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1177\/2042018811419889","article-title":"Thyroid cancer: pathogenesis and targeted therapy","volume":"2","author":"Liebner","year":"2011","journal-title":"Ther. Adv. Endocrinol. Metabol."},{"key":"10.1016\/j.fsi.2022.09.001_bib51","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2741\/3696","article-title":"A minireview: the role of MAPK\/ERK and PI3K\/Akt pathways in thyroid follicular cell-derived neoplasm","volume":"16","author":"Brzezianska","year":"2011","journal-title":"Front. Biosci.(Landmark edition)"},{"issue":"8","key":"10.1016\/j.fsi.2022.09.001_bib52","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.bbamcr.2007.05.001","article-title":"Raf kinases: function, regulation and role in human cancer","volume":"1773","author":"Leicht","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"14","key":"10.1016\/j.fsi.2022.09.001_bib53","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1001\/jama.2013.3190","article-title":"Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer","volume":"309","author":"Xing","year":"2013","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib54","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.canlet.2013.02.033","article-title":"(V600E)BRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism","volume":"335","author":"Baquero","year":"2013","journal-title":"Cancer Lett."},{"issue":"10","key":"10.1016\/j.fsi.2022.09.001_bib55","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1158\/0008-5472.CAN-05-0047","article-title":"Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation","volume":"65","author":"Knauf","year":"2005","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.fsi.2022.09.001_bib56","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1172\/JCI46382","article-title":"Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation","volume":"121","author":"Chakravarty","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fsi.2022.09.001_bib57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.20728","article-title":"Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression","volume":"6","author":"Anelli","year":"2017","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s40618-019-01084-9","article-title":"Clinical recognition and evaluation of patients with inherited serum thyroid hormone-binding protein mutations","volume":"43","author":"Mimoto","year":"2020","journal-title":"J. Endocrinol. Invest."},{"issue":"2","key":"10.1016\/j.fsi.2022.09.001_bib59","first-page":"241","article-title":"Disorder of thyroid hormone transport into the tissues, Best practice & research","volume":"31","author":"Groeneweg","year":"2017","journal-title":"Clin. Endocrinol. Metabol."},{"issue":"7","key":"10.1016\/j.fsi.2022.09.001_bib60","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1016\/j.bbagen.2012.08.005","article-title":"The syndromes of reduced sensitivity to thyroid hormone","volume":"1830","author":"Dumitrescu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.fsi.2022.09.001_bib61","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1172\/JCI70324","article-title":"Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis","volume":"124","author":"Mayerl","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/me.2010-0095","article-title":"Minireview: thyroid hormone transporters: the knowns and the unknowns","volume":"25","author":"Visser","year":"2011","journal-title":"Mol. Endocrinol. (Baltimore, Md.)"},{"issue":"41","key":"10.1016\/j.fsi.2022.09.001_bib63","doi-asserted-by":"crossref","first-page":"40128","DOI":"10.1074\/jbc.M300909200","article-title":"Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter","volume":"278","author":"Friesema","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.fsi.2022.09.001_bib64","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.1210\/en.2011-1166","article-title":"Identification and functional characterization of zebrafish solute carrier Slc16a2 (Mct8) as a thyroid hormone membrane transporter","volume":"152","author":"Arjona","year":"2011","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1074\/jbc.M112.413831","article-title":"Zebrafish as a model for monocarboxyl transporter 8-deficiency","volume":"288","author":"Vatine","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.fsi.2022.09.001_bib66","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1210\/me.2014-1032","article-title":"Maternal thyroid hormones are essential for neural development in zebrafish","volume":"28","author":"Campinho","year":"2014","journal-title":"Mol. Endocrinol. (Baltimore, Md.)"},{"issue":"9","key":"10.1016\/j.fsi.2022.09.001_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004615","article-title":"Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation","volume":"10","author":"Zada","year":"2014","journal-title":"PLoS Genet."},{"issue":"11","key":"10.1016\/j.fsi.2022.09.001_bib68","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1242\/dmm.027227","article-title":"Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish","volume":"9","author":"Zada","year":"2016","journal-title":"Dis. Models Mech."},{"issue":"6","key":"10.1016\/j.fsi.2022.09.001_bib69","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1210\/en.2013-1962","article-title":"Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish","volume":"155","author":"de Vrieze","year":"2014","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.fsi.2022.09.001_bib70","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/thy.2005.15.799","article-title":"Thyroid hormone deiodination in fish, Thyroid","volume":"15","author":"Orozco","year":"2005","journal-title":"Off. J. Am. Thyroid Assoc."},{"key":"10.1016\/j.fsi.2022.09.001_bib71","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ygcen.2013.04.004","article-title":"Zebrafish as a model to study peripheral thyroid hormone metabolism in vertebrate development","volume":"188","author":"Heijlen","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"issue":"9","key":"10.1016\/j.fsi.2022.09.001_bib72","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1210\/en.2016-1077","article-title":"Permanent deiodinase type 2 deficiency strongly perturbs zebrafish development, growth, and fertility","volume":"157","author":"Houbrechts","year":"2016","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.fsi.2022.09.001_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123285","article-title":"Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction","volume":"10","author":"Bagci","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.fsi.2022.09.001_bib74","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1210\/en.2013-1660","article-title":"Knockdown of type 3 iodothyronine deiodinase severely perturbs both embryonic and early larval development in zebrafish","volume":"155","author":"Heijlen","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.fsi.2022.09.001_bib75","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/402320","article-title":"Thyroid hormone receptors in two model species for vertebrate embryonic development: chicken and zebrafish","volume":"2011","author":"Darras","year":"2011","journal-title":"J. Thyroid Res."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib76","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000358180","article-title":"Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism","volume":"3","author":"Refetoff","year":"2014","journal-title":"Eur. Thyroid J."},{"issue":"3","key":"10.1016\/j.fsi.2022.09.001_bib77","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1432-0436.1997.6230107.x","article-title":"The zebrafish thyroid hormone receptor \u03b11 is expressed during early embryogenesis and can function in transcriptional repression","volume":"62","author":"Essner","year":"1997","journal-title":"J. Differ."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1432-0436.1999.6510001.x","article-title":"Overexpression of thyroid hormone receptor \u03b11 during zebrafish embryogenesis disrupts hindbrain patterning and implicates retinoic acid receptors in the control of hox gene expression","volume":"65","author":"Essner","year":"1999","journal-title":"J. Differ."},{"key":"10.1016\/j.fsi.2022.09.001_bib79","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mce.2016.01.020","article-title":"Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action","volume":"424","author":"Marelli","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"37","key":"10.1016\/j.fsi.2022.09.001_bib80","doi-asserted-by":"crossref","first-page":"15109","DOI":"10.1073\/pnas.1303551110","article-title":"Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors","volume":"110","author":"Suzuki","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.fsi.2022.09.001_bib81","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008869","article-title":"Thyroid hormone receptor beta mutations alter photoreceptor development and function in Danio rerio (zebrafish)","volume":"16","author":"Deveau","year":"2020","journal-title":"PLoS Genet."},{"issue":"2","key":"10.1016\/j.fsi.2022.09.001_bib82","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1089\/thy.2019.0598","article-title":"Generation of novel genetic models to dissect resistance to thyroid hormone receptor \u03b1 in zebrafish, thyroid","volume":"30","author":"Han","year":"2020","journal-title":"Off. J. Am. Thyroid Assoc."},{"key":"10.1016\/j.fsi.2022.09.001_bib83","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fendo.2019.00156","article-title":"Knock-down of specific thyroid hormone receptor isoforms impairs body plan development in zebrafish","volume":"10","author":"Lazcano","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.fsi.2022.09.001_bib84","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0031-6997(24)01350-4","article-title":"Perchlorate and the thyroid gland","volume":"50","author":"Wolff","year":"1998","journal-title":"Pharmacol. Rev."},{"issue":"8","key":"10.1016\/j.fsi.2022.09.001_bib85","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/tox.20655","article-title":"The effects of ammonium perchlorate on thyroid homeostasis and thyroid-specific gene expression in rat","volume":"27","author":"Wu","year":"2012","journal-title":"Environ. Toxicol."},{"issue":"1\u20133","key":"10.1016\/j.fsi.2022.09.001_bib86","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1385\/BTER:90:1-3:83","article-title":"Fish arsenic may influence human blood arsenic, selenium, and T4:T3 ratio","volume":"90","author":"Meltzer","year":"2002","journal-title":"Biol. Trace Elem. Res."},{"issue":"10","key":"10.1016\/j.fsi.2022.09.001_bib87","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1021\/es052538g","article-title":"Thyrotoxicity of sodium arsenate, sodium perchlorate, and their mixture in zebrafish Danio rerio","volume":"40","author":"Liu","year":"2006","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.fsi.2022.09.001_bib88","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol. (Elmsford, N.Y.)"},{"issue":"4","key":"10.1016\/j.fsi.2022.09.001_bib89","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3803\/EnM.2019.34.4.340","article-title":"Bisphenols and thyroid hormone","volume":"34","author":"Kim","year":"2019","journal-title":"Endocrinol. Metabol. (Seoul, Korea)"},{"issue":"10","key":"10.1016\/j.fsi.2022.09.001_bib90","doi-asserted-by":"crossref","first-page":"13069","DOI":"10.3390\/ijerph121013069","article-title":"Thyroid disruption in zebrafish larvae by short-term exposure to bisphenol AF","volume":"12","author":"Tang","year":"2015","journal-title":"Int. J. Environ. Res. Publ. Health"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822005514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822005514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:36:24Z","timestamp":1760938584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822005514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":90,"alternative-id":["S1050464822005514"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.09.001","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zebrafish as an emerging tool for drug discovery and development for thyroid diseases","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}