{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:01:20Z","timestamp":1790611280470,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31930115"],"award-info":[{"award-number":["31930115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20102"],"award-info":[{"award-number":["U20A20102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2021B0202040002"],"award-info":[{"award-number":["2021B0202040002"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010203","name":"Agriculture Research System of China","doi-asserted-by":"publisher","award":["CARS-47-G16"],"award-info":[{"award-number":["CARS-47-G16"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.fsi.2022.09.074","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T11:28:37Z","timestamp":1664882917000},"page":"84-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Modulatory effects of curcumin on Singapore grouper iridovirus infection-associated apoptosis and autophagy in vitro"],"prefix":"10.1016","volume":"131","author":[{"given":"Yuexuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suifeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0724-5521","authenticated-orcid":false,"given":"Chengzong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youhua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingguang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shina","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2022.09.074_bib1","first-page":"363","article-title":"Anticancer potential of curcumin: preclinical and clinical studies","volume":"23","author":"Aggarwal","year":"2003","journal-title":"Anticancer Res."},{"key":"10.1016\/j.fsi.2022.09.074_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/biof.1041","article-title":"Molecular mechanisms of curcumin action: gene expression","volume":"39","author":"Shishodia","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.fsi.2022.09.074_bib3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bcp.2007.08.016","article-title":"Curcumin as \"curecumin\": from kitchen to clinic","volume":"75","author":"Goel","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fsi.2022.09.074_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26226900","article-title":"Curcumin inhibits in vitro SARS-cov-2 infection in vero e6 cells through multiple antiviral mechanisms","volume":"26","author":"Marin-Palma","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.fsi.2022.09.074_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010337","article-title":"Curcumin can decrease tissue inflammation and the severity of hsv-2 infection in the female reproductive mucosa","volume":"21","author":"Vitali","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2022.09.074_bib6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2017.03.014","article-title":"Curcumin inhibits zika and chikungunya virus infection by inhibiting cell binding","volume":"142","author":"Mounce","year":"2017","journal-title":"Antivir. Res."},{"key":"10.1016\/j.fsi.2022.09.074_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006289","article-title":"An ape1 inhibitor reveals critical roles of the redox function of ape1 in kshv replication and pathogenic phenotypes","volume":"13","author":"Zhong","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2022.09.074_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.antiviral.2015.11.007","article-title":"Curcumin and boswellia serrata gum resin extract inhibit chikungunya and vesicular stomatitis virus infections in vitro","volume":"125","author":"von Rhein","year":"2016","journal-title":"Antivir. Res."},{"key":"10.1016\/j.fsi.2022.09.074_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124903","article-title":"The anti-inflammatory activity of curcumin protects the genital mucosal epithelial barrier from disruption and blocks replication of hiv-1 and hsv-2","volume":"10","author":"Ferreira","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2022.09.074_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00705-013-1849-6","article-title":"Inhibitory effects of curcumin on dengue virus type 2-infected cells in vitro","volume":"159","author":"Padilla-S","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.fsi.2015.03.042","article-title":"Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment","volume":"45","author":"Jeong","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrmicro2071","article-title":"Apoptosis in animal models of virus-induced disease","volume":"7","author":"Clarke","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2022.09.074_bib13","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/sj.cdd.4401941","article-title":"Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis","volume":"13","author":"White","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2022.09.074_bib14","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3892\/or.2015.3847","article-title":"Lmp-1 induces survivin expression to inhibit cell apoptosis through the nf-kappab and pi3k\/akt signaling pathways in nasal nk\/t-cell lymphoma","volume":"33","author":"Sun","year":"2015","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.fsi.2022.09.074_bib15","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1128\/JVI.77.1.790-798.2003","article-title":"Poliovirus-induced apoptosis is reduced in cells expressing a mutant cd155 selected during persistent poliovirus infection in neuroblastoma cells","volume":"77","author":"Gosselin","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib16","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.1128\/JVI.72.9.7638-7641.1998","article-title":"Attachment but not penetration of bovine herpesvirus 1 is necessary to induce apoptosis in target cells","volume":"9","author":"Hanon","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib17","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1128\/JVI.02690-06","article-title":"Poliovirus induces bax-dependent cell death mediated by c-jun nh2-terminal kinase","volume":"81","author":"Autret","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib18","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/JVI.01860-06","article-title":"Ikappab kinase subunits alpha and gamma are required for activation of nf-kappab and induction of apoptosis by mammalian reovirus","volume":"81","author":"Hansberger","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib19","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10495-005-1881-4","article-title":"Inhibition of nf-kappa b activity and cflip expression contribute to viral-induced apoptosis","volume":"10","author":"Clarke","year":"2005","journal-title":"Apoptosis"},{"key":"10.1016\/j.fsi.2022.09.074_bib20","series-title":"Inhibition of Ulk1 and Beclin1 by an Alpha-Herpesvirus Akt-like Ser\/thr Kinase Limits Autophagy to Stimulate Virus Replication","author":"Rubio","year":"2019"},{"key":"10.1016\/j.fsi.2022.09.074_bib21","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3390\/v3071166","article-title":"Beclin-1 targeting for viral immune escape","volume":"3","author":"Munz","year":"2011","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2022.09.074_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104503","article-title":"Promising role of curcumin against viral diseases emphasizing covid-19 management: a review on the mechanistic insights with reference to host-pathogen interaction and immunomodulation","volume":"82","author":"Dhar","year":"2021","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.fsi.2022.09.074_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78903-0","article-title":"Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the bdnf\/trkb pathway","volume":"10","author":"Yang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2022.09.074_bib24","article-title":"Curcumin protects microglia and primary rat cortical neurons against hiv-1 gp120-mediated inflammation and apoptosis","volume":"8","author":"Guo","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2022.09.074_bib25","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1128\/JVI.02028-06","article-title":"Dysregulation of the ubiquitin-proteasome system by curcumin suppresses coxsackievirus b3 replication","volume":"81","author":"Si","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0021-9975(03)00010-0","article-title":"The pathology of systemic iridoviral disease in fish","volume":"129","author":"Gibson-Kueh","year":"2003","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.fsi.2022.09.074_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0166-0934(01)00350-0","article-title":"Electron microscopic observations of a marine fish iridovirus isolated from brown-spotted grouper, epinephelus tauvina","volume":"98","author":"Qin","year":"2001","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.fsi.2022.09.074_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10495-011-0616-y","article-title":"Singapore grouper iridovirus, a large dna virus, induces nonapoptotic cell death by a cell type dependent fashion and evokes erk signaling","volume":"16","author":"Huang","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.fsi.2022.09.074_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103916","article-title":"Identification of bag5 from orange-spotted grouper (epinephelus coioides) involved in viral infection","volume":"116","author":"Zou","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.fsi.2019.09.004","article-title":"Molecular cloning, expression and functional analysis of atg16l1 from orange-spotted grouper (epinephelus coioides)","volume":"94","author":"Li","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib31","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3389\/fimmu.2019.00517","article-title":"Fish autophagy protein 5 exerts negative regulation on antiviral immune response against iridovirus and nodavirus","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib32","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s10126-021-10023-w","article-title":"The roles of epinephelus coioides mir-122 in sgiv infection and replication","volume":"23","author":"Sun","year":"2021","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.fsi.2022.09.074_bib33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.virol.2009.01.010","article-title":"Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (erk) signaling pathway","volume":"386","author":"Wei","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2022.09.074_bib34","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.virol.2007.09.040","article-title":"Reactivation of kaposi's sarcoma-associated herpesvirus from latency requires mek\/erk, jnk and p38 multiple mitogen-activated protein kinase pathways","volume":"371","author":"Xie","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2022.09.074_bib35","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3389\/fmicb.2020.01446","article-title":"Singapore grouper iridovirus (sgiv) inhibited autophagy for efficient viral replication","volume":"11","author":"Li","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2022.09.074_bib36","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1038\/sj.onc.1209096","article-title":"Akt-regulated pathways in prostate cancer","volume":"24","author":"Majumder","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.fsi.2022.09.074_bib37","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0898-6568(01)00271-6","article-title":"The protein kinase b\/akt signalling pathway in human malignancy","volume":"14","author":"Nicholson","year":"2002","journal-title":"Cell. Signal."},{"key":"10.1016\/j.fsi.2022.09.074_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197150","article-title":"Curcumin and photobiomodulation in chronic viral hepatitis and hepatocellular carcinoma","volume":"21","author":"Ailioaie","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2022.09.074_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/v12010110","article-title":"Bright and early: inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function","volume":"12","author":"Adamson","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2022.09.074_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/v13102029","article-title":"Usp38 inhibits zika virus infection by removing envelope protein ubiquitination","volume":"13","author":"Wang","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2022.09.074_bib41","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00042-20","article-title":"The carboxyl terminus of the porcine circovirus type 2 capsid protein is critical to virus-like particle assembly, cell entry, and propagation","volume":"94","author":"Zhan","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib42","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.fsi.2013.09.023","article-title":"Characterization of lps-induced tnfalpha factor (litaf) from orange-spotted grouper, epinephelus coioides","volume":"35","author":"Cai","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib43","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/ptr.6738","article-title":"Potential effects of curcumin in the treatment of covid-19 infection","volume":"34","author":"Zahedipour","year":"2020","journal-title":"Phytother Res."},{"key":"10.1016\/j.fsi.2022.09.074_bib44","first-page":"327","article-title":"\u00a3\u00f2esearch progress on anti\u00a3-tumor effect of curcumin via regulating cell apoptosis signal pathway","volume":"42","author":"Zhidan","year":"2021","journal-title":"J Qiqihar Med Univ"},{"key":"10.1016\/j.fsi.2022.09.074_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78903-0","article-title":"Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the bdnf\/trkb pathway","volume":"10","author":"Yang","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2022.09.074_bib46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3892\/or_00000762","article-title":"Curcumin induces apoptosis in human lung adenocarcinoma a549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway","volume":"23","author":"Chen","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.fsi.2022.09.074_bib47","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.fsi.2015.03.042","article-title":"Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment","volume":"45","author":"Jeong","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib48","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fcimb.2019.00329","article-title":"Grouper tradd mediates innate antiviral immune responses and apoptosis induced by Singapore grouper iridovirus (sgiv) infection","volume":"9","author":"Zhang","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.fsi.2022.09.074_bib49","first-page":"4450","article-title":"The c-jun nh(2)-terminal protein kinase\/ap-1 pathway is required for efficient apoptosis induced by vinblastine","volume":"61","author":"Fan","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.fsi.2022.09.074_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109061","article-title":"Highly pathogenic porcine reproductive and respiratory syndrome virus (hp-prrsv) induces il-6 production through tak-1\/jnk\/ap-1 and tak-1\/nf-kappab signaling pathways","volume":"256","author":"Xu","year":"2021","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fsi.2022.09.074_bib51","doi-asserted-by":"crossref","first-page":"7898","DOI":"10.1002\/jcb.26829","article-title":"Effects of curcumin on nf-kappab, ap-1, and wnt\/beta-catenin signaling pathway in hepatitis b virus infection","volume":"119","author":"Hesari","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fsi.2022.09.074_bib52","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1055\/s-0038-1656049","article-title":"The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of ap-1 to the dna and activation of nf-kappa b","volume":"77","author":"Bierhaus","year":"1997","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.fsi.2022.09.074_bib53","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.fsi.2022.04.039","article-title":"Molecular cloning, inducible expression and function analysis of epinephelus coioides sec6 response to sgiv infection","volume":"124","author":"Li","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib54","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.virol.2007.09.010","article-title":"Modulation of iridovirus-induced apoptosis by endocytosis, early expression, jnk, and apical caspase","volume":"370","author":"Chitnis","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2022.09.074_bib55","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10495-011-0595-z","article-title":"Involvement of the mitogen-activated protein kinase pathway in soft-shelled turtle iridovirus-induced apoptosis","volume":"16","author":"Huang","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.fsi.2022.09.074_bib56","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.fsi.2019.12.017","article-title":"Identification and characterization of c-raf from orange-spotted grouper (epinephelus coioides)","volume":"96","author":"Mo","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib57","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fmicb.2016.00121","article-title":"Jnk1 derived from orange-spotted grouper, epinephelus coioides, involving in the evasion and infection of Singapore grouper iridovirus (sgiv)","volume":"7","author":"Guo","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2022.09.074_bib58","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.fsi.2014.12.033","article-title":"Characterization of c-jun from orange-spotted grouper, epinephelus coioides involved in sgiv infection","volume":"43","author":"Wei","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib59","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.biopha.2017.05.099","article-title":"Curcumin accelerates the repair of sciatic nerve injury in rats through reducing schwann cells apoptosis and promoting myelinization","volume":"92","author":"Zhao","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.fsi.2022.09.074_bib60","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12035-014-9021-1","article-title":"Strategy to suppress oxidative damage-induced neurotoxicity in pc12 cells by curcumin: the role of ros-mediated dna damage and the mapk and akt pathways","volume":"53","author":"Fu","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.fsi.2022.09.074_bib61","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.toxrep.2014.12.017","article-title":"Curcumin protects rat liver from streptozotocin-induced diabetic pathophysiology by counteracting reactive oxygen species and inhibiting the activation of p53 and mapks mediated stress response pathways","volume":"2","author":"Ghosh","year":"2015","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.fsi.2022.09.074_bib62","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1021\/acsabm.1c00874","article-title":"Nanocurcumin potently inhibits SARS-cov-2 spike protein-induced cytokine storm by deactivation of mapk\/nf-kappab signaling in epithelial cells","volume":"5","author":"Sharma","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.fsi.2022.09.074_bib63","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.chom.2014.04.004","article-title":"Phosphoprotein of human parainfluenza virus type 3 blocks autophagosome-lysosome fusion to increase virus production","volume":"15","author":"Ding","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.fsi.2022.09.074_bib64","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.immuni.2009.02.009","article-title":"Autophagy is an essential component of drosophila immunity against vesicular stomatitis virus","volume":"30","author":"Shelly","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.fsi.2022.09.074_bib65","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.fsi.2019.09.029","article-title":"Identification of beclin-1 from orange-spotted grouper (epinephelus coioides) involved in viral infection","volume":"94","author":"Cai","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2022.09.074_bib66","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbrc.2019.02.107","article-title":"Full anti-apoptotic function of bcl-xl complexed with beclin-1 verified by live-cell fret assays","volume":"511","author":"Wen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2022.09.074_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109442","article-title":"Novel compounds for the modulation of mtor and autophagy to treat neurodegenerative diseases","volume":"65","author":"Heras-Sandoval","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.fsi.2022.09.074_bib68","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.semcdb.2014.09.024","article-title":"The structural basis for mtor function","volume":"36","author":"Baretic","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.fsi.2022.09.074_bib69","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"Mtor: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.fsi.2022.09.074_bib70","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.molcel.2007.03.003","article-title":"Pras40 is an insulin-regulated inhibitor of the mtorc1 protein kinase","volume":"25","author":"Sancak","year":"2007","journal-title":"Mol. Cell."},{"key":"10.1016\/j.fsi.2022.09.074_bib71","doi-asserted-by":"crossref","first-page":"20036","DOI":"10.1074\/jbc.M702376200","article-title":"Pras40 regulates mtorc1 kinase activity by functioning as a direct inhibitor of substrate binding","volume":"282","author":"Wang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2022.09.074_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101600","article-title":"Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy","volume":"36","author":"Kong","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.fsi.2022.09.074_bib73","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ejphar.2014.06.051","article-title":"Downregulation of pi3k\/akt\/mtor signaling pathway in curcumin-induced autophagy in app\/ps1 double transgenic mice","volume":"740","author":"Wang","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.fsi.2022.09.074_bib74","doi-asserted-by":"crossref","first-page":"812","DOI":"10.4161\/auto.19471","article-title":"Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage","volume":"8","author":"Han","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.fsi.2022.09.074_bib75","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/mnfr.201100454","article-title":"Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of pi3k\/akt-mtor and mapk signaling pathways in human leukemia hl-60 cells","volume":"55","author":"Wu","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.fsi.2022.09.074_bib76","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/mc.22933","article-title":"Interleukin 7 receptor activates pi3k\/akt\/mtor signaling pathway via downregulation of beclin-1 in lung cancer","volume":"58","author":"Jian","year":"2019","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.fsi.2022.09.074_bib77","first-page":"1917","article-title":"Inhibition of autophagy via activation of pi3k\/akt\/mtor pathway contributes to the protection of hesperidin against myocardial ischemia\/reperfusion injury","volume":"42","author":"Li","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.fsi.2022.09.074_bib78","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1099\/vir.0.056135-0","article-title":"An insulin-like growth factor homologue of Singapore grouper iridovirus modulates cell proliferation, apoptosis and enhances viral replication","volume":"94","author":"Yan","year":"2013","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.fsi.2022.09.074_bib79","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.virusres.2018.06.011","article-title":"Rgnnv-induced cell cycle arrest at g1\/s phase enhanced viral replication via p53-dependent pathway in gs cells","volume":"256","author":"Mai","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.fsi.2022.09.074_bib80","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.2174\/1381612823666170704123620","article-title":"Protein phosphatase-1 -targeted small molecules, iron chelators and curcumin analogs as hiv-1 antivirals","volume":"23","author":"Lin","year":"2017","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.fsi.2022.09.074_bib81","first-page":"5051","article-title":"Inhibition of hiv-1 by curcumin a, a novel curcumin analog","volume":"9","author":"Kumari","year":"2015","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.fsi.2022.09.074_bib82","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1080\/01635581.2018.1559933","article-title":"Isochamanetin is a selective inhibitor for cyclind1 in skov3 cell lines","volume":"71","author":"Swarnalatha","year":"2019","journal-title":"Nutr. Cancer"},{"key":"10.1016\/j.fsi.2022.09.074_bib83","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.mad.2016.07.006","article-title":"Cell-cycle involvement in autophagy and apoptosis in yeast","volume":"161","author":"Azzopardi","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.fsi.2022.09.074_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109353","article-title":"The role of beclin 1 in ir-induced crosstalk between autophagy and g2\/m cell cycle arrest","volume":"62","author":"Liang","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.fsi.2022.09.074_bib85","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41556-020-0554-4","article-title":"P27 controls ragulator and mtor activity in amino acid-deprived cells to regulate the autophagy-lysosomal pathway and coordinate cell cycle and cell growth","volume":"22","author":"Nowosad","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.fsi.2022.09.074_bib86","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.aquaculture.2009.04.019","article-title":"Characterization of two grouper epinephelus akaara cell lines: application to studies of Singapore grouper iridovirus (sgiv) propagation and viruschost interaction","volume":"292","author":"Huang","year":"2009","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2022.09.074_bib87","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.fsi.2013.01.010","article-title":"Molecular cloning, expression and functional analysis of isg15 in orange-spotted grouper, epinephelus coioides","volume":"34","author":"Huang","year":"2013","journal-title":"Fish Shellfish Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822006404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822006404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:10:54Z","timestamp":1778584254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822006404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":87,"alternative-id":["S1050464822006404"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.09.074","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulatory effects of curcumin on Singapore grouper iridovirus infection-associated apoptosis and autophagy in vitro","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.09.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}