{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:52:49Z","timestamp":1772092369348,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.fsi.2022.10.002","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T11:06:34Z","timestamp":1665227194000},"page":"206-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Grass carp (Ctenopharyngodon idella) NLK2 inhibits IFN I response through blocking MAVS-IRF3 axis"],"prefix":"10.1016","volume":"131","author":[{"given":"Tingting","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanghong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.fsi.2022.10.002_bib1","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.1073\/pnas.0500679102","article-title":"STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation","volume":"102","author":"Kojima","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.fsi.2022.10.002_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1101\/gad.1166904","article-title":"Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction","volume":"18","author":"Ohkawara","year":"2004","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.fsi.2022.10.002_bib3","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1021\/cr000241p","article-title":"MAP kinases","volume":"101","author":"Chen","year":"2001","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.fsi.2022.10.002_bib4","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10571-011-9766-2","article-title":"Nemo-like kinase (NLK) involves in neuronal apoptosis after traumatic brain injury","volume":"32","author":"Li","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.fsi.2022.10.002_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s12013-012-9511-6","article-title":"Expression of Nemo-like kinase (NLK) in the brain in a rat experimental subarachnoid hemorrhage model","volume":"66","author":"Chen","year":"2013","journal-title":"Cell Biochem. Biophys."},{"issue":"14","key":"10.1016\/j.fsi.2022.10.002_bib6","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/pros.20998","article-title":"Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells","volume":"69","author":"Emami","year":"2009","journal-title":"Prostate"},{"issue":"3","key":"10.1016\/j.fsi.2022.10.002_bib7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/jcb.22579","article-title":"Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma","volume":"110","author":"Jung","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.fsi.2022.10.002_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.canlet.2018.05.032","article-title":"Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1","volume":"431","author":"Li","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.fsi.2022.10.002_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104105","article-title":"NLK suppresses MAVS-mediated signaling in black carp antiviral innate immunity","volume":"122","author":"Chen","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2022.10.002_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-1119(01)00710-7","article-title":"Only one nemo-like kinase gene homologue in invertebrate and mammalian genomes","volume":"278","author":"Kortenjann","year":"2001","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.fsi.2022.10.002_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cellsig.2012.09.017","article-title":"Nemo-like kinase, a multifaceted cell signaling regulator","volume":"25","author":"Ishitani","year":"2013","journal-title":"Cell. Signal."},{"issue":"7","key":"10.1016\/j.fsi.2022.10.002_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101945","article-title":"CACN-1\/Cactin plays a role in Wnt signaling in C. elegans","volume":"9","author":"LaBonty","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.fsi.2022.10.002_bib13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1242\/dev.128.4.581","article-title":"C. elegans POP-1\/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity","volume":"128","author":"Herman","year":"2001","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.fsi.2022.10.002_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dev.129.2.443","article-title":"POP-1 controls axis formation during early gonadogenesis in C. elegans","volume":"129","author":"Siegfried","year":"2002","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.fsi.2022.10.002_bib15","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.bbamcr.2014.03.028","article-title":"Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK\u03b2","volume":"1843","author":"Li","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"6738","key":"10.1016\/j.fsi.2022.10.002_bib16","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/21674","article-title":"The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF","volume":"399","author":"Ishitani","year":"1999","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.fsi.2022.10.002_bib17","doi-asserted-by":"crossref","first-page":"9328","DOI":"10.1523\/JNEUROSCI.3465-12.2013","article-title":"Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1","volume":"33","author":"Ju","year":"2013","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.fsi.2022.10.002_bib18","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1243","article-title":"IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction","volume":"6","author":"Kawai","year":"2005","journal-title":"Nat. Immunol."},{"issue":"6227","key":"10.1016\/j.fsi.2022.10.002_bib19","doi-asserted-by":"crossref","first-page":"aaa2630","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.fsi.2022.10.002_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2010.03.029","article-title":"Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity","volume":"141","author":"Zeng","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.fsi.2022.10.002_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/pro.3776","article-title":"Oligomerization of RIG-I and MDA5 2CARD domains","volume":"29","author":"Zerbe","year":"2020","journal-title":"Protein Sci."},{"issue":"1","key":"10.1016\/j.fsi.2022.10.002_bib22","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1038\/s41467-019-11258-x","article-title":"Phosphorylation of MAVS\/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.fsi.2022.10.002_bib23","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.dci.2011.07.001","article-title":"Teleost fish interferons and their role in immunity","volume":"35","author":"Zou","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.10.002_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.dci.2016.03.020","article-title":"Bioinformatics analysis of organizational and expressional characterizations of the IFNs, IRFs and CRFBs in grass carp Ctenopharyngodon idella","volume":"61","author":"Liao","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.10.002_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104014","article-title":"Grass carp (Ctenopharyngodon idellus) Cdc25a down-regulates IFN 1 expression by reducing TBK1 phosphorylation","volume":"118","author":"Deng","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.10.002_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103909","article-title":"Grass carp Mre11A activates IFN 1 response by targeting STING to defend against GCRV infection","volume":"116","author":"Xu","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"8","key":"10.1016\/j.fsi.2022.10.002_bib27","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1038\/emboj.2012.46","article-title":"NLK positively regulates Wnt\/\u03b2-catenin signalling by phosphorylating LEF1 in neural progenitor cells","volume":"31","author":"Ota","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2022.10.002_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.biochi.2017.07.014","article-title":"Nanog suppresses the expression of vasa by directly regulating nlk1 in the early zebrafish embryo","volume":"142","author":"Liu","year":"2017","journal-title":"Biochimie"},{"issue":"12","key":"10.1016\/j.fsi.2022.10.002_bib29","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1242\/dev.01171","article-title":"nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development","volume":"131","author":"Thorpe","year":"2004","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.fsi.2022.10.002_bib30","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/ncb2028","article-title":"Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex","volume":"12","author":"Ishitani","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.fsi.2022.10.002_bib31","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.4049\/jimmunol.1700750","article-title":"Endoplasmic reticulum transmembrane proteins ZDHHC1 and STING both act as direct adaptors for IRF3 activation in teleost","volume":"199","author":"Xu","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2022.10.002_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103410","article-title":"Grass carp STK38 regulates IFN I expression by decreasing the phosphorylation level of GSK3\u03b2","volume":"99","author":"Xu","year":"2019","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2022.10.002_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.597775","article-title":"Grass carp (Ctenopharyngodon idellus) NIMA-related kinase 6 blocks dsRNA-induced IFN I response by targeting IRF3","volume":"11","author":"Xu","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2022.10.002_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.gene.2014.09.036","article-title":"SiRNA-mediated knockdown of CiGRP78 gene expression leads cell susceptibility to heavy metal cytotoxicity","volume":"552","author":"Zhong","year":"2014","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.fsi.2022.10.002_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20090272","article-title":"Pathogen recognition in the innate immune response","volume":"420","author":"Kumar","year":"2009","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.fsi.2022.10.002_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.imbio.2006.01.001","article-title":"Pathogen recognition and signalling in the Drosophila innate immune response","volume":"211","author":"Wang","year":"2006","journal-title":"Immunobiology"},{"issue":"5","key":"10.1016\/j.fsi.2022.10.002_bib37","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.coi.2011.08.001","article-title":"Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter","volume":"23","author":"Belgnaoui","year":"2011","journal-title":"Curr. Opin. Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2022.10.002_bib38","doi-asserted-by":"crossref","first-page":"6249","DOI":"10.4049\/jimmunol.0903748","article-title":"The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation","volume":"184","author":"Zhong","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2022.10.002_bib39","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1038\/ncomms8910","article-title":"The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling","volume":"6","author":"Yoo","year":"2015","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.fsi.2022.10.002_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006648","article-title":"PKACs attenuate innate antiviral response by phosphorylating VISA and priming it for MARCH5-mediated degradation","volume":"13","author":"Yan","year":"2017","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.fsi.2022.10.002_bib41","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1073\/pnas.95.3.963","article-title":"Nlk is a murine protein kinase related to Erk\/MAP kinases and localized in the nucleus","volume":"95","author":"Brott","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.fsi.2022.10.002_bib42","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1097\/IGC.0b013e3182262030","article-title":"Expression of NLK and its potential effect in ovarian cancer chemotherapy","volume":"21","author":"Zhang","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"14","key":"10.1016\/j.fsi.2022.10.002_bib43","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/pros.20998","article-title":"Nemo-like kinase induces apoptosis and inhibits androgen receptor signaling in prostate cancer cells","volume":"69","author":"Emami","year":"2009","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.fsi.2022.10.002_bib44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.fsi.2014.09.002","article-title":"Fish MAVS is involved in RLR pathway-mediated IFN response","volume":"41","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2022.10.002_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004726","article-title":"TRIM26 negatively regulates interferon-\u03b2 production and antiviral response through polyubiquitination and degradation of nuclear IRF3","volume":"11","author":"Wang","year":"2015","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.fsi.2022.10.002_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.dci.2014.11.014","article-title":"Ctenopharyngodon idella IRF2 plays an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genes","volume":"49","author":"Gu","year":"2015","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822006453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464822006453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:38:52Z","timestamp":1760938732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464822006453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":46,"alternative-id":["S1050464822006453"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2022.10.002","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Grass carp (Ctenopharyngodon idella) NLK2 inhibits IFN I response through blocking MAVS-IRF3 axis","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2022.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}