{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:58:47Z","timestamp":1786989527979,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.fsi.2023.108569","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T18:38:41Z","timestamp":1674931121000},"page":"108569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Molecular characterization of the cytotoxic and regulatory T cell coreceptor (CRTAM), and its ligand CADM1, in the European seabass and gilthead seabream"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8868-8561","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Garc\u00eda-\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Gonz\u00e1lez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-1458","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0906-7995","authenticated-orcid":false,"given":"Alberto","family":"Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2023.108569_bib1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jaci.2009.12.980","article-title":"Overview of the immune response","volume":"125","author":"Chaplin","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib2","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.bpj.2018.08.020","article-title":"Characterization of CTLA4 trafficking and implications for its function","volume":"115","author":"Khailaie","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.fsi.2023.108569_bib3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/jlb.67.5.725","article-title":"A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM)","volume":"67","author":"Kennedy","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.fsi.2023.108569_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1084\/jem.20150519","article-title":"CRTAM determines the CD4+ cytotoxic T lymphocyte lineage","volume":"213","author":"Takeuchi","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2023.108569_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jneuroim.2005.09.017","article-title":"Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes","volume":"171","author":"Pati\u00f1o-Lopez","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.fsi.2023.108569_bib6","doi-asserted-by":"crossref","first-page":"21955","DOI":"10.1074\/jbc.M502095200","article-title":"Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule","volume":"280","author":"Galibert","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2023.108569_bib7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1182\/blood-2005-02-0817","article-title":"The tumor suppressor TSLC1\/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM","volume":"106","author":"Boles","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.fsi.2023.108569_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ygeno.2005.08.017","article-title":"Bioinformatic characterization of the SynCAM family of immunoglobulin-like domain-containing adhesion molecules","volume":"87","author":"Biederer","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.fsi.2023.108569_bib9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/jb\/mvg198","article-title":"Roles of the intercellular adhesion molecule nectin in intracellular signaling","volume":"134","author":"Shimizu","year":"2003","journal-title":"J. Biochem."},{"key":"10.1016\/j.fsi.2023.108569_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1084\/jem.20130904","article-title":"CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection","volume":"211","author":"Cortez","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2023.108569_bib11","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.4049\/jimmunol.0901248","article-title":"CRTAM confers late-stage activation of CD8 + T cells to regulate retention within lymph node","volume":"183","author":"Takeuchi","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib12","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/biology4040640","article-title":"T cells in fish","volume":"4","author":"Nakanishi","year":"2015","journal-title":"Biology"},{"key":"10.1016\/j.fsi.2023.108569_bib13","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.4049\/jimmunol.1500439","article-title":"Isolation and characterization of salmonid CD4 + T cells","volume":"196","author":"Maisey","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-15629-6","article-title":"Innate cell-mediated cytotoxic activity of European sea bass leucocytes against nodavirus-infected cells: a functional and RNA-seq study","volume":"7","author":"Chaves-Pozo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2023.108569_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/dvdy.21397","article-title":"Six cadm\/SynCAM genes are expressed in the nervous system of developing zebrafish","volume":"237","author":"Pietri","year":"2008","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.fsi.2023.108569_bib16","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/cne.22627","article-title":"Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system","volume":"519","author":"Hunter","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.fsi.2023.108569_bib17","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.fsi.2023.108569_bib18","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2023.108569_bib19","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.fsi.2012.09.002","article-title":"Nodavirus infection induces a great innate cell-mediated cytotoxic activity in resistant, gilthead seabream, and susceptible, European sea bass, teleost fish","volume":"33","author":"Chaves-Pozo","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.molimm.2013.02.009","article-title":"Regulation of natural killer enhancing factor (NKEF) genes in teleost fish, gilthead seabream and European sea bass","volume":"55","author":"Esteban","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib21","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.3389\/fimmu.2019.02579","article-title":"Fish granzyme A shows a greater role than granzyme B in fish innate cell-mediated cytotoxicity","volume":"10","author":"Chaves-Pozo","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2023.108569_bib23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.fsi.2018.11.024","article-title":"European sea bass brain DLB-1 cell line is susceptible to nodavirus: a transcriptomic study","volume":"86","author":"Chaves-Pozo","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib24","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1098\/rstb.2001.0975","article-title":"Comparative genomics provides evidence for an ancient genome duplication event in fish","volume":"356","author":"Taylor","year":"2001","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.fsi.2023.108569_bib25","article-title":"Class-I MHC-restricted T-cell associated molecule (CRTAM) expression in cerebellum","volume":"3","author":"L\u00f3pez-Bayghen","year":"2020","journal-title":"Acta Sci. Neurol."},{"key":"10.1016\/j.fsi.2023.108569_bib26","series-title":"Mucosal Health in Aquaculture Fish Mucosal Immunity: Gill","author":"Koppang","year":"2015"},{"key":"10.1016\/j.fsi.2023.108569_bib27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1523\/JNEUROSCI.3165-04.2005","article-title":"Selective capability of SynCAM and neuroligin for functional synapse assembly","volume":"25","author":"Sara","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.fsi.2023.108569_bib28","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1126\/science.1072356","article-title":"SynCAM, a synaptic adhesion molecule that drives synapse assembly","volume":"297","author":"Biederer","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.fsi.2023.108569_bib29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/mrd.1072","article-title":"Cloning and characterization of a novel mouse immunoglobulin superfamily gene expressed in early spermatogenic cells","volume":"60","author":"Wakayama","year":"2001","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.fsi.2023.108569_bib30","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1084\/jem.20092618","article-title":"Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8\u03b1+ dendritic cells","volume":"207","author":"Poulin","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2023.108569_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033196","article-title":"Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss)","volume":"7","author":"Bassity","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2023.108569_bib32","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.dci.2014.11.010","article-title":"Characterization of surface phenotypic molecules of teleost dendritic cells","volume":"49","author":"Shao","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib33","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.1500322","article-title":"Identification of teleost skin CD8\u03b1 + dendritic-like cells, representing a potential common ancestor for mammalian cross-presenting dendritic cells","volume":"195","author":"Granja","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.fsi.2020.12.006","article-title":"Molecular characterization of the T cell costimulatory receptors CD28 and CTLA4 in the European sea bass","volume":"109","author":"Gonz\u00e1lez-Fernandez","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib35","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.4049\/jimmunol.1801090","article-title":"Cutting edge: transcriptional profiling reveals multifunctional and cytotoxic antiviral responses of Zika virus\u2013specific CD8 + T cells","volume":"201","author":"Grifoni","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2023.108569_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.dci.2012.02.007","article-title":"Viral nervous necrosis virus persistently replicates in the central nervous system of asymptomatic gilthead seabream and promotes a transient inflammatory response followed by the infiltration of IgM + B lymphocytes","volume":"37","author":"L\u00f3pez-Mu\u00f1oz","year":"2012","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823000554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823000554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:38:03Z","timestamp":1760938683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464823000554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":36,"alternative-id":["S1050464823000554"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2023.108569","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular characterization of the cytotoxic and regulatory T cell coreceptor (CRTAM), and its ligand CADM1, in the European seabass and gilthead seabream","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2023.108569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108569"}}