{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:20:03Z","timestamp":1792034403480,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.fsi.2023.108672","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T20:45:42Z","timestamp":1678221942000},"page":"108672","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4\/ NF-\u03baB\/ p53 pathway"],"prefix":"10.1016","volume":"135","author":[{"given":"Kun","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinze","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.fsi.2023.108672_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-04215-4","article-title":"The spliceosome factor sart3 regulates hematopoietic stem\/progenitor cell development in zebrafish through the p53 pathway","volume":"12","author":"Zhao","year":"2021","journal-title":"Cell Death Dis."},{"issue":"19","key":"10.1016\/j.fsi.2023.108672_bib2","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.3390\/ijms21196996","article-title":"Cellular and molecular mechanisms of environmental pollutants on hematopoiesis","volume":"21","author":"Scharf","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.fsi.2023.108672_bib3","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.celrep.2018.01.013","article-title":"TRAF6 mediates basal activation of NF-\u03baB necessary for hematopoietic stem cell homeostasis","volume":"22","author":"Fang","year":"2018","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.fsi.2023.108672_bib4","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1128\/MCB.01061-13","article-title":"TET2 plays an essential role in erythropoiesis by regulating lineage-specific genes via DNA oxidative demethylation in a zebrafish model","volume":"34","author":"Ge","year":"2014","journal-title":"Molcul. Cell. Biol."},{"issue":"2","key":"10.1016\/j.fsi.2023.108672_bib5","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1001\/jama.1965.03090020024006","article-title":"Aplastic anemia following exposure to benzene hexachloride (lindane)","volume":"193","author":"Loge","year":"1965","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.fsi.2023.108672_bib6","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/carcin\/bgi078","article-title":"Hemoglobin adducts, urinary metabolites and health effects in 2, 4, 6-trinitrotoluene exposed workers","volume":"26","author":"Sabbioni","year":"2005","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.fsi.2023.108672_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00007611-198301000-00013","article-title":"Aplastic anemia and red cell aplasia due to pentachlorophenol","volume":"76","author":"Roberts","year":"1983","journal-title":"South. Med. J."},{"issue":"7","key":"10.1016\/j.fsi.2023.108672_bib8","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1021\/tx3001169","article-title":"Stem cell and benzene-induced malignancy and hematotoxicity","volume":"25","author":"Wang","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.fsi.2023.108672_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111490","article-title":"Toxicity in hematopoietic stem cells from bone marrow and peripheral blood in mice after benzene exposure: single-cell transcriptome sequencing analysis","volume":"207","author":"Sun","year":"2021","journal-title":"Ecotoxicol. Environ. Safety"},{"issue":"3","key":"10.1016\/j.fsi.2023.108672_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/10408444.2017.1401581","article-title":"Shanghai Health Study (2001\u20132009): what was learned about benzene health effects?","volume":"48","author":"Gross","year":"2018","journal-title":"Crit. Rev. Toxicol."},{"issue":"8","key":"10.1016\/j.fsi.2023.108672_bib11","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/jat.3961","article-title":"Benzene and its effects on cell signaling pathways related to hematopoiesis and leukemia","volume":"40","author":"Lu","year":"2020","journal-title":"J. Appl. Toxicol."},{"issue":"4","key":"10.1016\/j.fsi.2023.108672_bib12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/01647954.2019.1607550","article-title":"Sublethal effects of diflovidazin on demographic parameters of the predatory mite, Neoseiulus californicus (Acari: Phytoseiidae)","volume":"45","author":"Havasi","year":"2019","journal-title":"Int. J. Acarol"},{"key":"10.1016\/j.fsi.2023.108672_bib13","first-page":"62","article-title":"Evaluation of a Hungarian acaricide original molecule based on its environmental toxicological studies","volume":"8","author":"Szamosi","year":"2000","journal-title":"Cent. Eur. J. Publ. Health"},{"issue":"2","key":"10.1016\/j.fsi.2023.108672_bib14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2353\/ajpath.2006.060312","article-title":"Hematopoietic stem cells: the paradigmatic tissue-specific stem cell","volume":"169","author":"Bryder","year":"2006","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.fsi.2023.108672_bib15","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.cell.2014.10.031","article-title":"Proinflammatory signaling regulates hematopoietic stem cell emergence","volume":"159","author":"Esp\u00edn-Palaz\u00f3n","year":"2014","journal-title":"Cell"},{"issue":"25","key":"10.1016\/j.fsi.2023.108672_bib16","first-page":"5015","article-title":"Deletion of the NF-\u03baB subunit p65\/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function, Blood","volume":"121","author":"Stein","year":"2013","journal-title":"J. Am. Soc. Hematol."},{"issue":"1","key":"10.1016\/j.fsi.2023.108672_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.leu.2403171","article-title":"NF-\u03ba B\/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors","volume":"18","author":"Turco","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.fsi.2023.108672_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117146","article-title":"HMGB1 upregulates NF-kB by inhibiting IKB-\u03b1 and associates with diabetic retinopathy","volume":"241","author":"Liang","year":"2020","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.fsi.2023.108672_bib19","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.4049\/jimmunol.1003438","article-title":"Chronic exposure to a TLR ligand injures hematopoietic stem cells","volume":"186","author":"Esplin","year":"2011","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2023.108672_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20001858","article-title":"Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4","volume":"195","author":"Termeer","year":"2002","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.fsi.2023.108672_bib21","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-\u03baB by toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.fsi.2023.108672_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116479","article-title":"Trichlorocarban induces developmental and immune toxicity to zebrafish (Danio rerio) by targeting TLR4\/MyD88\/NF-\u03baB signaling pathway","volume":"273","author":"Xu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fsi.2023.108672_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.125870","article-title":"The immunotoxicity and neurobehavioral toxicity of zebrafish induced by famoxadone-cymoxanil","volume":"247","author":"Cheng","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2023.108672_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.chemosphere.2019.05.159","article-title":"Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)","volume":"232","author":"Qiu","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.fsi.2023.108672_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.125941","article-title":"Thiophanate-methyl induces severe hepatotoxicity in zebrafish","volume":"248","author":"Jia","year":"2020","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.fsi.2023.108672_bib26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1053\/j.gastro.2013.11.045","article-title":"Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish","volume":"146","author":"He","year":"2014","journal-title":"Gastroenterology"},{"issue":"19","key":"10.1016\/j.fsi.2023.108672_bib27","first-page":"2974","article-title":"Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish, Blood","volume":"125","author":"Shi","year":"2015","journal-title":"J. Am. Soc. Hematol."},{"issue":"5","key":"10.1016\/j.fsi.2023.108672_bib28","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/leu.2016.320","article-title":"Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte\u2013specific reporter line in zebrafish","volume":"31","author":"Lin","year":"2017","journal-title":"Leukemia"},{"issue":"6431","key":"10.1016\/j.fsi.2023.108672_bib29","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1126\/science.aav1749","article-title":"AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate","volume":"363","author":"Gu","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.fsi.2023.108672_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112385","article-title":"Effects of sulfometuron-methyl on zebrafish at early developmental stages","volume":"220","author":"Yuan","year":"2021","journal-title":"Ecotoxicol. Environ. Safety"},{"issue":"20","key":"10.1016\/j.fsi.2023.108672_bib31","doi-asserted-by":"crossref","first-page":"12998","DOI":"10.1021\/acs.est.0c02934","article-title":"Tetrabromobisphenol A Perturbs erythropoiesis and impairs blood circulation in zebrafish embryos","volume":"54","author":"Pang","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.fsi.2023.108672_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115895","article-title":"Bioconcentration and developmental neurotoxicity of novel brominated flame retardants, hexabromobenzene and pentabromobenzene in zebrafish","volume":"268","author":"Chen","year":"2021","journal-title":"Environ. Pollut."},{"issue":"21","key":"10.1016\/j.fsi.2023.108672_bib33","doi-asserted-by":"crossref","first-page":"8785","DOI":"10.1007\/s00253-019-10103-x","article-title":"Production of sesterterpene ophiobolin by a bifunctional terpene synthase in Escherichia coli","volume":"103","author":"Yuan","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"2","key":"10.1016\/j.fsi.2023.108672_bib34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"5","key":"10.1016\/j.fsi.2023.108672_bib35","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1476-5381.2009.00223.x","article-title":"Comprehensive evaluation of a novel nuclear factor\u2010\u03baB inhibitor, quinoclamine, by transcriptomic analysis","volume":"157","author":"Cheng","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.fsi.2023.108672_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117323","article-title":"Effect of flupyradifurone on zebrafish embryonic development","volume":"285","author":"Zhong","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fsi.2023.108672_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113218","article-title":"Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life","volume":"255","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"issue":"15","key":"10.1016\/j.fsi.2023.108672_bib38","first-page":"4093","article-title":"cMyb regulates hematopoietic stem\/progenitor cell mobilization during zebrafish hematopoiesis, Blood","volume":"118","author":"Zhang","year":"2011","journal-title":"J. Am. Soc. Hematol."},{"issue":"7","key":"10.1016\/j.fsi.2023.108672_bib39","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1182\/blood-2005-02-0557","article-title":"SCL\/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment","volume":"106","author":"Reynaud","year":"2005","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.fsi.2023.108672_bib40","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201910316","article-title":"The genetics of human hematopoiesis and its disruption in disease","volume":"11","author":"Bao","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.fsi.2023.108672_bib41","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00420-020-01619-1","article-title":"Effect of lead exposure from electronic waste on haemoglobin synthesis in children","volume":"94","author":"Wang","year":"2021","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.fsi.2023.108672_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.111917","article-title":"Protective effects of folic acid on oxidative damage of rat spleen induced by lead acetate","volume":"211","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Safety"},{"key":"10.1016\/j.fsi.2023.108672_bib43","article-title":"Hematopoietic stem cell and immunotoxicity in zebrafish embryos induced by exposure to Metalaxyl-M","volume":"809","author":"Zeng","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"3","key":"10.1016\/j.fsi.2023.108672_bib44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0968-0896(02)00440-6","article-title":"Discovery of quinazolines as a novel structural class of potent inhibitors of NF-\u03baB activation","volume":"11","author":"Tobe","year":"2003","journal-title":"Bioorg. Med. Chem."},{"issue":"5","key":"10.1016\/j.fsi.2023.108672_bib45","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1128\/MCB.19.5.3485","article-title":"Transcriptional cross talk between NF-\u03baB and p53","volume":"19","author":"Webster","year":"1999","journal-title":"Molcul. Cell. Biol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823001584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823001584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:40:56Z","timestamp":1760938856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464823001584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":45,"alternative-id":["S1050464823001584"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2023.108672","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4\/ NF-\u03baB\/ p53 pathway","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2023.108672","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108672"}}