{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T13:52:52Z","timestamp":1777038772322,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.fsi.2023.108858","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T11:50:55Z","timestamp":1686397855000},"page":"108858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Differentiation and traffic of IgM+ B cells between focal dark spots in skeletal muscle of Atlantic salmon, lymphoid and adipose tissues"],"prefix":"10.1016","volume":"139","author":[{"given":"Ra\u00fal","family":"Jim\u00e9nez-Guerrero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Karlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Boudinot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Afanasyev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turid","family":"M\u00f8rk\u00f8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksei","family":"Krasnov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2023.108858_bib1","series-title":"EX-Spot","first-page":"78","author":"M\u00f8rk\u00f8re","year":"2022"},{"key":"10.1016\/j.fsi.2023.108858_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.fsi.2016.05.012","article-title":"Gene expression profiling in melanised sites of Atlantic salmon fillets","volume":"55","author":"Krasnov","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.108858_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738697","article-title":"Rib abnormalities and their association with focal dark spots in Atlantic salmon fillets","volume":"561","author":"Jim\u00e9nez-Guerrero","year":"2022","journal-title":"Aquac"},{"key":"10.1016\/j.fsi.2023.108858_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.664624","article-title":"PRV-1 Infected macrophages in melanized focal changes in white muscle of Atlantic Salmon (Salmo salar) correlates with a pro-inflammatory environment","volume":"12","author":"Malik","year":"2021","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.fsi.2023.108858_bib5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/jfd.12995","article-title":"Melanized focal changes in skeletal muscle in farmed Atlantic salmon after natural infection with Piscine orthoreovirus (PRV)","volume":"42","author":"Bj\u00f8rgen","year":"2019","journal-title":"J. Fish. Dis."},{"issue":"2","key":"10.1016\/j.fsi.2023.108858_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.fsi.2012.05.012","article-title":"Pigment-producing granulomatous myopathy in Atlantic salmon: a novel inflammatory response","volume":"33","author":"Larsen","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.108858_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.611795","article-title":"Immunosuppressive mechanisms of regulatory B cells","volume":"12","author":"Catal\u00e1n","year":"2021","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2023.108858_bib8","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101095RR","article-title":"B cells support the repair of injured tissues by adopting MyD88-dependent regulatory functions and phenotype","volume":"35","author":"S\u00eerbulescu","year":"2021","journal-title":"Faseb. J."},{"issue":"3","key":"10.1016\/j.fsi.2023.108858_bib9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"Nutt","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2023.108858_bib10","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/ni.1814","article-title":"Multiple layers of B cell memory with different effector functions","volume":"10","author":"Dogan","year":"2009","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2023.108858_bib11","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1073\/pnas.94.1.208","article-title":"Memory B lymphocytes migrate to bone marrow in humans","volume":"94","author":"Paramithiotis","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.fsi.2023.108858_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ai.2022.08.001","article-title":"Development and function of tissue-resident memory B cells","volume":"155","author":"Chen","year":"2022","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.fsi.2023.108858_bib13","series-title":"Principles of Fish Immunology : from Cells and Molecules to Host Protection","first-page":"1","article-title":"Anatomy of teleost fish immune structures and organs","author":"Bj\u00f8rgen","year":"2022"},{"key":"10.1016\/j.fsi.2023.108858_bib14","series-title":"Principles of Fish Immunology : from Cells and Molecules to Host Protection","first-page":"105","article-title":"Adaptive immunity","author":"Ab\u00f3s","year":"2022"},{"key":"10.1016\/j.fsi.2023.108858_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molimm.2017.06.022","article-title":"Ig-seq: deep sequencing of the variable region of Atlantic salmon IgM heavy chain transcripts","volume":"88","author":"Krasnov","year":"2017","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2023.108858_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines8030493","article-title":"IgM+ and IgT+ B cell traffic to the heart during SAV infection in atlantic salmon","volume":"8","author":"Bakke","year":"2020","journal-title":"Vaccines"},{"issue":"Suppl","key":"10.1016\/j.fsi.2023.108858_bib17","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/S0092-8674(02)00675-X","article-title":"The mechanism and regulation of chromosomal V(D)J recombination","volume":"109","author":"Bassing","year":"2002","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.fsi.2023.108858_bib18","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/1471-2164-11-486","article-title":"Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar","volume":"11","author":"Yasuike","year":"2010","journal-title":"BMC Genom."},{"issue":"5","key":"10.1016\/j.fsi.2023.108858_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/genes13050736","article-title":"Evaluation of immune status in two cohorts of atlantic salmon raised in different aquaculture systems (case study)","volume":"13","author":"Lund","year":"2022","journal-title":"Genes"},{"issue":"3","key":"10.1016\/j.fsi.2023.108858_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/vaccines8030493","article-title":"IgM+ and IgT+ B cell traffic to the heart during SAV infection in atlantic salmon","volume":"8","author":"Bakke","year":"2020","journal-title":"Vaccines"},{"issue":"5","key":"10.1016\/j.fsi.2023.108858_bib21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ni1454","article-title":"Pax5: the guardian of B cell identity and function","volume":"8","author":"Cobaleda","year":"2007","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2023.108858_bib22","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2204","article-title":"BLIMP1 guides the fate of effector B and T cells","volume":"7","author":"Nutt","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2023.108858_bib23","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.dci.2011.01.009","article-title":"Dissecting teleost B cell differentiation using transcription factors","volume":"35","author":"Zwollo","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2023.108858_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00129039-200106000-00001","article-title":"CD79: a review","volume":"9","author":"Chu","year":"2001","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"7","key":"10.1016\/j.fsi.2023.108858_bib25","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1016\/S0021-9258(18)42905-5","article-title":"Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk","volume":"267","author":"Dymecki","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.fsi.2023.108858_bib26","first-page":"427","article-title":"BTLA, a new inhibitory B7 family receptor with a TNFR family ligand","volume":"2","author":"Zeng","year":"2005","journal-title":"Cell. Mol. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2023.108858_bib27","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.176.7.3942","article-title":"Phenotypic and functional similarity of gut intraepithelial and systemic T cells in a teleost fish","volume":"176","author":"Bernard","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2023.108858_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-065X.1997.tb00956.x","article-title":"Dendritic cells in the T-cell areas of lymphoid organs","volume":"156","author":"Steinman","year":"1997","journal-title":"Immunol. Rev."},{"issue":"12","key":"10.1016\/j.fsi.2023.108858_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082737","article-title":"Transcriptional heterogeneity of IgM+ cells in rainbow trout (Oncorhynchus mykiss) tissues","volume":"8","author":"Ab\u00f3s","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.fsi.2023.108858_bib30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.dci.2012.07.011","article-title":"CD40L--a costimulatory molecule involved in the maturation of antigen presenting cells in Atlantic salmon (Salmo salar)","volume":"38","author":"Lagos","year":"2012","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2023.108858_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.736964","article-title":"Secretome profiling of atlantic salmon head kidney leukocytes highlights the role of phagocytes in the immune response to soluble \u03b2-glucan","volume":"12","author":"Iliev","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2023.108858_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fimmu.2019.00037","article-title":"Profiling the atlantic salmon IgM(+) B cell surface proteome: novel information on teleost fish B cell protein repertoire and identification of potential B cell markers","volume":"10","author":"Pe\u00f1aranda","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2023.108858_bib33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.vetimm.2010.07.024","article-title":"Molecular cloning of IgT from Atlantic salmon, and analysis of the relative expression of \u03c4, \u03bc, and \u03b4 in different tissues","volume":"139","author":"Tadiso","year":"2011","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2023.108858_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104125","article-title":"The importance of the Atlantic salmon peritoneal cavity B cell response: local IgM secreting cells are predominant upon Piscirickettsia salmonis infection","volume":"123","author":"van der Wal","year":"2021","journal-title":"Dev. Comp. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2023.108858_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jviromet.2009.07.003","article-title":"Reference genes evaluated for use in infectious pancreatic necrosis virus real-time RT-qPCR assay applied during different stages of an infection","volume":"162","author":"Julin","year":"2009","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.fsi.2023.108858_bib36","author":"Lefranc"},{"key":"10.1016\/j.fsi.2023.108858_bib37","series-title":"M\u00f8rke Flekker I Laksefilet \u2013 Kunnskapsstatus Og Tiltak for \u00c5 Begrense Omfanget","author":"M\u00f8rk\u00f8re","year":"2012"},{"issue":"3","key":"10.1016\/j.fsi.2023.108858_bib38","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1439-0426.2012.01988.x","article-title":"Vaccinated farmed Atlantic salmon are susceptible to spinal and skull deformities","volume":"28","author":"Berg","year":"2012","journal-title":"J. Appl. Ichthyol."},{"issue":"5","key":"10.1016\/j.fsi.2023.108858_bib39","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/eji.1830040505","article-title":"Phylogeny of the lymphoid system. I. A study of the fate of circulating lymphocytes in plaice","volume":"4","author":"Ellis","year":"1974","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.fsi.2023.108858_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1058877","article-title":"Immunoglobulin VDJ repertoires reveal hallmarks of germinal centers in unique cell clusters isolated from zebrafish (Danio rerio) lymphoid tissues","volume":"13","author":"Waly","year":"2022","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2023.108858_bib41","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1046\/j.1365-2761.2003.00485.x","article-title":"Melano-macrophage centres and their role in fish pathology","volume":"26","author":"Agius","year":"2003","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2023.108858_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.666879","article-title":"Role of immunoglobulins in muscular dystrophies and inflammatory myopathies","volume":"12","author":"Farini","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2023.108858_bib43","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/art.39017","article-title":"Injury and subsequent regeneration of muscles for activation of local innate immunity to facilitate the development and relapse of autoimmune myositis in C57BL\/6 Mice","volume":"67","author":"Kimura","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"6","key":"10.1016\/j.fsi.2023.108858_bib44","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/cdd.2015.171","article-title":"Cell death, clearance and immunity in the skeletal muscle","volume":"23","author":"Sciorati","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2023.108858_bib45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.coi.2018.09.012","article-title":"Natural regulatory plasma cells","volume":"55","author":"Fillatreau","year":"2018","journal-title":"Curr. Opin. Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2023.108858_bib46","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ncprheum0760","article-title":"Mechanisms of disease: autoantigens as clues to the pathogenesis of myositis","volume":"4","author":"Suber","year":"2008","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1016\/j.fsi.2023.108858_bib47","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.fsi.2023.108858_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103116","article-title":"The role of B cell metabolism in autoimmune diseases","volume":"21","author":"Mubariki","year":"2022","journal-title":"Autoimmun. Rev."},{"issue":"4","key":"10.1016\/j.fsi.2023.108858_bib49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/mus.21739","article-title":"Permissive environment for B-cell maturation in myositis muscle in the absence of B-cell follicles","volume":"42","author":"Salajegheh","year":"2010","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.fsi.2023.108858_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.868551","article-title":"Functional and phenotypic characterization of B cells in the teleost adipose tissue","volume":"13","author":"Sim\u00f3n","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823003443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823003443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:48:11Z","timestamp":1760939291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464823003443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":50,"alternative-id":["S1050464823003443"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2023.108858","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differentiation and traffic of IgM+ B cells between focal dark spots in skeletal muscle of Atlantic salmon, lymphoid and adipose tissues","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2023.108858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108858"}}