{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:59:12Z","timestamp":1788184752258,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"National Natural Science Foundation of China National Outstanding Youth Science Fund Project","doi-asserted-by":"publisher","award":["81773968"],"award-info":[{"award-number":["81773968"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.fsi.2023.109054","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T05:02:27Z","timestamp":1693717347000},"page":"109054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Quercetin attenuates avermectin-induced cardiac injury in carp through inflammation, oxidative stress, apoptosis and autophagy"],"prefix":"10.1016","volume":"141","author":[{"given":"Baoshi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchao","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajie","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunhan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9379-0282","authenticated-orcid":false,"given":"Zibo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.fsi.2023.109054_bib1","article-title":"Ameliorative effect of quercetin against abamectin-induced hemato-biochemical alterations and hepatorenal oxidative damage in nile Tilapia","volume":"12","author":"Mansour","year":"2022","journal-title":"Oreochromis Niloticus, Animals"},{"issue":"Pt 1","key":"10.1016\/j.fsi.2023.109054_bib2","article-title":"Abamectin promotes behavior changes and liver injury in zebrafish","volume":"311","author":"Santos","year":"2023","journal-title":"Chemosphere"},{"issue":"19","key":"10.1016\/j.fsi.2023.109054_bib3","doi-asserted-by":"crossref","first-page":"55200","DOI":"10.1007\/s11356-023-26166-3","article-title":"Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy","volume":"30","author":"Feng","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fsi.2023.109054_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ecoenv.2013.09.021","article-title":"Avermectin induced liver injury in pigeon: mechanisms of apoptosis and oxidative stress","volume":"98","author":"Zhu","year":"2013","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fsi.2023.109054_bib5","article-title":"Avermectin induces toxic effects in insect nontarget cells involves DNA damage and its associated programmed cell death, Comparative biochemistry and physiology","volume":"249","author":"Li","year":"2021","journal-title":"Toxicol. Pharmacol. : CBP"},{"issue":"Pt B","key":"10.1016\/j.fsi.2023.109054_bib6","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.envpol.2016.11.022","article-title":"Cytotoxic effects of Avermectin on human HepG2 cells in vitro bioassays","volume":"220","author":"Zhang","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fsi.2023.109054_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2022.105190","article-title":"Non-target toxic effects of avermectin on carp spleen involve oxidative stress, inflammation, and apoptosis","volume":"187","author":"Zhang","year":"2022","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fsi.2023.109054_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113961","article-title":"Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K\/Akt and NF-\u03baB pathways","volume":"243","author":"Zhang","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.fsi.2023.109054_bib9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.pestbp.2016.06.005","article-title":"Avermectin induced global DNA hypomethylation and over-expression of heat shock proteins in cardiac tissues of pigeon","volume":"135","author":"Liu","year":"2017","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.fsi.2023.109054_bib10","article-title":"Avermectin induces cardiac toxicity in early embryonic stage of zebrafish, Comparative biochemistry and physiology","volume":"264","author":"Du","year":"2023","journal-title":"Toxicol. Pharmacol. : CBP"},{"issue":"11","key":"10.1016\/j.fsi.2023.109054_bib11","doi-asserted-by":"crossref","first-page":"29494","DOI":"10.1007\/s11356-022-24004-6","article-title":"Abamectin causes cardiac dysfunction in carp via inhibiting redox equilibrium and resulting in immune inflammatory response and programmed cell death","volume":"30","author":"Zhao","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.fsi.2023.109054_bib12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.plaphy.2021.05.023","article-title":"The role of quercetin in plants","volume":"166","author":"Singh","year":"2021","journal-title":"Plant Physiol. Biochem. : PPB (Plant Physiol. Biochem.)"},{"issue":"4","key":"10.1016\/j.fsi.2023.109054_bib13","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/ptr.7397","article-title":"Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin","volume":"36","author":"Chen","year":"2022","journal-title":"Phytother Res. : PTR"},{"issue":"22","key":"10.1016\/j.fsi.2023.109054_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26226949","article-title":"Quercetin prevents LPS-induced oxidative stress and inflammation by modulating NOX2\/ROS\/NF-kB in lung epithelial cells","volume":"26","author":"Sul","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.fsi.2023.109054_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118036","article-title":"Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN\/PI3K\/AKT in grass carp hepatocytes","volume":"290","author":"Miao","year":"2021","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.fsi.2023.109054_bib16","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/1759-7714.13925","article-title":"Quercetin induces pro-apoptotic autophagy via SIRT1\/AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro","volume":"12","author":"Guo","year":"2021","journal-title":"Thoracic cancer"},{"issue":"11","key":"10.1016\/j.fsi.2023.109054_bib17","doi-asserted-by":"crossref","first-page":"15896","DOI":"10.1007\/s11356-021-16965-x","article-title":"Assessment of reproductive toxicity of carbofuran and copper sulfate in male Nile tilapia (Oreochromis niloticus)","volume":"29","author":"Oda","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"6","key":"10.1016\/j.fsi.2023.109054_bib18","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/jwas.12663","article-title":"Dietary quercetin improved the growth, antioxidation, and flesh quality of grass carp (Ctenopharyngodon idella)","volume":"50","author":"Xu","year":"2019","journal-title":"J. World Aquacult. Soc."},{"key":"10.1016\/j.fsi.2023.109054_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.769777","article-title":"Vibrio alginolyticus triggers inflammatory response in mouse peritoneal macrophages via activation of NLRP3 inflammasome","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"8","key":"10.1016\/j.fsi.2023.109054_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.219","article-title":"\u03b1-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt\/mTOR pathway","volume":"6","author":"Hasanain","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.fsi.2023.109054_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.114068","article-title":"Quercetin derivatives: drug design, development, and biological activities, a review","volume":"229","author":"Alizadeh","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.fsi.2023.109054_bib22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11250-022-03429-8","article-title":"The protective effects of quercetin on the physiological responses in malathion-exposed common carp, Cyprinus carpio","volume":"55","author":"Nasirin","year":"2022","journal-title":"Trop. Anim. Health Prod."},{"key":"10.1016\/j.fsi.2023.109054_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1168262","article-title":"Quercetin application for common carp (Cyprinus carpio): I. Effects on growth performance, humoral immunity, antioxidant status, immune-related genes, and resistance against heat stress","volume":"2023","author":"Armobin","year":"2023","journal-title":"Aquacult. Nutr."},{"issue":"2","key":"10.1016\/j.fsi.2023.109054_bib24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.fsi.2014.02.015","article-title":"Regulatory effect of quercetin on hazardous microcystin-LR-induced apoptosis of Carassius auratus lymphocytes in vitro","volume":"37","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109054_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.fsi.2022.08.042","article-title":"Modulatory role of dietary curcumin and resveratrol on growth performance, serum immunity responses, mucus enzymes activity, antioxidant capacity and serum and mucus biochemicals in the common carp, Cyprinus carpio exposed to abamectin","volume":"129","author":"Rohmah","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109054_bib26","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jhazmat.2018.12.014","article-title":"Immunosuppression, oxidative stress, and glycometabolism disorder caused by cadmium in common carp (Cyprinus carpio L.): application of transcriptome analysis in risk assessment of environmental contaminant cadmium","volume":"366","author":"Chen","year":"2019","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.fsi.2023.109054_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108883","article-title":"Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills","volume":"139","author":"Li","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109054_bib28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.scitotenv.2019.01.245","article-title":"Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish","volume":"662","author":"Qiao","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2023.109054_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108508","article-title":"Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp","volume":"132","author":"Wu","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109054_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101338","article-title":"Autophagy in the diabetic heart: a potential pharmacotherapeutic target in diabetic cardiomyopathy","volume":"68","author":"Dewanjee","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"7","key":"10.1016\/j.fsi.2023.109054_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22336","article-title":"Abamectin induces apoptosis and autophagy by inhibiting reactive oxygen species-mediated PI3K\/AKT signaling in MGC803 cells","volume":"33","author":"Zhu","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"8","key":"10.1016\/j.fsi.2023.109054_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22505","article-title":"ROS accumulation contributes to abamectin-induced apoptosis and autophagy via the inactivation of PI3K\/AKT\/mTOR pathway in TM3 Leydig cells","volume":"34","author":"Zhu","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.fsi.2023.109054_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2021.737182","article-title":"Deoxynivalenol induces carp neutrophil apoptosis and necroptosis via CYP450s\/ROS\/PI3K\/AKT pathway","volume":"545","author":"Ding","year":"2021","journal-title":"Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2023.109054_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tibs.2010.07.007","article-title":"Regulation of autophagy by ROS: physiology and pathology","volume":"36","author":"Scherz-Shouval","year":"2011","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.fsi.2023.109054_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/cdd.2008.163","article-title":"The role of autophagy in the heart","volume":"16","author":"Nishida","year":"2009","journal-title":"Cell Death Differ."},{"issue":"7","key":"10.1016\/j.fsi.2023.109054_bib36","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1080\/15548627.2016.1179410","article-title":"Autophagy in sepsis: degradation into exhaustion?","volume":"12","author":"Ho","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.fsi.2023.109054_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175252","article-title":"Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy","volume":"933","author":"Fan","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.fsi.2023.109054_bib38","doi-asserted-by":"crossref","first-page":"9289","DOI":"10.1038\/s41598-017-09673-5","article-title":"Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-\u03b21\/Smads and PI3K\/Akt pathways","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.fsi.2023.109054_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ani12243524","article-title":"Quercetin ameliorates lipopolysaccharide-induced duodenal inflammation through modulating autophagy, programmed cell death and intestinal mucosal barrier function in chicken embryos","volume":"12","author":"Yu","year":"2022","journal-title":"Animals"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823005405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823005405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:49:01Z","timestamp":1760939341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464823005405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":39,"alternative-id":["S1050464823005405"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2023.109054","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin attenuates avermectin-induced cardiac injury in carp through inflammation, oxidative stress, apoptosis and autophagy","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2023.109054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109054"}}