{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:28:37Z","timestamp":1793881717804,"version":"4.7.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.fsi.2023.109303","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T22:05:41Z","timestamp":1702677941000},"page":"109303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Effects of geniposide on innate immunity and antiviral activity of Scylla paramamosain"],"prefix":"10.1016","volume":"145","author":[{"given":"Jing","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingri","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2023.109303_bib1","first-page":"1","article-title":"A revision of the genus Scylla de haan, 1833 (Crustacea: Decapoda: Brachyura: portunidae)","volume":"46","author":"Keenan","year":"1998","journal-title":"Raffles Bull. Zool."},{"key":"10.1016\/j.fsi.2023.109303_bib2","first-page":"617","article-title":"Status of mud crabs (Scylla spp.) farming and studies on the population biology of S. paramamosain","volume":"55","author":"L i","year":"2016","journal-title":"J. Xiamen Univ."},{"key":"10.1016\/j.fsi.2023.109303_bib3","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3390\/v14040743","article-title":"Role of cellular receptors in the innate immune system of Crustaceans in response to white spot syndrome virus","volume":"14","author":"Tran","year":"2022","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.fsi.2023.109303_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.24018\/ejmed.2020.2.4.359","article-title":"Use essential oil and power of Antihelium Tsihanimposa to eliminate the White Spot Syndrome Virus (WSSV) in organic shrimp culture in Madagascar","volume":"2","author":"Zafilaza","year":"2020","journal-title":"European Journal of Medical and Health Sciences"},{"key":"10.1016\/j.fsi.2023.109303_bib5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.fsi.2018.10.043","article-title":"WSSV-host interaction: host response and immune evasion","volume":"84","author":"Li","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735422","article-title":"A review on the application of herbal medicines in the disease control of aquatic animals","volume":"526","author":"Zhu","year":"2020","journal-title":"Aquaculture"},{"issue":"2","key":"10.1016\/j.fsi.2023.109303_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/biomedicines6020039","article-title":"Plant-derived anticancer agents: lessons from the pharmacology of geniposide and its aglycone","volume":"6","author":"Solomon","year":"2018","journal-title":"Genipin. Biomedicines."},{"issue":"6\u20137","key":"10.1016\/j.fsi.2023.109303_bib8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.neuint.2007.04.021","article-title":"Geniposide, a novel agonist for GLP-1 receptor, prevents PC12 cells from oxidative damage via MAP kinase pathway","volume":"51","author":"Liu","year":"2007","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.fsi.2023.109303_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000445634","article-title":"Geniposide prevents hypoxia\/reoxygenation-induced apoptosis in H9c2 cells: improvement of mitochondrial dysfunction and activation of GLP-1R and the PI3K\/AKT signaling pathway","volume":"39","author":"Jiang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"2","key":"10.1016\/j.fsi.2023.109303_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/13880209.2012.717088","article-title":"Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent","volume":"51","author":"Zhang","year":"2013","journal-title":"Pharmaceut. Biol."},{"issue":"34","key":"10.1016\/j.fsi.2023.109303_bib11","doi-asserted-by":"crossref","first-page":"18926","DOI":"10.1039\/C8RA01038B","article-title":"Geniposide attenuates A\u03b225-35-induced neurotoxicity via the TLR4\/NF-\u03baB pathway in HT22 cells","volume":"8","author":"Huang","year":"2018","journal-title":"RSC Adv."},{"issue":"3","key":"10.1016\/j.fsi.2023.109303_bib12","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s10787-022-00975-3","article-title":"The anti-angiogenesis mechanism of Geniposide on rheumatoid arthritis is related to the regulation of PTEN","volume":"30","author":"Bu","year":"2022","journal-title":"Inflammopharmacology"},{"issue":"12","key":"10.1016\/j.fsi.2023.109303_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081349","article-title":"Eucommia ulmoides Oliver extract, aucubin, and geniposide enhance lysosomal activity to regulate ER stress and hepatic lipid accumulation","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.fsi.2023.109303_bib14","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3923\/pjbs.2009.949.956","article-title":"Isolation of antifungal compounds from Gardenia jasminoides","volume":"12","author":"Lelono","year":"2009","journal-title":"Pakistan J. Biol. Sci."},{"key":"10.1016\/j.fsi.2023.109303_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.755796","article-title":"An integrated analysis reveals geniposide extracted from Gardenia jasminoides J.Ellis regulates calcium signaling pathway essential for influenza A virus replication","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.fsi.2023.109303_bib16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.foodchem.2011.03.090","article-title":"Antioxidant activity of Gardenia jasminoides Ellis fruit extracts","volume":"128","author":"Debnath","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.fsi.2023.109303_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12272-012-0101-3","article-title":"Bioactivity-guided fractionation and analysis of compounds with anti-influenza virus activity from Gardenia jasminoides ellis","volume":"35","author":"Yang","year":"2012","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"7","key":"10.1016\/j.fsi.2023.109303_bib18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3851\/IMP3152","article-title":"Geniposide demonstrates anti-inflammatory and antiviral activity against pandemic A\/Jiangsu\/1\/2009 (H1N1) influenza virus infection in vitro and in vivo","volume":"22","author":"Yunshi","year":"2017","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.fsi.2023.109303_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.fsi.2022.05.037","article-title":"Natural component geniposide enhances survival rate of crayfish Procambarus clarkii infected with white spot syndrome virus","volume":"126","author":"Huang","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.aquaculture.2019.02.008","article-title":"Gardenia jasminoides Ellis inhibit white spot syndrome virus replication in red swamp crayfish Procambarus clarkii","volume":"504","author":"Huang","year":"2019","journal-title":"Aquaculture"},{"issue":"10","key":"10.1016\/j.fsi.2023.109303_bib21","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/jfd.13494","article-title":"iTRAQ-based quantitative proteomic analysis of haemocyte proteins from crayfish (Procambarus clarkii) infected with white spot syndrome virus (WSSV)","volume":"44","author":"Zhou","year":"2021","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2023.109303_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.fsi.2016.04.009","article-title":"Dietary chitosan nanoparticles protect crayfish Procambarus clarkii against white spot syndrome virus (WSSV) infection","volume":"54","author":"Sun","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib23","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.fsi.2017.06.050","article-title":"Epigallocatechin-3-gallate inhibit replication of white spot syndrome virus in Scylla paramamosain","volume":"67","author":"Wang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.118229","article-title":"Immunotoxicity of polychlorinated biphenyls (PCBs) to the marine crustacean species, Scylla paramamosain","volume":"291","author":"Xiao","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.fsi.2023.109303_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738404","article-title":"The mechanism of semicarbazide (SEM) exposure cause immunosuppression and reduce disease resistance of marine crustacean species, Scylla paramamosain","volume":"558","author":"Zhou","year":"2022","journal-title":"Aquaculture"},{"issue":"6","key":"10.1016\/j.fsi.2023.109303_bib26","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.fsi.2011.08.022","article-title":"Effects of immunostimulants targeting Ran GTPase on phagocytosis against virus infection in shrimp","volume":"31","author":"Zhao","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.fsi.2020.04.050","article-title":"Dietary Hizikia fusiforme enhance survival of white spot syndrome virus infected crayfish Procambarus clarkii","volume":"103","author":"Jiang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib28","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1038\/srep02069","article-title":"The Wnt signaling pathway is involved in the regulation of phagocytosis of virus in Drosophila","volume":"3","author":"Zhu","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2023.109303_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.fsi.2018.06.003","article-title":"Comparative transcriptomic analysis of crab hemocytes in response to white spot syndrome virus or Vibrio alginolyticus infection","volume":"80","author":"Zhu","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-DDCt method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2023.109303_bib31","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.fsi.2019.07.076","article-title":"Characterization of the innate immunity in the mud crab Scylla paramamosain","volume":"93","author":"Chen","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2023.109303_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2240","article-title":"Phagocytosis and comparative innate immunity: learning on the fly","volume":"8","author":"Stuart","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.fsi.2023.109303_bib33","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/are.12194","article-title":"Innate immune response and gene expression of Scylla paramamosain under Vibrio parahaemolyticus infection","volume":"46","author":"Zhang","year":"2015","journal-title":"Aquacult. Res."},{"key":"10.1016\/j.fsi.2023.109303_bib34","first-page":"21","article-title":"The prophenoloxidase-activating system in invertebrates","volume":"77","author":"Ashida","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2023.109303_bib35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.it.2008.02.009","article-title":"The proPO-system: pros and cons for its role in invertebrate immunity","volume":"29","author":"Cerenius","year":"2008","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2023.109303_bib36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/fsim.2001.0377","article-title":"Generation of superoxide anion and SOD activity in haemocytes and muscle of American white shrimp (Litopenaeus vannamei) as a response to beta-glucan and sulphated polysaccharide","volume":"12","author":"Campa-C\u00f3rdova","year":"2002","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.146057","article-title":"Gene cloning and transcriptional regulation of the alkaline and acid phosphatase genes in Scylla paramamosain","volume":"810","author":"Wang","year":"2022","journal-title":"Gene"},{"issue":"Suppl","key":"10.1016\/j.fsi.2023.109303_bib38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1085\/jgp.50.6.197","article-title":"ATPase activity of Myosin correlated with speed of muscle shortening","volume":"50","author":"Barany","year":"1967","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.fsi.2023.109303_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.biocel.2015.03.018","article-title":"Azadirachtin-induced apoptosis involves lysosomal membrane permeabilization and cathepsin L release in Spodoptera frugiperda Sf9 cells","volume":"64","author":"Wang","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.fsi.2023.109303_bib40","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.fsi.2014.04.002","article-title":"Function of shrimp STAT during WSSV infection","volume":"38","author":"Wen","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.fsi.2019.07.083","article-title":"Evaluation on the antiviral activity of genipin against white spot syndrome virus in crayfish","volume":"93","author":"Huang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2023.109303_bib42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/viro.2001.0928","article-title":"White spot syndrome virus envelope protein VP28 is involved in the systemic infection of shrimp","volume":"285","author":"Hulten","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.fsi.2023.109303_bib43","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00705-005-0719-2","article-title":"Multiple envelope proteins are involved in white spot syndrome virus (WSSV) infection in crayfish","volume":"151","author":"Li","year":"2006","journal-title":"Arch. Virol."},{"issue":"24","key":"10.1016\/j.fsi.2023.109303_bib44","doi-asserted-by":"crossref","first-page":"12598","DOI":"10.1128\/JVI.01732-08","article-title":"VP26 of white spot syndrome virus functions as a linker protein between the envelope and nucleocapsid of virions by binding with VP51","volume":"82","author":"Wan","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2023.109303_bib45","first-page":"726","article-title":"Vp28 of shrimp white spot syndrome virus is involved in the attachment and penetration into shrimp cells","volume":"37","author":"Yi","year":"2004","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2023.109303_bib46","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/biomedicines6020039","article-title":"Plant-derived anticancer agents: lessons from the pharmacology of geniposide and its aglycone","volume":"6","author":"Habtemariam","year":"2018","journal-title":"Genipin. Biomedicines."},{"key":"10.1016\/j.fsi.2023.109303_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2020.735533","article-title":"Antiviral activity of geniposidic acid against white spot syndrome virus replication in red swamp crayfish Procambarus clarkii","volume":"528","author":"Huang","year":"2020","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2023.109303_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738496","article-title":"scFv antibody-mediated targeted drug delivery system improves the antiviral activity of geniposidic acid against WSSV","volume":"560","author":"Huang","year":"2022","journal-title":"Aquaculture"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823007891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464823007891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:46:40Z","timestamp":1760939200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464823007891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"alternative-id":["S1050464823007891"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2023.109303","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of geniposide on innate immunity and antiviral activity of Scylla paramamosain","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2023.109303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109303"}}