{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:47:47Z","timestamp":1789541267078,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011705","name":"Korea Institute of Marine Science and Technology promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2019R1A6A1A03033553"],"award-info":[{"award-number":["2019R1A6A1A03033553"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["RS-2022-KS221670"],"award-info":[{"award-number":["RS-2022-KS221670"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["RS-2022-KS221673"],"award-info":[{"award-number":["RS-2022-KS221673"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.fsi.2024.109434","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T04:21:09Z","timestamp":1707279669000},"page":"109434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Involvement of tumor necrosis factor receptor-associated factor 6 (TRAF6) in NF-\u03baB activation and antiviral immunity: Molecular and functional characterization of TRAF6 in red-spotted grouper (Epinephelus akaara)"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5495-6160","authenticated-orcid":false,"given":"E.M.T.","family":"Tharanga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishanthini","family":"Nadarajapillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.K.P.","family":"Sirisena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-2070","authenticated-orcid":false,"given":"Taehyug","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-4622","authenticated-orcid":false,"given":"Jehee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2024.109434_bib1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.dci.2013.12.011","article-title":"Molecular characterization and functional analysis of TRAF6 in orange-spotted grouper (Epinephelus coioides)","volume":"44","author":"Li","year":"2014","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.dci.2010.08.013","article-title":"Litopenaeus vannamei tumor necrosis factor receptor-associated factor 6 (TRAF6) responds to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection and activates antimicrobial peptide genes","volume":"35","author":"Wang","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.fsi.2017.06.049","article-title":"Molecular cloning and functional analysis of tumor necrosis factor receptor-associated factor 6 (TRAF6) in Crossastrea gigas","volume":"68","author":"Mao","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib4","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.4049\/jimmunol.0901537","article-title":"Genomic and functional uniqueness of the TNF receptor-associated factor gene family in amphioxus, the basal chordate","volume":"183","author":"Yuan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib5","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/383443a0","article-title":"TRAF6 is a signal transducer for interleukin-1","volume":"383","author":"Cao","year":"1996","journal-title":"Nature (London, U. K.)"},{"key":"10.1016\/j.fsi.2024.109434_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/978-0-387-70630-6_10","article-title":"Molecular basis for the unique specificity of TRAF6","volume":"597","author":"Chung","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.fsi.2024.109434_bib7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.fsi.2010.11.012","article-title":"Molecular cloning, characterization and expression analysis of TLR9, MyD88 and TRAF6 genes in common carp (Cyprinus carpio)","volume":"30","author":"Kongchum","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib8","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.fsi.2019.02.034","article-title":"Molecular cloning and expression analysis of MyD88 and TRAF6 in Qihe crucian carp Carassius auratus","volume":"87","author":"Zhang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib9","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.3390\/ijms16047077","article-title":"Blunt Snout Bream (Megalobrama amblycephala) MyD88 and TRAF6: characterisation, comparative homology modelling and expression","volume":"16","author":"Tran","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2024.109434_bib10","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.molimm.2004.11.005","article-title":"Functional characterization of full-length TLR3, IRAK-4, and TRAF6 in zebrafish (Danio rerio)","volume":"42","author":"Phelan","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.fsi.2013.11.002","article-title":"Cloning and immune characterization of the c-type lysozyme gene in red-spotted grouper, Epinephelus akaara","volume":"36","author":"Mai","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.aquaculture.2015.08.007","article-title":"Dietary protein requirement of juvenile red spotted grouper (Epinephelus akaara)","volume":"450","author":"Wang","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2024.109434_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquaculture.2011.07.022","article-title":"Fish health aspects in grouper aquaculture","volume":"320","author":"Harikrishnan","year":"2011","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2024.109434_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.fsi.2021.12.056","article-title":"Molecular characterization and expression profiling of tandem-repeat galectin-8 from red-spotted grouper (Epinephelus akaara): potential antibacterial, antiviral, and wound healing activities","volume":"121","author":"Ganeshalingam","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib15","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.apjtm.2016.06.014","article-title":"Development and application of quantitative detection method for nervous necrosis virus (NNV) isolated from sevenband grouper Hyporthodus septemfasciatus","volume":"9","author":"Kim","year":"2016","journal-title":"Asian Pac. J. Tropical Med."},{"key":"10.1016\/j.fsi.2024.109434_bib16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2024.109434_bib17","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.3390\/v6052204","article-title":"Development and application of quantitative detection method for viral hemorrhagic septicemia virus (VHSV) genogroup IVa","volume":"6","author":"Kim","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2024.109434_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104502","article-title":"Functional analysis of the cystatin A gene response to SGIV infection in orange-spotted grouper, Epinephelus coioides","volume":"136","author":"Xu","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2020.04.043","article-title":"FTR67, a member of the fish-specific finTRIM family, triggers IFN pathway and against spring viremia of carp virus","volume":"103","author":"Huo","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.fsi.2020.06.048","article-title":"Molecular characterization and functional analysis of TRAF6 in the spotted sea bass (Lateolabrax maculatus)","volume":"105","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fsi.2017.06.011","article-title":"Characterization of the black carp TRAF6 signaling molecule in innate immune defense","volume":"67","author":"Jiang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib22","doi-asserted-by":"crossref","first-page":"24871","DOI":"10.1074\/jbc.M802749200","article-title":"The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL","volume":"283","author":"Lamothe","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.109434_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.febslet.2004.04.038","article-title":"The TRAF6 RING finger domain mediates physical interaction with Ubc13","volume":"566","author":"Wooff","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.fsi.2024.109434_bib24","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.fsi.2022.07.001","article-title":"Molecular characterization and expression analysis of TRIF, TRAF6, and TBK1 of golden pompano (Trachinotus ovatus)","volume":"127","author":"He","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib25","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbrc.2004.09.070","article-title":"The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination","volume":"324","author":"Yang","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2024.109434_bib26","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.fsi.2018.11.002","article-title":"Molecular cloning and functional characterization of TRAF6 and TAK1 in rainbow trout, Oncorhynchus mykiss","volume":"84","author":"Jang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2003.11.002","article-title":"Blood cells of Drosophila: cell lineages and role in host defence","volume":"16","author":"Meister","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib28","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/febs.13235","article-title":"Drosophila blood cells and their role in immune responses","volume":"282","author":"Vlisidou","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.fsi.2024.109434_bib29","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.fsi.2011.10.031","article-title":"Inductive expression of toll-like receptor 5 (TLR5) and associated downstream signaling molecules following ligand exposure and bacterial infection in the Indian major carp, mrigal (Cirrhinus mrigala)","volume":"32","author":"Basu","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.fsi.2024.109434_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/labinvest.3700366","article-title":"Lipopolysaccharide signaling in endothelial cells","volume":"86","author":"Dauphinee","year":"2006","journal-title":"Lab. Invest."},{"key":"10.1016\/j.fsi.2024.109434_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetvac.2023.100016","article-title":"Poly(I:C), a double stranded RNA analog, activates the anti-viral DNA sensors in buffalo fibroblasts","author":"Chera","year":"2023","journal-title":"Vet. Vaccine."},{"key":"10.1016\/j.fsi.2024.109434_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108685","article-title":"Singapore grouper iridovirus infection counteracts poly I:C induced antiviral immune response in vitro","volume":"135","author":"Wang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib34","doi-asserted-by":"crossref","first-page":"16713","DOI":"10.1074\/jbc.M300562200","article-title":"Poly(dI\u00b7dC)-induced toll-like receptor 3 (TLR3)-mediated activation of NF\u03baB and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR","volume":"278","author":"Jiang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.109434_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005674","article-title":"TRAF6 establishes innate immune responses by activating NF-\u03baB and IRF7 upon sensing cytosolic viral RNA and DNA","volume":"4","author":"Konno","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2024.109434_bib36","first-page":"1","article-title":"Sites responsible for infectivity and antigenicity on nervous necrosis virus (NNV) appear to be distinct","volume":"111","author":"Gye","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2024.109434_bib37","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.fsi.2022.11.006","article-title":"Differential gene expression of red-spotted grouper (Epinephelus akaara) in response to lipopolysaccharide, poly I:C, and nervous necrosis virus revealed by RNA-seq data","volume":"131","author":"Sandamalika","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3934\/Allergy.2021001","article-title":"Spleen in innate and adaptive immunity regulation","volume":"5","author":"Aliyu","year":"2021","journal-title":"AIMS Allergy Immunol"},{"key":"10.1016\/j.fsi.2024.109434_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.fsi.2014.04.022","article-title":"Isolation and characterization of tumor necrosis factor receptor-associated factor 6 (TRAF6) from grouper, Epinephelus tauvina","volume":"39","author":"Wei","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fsi.2014.10.022","article-title":"Molecular genomic- and transcriptional-aspects of a teleost TRAF6 homolog: possible involvement in immune responses of Oplegnathus fasciatus against pathogens","volume":"42","author":"Umasuthan","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib42","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1074\/jbc.M706307200","article-title":"Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification","volume":"283","author":"Pham","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.109434_bib43","doi-asserted-by":"crossref","first-page":"30861","DOI":"10.1074\/jbc.M802525200","article-title":"Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts","volume":"283","author":"Bai","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.109434_bib44","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1038\/sj.emboj.7600845","article-title":"TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor","volume":"24","author":"Geetha","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2024.109434_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms1332","article-title":"TRAF6 ubiquitinates TGF\u03b2 type I receptor to promote its cleavage and nuclear translocation in cancer","volume":"2","author":"Mu","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.fsi.2024.109434_bib46","doi-asserted-by":"crossref","first-page":"7564","DOI":"10.1093\/nar\/gkz537","article-title":"TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity","volume":"47","author":"Meng","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.fsi.2024.109434_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107990","article-title":"Macrophage K63-linked ubiquitination of YAP promotes its nuclear localization and exacerbates atherosclerosis","volume":"32","author":"Liu","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.fsi.2024.109434_bib48","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899766","article-title":"TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination","volume":"38","author":"Ni","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.fsi.2024.109434_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004064","article-title":"TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL","volume":"3","author":"Walsh","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2024.109434_bib50","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(03)00895-X","article-title":"Sequential modification of NEMO\/IKK\u03b3 by SUMO-1 and ubiquitin mediates NF-\u03baB activation by genotoxic stress","volume":"115","author":"Huang","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2024.109434_bib51","article-title":"K63-linked Polyubiquitination on TraF6 regulates lPs-Mediated MaPK activation, cytokine Production, and Bacterial clearance","volume":"9","author":"Kufer","year":"2018"},{"key":"10.1016\/j.fsi.2024.109434_bib52","article-title":"Mechanism by which TRAF6 participates in the immune regulation of autoimmune diseases and cancer","volume":"2020","author":"Wang","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fsi.2024.109434_bib53","article-title":"MicroRNA-2187 modulates the NF-\u03baB and IRF3 pathway in teleost fish by targeting TRAF6","volume":"12","author":"Gao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib54","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.fsi.2016.11.008","article-title":"TRAF6 is a critical factor in fish immune response to virus infection","volume":"60","author":"Wei","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib55","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2024.109434_bib56","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-03780-z","article-title":"Image based Machine Learning for identification of macrophage subsets","volume":"7","author":"Rostam","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2024.109434_bib58","article-title":"Comparative proteomic analysis of polarized human THP-1 and mouse RAW264.7 macrophages","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fsi.2010.09.003","article-title":"Molecular characterization and functional analysis of MyD88 in Chinese soft-shelled turtle Trionyx sinensis","volume":"30","author":"Li","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109434_bib60","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.rinim.2011.08.005","article-title":"Cloning of crystallin from orange-spotted grouper and characterization of its activity as potential protective agent","volume":"1","author":"Chen","year":"2011","journal-title":"Results Immunol"},{"key":"10.1016\/j.fsi.2024.109434_bib61","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2183\/pjab.97.009","article-title":"TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-\u03baB activation","volume":"97","author":"Yamamoto","year":"2021","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.fsi.2024.109434_bib62","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.biocel.2009.12.023","article-title":"The TAK1\u2013TRAF6 signalling pathway","volume":"42","author":"Landstr\u00f6m","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.fsi.2024.109434_bib63","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cellsig.2013.11.004","article-title":"Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways","volume":"26","author":"Zhou","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.fsi.2024.109434_bib64","article-title":"Mechanism by which TRAF6 participates in the immune regulation of autoimmune diseases and cancer","volume":"2020","author":"Wang","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.fsi.2024.109434_bib65","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molimm.2020.09.001","article-title":"TRAF6 promotes IL-4-induced M2 macrophage activation by stabilizing STAT6","volume":"127","author":"Zhou","year":"2020","journal-title":"Mol. Immunol."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824000780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824000780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T05:54:35Z","timestamp":1760939675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464824000780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":65,"alternative-id":["S1050464824000780"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109434","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of tumor necrosis factor receptor-associated factor 6 (TRAF6) in NF-\u03baB activation and antiviral immunity: Molecular and functional characterization of TRAF6 in red-spotted grouper (Epinephelus akaara)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109434","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109434"}}