{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:47:29Z","timestamp":1784742449526,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2023R1A2C1006901"],"award-info":[{"award-number":["2023R1A2C1006901"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.fsi.2024.109508","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T22:08:38Z","timestamp":1710972518000},"page":"109508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Immunomodulatory responses of extracellular vesicles released by gram-positive fish pathogen Streptococcus parauberis"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7722-6823","authenticated-orcid":false,"given":"E.H.T.Thulshan","family":"Jayathilaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mawallage Kankanamge Hasitha Madhawa","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamilani","family":"Nikapitiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-659X","authenticated-orcid":false,"given":"Mahanama","family":"De Zoysa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2024.109508_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.15698\/mic2020.12.737","article-title":"Extracellular vesicles: an emerging platform in gram-positive bacteria","volume":"7","author":"Bose","year":"2021","journal-title":"Microb. Cell"},{"key":"10.1016\/j.fsi.2024.109508_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009508","article-title":"Microbiota\u2013host communications: bacterial extracellular vesicles as a common language","volume":"17","author":"\u00d1ahui Palomino","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2024.109508_bib3","article-title":"Bacterial extracellular vesicles: a position paper by the microbial vesicles task force of the Chinese society for extracellular vesicles","volume":"1","author":"Wen","year":"2023","journal-title":"Interdiscipl.Med."},{"key":"10.1016\/j.fsi.2024.109508_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.557902","article-title":"Outer membrane vesicles of gram-negative bacteria: an outlook on biogenesis","volume":"12","author":"Avila-Calder\u00f3n","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2024.109508_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.962216","article-title":"Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer","volume":"12","author":"Hosseini-Giv","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.fsi.2024.109508_bib6","article-title":"Gram-positive bacterial extracellular vesicles and their impact on health and disease","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2024.109508_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jprot.2014.04.023","article-title":"Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae","volume":"106","author":"Olaya-Abril","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.fsi.2024.109508_bib8","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/jfd.13362","article-title":"Evidence for the existence of extracellular vesicles in Renibacterium salmoninarum and related cytotoxic effects on SHK-1 cells","volume":"44","author":"Echeverr\u00eda-Bugue\u00f1o","year":"2021","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2024.109508_bib9","doi-asserted-by":"crossref","first-page":"19002","DOI":"10.1073\/pnas.1008843107","article-title":"Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins","volume":"107","author":"Rivera","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.fsi.2024.109508_bib10","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1002\/pmic.200900338","article-title":"Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles","volume":"9","author":"Lee","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/j.fsi.2024.109508_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00433-20","article-title":"Extracellular vesicle biogenesis and functions in gram-positive bacteria","volume":"88","author":"Briaud","year":"2020","journal-title":"Infect. Immun."},{"key":"10.1016\/j.fsi.2024.109508_bib12","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","article-title":"Extracellular vesicles as a next-generation drug delivery platform","volume":"16","author":"Herrmann","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.fsi.2024.109508_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.addr.2021.03.016","article-title":"Extracellular vesicles as antigen carriers for novel vaccination avenues","volume":"173","author":"Mehanny","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.fsi.2024.109508_bib14","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/wrr.12949","article-title":"The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges","volume":"29","author":"Brown","year":"2021","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.fsi.2024.109508_bib15","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/14737159.2022.2166403","article-title":"Bacterial extracellular vesicles in biofluids as potential diagnostic biomarkers","volume":"22","author":"Su","year":"2022","journal-title":"Expert Rev. Mol. Diagn"},{"key":"10.1016\/j.fsi.2024.109508_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ani11071849","article-title":"Environmental Streptococcus uberis associated with clinical mastitis in dairy cows: virulence traits, antimicrobial and biocide resistance, and epidemiological typing","volume":"11","author":"Abd El-Aziz","year":"2021","journal-title":"Animals"},{"key":"10.1016\/j.fsi.2024.109508_bib17","first-page":"538","article-title":"Isolation, identification and vaccine development of serotype III Streptococcus parauberis in turbot (Scophthalmus maximus) in China","author":"Gao","year":"2021","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2024.109508_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.fsi.2020.12.017","article-title":"Octominin: an antibacterial and anti-biofilm peptide for controlling the multidrug resistance and pathogenic Streptococcus parauberis","volume":"110","author":"Jayathilaka","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109508_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138309","article-title":"Engineered bacterial extracellular vesicles for osteoporosis therapy","volume":"450","author":"Liu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.fsi.2024.109508_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108777","article-title":"Exosomes from bacteria (Streptococcus parauberis) challenged olive flounder (Paralichthys olivaceus): isolation, molecular characterization, wound healing, and regeneration activities","volume":"137","author":"Jayathilaka","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109508_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/fishes7010036","article-title":"Isolation and characterization of plasma-derived exosomes from the marine fish rock bream (Oplegnathus fasciatus) by two isolation techniques","volume":"7","author":"Nikapitiya","year":"2022","journal-title":"Fishes"},{"key":"10.1016\/j.fsi.2024.109508_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2024.109508_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.01040","article-title":"Detection and physicochemical characterization of membrane vesicles (MVs) of Lactobacillus reuteri DSM 17938","volume":"8","author":"Grande","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2024.109508_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/mmi.12650","article-title":"Extracellular vesicles produced by the gram-positive bacterium Bacillus subtilis are disrupted by the lipopeptide surfactin","volume":"93","author":"Brown","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.fsi.2024.109508_bib25","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2017.1324731","article-title":"Isolation of membrane vesicles from prokaryotes: a technical and biological comparison reveals heterogeneity","volume":"6","author":"Dauros Singorenko","year":"2017","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.fsi.2024.109508_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.fsi.2024.109508_bib27","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1128\/AEM.02794-09","article-title":"Variation of physiochemical properties and cell association activity of membrane vesicles with growth phase in Pseudomonas aeruginosa","volume":"76","author":"Tashiro","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.fsi.2024.109508_bib28","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2288200","article-title":"Characterization of markers, functional properties, and microbiome composition in human gut-derived bacterial extracellular vesicles","volume":"15","author":"Li","year":"2023","journal-title":"Gut Microb."},{"key":"10.1016\/j.fsi.2024.109508_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027958","article-title":"Staphylococcus aureus produces membrane-derived vesicles that induce host cell death","volume":"6","author":"Gurung","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2024.109508_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.00432","article-title":"Bacterial membrane vesicles as mediators of microbe-microbe and microbe-host community interactions","volume":"11","author":"Caruana","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2024.109508_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78920-z","article-title":"Proteomic profile of extracellular vesicles released by Lactiplantibacillus plantarum BGAN8 and their internalization by non-polarized HT29 cell line","volume":"10","author":"Bajic","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2024.109508_bib32","author":"Keyhani"},{"key":"10.1016\/j.fsi.2024.109508_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202207479","article-title":"Cell-derived vesicles for antibiotic delivery understanding the challenges of a biogenic carrier system","volume":"19","author":"Heinrich","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.fsi.2024.109508_bib34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4161\/hv.18500","article-title":"Bexsero: a multicomponent vaccine for prevention of meningococcal disease","volume":"8","author":"Gorringe","year":"2012","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.fsi.2024.109508_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114294","article-title":"Bacterial membrane vesicles for vaccine applications","volume":"185","author":"Krishnan","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.fsi.2024.109508_bib36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition","volume":"21","author":"Kawai","year":"2009","journal-title":"Int. Immunol."},{"key":"10.1016\/j.fsi.2024.109508_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/imr.12671","article-title":"Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology","volume":"285","author":"Cicchese","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.fsi.2024.109508_bib38","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3382\/ps.2013-03423","article-title":"Resveratrol induces antioxidant and heat shock protein mRNA expression in response to heat stress in black-boned chickens","volume":"93","author":"Liu","year":"2014","journal-title":"Poultry Sci."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824001529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824001529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T12:38:33Z","timestamp":1712493513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464824001529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":38,"alternative-id":["S1050464824001529"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109508","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunomodulatory responses of extracellular vesicles released by gram-positive fish pathogen Streptococcus parauberis","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109508"}}