{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T18:23:49Z","timestamp":1794507829675,"version":"4.9.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.fsi.2024.109572","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T13:43:06Z","timestamp":1713274986000},"page":"109572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Recombinant lactococcal-based oral vaccine for protection against Streptococcus agalactiae infections in tilapia (Oreochromis niloticus)"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9997-1947","authenticated-orcid":false,"given":"Kuan Yee","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-1632","authenticated-orcid":false,"given":"Megat Hamzah","family":"Megat Mazhar Khair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelene Ai Lian","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0695-2136","authenticated-orcid":false,"given":"Mas Jaffri","family":"Masarudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2857-9184","authenticated-orcid":false,"given":"Jiun Yan","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chou Min","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-446X","authenticated-orcid":false,"given":"John","family":"Beardall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-8858","authenticated-orcid":false,"given":"Michelle Yee Mun","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel Lian Aun","family":"In","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"May","key":"10.1016\/j.fsi.2024.109572_bib1","first-page":"846","article-title":"Immune response of tilapia (Oreochromis niloticus) after vaccination with autoclave-killed, heat-killed, and formalin-killed whole cell Aeromonas hydrophila vaccines as possible serotype-independent vaccines","volume":"20","author":"Bactol","year":"2018","journal-title":"Int. J. Agric. Biol."},{"issue":"December 2021","key":"10.1016\/j.fsi.2024.109572_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.fsi.2021.12.043","article-title":"Development and efficacy of Streptococcus iniae live-attenuated vaccines in Nile tilapia, Oreochromis niloticus","volume":"121","author":"Heckman","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"March","key":"10.1016\/j.fsi.2024.109572_bib3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.fsi.2022.03.007","article-title":"Pre-treatment of Nile tilapia (Oreochromis niloticus) with ozone nanobubbles improve efficacy of heat-killed Streptococcus agalactiae immersion vaccine","volume":"123","author":"Linh","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"12","key":"10.1016\/j.fsi.2024.109572_bib4","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1111\/jfd.13523","article-title":"Efficacy of heat\u2010killed and formalin\u2010killed vaccines against Tilapia tilapinevirus in juvenile Nile tilapia (Oreochromis niloticus)","volume":"44","author":"Mai","year":"2021","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2024.109572_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-020-02443-y","article-title":"Haemato-immunological responses and effectiveness of feed-based bivalent vaccine against Streptococcus iniae and Aeromonas hydrophila infections in hybrid red tilapia (Oreochromis mossambicus \u00d7 O. niloticus)","volume":"16","author":"Monir","year":"2020","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.fsi.2024.109572_bib6","series-title":"Tilapia Culture","author":"El-sayed","year":"2016"},{"issue":"12","key":"10.1016\/j.fsi.2024.109572_bib7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/jfd.12337","article-title":"Persistence of a single clone of Streptococcus agalactiae causing disease in tilapia (Oreochromis sp.) cultured in Colombia over 8 years","volume":"38","author":"Barato","year":"2015","journal-title":"J. Fish. Dis."},{"key":"10.1016\/j.fsi.2024.109572_bib8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.aqrep.2015.12.002","article-title":"Evidence of vertical transmission and tissue tropism of Streptococcosis from naturally infected red tilapia (Oreochromis spp.)","volume":"3","author":"Pradeep","year":"2016","journal-title":"Aquaculture Reports"},{"issue":"2","key":"10.1016\/j.fsi.2024.109572_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jfd.12347","article-title":"Experimental early pathogenesis of Streptococcus agalactiae infection in red tilapia Oreochromis spp","volume":"39","author":"Iregui","year":"2016","journal-title":"J. Fish. Dis."},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-017-1289-8","article-title":"Characterization and susceptibility of streptococci and enterococci isolated from Nile tilapia (Oreochromis niloticus) showing septicaemia in aquaculture and wild sites in Egypt","volume":"13","author":"Osman","year":"2017","journal-title":"BMC Vet. Res."},{"issue":"2","key":"10.1016\/j.fsi.2024.109572_bib11","first-page":"195","article-title":"Streptococcosis in Tilapia (Oreochromis niloticus): a review","volume":"34","author":"Azmai","year":"2011","journal-title":"Pertanika J. Trop. Agric. Sci."},{"key":"10.1016\/j.fsi.2024.109572_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.aqrep.2020.100538","article-title":"Oral immunization with surface immunogenic protein from Streptococcus agalactiae expressed in Lactococcus lactis induces protective immune responses of tilapia (Oreochromis niloticus)","volume":"18","author":"Cai","year":"2020","journal-title":"Aquaculture Reports"},{"issue":"3","key":"10.1016\/j.fsi.2024.109572_bib13","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.fsi.2019.11.044","article-title":"An effective live attenuated vaccine against Streptococcus agalactiae infection in farmed Nile tilapia (Oreochromis niloticus)","volume":"98","author":"Zhang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2024.109572_bib14","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s10499-021-00751-0","article-title":"Molecular identification of Streptococcus sp. and antibiotic resistance genes present in Tilapia farms (Oreochromis niloticus) from the Northern Pacific region, Costa Rica","volume":"29","author":"Oviedo-Bola\u00f1os","year":"2021","journal-title":"Aquacult. Int."},{"key":"10.1016\/j.fsi.2024.109572_bib15","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.3389\/fmicb.2022.935145","article-title":"Endolysins against Streptococci as an antibiotic alternative","volume":"13","author":"Wong","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2024.109572_bib16","first-page":"867","article-title":"Oral vaccination for sustainable disease prevention in aquaculture\u2014an encapsulation approach","author":"Radhakrishnan","year":"2022","journal-title":"Aquacult. Int."},{"issue":"2","key":"10.1016\/j.fsi.2024.109572_bib17","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10499-019-00491-2","article-title":"An overview of the immunomodulatory effects exerted by probiotics and prebiotics in grouper fish","volume":"28","author":"Loh","year":"2020","journal-title":"Aquacult. Int."},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12934-017-0669-x","article-title":"A review on Lactococcus lactis: from food to factory","volume":"16","author":"Song","year":"2017","journal-title":"Microb. Cell Factories"},{"issue":"7","key":"10.1016\/j.fsi.2024.109572_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0219912","article-title":"Enhanced gastrointestinal survivability of recombinant Lactococcus lactis using a double coated mucoadhesive film approach","volume":"14","author":"Tan","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1475-2859-11-157","article-title":"Lactic acid bacteria: a promising alternative for recombinant protein production","volume":"11","author":"Garc\u00eda-Fruit\u00f3s","year":"2012","journal-title":"Microb. Cell Factories"},{"issue":"21","key":"10.1016\/j.fsi.2024.109572_bib21","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1128\/JB.00533-10","article-title":"Genome sequences of Lactococcus lactis MG1363 (revised) and NZ9000 and comparative physiological studies","volume":"192","author":"Linares","year":"2010","journal-title":"J. Bacteriol."},{"issue":"12","key":"10.1016\/j.fsi.2024.109572_bib22","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrmicro1552","article-title":"Group B Streptococcus: global incidence and vaccine development","volume":"4","author":"Johri","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.fsi.2024.109572_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/21645515.2018.1493326","article-title":"Progress toward a Group B streptococcal vaccine","author":"Song","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"issue":"51","key":"10.1016\/j.fsi.2024.109572_bib24","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1016\/j.vaccine.2014.08.017","article-title":"A recombinant truncated surface immunogenic protein (tSip) plus adjuvant FIA confers active protection against Group B Streptococcus infection in tilapia","volume":"32","author":"He","year":"2014","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines8010029","article-title":"Surface immunogenic protein of Streptococcus Group B is an agonist of toll-like receptors 2 and 4 and a potential immune adjuvant","volume":"8","author":"Diaz-Dinamarca","year":"2020","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/AEM.02667-12","article-title":"Engineering signal peptides for enhanced protein secretion from Lactococcus lactis","volume":"79","author":"Ng","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"issue":"2","key":"10.1016\/j.fsi.2024.109572_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.femsle.2004.08.018","article-title":"A xylose-inducible expression system for Lactococcus lactis","volume":"239","author":"Miyoshi","year":"2004","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Lett."},{"issue":"12","key":"10.1016\/j.fsi.2024.109572_bib28","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1128\/aem.55.12.3119-3123.1989","article-title":"High-frequency transformation, by electroporation, of Lactococcus lactis subsp. cremoris grown with Glycine in osmotically stabilized media","volume":"55","author":"Holo","year":"1989","journal-title":"Appl. Environ. Microbiol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109572_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/vaccines9030195","article-title":"K-ras peptide mimotope induces antigen specific Th1 and B-cell immune responses against g12a-mutated K-ras antigen in balb\/c mice","volume":"9","author":"Siak","year":"2021","journal-title":"Vaccines"},{"issue":"17","key":"10.1016\/j.fsi.2024.109572_bib30","doi-asserted-by":"crossref","first-page":"17204","DOI":"10.1007\/s11356-019-05033-0","article-title":"How to preserve and handle fish liver samples to conserve RNA integrity","volume":"26","author":"Vehni\u00e4inen","year":"2019","journal-title":"Environ. Sci. Pollut. Control Ser."},{"issue":"May","key":"10.1016\/j.fsi.2024.109572_bib31","first-page":"1","article-title":"Recombinant Lactococcus lactis expressing grass carp reovirus VP6 induces mucosal immunity against grass carp reovirus infection","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109572_bib32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Epidemiol."},{"issue":"8","key":"10.1016\/j.fsi.2024.109572_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/vaccines9080819","article-title":"Oral immunization of larvae and juvenile of lumpfish (Cyclopterus lumpus) against Vibrio anguillarum does not influence systemic immunity","volume":"9","author":"Dang","year":"2021","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib34","first-page":"1","article-title":"Life cycle assessment of nile Tilapia (Oreochromis niloticus) farming in kenyir lake, terengganu","volume":"12","author":"Dullah","year":"2020","journal-title":"Sustainability"},{"issue":"3","key":"10.1016\/j.fsi.2024.109572_bib35","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1080\/23308249.2016.1261277","article-title":"Advances in aquaculture vaccines against fish pathogens: global status and current trends","volume":"25","author":"Dadar","year":"2016","journal-title":"Reviews in Fisheries Science & Aquaculture"},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib36","article-title":"Prospects and challenges of developing and commercializing immersion vaccines for aquaculture","volume":"1","author":"Sudheesh","year":"2017","journal-title":"International Biology Review"},{"key":"10.1016\/j.fsi.2024.109572_bib37","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.dci.2016.03.024","article-title":"Oral vaccination of fish: lessons from humans and veterinary species","volume":"64","author":"Embregts","year":"2016","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109572_bib38","first-page":"17","article-title":"Lactic acid bacteria as live vaccines","volume":"2","author":"Mercenier","year":"2000","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.fsi.2024.109572_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fsi.2018.11.022","article-title":"Effects of Lactococcus lactis subsp. lactis JCM5805 on colonization dynamics of gut microbiota and regulation of immunity in early ontogenetic stages of tilapia","volume":"86","author":"Xia","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2024.109572_bib40","first-page":"1632","article-title":"Live recombinant Lactococcus lactis vaccine expressing aerolysin genes D1 and D4 for protection against Aeromonas hydrophila in tilapia (Oreochromis niloticus)","volume":"109","author":"Anuradha","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.fsi.2024.109572_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108684","article-title":"Immune response and protective efficacy of mannosylated polyethylenimine (PEI) as an antigen delivery vector, administered with a Streptococcus agalactiae DNA vaccine in Nile tilapia (Oreochromis niloticus)","volume":"135","author":"Chen","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2024.109572_bib42","first-page":"79","article-title":"A review of bacterial zoonoses and antimicrobial resistant (AMR) on grouper fish (Epinepholus sp.)","volume":"11","author":"Helmi","year":"2020","journal-title":"Sys. Rev. Pharm."},{"key":"10.1016\/j.fsi.2024.109572_bib43","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.fsi.2018.12.060","article-title":"Oral vaccination of tilapia against Streptococcus agalactiae using Bacillus subtilis spores expressing Sip","volume":"86","author":"Yao","year":"2019","journal-title":"Fish Shellfish Immunol."},{"issue":"4","key":"10.1016\/j.fsi.2024.109572_bib44","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0968-0004(00)01776-X","article-title":"Translation control: bridging the gap between genomics and proteomics?","volume":"26","author":"Pradet-balade","year":"2001","journal-title":"Trends Biochem. Sci."},{"issue":"October 2020","key":"10.1016\/j.fsi.2024.109572_bib45","article-title":"The involvement of TNF-\u03b1 and TNF-\u03b2 as proinflammatory cytokines in lymphocyte-mediated adaptive immunity of Nile tilapia by initiating apoptosis","volume":"115","author":"Li","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109572_bib46","article-title":"Cross-immunity in Nile tilapia vaccinated with Streptococcus agalactiae and Streptococcus iniae vaccines","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109572_bib47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.fsi.2017.02.019","article-title":"GapA, a potential vaccine candidate antigen against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus)","volume":"63","author":"Zhang","year":"2017","journal-title":"Fish Shellfish Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2024.109572_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/biology11091268","article-title":"Effect of an oral bivalent vaccine on immune response and immune gene profiling in vaccinated red Tilapia (Oreochromis spp.) during infections with Streptococcus iniae and Aeromonas hydrophila","volume":"11","author":"Monir","year":"2022","journal-title":"Biology"},{"issue":"5","key":"10.1016\/j.fsi.2024.109572_bib49","first-page":"1387","article-title":"Comparative effect of different vaccines on immune-related gene expressions of rainbow trout (Oncorhynchus mykiss) and experimentally infected with Streptococcus iniae and Lactococus garvie","volume":"20","author":"Khaj","year":"2021","journal-title":"Iran. J. Fish. Sci."},{"issue":"11","key":"10.1016\/j.fsi.2024.109572_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pathogens9110919","article-title":"Probiotics modulate tilapia resistance and immune response against tilapia lake virus infection","volume":"9","author":"Waiyamitra","year":"2020","journal-title":"Pathogens"},{"issue":"5","key":"10.1016\/j.fsi.2024.109572_bib51","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s10499-016-9995-y","article-title":"The changes in cortisol and expression of immune genes of GIFT tilapia Oreochromis niloticus (L.) at different rearing densities under Streptococcus iniae infection","volume":"24","author":"Qiang","year":"2016","journal-title":"Aquacult. Int."},{"key":"10.1016\/j.fsi.2024.109572_bib52","first-page":"3","article-title":"Fish cytokines and immune response","author":"Reyes-Cerpa","year":"2012","journal-title":"New Advances and Contributions to Fish Biology"},{"issue":"55","key":"10.1016\/j.fsi.2024.109572_bib53","article-title":"Interleukin-10 (IL-10) participates in host defense against bacterial pathogens and promotes IgM antibody production in Nile tilapia (Oreochromis niloticus)","volume":"531","author":"Wu","year":"2021","journal-title":"Aquaculture"},{"issue":"2","key":"10.1016\/j.fsi.2024.109572_bib54","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.gene.2015.09.082","article-title":"Molecular characterization and comparative expression analysis of two teleostean pro-inflammatory cytokines, IL-1\u03b2 and IL-8, from Sebastes schlegeli","volume":"575","author":"Herath","year":"2016","journal-title":"Gene"},{"issue":"51","key":"10.1016\/j.fsi.2024.109572_bib55","doi-asserted-by":"crossref","first-page":"7014","DOI":"10.1016\/j.vaccine.2014.08.039","article-title":"Efficacy of a formalin-inactivated vaccine against Streptococcus iniae infection in the farmed grouper Epinephelus coioides by intraperitoneal immunization","volume":"32","author":"Huang","year":"2014","journal-title":"Vaccine"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824002171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824002171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T01:21:20Z","timestamp":1717291280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464824002171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":55,"alternative-id":["S1050464824002171"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109572","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant lactococcal-based oral vaccine for protection against Streptococcus agalactiae infections in tilapia (Oreochromis niloticus)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109572"}}