{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:52:27Z","timestamp":1779299547781,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41976102"],"award-info":[{"award-number":["41976102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.fsi.2024.109706","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T16:08:51Z","timestamp":1718640531000},"page":"109706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Manipulated C5aR1 over\/down-expression associates with IL-6 expression during bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)"],"prefix":"10.1016","volume":"151","author":[{"given":"Zhendong","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqing","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suxu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunpeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ningning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxia","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.dci.2014.01.010","article-title":"Complement system in zebrafish","volume":"46","author":"Zhang","year":"2014","journal-title":"Dev. Comp. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/cr.2009.139","article-title":"Complement and its role in innate and adaptive immune responses","volume":"20","author":"Dunkelberger","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.fsi.2024.109706_bib3","first-page":"73","article-title":"New developments in C5a receptor signaling","volume":"4","author":"Sarma","year":"2012","journal-title":"Cell Health Cytoskeleton"},{"key":"10.1016\/j.fsi.2024.109706_bib4","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.fsi.2017.11.017","article-title":"Identification and expression of complement component C8alpha, C8beta and C8gamma gene in half-smooth tongue sole (Cynoglossus semilaevis) and C8alpha recombinant protein antibacterial activity analysis","volume":"72","author":"Yang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"issue":"17","key":"10.1016\/j.fsi.2024.109706_bib5","doi-asserted-by":"crossref","first-page":"R733","DOI":"10.1016\/j.cub.2012.07.029","article-title":"Evolution of inflammatory diseases","volume":"22","author":"Okin","year":"2012","journal-title":"Curr. Biol."},{"issue":"31","key":"10.1016\/j.fsi.2024.109706_bib6","doi-asserted-by":"crossref","first-page":"E6390","DOI":"10.1073\/pnas.1706818114","article-title":"Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis","volume":"114","author":"Keshari","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.fsi.2024.109706_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/cei.12338","article-title":"Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model","volume":"177","author":"Andersson","year":"2014","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.fsi.2024.109706_bib9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nm1753","article-title":"Functional roles for C5a receptors in sepsis","volume":"14","author":"Rittirsch","year":"2008","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.fsi.2024.109706_bib10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.intimp.2014.05.008","article-title":"Treatment with the C5a receptor\/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma","volume":"21","author":"Staab","year":"2014","journal-title":"Int. Immunopharm."},{"issue":"6","key":"10.1016\/j.fsi.2024.109706_bib11","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.kint.2016.11.018","article-title":"C5 inhibition prevents renal failure in a mouse model of lethal C3 glomerulopathy","volume":"91","author":"Williams","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.fsi.2024.109706_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108074","article-title":"Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists","volume":"100","author":"Li","year":"2021","journal-title":"Int. Immunopharm."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2024.109706_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vetimm.2005.07.009","article-title":"Evolution of anaphylatoxins, their diversity and novel roles in innate immunity: insights from the study of fish complement","volume":"108","author":"Sunyer","year":"2005","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109706_bib14","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1006\/bbrc.1997.8034","article-title":"Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation","volume":"242","author":"Fukuoka","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"21","key":"10.1016\/j.fsi.2024.109706_bib15","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1021\/acschemneuro.1c00244","article-title":"C5aR1 mediates the progression of inflammatory responses in the brain of rats in the early stage after ischemia and reperfusion","volume":"12","author":"Shi","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"24","key":"10.1016\/j.fsi.2024.109706_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124646","article-title":"C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans","volume":"3","author":"Verghese","year":"2018","journal-title":"Jci Insight"},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ymthe.2020.09.008","article-title":"Targeting complement C5a receptor 1 for the treatment of immunosuppression in sepsis","volume":"29","author":"Sommerfeld","year":"2021","journal-title":"Mol. Ther."},{"issue":"7","key":"10.1016\/j.fsi.2024.109706_bib18","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/j.ekir.2019.05.342","article-title":"Sat-302 inhibition of complement C5a\/C5a receptor 1 decreases renal injury in diabetic kidney disease via metabolic reprogramming","volume":"4","author":"Tan","year":"2019","journal-title":"Kidney International Reports"},{"issue":"2","key":"10.1016\/j.fsi.2024.109706_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.fsi.2014.08.013","article-title":"Complement C5a acts as molecular adjuvant in fish by enhancing antibody response to soluble antigen","volume":"40","author":"Wu","year":"2014","journal-title":"Fish Shellfish Immunol."},{"issue":"11","key":"10.1016\/j.fsi.2024.109706_bib20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.it.2020.09.008","article-title":"The complement C5a-C5aR1 GPCR Axis in COVID-19 therapeutics","volume":"41","author":"Woodruff","year":"2020","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41426-018-0063-8","article-title":"Blockade of the C5a-C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV","volume":"7","author":"Jiang","year":"2018","journal-title":"Emerg. Microb. Infect."},{"issue":"4","key":"10.1016\/j.fsi.2024.109706_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095160","article-title":"Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice","volume":"9","author":"Tong","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.fsi.2024.109706_bib23","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/cid\/ciu887","article-title":"Treatment with anti-C5a antibody improves the outcome of H7N9 virus infection in African green monkeys","volume":"60","author":"Sun","year":"2015","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13075-018-1744-3","article-title":"The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice","volume":"20","author":"Munenaga","year":"2018","journal-title":"Arthritis Res. Ther."},{"issue":"7836","key":"10.1016\/j.fsi.2024.109706_bib25","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-020-2600-6","article-title":"Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis","volume":"588","author":"Carvelli","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2024.109706_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.dci.2016.02.028","article-title":"C5a of Cynoglossus semilaevis has anaphylatoxin-like properties and promotes antibacterial and antiviral defense","volume":"60","author":"Li","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109706_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106211","article-title":"Immunosuppression participated in complement activation-mediated inflammatory injury caused by 4-octylphenol via TLR7\/IkappaBalpha\/NF-kappaB pathway in common carp (Cyprinus carpio) gills","volume":"249","author":"Sun","year":"2022","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.fsi.2024.109706_bib28","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8801","article-title":"Integrative analysis reveals pathways associated with sex reversal in Cynoglossus semilaevis","volume":"8","author":"Ye","year":"2020","journal-title":"PeerJ"},{"issue":"5","key":"10.1016\/j.fsi.2024.109706_bib29","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s10695-022-01125-w","article-title":"Effects of long-term sex steroid hormones (estradiol and testosterone)-supplemented feeds on the growth performance of Chinese tongue sole (Cynoglossus semilaevis)","volume":"48","author":"Zhang","year":"2022","journal-title":"Fish Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s40168-022-01346-4","article-title":"Intestinal microbiome-mediated resistance against vibriosis for Cynoglossus semilaevis","volume":"10","author":"Zhou","year":"2022","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/vaccines11010098","article-title":"Strategies for prevention and control of vibriosis in asian fish culture","volume":"11","author":"Xu","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2024.109706_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.879337","article-title":"Molecular mechanisms underlying Vibrio tolerance in Ruditapes philippinarum revealed by comparative transcriptome profiling","volume":"13","author":"Yin","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib33","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/jfd.12213","article-title":"Splenic necrosis signs and pathogen detection in cultured half-smooth tongue sole, Cynoglossus semilaevis Gunther","volume":"38","author":"Xiao","year":"2015","journal-title":"J. Fish. Dis."},{"issue":"1\u20132","key":"10.1016\/j.fsi.2024.109706_bib34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0044-8486(87)90006-8","article-title":"Homology of Vibrio anguillarum strains causing epizootics in turbot, salmon and trout reared on the Atlantic coast of Spain","volume":"67","author":"Toranzo","year":"1987","journal-title":"Aquaculture"},{"issue":"2\u20133","key":"10.1016\/j.fsi.2024.109706_bib35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0044-8486(92)90074-U","article-title":"Epizootic study in a turbot farm: bacteriology, virology, parasitology and histology","volume":"107","author":"Novoa","year":"1992","journal-title":"Aquaculture"},{"issue":"4","key":"10.1016\/j.fsi.2024.109706_bib36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/fsim.1999.0240","article-title":"Susceptibility of juvenile and sub-adult Atlantic halibut (Hippoglossus hippoglossusL.) to infection by Vibrio anguillarum and efficacy of protection induced by vaccination","volume":"10","author":"Bricknell","year":"2000","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109706_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2022.106097","article-title":"A comparison of the bacterial CYP51 cytochrome P450 enzymes from Mycobacterium marinum and Mycobacterium tuberculosis","volume":"221","author":"Mohamed","year":"2022","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109706_bib38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3354\/dao039211","article-title":"Mycobacteriosis in wild rabbitfish Siganus rivulatus associated with cage farming in the Gulf of Eilat, Red Sea","volume":"39","author":"Diamant","year":"2000","journal-title":"Dis. Aquat. Org."},{"issue":"6","key":"10.1016\/j.fsi.2024.109706_bib39","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1095-8649.1977.tb04085.x","article-title":"Mycobacteriosis in hatchery\u2013confined chinook salmon (Oncorhynchus tshawytscua Walbaum) in Australia","volume":"10","author":"Ashburner","year":"1977","journal-title":"J. Fish. Biol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109706_bib40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.7589\/0090-3558-23.3.391","article-title":"Mycobacteriosis in cultured striped bass from California","volume":"23","author":"Hedrick","year":"1987","journal-title":"J. Wildl. Dis."},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.33899\/ijvs.2005.37335","article-title":"Isolation and diagnosis of Mycobacteria species in local water Fishes in Ninevah province","volume":"19","author":"Hammad","year":"2005","journal-title":"Iraqi J. Vet. Sci."},{"key":"10.1016\/j.fsi.2024.109706_bib42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.aquaculture.2018.02.036","article-title":"Mycobacterium marinum is the causative agent of splenic and renal granulomas in half-smooth tongue sole (Cynoglossus semilaevis G\u00fcnther) in China","volume":"490","author":"Luo","year":"2018","journal-title":"Aquaculture"},{"issue":"6","key":"10.1016\/j.fsi.2024.109706_bib43","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.fsi.2011.03.023","article-title":"Interleukin-8 of Cynoglossus semilaevis is a chemoattractant with immunoregulatory property","volume":"30","author":"Sun","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"3\u20134","key":"10.1016\/j.fsi.2024.109706_bib44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.vetimm.2012.02.011","article-title":"Molecular cloning and characterization of interleukin-1\u03b2 in half-smooth tongue sole Cynoglossus semilaevis","volume":"146","author":"Yu","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.fsi.2024.109706_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126445","article-title":"Regulatory mechanism of miR-722 on C5aR1 and its functions against bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)","volume":"252","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2024.109706_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109043","article-title":"Inflammatory reaction and immune response of half-smooth tongue sole (Cynoglossus semilaevis) after infection with Vibrio anguillarum","volume":"141","author":"Wang","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109706_bib47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ng.2890","article-title":"Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle","volume":"46","author":"Chen","year":"2014","journal-title":"Nat. Genet."},{"issue":"6","key":"10.1016\/j.fsi.2024.109706_bib48","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.18632\/aging.202671","article-title":"Inhibition of complement C5a receptor protects lung cells and tissues against lipopolysaccharide-induced injury via blocking pyroptosis","volume":"13","author":"Wang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.fsi.2024.109706_bib49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.fsi.2017.01.006","article-title":"The effects of emodin on cell viability, respiratory burst and gene expression of Nrf2-Keap1 signaling molecules in the peripheral blood leukocytes of blunt snout bream (Megalobrama amblycephala)","volume":"62","author":"Zhao","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109706_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2023.740526","article-title":"Analysis of alternative splicing provides insights into its vital roles in immune responses of half-smooth tongue sole (Cynoglossus semilaevis) against Vibrio anguillarum","volume":"582","author":"Han","year":"2024","journal-title":"Aquaculture"},{"issue":"23","key":"10.1016\/j.fsi.2024.109706_bib51","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.fsi.2024.109706_bib52","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.4049\/jimmunol.172.7.4381","article-title":"Cloning, expression, cellular distribution, and role in chemotaxis of a C5a receptor in rainbow trout: the first identification of a C5a receptor in a nonmammalian species","volume":"172","author":"Boshra","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.fsi.2024.109706_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108873","article-title":"C5a drives the inflammatory response with bacterial dose effect by binding to C5aR1 in zebrafish infected with Aeromonas hydrophila","volume":"139","author":"Liu","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"9","key":"10.1016\/j.fsi.2024.109706_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110851","article-title":"Intracellular complement C5a\/C5aR1 stabilizes beta-catenin to promote colorectal tumorigenesis","volume":"39","author":"Ding","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.fsi.2024.109706_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104372","article-title":"The effects of blunt snout bream (Megalobrama amblycephala) IL-6 trans-signaling on immunity and iron metabolism via JAK\/STAT3 pathway","volume":"131","author":"Wang","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109706_bib56","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.fsi.2016.03.005","article-title":"Cloning, characterization and mRNA expression of interleukin-6 in blunt snout bream (Megalobrama amblycephala)","volume":"54","author":"Zhang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109706_bib57","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10695-019-00753-z","article-title":"Molecular characterization and expression pattern of inositol-requiring enzyme 1 (IRE1) in blunt snout bream (Megalobrama amblycephala): its role of IRE1 involved in inflammatory response induced by lipopolysaccharide","volume":"46","author":"Cao","year":"2020","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.fsi.2024.109706_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103629","article-title":"Molecular and functional characterization of IL-6 receptor (IL-6R) and glycoprotein 130 (gp130) in Nile tilapia (Oreochromis niloticus)","volume":"106","author":"Zhou","year":"2020","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109706_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.dci.2018.08.012","article-title":"Interleukin-6 gets involved in response to bacterial infection and promotes antibody production in Nile tilapia (Oreochromis niloticus)","volume":"89","author":"Wei","year":"2018","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109706_bib60","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.ijbiomac.2021.10.080","article-title":"CsIL-11, a teleost interleukin-11, is involved in promoting phagocytosis and antibacterial immune defense","volume":"192","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol.: Structure, Function and Interactions"},{"issue":"1","key":"10.1016\/j.fsi.2024.109706_bib61","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tvjl.2008.05.012","article-title":"Mycobacteriosis in fishes: a review","volume":"180","author":"Gauthier","year":"2009","journal-title":"Vet. J."}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824003516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824003516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T15:42:43Z","timestamp":1721317363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464824003516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":61,"alternative-id":["S1050464824003516"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109706","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Manipulated C5aR1 over\/down-expression associates with IL-6 expression during bacterial inflammation in half-smooth tongue sole (Cynoglossus semilaevis)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109706","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109706"}}