{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:09:52Z","timestamp":1778857792904,"version":"3.51.4"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.fsi.2024.109958","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T13:53:32Z","timestamp":1728654812000},"page":"109958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR\/NF\u03baB pathway"],"prefix":"10.1016","volume":"154","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenteng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-5609","authenticated-orcid":false,"given":"Zhangfan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8055-6150","authenticated-orcid":false,"given":"Songlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2024.109958_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.fsi.2022.07.055","article-title":"Tools and techniques for rational designing of antimicrobial peptides for aquaculture","volume":"127","author":"Bhat","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib2","article-title":"Teleost innate immunity, an intricate game between immune cells and parasites of fish organs: who wins, who loses","volume":"14","author":"Sayyaf","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12275-017-6452-1","article-title":"The therapeutic applications of antimicrobial peptides (AMPs): a patent review","volume":"55","author":"Kang","year":"2017","journal-title":"J. Microbiol."},{"key":"10.1016\/j.fsi.2024.109958_bib4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.micpath.2017.11.039","article-title":"Fish antimicrobial peptides (AMP's) as essential and promising molecular therapeutic agents: a review","volume":"114","author":"Shabir","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fsi.2024.109958_bib5","article-title":"Comparative study on antibacterial characteristics of the multiple liver expressed antimicrobial peptides (LEAPs) in teleost fish","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib6","article-title":"Immune modulation ability of hepcidin from teleost fish","volume":"12","author":"Alvarez","year":"2022","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.fsi.2024.109958_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108899","article-title":"Hepcidin and piscidin modulation and antibacterial response in gilthead seabream (Sparus aurata) infected with Vibrio harveyi","volume":"139","author":"Serna-Duque","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s43141-022-00330-7","article-title":"A hepatic antimicrobial peptide, hepcidin from Indian major carp, Catla catla: molecular identification and functional characterization","volume":"20","author":"Athira","year":"2022","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"10.1016\/j.fsi.2024.109958_bib9","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.3390\/ijms20225602","article-title":"Expression and functional analysis of hepcidin from Mandarin fish (Siniperca chuatsi)","volume":"20","author":"Shen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2024.109958_bib10","first-page":"e2767","article-title":"Hepcidin gene cloning and expression pattern in Turbot (Scophthalmus maximus) after Vibrio. anguillarum infection","volume":"18","author":"Deng","year":"2020","journal-title":"Iran. J. Biotechnol."},{"key":"10.1016\/j.fsi.2024.109958_bib11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.peptides.2014.04.014","article-title":"Characterization and bioactivity of hepcidin-2 in zebrafish: dependence of antibacterial activity upon disulfide bridges","volume":"57","author":"Lin","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2024.109958_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127590","article-title":"Anti-microbial activity and immunomodulation of recombinant hepcidin 2 and NK-lysin from flounder (Paralichthys olivaceus)","volume":"253","author":"Li","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2024.109958_bib13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.fsi.2010.05.001","article-title":"Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species","volume":"29","author":"Hsieh","year":"2010","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib14","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.fsi.2022.04.026","article-title":"Genome-wide identification, immune response profile and functional characterization of IL-10 from spotted knifejaw (Oplegnathus punctatus) during host defense against bacterial and viral infection","volume":"124","author":"Wang","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104432","article-title":"Transcriptomic analysis reveals the gene expression profiles in the spleen of spotted knifejaw (Oplegnathus punctatus) infected by Vibrio harveyi","volume":"133","author":"Wang","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib16","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1016\/j.celrep.2019.08.013","article-title":"alphaKlotho regulates age-associated vascular calcification and lifespan in zebrafish","volume":"28","author":"Singh","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.fsi.2024.109958_bib17","doi-asserted-by":"crossref","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2024.109958_bib18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.fsi.2018.04.007","article-title":"Cloning, characterization and functional analysis of dctn5 in immune response of Chinese tongue sole (Cynoglossus semilaevis)","volume":"77","author":"Wei","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109187","article-title":"Hepcidin from Onychostoma macrolepis: response to Aeromonas hydrophila infection by down-regulating expression of inflammatory factor genes and regulating iron homeostasis potentially","volume":"143","author":"Pan","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib20","doi-asserted-by":"crossref","first-page":"9251","DOI":"10.3390\/ijms24119251","article-title":"Antibacterial activity and mechanisms of TroHepc2-22, a derived peptide of Hepcidin2 from golden pompano (Trachinotus ovatus)","volume":"24","author":"Zhang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2024.109958_bib21","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.3390\/ijms20225602","article-title":"Expression and functional analysis of hepcidin from Mandarin fish (Siniperca chuatsi)","volume":"20","author":"Shen","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2024.109958_bib22","article-title":"Characterization, expression, and functional analysis of the Northern Snakehead (Channa argus) hepcidin","author":"Liao","year":"2023","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.fsi.2024.109958_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12602-017-9352-0","article-title":"Mudskipper (Boleophthalmus pectinirostris) Hepcidin-1 and Hepcidin-2 present different gene expression profile and antibacterial activity and possess distinct protective effect against Edwardsiella tarda infection","volume":"10","author":"Chen","year":"2018","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.fsi.2024.109958_bib24","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.fsi.2007.04.011","article-title":"Genomic organization and tissue-specific expression analysis of hepcidin-like genes from black porgy (Acanthopagrus schlegelii B)","volume":"23","author":"Yang","year":"2007","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib25","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.fsi.2020.01.038","article-title":"Antibacterial and immunoregulatory activity of a novel hepcidin homologue in diploid hybrid fish (Carassius auratus cuvieri female symbol x Carassius auratus red var male symbol)","volume":"98","author":"Luo","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103845","article-title":"Sequence analysis of hepcidin in barbel steed (Hemibarbus labeo): QSHLS motif confers hepcidin iron-regulatory activity but limits its antibacterial activity","volume":"114","author":"Chen","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib27","article-title":"Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types","volume":"7","author":"Neves","year":"2017","journal-title":"SCI REP-UK"},{"key":"10.1016\/j.fsi.2024.109958_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fsi.2016.07.027","article-title":"Genomic organization, expression and antimicrobial activity of a hepcidin from taimen (Hucho taimen, Pallas)","volume":"56","author":"Wang","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fsi.2016.07.025","article-title":"Cloning and expression of two hepcidin genes in the mudskipper (Boleophthalmus pectinirostris) provides insights into their roles in male reproductive immunity","volume":"56","author":"Li","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fsi.2016.10.049","article-title":"cDNA cloning and expression analysis of a hepcidin gene from yellow catfish Pelteobagrus fulvidraco (Siluriformes: bagridae)","volume":"60","author":"Liu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib31","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.fsi.2022.04.032","article-title":"Massive gene expansion of hepcidin, a host defense peptide, in gilthead seabream (Sparus aurata)","volume":"124","author":"Serna-Duque","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2022.109486","article-title":"Antimicrobial peptide hepcidin contributes to restoration of the intestinal flora after Aeromonas hydrophila infection in Acrossocheilus fasciatus","volume":"263","author":"Zhu","year":"2023","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.fsi.2024.109958_bib33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.dci.2008.07.009","article-title":"Gene structure and differential modulation of multiple rockbream (Oplegnathus fasciatus) hepcidin isoforms resulting from different biological stimulations","volume":"33","author":"Cho","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1254677","article-title":"Early innate immune responses in European sea bass (Dicentrarchus labrax L.) following Tenacibaculum maritimum infection","volume":"14","author":"Ferreira","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib35","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.fsi.2013.07.001","article-title":"Molecular characterization of hepcidin gene in common carp (Cyprinus carpio L.) and its expression pattern responding to bacterial challenge","volume":"35","author":"Li","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib36","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.fsi.2019.08.017","article-title":"Biochemical and molecular identification of a novel hepcidin type 2-like antimicrobial peptide in the skin mucus of the pufferfish Takifugu pardalis","volume":"93","author":"Go","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.fsi.2019.01.020","article-title":"Identification and expression of the hepcidin gene from brown trout (Salmo trutta) and functional analysis of its synthetic peptide","volume":"87","author":"Huang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib38","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12602-017-9352-0","article-title":"Mudskipper (Boleophthalmus pectinirostris) Hepcidin-1 and Hepcidin-2 present different gene expression profile and antibacterial activity and possess distinct protective effect against Edwardsiella tarda infection","volume":"10","author":"Chen","year":"2018","journal-title":"Probiotics Antimicrob Proteins"},{"key":"10.1016\/j.fsi.2024.109958_bib39","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.peptides.2008.12.014","article-title":"Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide","volume":"30","author":"Wang","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2024.109958_bib40","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/ph7030265","article-title":"Antimicrobial peptides from fish","volume":"7","author":"Masso-Silva","year":"2014","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.fsi.2024.109958_bib41","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.peptides.2010.02.025","article-title":"Antiviral activity by fish antimicrobial peptides of epinecidin-1 and hepcidin 1-5 against nervous necrosis virus in medaka","volume":"31","author":"Wang","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.fsi.2024.109958_bib42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pep.2013.11.001","article-title":"Expression, purification and antibacterial activity of the channel catfish hepcidin mature peptide","volume":"94","author":"Tao","year":"2014","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.fsi.2024.109958_bib43","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/antibiotics10070848","article-title":"Hepcidin protects yellow catfish (Pelteobagrus fulvidraco) against Aeromonas veronii-induced ascites disease by regulating iron metabolism","volume":"10","author":"Fu","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.fsi.2024.109958_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124833","article-title":"Antibacterial and immunoregulatory activity of an antimicrobial peptide hepcidin in loach (Misgurnus anguillicaudatus)","volume":"242","author":"Jin","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2024.109958_bib45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1271\/bbb.120600","article-title":"Molecular cloning, recombinant expression, and antimicrobial activity of EC-hepcidin3, a new four-cysteine hepcidin isoform from Epinephelus coioides","volume":"77","author":"Qu","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.fsi.2024.109958_bib46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.fsi.2014.03.011","article-title":"Turbot (Scophthalmus maximus) hepcidin-1 and hepcidin-2 possess antimicrobial activity and promote resistance against bacterial and viral infection","volume":"38","author":"Zhang","year":"2014","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib47","doi-asserted-by":"crossref","first-page":"9272","DOI":"10.1074\/jbc.M411154200","article-title":"Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections","volume":"280","author":"Lauth","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.109958_bib48","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.fsi.2022.01.013","article-title":"Molecular characterization and antibacterial immunity functional analysis of the antimicrobial peptide hepcidin from Coregonus ussuriensis berg","volume":"122","author":"Liu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib49","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3390\/md20100651","article-title":"The antimicrobial peptide LJ-hep2 from Lateolabrax japonicus exerting activities against multiple pathogenic bacteria and immune protection in vivo","volume":"20","author":"Gong","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.fsi.2024.109958_bib50","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.vh.2019.01.007","article-title":"Hepcidin and IL-1beta","volume":"110","author":"Kanamori","year":"2019","journal-title":"Vitam Horm"},{"key":"10.1016\/j.fsi.2024.109958_bib51","article-title":"Hepcidin downregulation correlates with disease aggressiveness and immune infiltration in liver cancers","volume":"11","author":"Wang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.fsi.2024.109958_bib52","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1089\/jop.2014.0018","article-title":"IL-10 function, regulation, and in bacterial keratitis","volume":"30","author":"Hazlett","year":"2014","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.fsi.2024.109958_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fsi.2019.10.023","article-title":"Tongue sole (Cynoglossus semilaevis) interleukin 10 plays a negative role in the immune response against bacterial infection","volume":"95","author":"Li","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib54","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fsi.2020.01.063","article-title":"Immune and gut bacterial successions of large yellow croaker (Larimichthys crocea) during Pseudomonas plecoglossicida infection","volume":"99","author":"Li","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.109004","article-title":"Interleukin-8 involved in Nile Tilapia (Oreochromis niloticus) against bacterial infection","volume":"141","author":"Li","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib56","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.dci.2011.04.002","article-title":"CXCL8 of Scophthalmus maximus: expression, biological activity and immunoregulatory effect","volume":"35","author":"Hu","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib57","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/jfb.14934","article-title":"Insights into the functional role of grass carp IL-8 in head kidney leukocytes: pro-inflammatory effects and signalling mechanisms","volume":"100","author":"Zhao","year":"2022","journal-title":"J. Fish. Biol."},{"key":"10.1016\/j.fsi.2024.109958_bib58","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.fsi.2018.07.028","article-title":"Characterization of MyD88 in Japanese eel, Anguilla japonica","volume":"81","author":"Huang","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2020.110485","article-title":"Functional characterization of myeloid differentiation factor 88 in Nile tilapia (Oreochromis niloticus)","volume":"250","author":"Trung","year":"2020","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.fsi.2024.109958_bib60","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.fsi.2021.12.030","article-title":"Salmonid MyD88 is a key adapter protein that activates innate effector mechanisms through the TLR5M\/TLR5S signaling pathway and protects against Piscirickettsia salmonis infection","volume":"121","author":"Munoz-Flores","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib61","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002393RR","article-title":"Fish NF-kappaB couples TCR and IL-17 signals to regulate ancestral T-cell immune response against bacterial infection","volume":"35","author":"Wei","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.fsi.2024.109958_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103772","article-title":"Fish lysozyme gene family evolution and divergent function in early development","volume":"114","author":"Li","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2021.104232","article-title":"Identification and characterization of the c-type lysozyme gene from a marine fish, Bostrychus sinensis","volume":"125","author":"Shen","year":"2021","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109958_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2022.104412","article-title":"Characterization and functional analysis of a c-type lysozyme gene from obscure puffer Takifugu obscurus","volume":"133","author":"Wang","year":"2022","journal-title":"Dev. Comp. Immunol."}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482400603X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S105046482400603X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:53:24Z","timestamp":1752623604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S105046482400603X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":64,"alternative-id":["S105046482400603X"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109958","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR\/NF\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109958"}}