{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:09:08Z","timestamp":1793660948121,"version":"4.5.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002664","name":"Hunan Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010038","name":"Earmarked Fund for China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-45"],"award-info":[{"award-number":["CARS-45"]}],"id":[{"id":"10.13039\/501100010038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.fsi.2024.109968","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T14:12:42Z","timestamp":1729001562000},"page":"109968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["bcIRF5 activates bcTBK1 phosphorylation to enhance PANoptosis during GCRV infection"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-8980","authenticated-orcid":false,"given":"Can","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonggui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7089","key":"10.1016\/j.fsi.2024.109968_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature04734","article-title":"Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses","volume":"441","author":"Kato","year":"2006","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.fsi.2024.109968_bib2","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.4049\/jimmunol.2200508","article-title":"PANoptosis: a unique innate immune inflammatory cell death modality","volume":"209","author":"Pandian","year":"2022","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109968_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.056","article-title":"TBK1 and IKK\u03b5 act redundantly to mediate STING-induced NF-\u03baB responses in myeloid cells","volume":"31","author":"Balka","year":"2020","journal-title":"Cell Rep."},{"issue":"25","key":"10.1016\/j.fsi.2024.109968_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg2339","article-title":"VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation","volume":"9","author":"Hu","year":"2023","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.fsi.2024.109968_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111469","article-title":"Vimentin inhibits type I interferon production by disrupting the TBK1-IKK\u03b5-IRF3 axis","volume":"41","author":"Liu","year":"2022","journal-title":"Cell Rep."},{"issue":"214","key":"10.1016\/j.fsi.2024.109968_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal."},{"issue":"7950","key":"10.1016\/j.fsi.2024.109968_bib7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41586-023-05704-6","article-title":"Targeting TBK1 to overcome resistance to cancer immunotherapy","volume":"615","author":"Sun","year":"2023","journal-title":"Nature"},{"issue":"7269","key":"10.1016\/j.fsi.2024.109968_bib8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.fsi.2024.109968_bib9","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41556-018-0229-6","article-title":"TBK1 and IKK\u03b5 prevent TNF-induced cell death by RIPK1 phosphorylation","volume":"20","author":"Lafont","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"17","key":"10.1016\/j.fsi.2024.109968_bib10","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1016\/j.cell.2021.07.026","article-title":"Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death","volume":"184","author":"Taft","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2024.109968_bib11","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/j.ijbiomac.2021.06.022","article-title":"A review on the role of TANK-binding kinase 1 signaling in cancer","volume":"183","author":"Alam","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109968_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13046-022-02352-y","article-title":"The role of TBK1 in cancer pathogenesis and anticancer immunity","volume":"41","author":"Runde","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.fsi.2024.109968_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.molcel.2023.11.040","article-title":"The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death","volume":"84","author":"Ai","year":"2024","journal-title":"Mol. Cell."},{"issue":"7\u20138","key":"10.1016\/j.fsi.2024.109968_bib14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s10495-020-01610-8","article-title":"Smac mimetics can provoke lytic cell death that is neither apoptotic nor necroptotic","volume":"25","author":"Miles","year":"2020","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.fsi.2024.109968_bib15","doi-asserted-by":"crossref","first-page":"F4","DOI":"10.1152\/ajprenal.00275.2023","article-title":"Cell death induced by acute renal injury: a perspective on the contributions of accidental and programmed cell death","volume":"327","author":"Noh","year":"2024","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.fsi.2024.109968_bib16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.fsi.2024.109968_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"Newton","year":"2024","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.fsi.2024.109968_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.fsi.2024.109968_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101849","article-title":"Regulated cell death in neutrophils: from apoptosis to NETosis and pyroptosis","volume":"70","author":"Dejas","year":"2023","journal-title":"Semin. Immunol."},{"issue":"3","key":"10.1016\/j.fsi.2024.109968_bib20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxidants Redox Signal."},{"issue":"9","key":"10.1016\/j.fsi.2024.109968_bib21","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.7150\/thno.71086","article-title":"Pyroptosis in inflammatory diseases and cancer","volume":"12","author":"Rao","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.fsi.2024.109968_bib22","article-title":"Ferroptosis and musculoskeletal diseases: \"Iron Maiden\" cell death may be a promising therapeutic target","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109968_bib23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/imr.13279","article-title":"PANoptosis: mechanisms, biology, and role in disease","volume":"321","author":"Sun","year":"2024","journal-title":"Immunol. Rev."},{"issue":"3","key":"10.1016\/j.fsi.2024.109968_bib24","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191644","article-title":"Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease","volume":"217","author":"Malireddi","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.fsi.2024.109968_bib25","article-title":"Advances in mechanism and regulation of PANoptosis: prospects in disease treatment","volume":"14","author":"Zhu","year":"2023","journal-title":"Front. Immunol."},{"issue":"14","key":"10.1016\/j.fsi.2024.109968_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00390-17","article-title":"Grass carp reovirus VP41 targets fish MITA to abrogate the interferon response","volume":"91","author":"Lu","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2024.109968_bib27","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.fsi.2022.06.022","article-title":"Non-pathogenic grass carp reovirus infection leads to both apoptosis and autophagy in a grass carp cell line","volume":"127","author":"Dai","year":"2022","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"10.1016\/j.fsi.2024.109968_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.dci.2014.09.009","article-title":"Grass carp SARM1 and its two splice variants negatively regulate IFN-I response and promote cell death upon GCRV infection at different subcellular locations","volume":"48","author":"Yan","year":"2015","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109968_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2019.103426","article-title":"Black carp IRF5 interacts with TBK1 to trigger cell death following viral infection","volume":"100","author":"Yang","year":"2019","journal-title":"Dev. Comp. Immunol."},{"issue":"37","key":"10.1016\/j.fsi.2024.109968_bib30","doi-asserted-by":"crossref","first-page":"13469","DOI":"10.1073\/pnas.1405414111","article-title":"Two apextrin-like proteins mediate extracellular and intracellular bacterial recognition in amphioxus","volume":"111","author":"Huang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.fsi.2024.109968_bib31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41419-020-2625-7","article-title":"Annexin-A1 promotes RIG-I-dependent signaling and apoptosis via regulation of the IRF3-IFNAR-STAT1-IFIT1 pathway in A549 lung epithelial cells","volume":"11","author":"Yap","year":"2020","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.fsi.2024.109968_bib32","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/cdd.2009.190","article-title":"Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells","volume":"17","author":"Weber","year":"2010","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.fsi.2024.109968_bib33","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1097\/HEP.0000000000000611","article-title":"Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1","volume":"79","author":"Zhuang","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.fsi.2024.109968_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109772","article-title":"Cell death signalling in virus infection","volume":"76","author":"Imre","year":"2020","journal-title":"Cell. Signal."},{"issue":"6","key":"10.1016\/j.fsi.2024.109968_bib35","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cbin.11137","article-title":"Cell death: a review of the major forms of apoptosis, necrosis and autophagy","volume":"43","author":"D'Arcy","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.fsi.2024.109968_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109595","article-title":"Pyroptosis: a new frontier in cancer","volume":"121","author":"Fang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.fsi.2024.109968_bib37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.revmed.2023.03.016","article-title":"[Extensive cutaneous necrosis]","volume":"44","author":"Oubelkacem","year":"2023","journal-title":"Rev. Med. Interne"},{"key":"10.1016\/j.fsi.2024.109968_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.169642","article-title":"Gut microbiota disorders aggravate terbuthylazine-induced mitochondrial quality control disturbance and PANoptosis in chicken hepatocyte through gut-liver axis","volume":"913","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.fsi.2024.109968_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2024.106554","article-title":"PLA inhibits TNF-\u03b1-induced PANoptosis of prostate cancer cells through metabolic reprogramming","volume":"169","author":"Hao","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"6","key":"10.1016\/j.fsi.2024.109968_bib40","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cell.2018.07.041","article-title":"TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging","volume":"174","author":"Xu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2024.109968_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbrc.2021.12.047","article-title":"IKK\u03b5 protects against starvation-induced NLRP3 inflammasome and pyroptosis in H9c2 cells by alleviating mitochondrial injury","volume":"589","author":"Chen","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6227","key":"10.1016\/j.fsi.2024.109968_bib42","doi-asserted-by":"crossref","first-page":"aaa2630","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824006132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824006132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:53:41Z","timestamp":1752623621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464824006132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":42,"alternative-id":["S1050464824006132"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109968","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"bcIRF5 activates bcTBK1 phosphorylation to enhance PANoptosis during GCRV infection","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109968"}}