{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:20:30Z","timestamp":1790000430572,"version":"4.0.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011052","name":"Federal State Budget Scientific Institution Research Institute - Republican Research and Consulting Center of Expertise","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2024XT0501"],"award-info":[{"award-number":["2024XT0501"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2023SJXT2"],"award-info":[{"award-number":["2023SJXT2"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2023GH02"],"award-info":[{"award-number":["2023GH02"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2024CG02"],"award-info":[{"award-number":["2024CG02"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2022-SPY-00-018"],"award-info":[{"award-number":["2022-SPY-00-018"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2023TD49"],"award-info":[{"award-number":["2023TD49"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005906","name":"Chinese Academy of Fishery Sciences","doi-asserted-by":"publisher","award":["2022SJ-XK2"],"award-info":[{"award-number":["2022SJ-XK2"]}],"id":[{"id":"10.13039\/501100005906","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012428","name":"Chinese Academy of Fishery Sciences Central Public-interest Scientific Institution Basal Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish &amp; Shellfish Immunology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.fsi.2024.109969","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:27:29Z","timestamp":1729052849000},"page":"109969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Escherichia coli heat-labile enterotoxin B subunit as an adjuvant of mucosal immune combined with GCRV-II VP6 triggers innate immunity and enhances adaptive immune responses following oral vaccination of grass carp (Ctenopharyngodon idella)"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-9802","authenticated-orcid":false,"given":"Jiyuan","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubing","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houjun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2024.109969_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/670437","article-title":"Insights into the antiviral immunity against grass carp (ctenopharyngodon idella) reovirus (gcrv) in grass carp","volume":"2015","author":"Rao","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.fsi.2024.109969_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.fsi.2013.04.022","article-title":"Development of a novel candidate subunit vaccine against grass carp reovirus guangdong strain (gcrv-gd108)","volume":"35","author":"Tian","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2023.105077","article-title":"Involvement of transcriptional co-activator p300 in upregulated expression of hsp70 by aquareovirus non-structural protein ns31","volume":"150","author":"Fei","year":"2024","journal-title":"Dev. Comp. Immunol."},{"issue":"Pt 6","key":"10.1016\/j.fsi.2024.109969_bib4","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1099\/0022-1317-78-6-1385","article-title":"Identification of a new genogroup of aquareovirus by rna-rna hybridization","volume":"78","author":"Subramanian","year":"1997","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.fsi.2024.109969_bib5","article-title":"Recombinant lactococcus lactis expressing grass carp reovirus vp6 induces mucosal immunity against grass carp reovirus infection","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02333-12","article-title":"Complete genome sequence of a reovirus isolated from grass carp, indicating different genotypes of gcrv in China","volume":"86","author":"Wang","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2024.109969_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103715","article-title":"Establishment of a cell line from egg of rare minnow gobiocypris rarus for propagation of grass carp reovirus genotype ii","volume":"136","author":"Liu","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fsi.2024.109969_bib8","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.fsi.2019.04.066","article-title":"Progress, challenges and opportunities in fish vaccine development","volume":"90","author":"Adams","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.fsi.2016.04.133","article-title":"Immunogenicity of a cell culture-derived inactivated vaccine against a common virulent isolate of grass carp reovirus","volume":"54","author":"Zeng","year":"2016","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib10","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.fsi.2018.07.012","article-title":"Dna vaccination for finfish aquaculture","volume":"85","author":"Collins","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib11","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s00705-020-04654-y","article-title":"Studies on the clinical symptoms, virus distribution, and mrna expression of several antiviral immunity-related genes in grass carp after infection with genotype ii grass carp reovirus","volume":"165","author":"Wu","year":"2020","journal-title":"Arch. Virol."},{"key":"10.1016\/j.fsi.2024.109969_bib12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3390\/v13050807","article-title":"Identification, virulence, and molecular characterization of a recombinant isolate of grass carp reovirus genotype i","volume":"13","author":"Zeng","year":"2021","journal-title":"Viruses-Basel."},{"key":"10.1016\/j.fsi.2024.109969_bib13","doi-asserted-by":"crossref","first-page":"28647","DOI":"10.3390\/ijms161226118","article-title":"Cloning of the major capsid protein (mcp) of grouper iridovirus of taiwan (tgiv) and preliminary evaluation of a recombinant mcp vaccine against tgiv","volume":"16","author":"Liu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.fsi.2024.109969_bib14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.21775\/cimb.022.079","article-title":"Dna vaccines: regulatory considerations and safety aspects","volume":"22","author":"Myhr","year":"2017","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.fsi.2024.109969_bib15","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.dci.2011.03.007","article-title":"Advances in fish vaccine delivery","volume":"35","author":"Plant","year":"2011","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00415-21","article-title":"Oral probiotic vaccine expressing koi herpesvirus (khv) orf81 protein delivered by chitosan-alginate capsules is a promising strategy for mass oral vaccination of carps against khv infection","volume":"95","author":"Huang","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.fsi.2024.109969_bib17","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1007\/s12010-014-1012-1","article-title":"Enhanced expression of gcrv vp6 in cik cells by relative sequence optimization","volume":"173","author":"Xiao","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.fsi.2024.109969_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fsi.2018.01.047","article-title":"Comparative study of the immunoprotective effect of two dna vaccines against grass carp reovirus","volume":"75","author":"Chen","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib19","first-page":"427","article-title":"A review of the immunological mechanisms following mucosal vaccination of finfish","volume":"6","author":"Munang'Andu","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.fsi.2019.12.010","article-title":"Current use and development of fish vaccines in China","volume":"96","author":"Wang","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.fsi.2012.03.016","article-title":"Oral immunization of rainbow trout to infectious pancreatic necrosis virus (ipnv) induces different immune gene expression profiles in head kidney and pyloric ceca","volume":"33","author":"Ballesteros","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.fsi.2020.03.001","article-title":"Oral immunization with recombinant lactobacillus casei displayed aha1-ck6 and vp2 induces protection against infectious pancreatic necrosis in rainbow trout (oncorhynchus mykiss)","volume":"100","author":"Chen","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s40064-015-0847-4","article-title":"Expression and functional validation of heat-labile enterotoxin b (ltb) and cholera toxin b (ctb) subunits in transgenic rice (oryza sativa)","volume":"4","author":"Soh","year":"2015","journal-title":"SpringerPlus"},{"key":"10.1016\/j.fsi.2024.109969_bib24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijbiomac.2019.12.250","article-title":"Expression in algae of a chimeric protein carrying several epitopes from tumor associated antigens","volume":"147","author":"Hernandez-Ramirez","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.fsi.2024.109969_bib25","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.vaccine.2010.11.091","article-title":"Non-toxic derivatives of lt as potent adjuvants","volume":"29","author":"Da","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2024.109969_bib26","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.fsi.2015.10.029","article-title":"The protective immunity against grass carp reovirus in grass carp induced by a dna vaccination using single-walled carbon nanotubes as delivery vehicles","volume":"47","author":"Wang","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-5699(98)01397-8","article-title":"Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic","volume":"20","author":"Williams","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1016\/j.fsi.2024.109969_bib28","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1016\/j.vaccine.2006.04.036","article-title":"A recombinant chimera composed of r1 repeat region of mycoplasma hyopneumoniae p97 adhesin with escherichia coli heat-labile enterotoxin b subunit elicits immune response in mice","volume":"24","author":"Conceicao","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2024.109969_bib29","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1128\/CVI.05720-11","article-title":"Protection against lethal leptospirosis after vaccination with lipl32 coupled or coadministered with the b subunit of escherichia coli heat-labile enterotoxin","volume":"19","author":"Grassmann","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetmic.2014.07.009","article-title":"Local and systemic immune responses induced by a recombinant chimeric protein containing mycoplasma hyopneumoniae antigens fused to the b subunit of escherichia coli heat-labile enterotoxin ltb","volume":"173","author":"Marchioro","year":"2014","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.fsi.2024.109969_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109439","article-title":"Oral immunization with recombinant l. Lactis expressing gcrv-ii vp4 produces protection against grass carp reovirus infection","volume":"147","author":"Wu","year":"2024","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2022.114663","article-title":"Development of a rapid and sensitive reverse transcription real-time quantitative pcr assay for detection and quantification of grass carp reovirus ii","volume":"312","author":"Li","year":"2023","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.fsi.2024.109969_bib33","first-page":"74","article-title":"Isolation, identification and biological characteristics of lactobacillus from grass carp","volume":"6","author":"Wang","year":"2021","journal-title":"South China Fish. Sci."},{"key":"10.1016\/j.fsi.2024.109969_bib34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.fsi.2014.11.026","article-title":"Protective immunity of grass carp immunized with dna vaccine encoding the vp7 gene of grass carp reovirus using carbon nanotubes as a carrier molecule","volume":"42","author":"Zhu","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib35","first-page":"9","article-title":"Preparation and specification analysis of polyclonal antibody against grass carp reovirus type ii vp6 protein","volume":"1","author":"F","year":"2018","journal-title":"Freshw. Fish."},{"key":"10.1016\/j.fsi.2024.109969_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.fsi.2021.07.014","article-title":"Establishment of a rare minnow (gobiocypris rarus) model for evaluation of experimental vaccines against a disease induced by grass carp reovirus genotype ii","volume":"117","author":"Chen","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.micpath.2017.11.042","article-title":"Development of indirect immunofluorescence assay for tcid(50) measurement of grass carp reovirus genotype ii without cytopathic effect onto cells","volume":"114","author":"Wang","year":"2018","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.fsi.2024.109969_bib38","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.fsi.2011.01.006","article-title":"Evaluation of internal control genes for qrt-pcr normalization in tissues and cell culture for antiviral studies of grass carp (ctenopharyngodon idella)","volume":"30","author":"Su","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib39","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0264-410X(02)00572-8","article-title":"Virus-like particle and dna-based candidate aids vaccines","volume":"21","author":"Yao","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2024.109969_bib40","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3390\/vaccines11081373","article-title":"Vp4\/vp56\/vp35 virus-like particles effectively protect grass carp (ctenopharyngodon idella) against gcrv-ii infection","volume":"11","author":"Tian","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2024.109969_bib41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s11033-016-3984-0","article-title":"Baculovirus-mediated gcrv vp7 and vp6 genes expression in silkworm and grass carp","volume":"43","author":"Liu","year":"2016","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.fsi.2024.109969_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pep.2019.02.007","article-title":"Expression and active testing of vp7 from gcrv (grass carp reovirus) fused with cholera toxin b subunit in rice calli","volume":"158","author":"Zhang","year":"2019","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.fsi.2024.109969_bib43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fsi.2019.07.028","article-title":"Effects of lactococcus lactis from cyprinus carpio l. As probiotics on growth performance, innate immune response and disease resistance against aeromonas hydrophila","volume":"93","author":"Feng","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib44","article-title":"Oral immunization with a m cell-targeting recombinant l. Lactis vaccine ll-plsam-fvpe stimulate protective immunity against h. Pylori in mice","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib45","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.fsi.2018.10.008","article-title":"Oral delivery of bacillus subtilis spores expressing grass carp reovirus vp4 protein produces protection against grass carp reovirus infection","volume":"84","author":"Jiang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib46","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1292\/jvms.19-0057","article-title":"Th1-biased immunoadjuvant effect of the recombinant b subunit of an escherichia coli heat-labile enterotoxin on an inactivated porcine reproductive and respiratory syndrome virus antigen via intranasal immunization in mice","volume":"81","author":"Su","year":"2019","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.fsi.2024.109969_bib47","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/jcmm.12599","article-title":"The b subunit of escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells","volume":"19","author":"Ji","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.fsi.2024.109969_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142090","article-title":"Immunization with a double-mutant (r192g\/l211a) of the heat-labile enterotoxin of escherichia coli offers partial protection against campylobacter jejuni in an adult mouse intestinal colonization model","volume":"10","author":"Albert","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.fsi.2024.109969_bib49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/vaccines9030266","article-title":"Escherichia coli heat-labile enterotoxin b subunit combined with ginsenoside rg1 as an intranasal adjuvant triggers type i interferon signaling pathway and enhances adaptive immune responses to an inactivated prrsv vaccine in icr mice","volume":"9","author":"Su","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.fsi.2024.109969_bib50","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fimmu.2015.00519","article-title":"Oral vaccination of fish - antigen preparations, uptake, and immune induction","volume":"6","author":"Mutoloki","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib51","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000484258","article-title":"Interferon-stimulated genes as enhancers of antiviral innate immune signaling","volume":"10","author":"Crosse","year":"2018","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.fsi.2024.109969_bib52","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1462-5822.2005.00681.x","article-title":"Bacterial-associated cholera toxin and gm1 binding are required for transcytosis of classical biotype vibrio cholerae through an in vitro m cell model system","volume":"8","author":"Blanco","year":"2006","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.fsi.2024.109969_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006862","article-title":"Gm1 ganglioside-independent intoxication by cholera toxin","volume":"14","author":"Cervin","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.fsi.2024.109969_bib54","article-title":"Systemic and mucosal b and t cell responses upon mucosal vaccination of teleost fish","volume":"11","author":"Munoz-Atienza","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib55","doi-asserted-by":"crossref","first-page":"292","DOI":"10.3389\/fcimb.2019.00292","article-title":"Review of newly identified functions associated with the heat-labile toxin of enterotoxigenic escherichia coli","volume":"9","author":"Duan","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.fsi.2024.109969_bib56","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1016\/j.vaccine.2016.08.051","article-title":"An inflammatory response is essential for the development of 5adaptive immunity-immunogenicity and immunotoxicity","volume":"34","author":"Nakayama","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.fsi.2024.109969_bib57","first-page":"333","article-title":"Disentangling the immune response and host-pathogen interactions in francisella noatunensis infected atlantic cod","volume":"30","author":"Solbakken","year":"2019","journal-title":"Comp. Biochem. Physiol. D"},{"key":"10.1016\/j.fsi.2024.109969_bib58","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/vaccines9010041","article-title":"Oral vaccination of grass carp (ctenopharyngodon idella) with baculovirus-expressed grass carp reovirus (gcrv) proteins induces protective immunity against gcrv infection","volume":"9","author":"Mu","year":"2021","journal-title":"Vaccines-Basel."},{"key":"10.1016\/j.fsi.2024.109969_bib59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1128\/CVI.00304-06","article-title":"Protection against porcine reproductive and respiratory syndrome virus (prrsv) infection through passive transfer of prrsv-neutralizing antibodies is dose dependent","volume":"14","author":"Lopez","year":"2007","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.fsi.2024.109969_bib60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/viro.2002.1612","article-title":"Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity","volume":"302","author":"Osorio","year":"2002","journal-title":"Virology"}],"container-title":["Fish &amp; Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824006144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824006144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:53:48Z","timestamp":1752623628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464824006144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":60,"alternative-id":["S1050464824006144"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109969","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Escherichia coli heat-labile enterotoxin B subunit as an adjuvant of mucosal immune combined with GCRV-II VP6 triggers innate immunity and enhances adaptive immune responses following oral vaccination of grass carp (Ctenopharyngodon idella)","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.109969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109969"}}