{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:03:39Z","timestamp":1793480619562,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries","doi-asserted-by":"publisher","award":["RS-2022-KS221670"],"award-info":[{"award-number":["RS-2022-KS221670"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011705","name":"Korea Institute of Marine Science and Technology promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011705","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2019R1A6A1A03033553"],"award-info":[{"award-number":["2019R1A6A1A03033553"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Fish & Shellfish Immunology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.fsi.2024.110089","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T16:37:57Z","timestamp":1733848677000},"page":"110089","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Characterization of tumor necrosis factor receptor-associated factor 2 (TRAF2) in red-spotted grouper (Epinephelus akaara): In vivo and in vitro investigation of its role in the regulation of antiviral immunity and cell death"],"prefix":"10.1016","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5495-6160","authenticated-orcid":false,"given":"E.M.T.","family":"Tharanga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishanthini","family":"Nadarajapillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9701-9266","authenticated-orcid":false,"given":"W.A.D.L.R.","family":"Warnakula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaehyeon","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyerim","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.D.H.E.","family":"Jayasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeganathan Tharshan","family":"Jeyakanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.K.P.","family":"Sirisena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9008-8189","authenticated-orcid":false,"given":"U.P.E.","family":"Arachchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-4622","authenticated-orcid":false,"given":"Jehee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.fsi.2024.110089_bib1","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1038\/sj.onc.1204788","article-title":"Tumor necrosis factor receptor-associated factors (TRAFs)","volume":"20","author":"Bradley","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.fsi.2024.110089_bib2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0898-6568(01)00160-7","article-title":"The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators","volume":"13","author":"Wajant","year":"2001","journal-title":"Cell. Signal."},{"key":"10.1016\/j.fsi.2024.110089_bib3","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/jcs.115.4.679","article-title":"All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction","volume":"115","author":"Chung","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.fsi.2024.110089_bib4","doi-asserted-by":"crossref","first-page":"24242","DOI":"10.1074\/jbc.M100354200","article-title":"A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains","volume":"276","author":"Zapata","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.110089_bib5","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.3389\/fimmu.2018.01999","article-title":"Structure of TRAF family: current understanding of receptor recognition","volume":"9","author":"Park","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-2187-8-7","article-title":"TRAF molecules in cell signaling and in human diseases","volume":"8","author":"Xie","year":"2013","journal-title":"J. Mol. Signal."},{"key":"10.1016\/j.fsi.2024.110089_bib7","doi-asserted-by":"crossref","first-page":"19935","DOI":"10.1074\/jbc.271.33.19935","article-title":"Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins","volume":"271","author":"Takeuchi","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.110089_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2016.03.009","article-title":"TRAF2 multitasking in TNF receptor-induced signaling to NF-\u03baB, MAP kinases and cell death","volume":"116","author":"Borghi","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.fsi.2024.110089_bib9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2015.11.021","article-title":"TRAF2 mediates JNK and STAT3 activation in response to IL-1\u03b2 and IFN\u03b3 and facilitates apoptotic death of insulin-producing \u03b2-cells","volume":"420","author":"Prause","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.fsi.2024.110089_bib10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00785","article-title":"MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades","volume":"2","author":"Liu","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.fsi.2024.110089_bib11","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.molcel.2005.08.014","article-title":"VISA is an adapter protein required for virus-triggered IFN-beta signaling","volume":"19","author":"Xu","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.fsi.2024.110089_bib12","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1091\/mbc.e10-06-0556","article-title":"TRAF2 phosphorylation promotes NF-\u03baB-dependent gene expression and inhibits oxidative stress-induced cell death","volume":"22","author":"Zhang","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.fsi.2024.110089_bib13","doi-asserted-by":"crossref","first-page":"5914","DOI":"10.1128\/MCB.24.13.5914-5922.2004","article-title":"Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death","volume":"24","author":"Shen","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2024.110089_bib14","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1128\/MCB.20.6.2198-2208.2000","article-title":"Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin","volume":"20","author":"Liu","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2024.110089_bib15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.fsi.2018.10.070","article-title":"Molecular characteristics and functional study of tumor necrosis factor receptor-associated factor 2 from the orange-spotted grouper (Epinephelus coioides)","volume":"84","author":"Yang","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib16","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1745-7270.2007.00355.x","article-title":"Molecular identification and expression analysis of tumor necrosis factor receptor-associated factor 2 in grass carp Ctenopharyngodon idella","volume":"39","author":"Xu","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.fsi.2024.110089_bib17","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.fsi.2011.02.007","article-title":"Molecular cloning of rock bream's (Oplegnathus fasciatus) tumor necrosis factor receptor-associated factor 2 and its role in NF-\u03baB activiation","volume":"30","author":"Kim","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.fsi.2022.01.018","article-title":"Characterization of TRAF2 in Nile tilapia: expression profiles and the role in decreasing NF-\u03baB pathway","volume":"122","author":"Hu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fsi.2017.09.069","article-title":"TRAF2 of black carp upregulates MAVS-mediated antiviral signaling during innate immune response","volume":"71","author":"Chen","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.fsi.2020.04.021","article-title":"Fish TRAF2 promotes innate immune response to RGNNV infection","volume":"102","author":"Li","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/raq.12226","article-title":"A review of grouper (Family Serranidae: subfamily Epinephelinae) aquaculture from a sustainability science perspective","volume":"11","author":"Rimmer","year":"2019","journal-title":"Rev. Aquacult."},{"key":"10.1016\/j.fsi.2024.110089_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0044-8486(93)90375-9","article-title":"Effects of feeding frequency on the growth and body constituents of young red-spotted grouper, Epinephelus akaara","volume":"110","author":"Kayano","year":"1993","journal-title":"Aquaculture"},{"key":"10.1016\/j.fsi.2024.110089_bib23","series-title":"Diseases of Cultured Groupers","author":"Nagasawa","year":"2004"},{"key":"10.1016\/j.fsi.2024.110089_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.11.037","article-title":"Thioredoxin domain-containing protein 12 (TXNDC12) in red spotted grouper (Epinephelus akaara): molecular characteristics, disulfide reductase activities, and immune responses","volume":"132","author":"Hanchapola","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.apjtm.2016.06.014","article-title":"Development and application of quantitative detection method for nervous necrosis virus (NNV) isolated from sevenband grouper Hyporthodus septemfasciatus","volume":"9","author":"Kim","year":"2016","journal-title":"Asian Pac. J. Tropical Med."},{"key":"10.1016\/j.fsi.2024.110089_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.fsi.2024.110089_bib27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.fsi.2019.06.015","article-title":"Molecular characterization and expression analysis of rockfish (Sebastes schlegelii) viperin, and its ability to enervate RNA virus transcription and replication in vitro","volume":"92","author":"Shanaka","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib28","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.3390\/v6052204","article-title":"Development and application of quantitative detection method for viral hemorrhagic septicemia virus (VHSV) genogroup IVa","volume":"6","author":"Kim","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.fsi.2024.110089_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s12250-020-00230-5","article-title":"On the calculation of TCID50 for quantitation of virus infectivity","volume":"36","author":"Lei","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.fsi.2024.110089_bib30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.fsi.2024.110089_bib31","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jmb.2010.01.008","article-title":"The RING domain of TRAF2 plays an essential role in the inhibition of TNF\u03b1-induced cell death but not in the activation of NF-\u03baB","volume":"396","author":"Zhang","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.fsi.2024.110089_bib32","article-title":"Signaling to NF-kappaB: regulation by ubiquitination, cold spring harb","volume":"2","author":"Wertz","year":"2010","journal-title":"Perspect. Biol."},{"key":"10.1016\/j.fsi.2024.110089_bib33","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/jcp.24011","article-title":"The seventh ring: exploring TRAF7 functions","volume":"227","author":"Zotti","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.fsi.2024.110089_bib34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1749-6632.1993.tb32280.x","article-title":"The RING finger. A novel protein sequence motif related to the zinc finger","volume":"684","author":"Freemont","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.fsi.2024.110089_bib35","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/0092-8674(95)90149-3","article-title":"The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins","volume":"83","author":"Rothe","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2024.110089_bib36","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/19110","article-title":"Structural basis for self-association and receptor recognition of human TRAF2","volume":"398","author":"Park","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.fsi.2024.110089_bib37","article-title":"Crystal structure of TRAF1 TRAF domain and its implications in the TRAF1-mediated intracellular signaling pathway","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.fsi.2024.110089_bib38","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1111\/febs.13235","article-title":"Drosophila blood cells and their role in immune responses","volume":"282","author":"Vlisidou","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.fsi.2024.110089_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.coi.2003.11.002","article-title":"Blood cells of Drosophila: cell lineages and role in host defence","volume":"16","author":"Meister","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.aqrep.2023.101473","article-title":"Dynamic immune response in the spleens of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus revealed by transcriptome and immune-related genes expression analysis","volume":"29","author":"Pan","year":"2023","journal-title":"Aquac. Reports"},{"key":"10.1016\/j.fsi.2024.110089_bib41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.fsi.2015.03.022","article-title":"Cloning and characterization of three suppressors of cytokine signaling (SOCS) genes from the Pacific oyster, Crassostrea gigas","volume":"44","author":"Li","year":"2015","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.fsi.2011.11.020","article-title":"A novel protein with a fibrinogen-like domain involved in the innate immune response of Marsupenaeus japonicus","volume":"32","author":"Chai","year":"2012","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib43","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1745-7270.2007.00355.x","article-title":"Molecular identification and expression analysis of tumor necrosis factor receptor-associated factor 2 in grass carp Ctenopharyngodon idella","volume":"39","author":"Xu","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.fsi.2024.110089_bib44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.fsi.2017.09.076","article-title":"A molluscan TNF receptor-associated factor 2 (TRAF2) was involved in host defense against immune challenges","volume":"71","author":"Qu","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.fsi.2024.110089_bib45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/excr.1999.4733","article-title":"Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling","volume":"254","author":"Inoue","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.fsi.2024.110089_bib46","doi-asserted-by":"crossref","first-page":"15392","DOI":"10.1074\/jbc.M909520199","article-title":"Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling","volume":"275","author":"Hostager","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.fsi.2024.110089_bib47","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.bbrc.2013.05.107","article-title":"TRAF2 regulates the cytoplasmic\/nuclear distribution of TRAF4 and its biological function in breast cancer cells","volume":"436","author":"Zhang","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.fsi.2024.110089_bib48","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00785","article-title":"MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades","volume":"2","author":"Liu","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.fsi.2024.110089_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.01992","article-title":"Mitochondrial dynamics imbalance: a strategy for promoting viral infection","volume":"11","author":"Ren","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.fsi.2024.110089_bib50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13578-018-0268-5","article-title":"Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction","volume":"9","author":"Xie","year":"2019","journal-title":"Cell Biosci."},{"key":"10.1016\/j.fsi.2024.110089_bib51","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0092-8674(00)80984-8","article-title":"TRADD\u2013TRAF2 and TRADD\u2013FADD interactions define two distinct TNF receptor 1 signal transduction pathways","volume":"84","author":"Hsu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.fsi.2024.110089_bib52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000045282","article-title":"Hydrogen peroxide induces necrosis, apoptosis, oncosis and apoptotic oncosis of mouse terminal proximal straight tubule cells","volume":"81","author":"Takeda","year":"1999","journal-title":"Nephron"},{"key":"10.1016\/j.fsi.2024.110089_bib53","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/sj.cdd.4401249","article-title":"The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells","volume":"10","author":"Troyano","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.fsi.2024.110089_bib54","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1128\/MCB.20.6.2198-2208.2000","article-title":"Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin","volume":"20","author":"Liu","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.fsi.2024.110089_bib55","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00018-022-04230-4","article-title":"Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling","volume":"79","author":"Gehi","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.fsi.2024.110089_bib56","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/onc.2008.301","article-title":"JNK signaling in apoptosis","volume":"27","author":"Dhanasekaran","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.fsi.2024.110089_bib57","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/sj.neo.7900003","article-title":"The apoptosome: heart and soul of the cell death machine","volume":"1","author":"Chinnaiyan","year":"1999","journal-title":"Neoplasia"}],"container-title":["Fish & Shellfish Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824007356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1050464824007356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:37:08Z","timestamp":1737628628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1050464824007356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":57,"alternative-id":["S1050464824007356"],"URL":"https:\/\/doi.org\/10.1016\/j.fsi.2024.110089","relation":{},"ISSN":["1050-4648"],"issn-type":[{"value":"1050-4648","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of tumor necrosis factor receptor-associated factor 2 (TRAF2) in red-spotted grouper (Epinephelus akaara): In vivo and in vitro investigation of its role in the regulation of antiviral immunity and cell death","name":"articletitle","label":"Article Title"},{"value":"Fish & Shellfish Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.fsi.2024.110089","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110089"}}